{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:40:05Z","timestamp":1791322805511,"version":"4.3.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":1889,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1074\/jbc.m114.631705","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T14:34:23Z","timestamp":1432737263000},"page":"17390-17400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional"],"prefix":"10.1016","volume":"290","author":[{"given":"Kim Vanessa","family":"Steinke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Gorinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wojciechowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Todorov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Guseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeni","family":"Ponimaskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Fahlke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M114.631705_bib1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/35107099","article-title":"Barttin is a Cl\u2212 channel \u03b2-subunit crucial for renal Cl\u2212 reabsorption and inner ear K+ secretion","volume":"414","author":"Est\u00e9vez","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.631705_bib2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev.physiol.67.032003.153547","article-title":"Function of chloride channels in the kidney","volume":"67","author":"Uchida","year":"2005","journal-title":"Annu. Rev. Physiol"},{"key":"10.1074\/jbc.M114.631705_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/10409230701829110","article-title":"CLC chloride channels and transporters: from genes to protein structure, pathology, and physiology","volume":"43","author":"Jentsch","year":"2008","journal-title":"Crit. Rev. Biochem. Mol. Biol"},{"key":"10.1074\/jbc.M114.631705_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fphys.2010.00155","article-title":"Physiology and pathophysiology of ClC-K\/barttin channels","volume":"1","author":"Fahlke","year":"2010","journal-title":"Front Physiol"},{"key":"10.1074\/jbc.M114.631705_bib5","doi-asserted-by":"crossref","first-page":"6943","DOI":"10.1073\/pnas.91.15.6943","article-title":"Two highly homologous members of the ClC chloride channel family in both rat and human kidney","volume":"91","author":"Kieferle","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.631705_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/5036","article-title":"Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel","volume":"21","author":"Matsumura","year":"1999","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M114.631705_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ng1097-171","article-title":"Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III","volume":"17","author":"Simon","year":"1997","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M114.631705_bib8","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1056\/NEJMoa032843","article-title":"Salt wasting and deafness resulting from mutations in two chloride channels","volume":"350","author":"Schlingmann","year":"2004","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M114.631705_bib9","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng752","article-title":"Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure","volume":"29","author":"Birkenh\u00e4ger","year":"2001","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M114.631705_bib10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00424-002-0819-8","article-title":"Barttin increases surface expression and changes current properties of ClC-K channels","volume":"444","author":"Waldegger","year":"2002","journal-title":"Pflugers Arch"},{"key":"10.1074\/jbc.M114.631705_bib11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00418-003-0535-2","article-title":"Molecular mechanisms of Bartter syndrome caused by mutations in the BSND gene","volume":"119","author":"Hayama","year":"2003","journal-title":"Histochem. Cell Biol"},{"key":"10.1074\/jbc.M114.631705_bib12","doi-asserted-by":"crossref","first-page":"11411","DOI":"10.1073\/pnas.0601631103","article-title":"Barttin modulates trafficking and function of ClC-K channels","volume":"103","author":"Scholl","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.631705_bib13","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1681\/ASN.2009121274","article-title":"Barttin activates ClC-K channel function by modulating gating","volume":"21","author":"Fischer","year":"2010","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.M114.631705_bib14","doi-asserted-by":"crossref","first-page":"20213","DOI":"10.1073\/pnas.1108497108","article-title":"Palmitoylation influences the function and pharmacology of sodium channels","volume":"108","author":"Bosmans","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.631705_bib15","doi-asserted-by":"crossref","first-page":"26465","DOI":"10.1074\/jbc.271.43.26465","article-title":"Identification of palmitoylation sites within the L-type calcium channel \u03b22a subunit and effects on channel function","volume":"271","author":"Chien","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631705_bib16","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1073\/pnas.95.8.4690","article-title":"Unique regulatory properties of the type 2a Ca2+ channel \u03b2 subunit caused by palmitoylation","volume":"95","author":"Qin","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.631705_bib17","doi-asserted-by":"crossref","first-page":"8709","DOI":"10.1074\/jbc.R110.210005","article-title":"Ion channel regulation by protein palmitoylation","volume":"286","author":"Shipston","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631705_bib18","doi-asserted-by":"crossref","first-page":"21006","DOI":"10.1073\/pnas.0806700106","article-title":"Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels","volume":"105","author":"Tian","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M114.631705_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/09687680802620369","article-title":"Palmitoylation of membrane proteins (Review)","volume":"26","author":"Charollais","year":"2009","journal-title":"Mol. Membr. Biol"},{"key":"10.1074\/jbc.M114.631705_bib20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuron.2005.06.035","article-title":"Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites","volume":"47","author":"Hayashi","year":"2005","journal-title":"Neuron"},{"key":"10.1074\/jbc.M114.631705_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuron.2009.08.017","article-title":"Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking","volume":"64","author":"Hayashi","year":"2009","journal-title":"Neuron"},{"key":"10.1074\/jbc.M114.631705_bib22","doi-asserted-by":"crossref","first-page":"33307","DOI":"10.1074\/jbc.M110.153940","article-title":"Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels","volume":"285","author":"Jeffries","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631705_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrn2059","article-title":"Lipid raft microdomains and neurotransmitter signalling","volume":"8","author":"Allen","year":"2007","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1074\/jbc.M114.631705_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuron.2011.05.033","article-title":"S-Nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95","volume":"71","author":"Ho","year":"2011","journal-title":"Neuron"},{"key":"10.1074\/jbc.M114.631705_bib25","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1074\/jbc.M106529200","article-title":"The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity","volume":"277","author":"Ponimaskin","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631705_bib26","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1124\/mol.107.037085","article-title":"Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling","volume":"72","author":"Renner","year":"2007","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M114.631705_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/09687680802680108","article-title":"Palmitoylation cycles and regulation of protein function","volume":"26","author":"Baekkeskov","year":"2009","journal-title":"Mol. Membr. Biol"},{"key":"10.1074\/jbc.M114.631705_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1681\/ASN.2008010102","article-title":"Disease-causing dysfunctions of barttin in Bartter syndrome type IV","volume":"20","author":"Janssen","year":"2009","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.M114.631705_bib29","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ajhg.2009.07.003","article-title":"Molecular basis of DFNB73: mutations of BSND can cause nonsyndromic deafness or Bartter syndrome","volume":"85","author":"Riazuddin","year":"2009","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M114.631705_bib30","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1016\/j.bbamem.2014.05.017","article-title":"Targeting kidney CLC-K channels: Pharmacological profile in a human cell line versus Xenopus oocytes","volume":"1838","author":"Imbrici","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M114.631705_bib31","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1529\/biophysj.104.056093","article-title":"Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels","volume":"89","author":"Hebeisen","year":"2005","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M114.631705_bib32","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/nprot.2007.225","article-title":"Palmitoylated proteins: purification and identification","volume":"2","author":"Wan","year":"2007","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.M114.631705_bib33","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1681\/ASN.2006060633","article-title":"Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors","volume":"18","author":"Hautmann","year":"2007","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.M114.631705_bib34","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1085\/jgp.112.6.651","article-title":"Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome","volume":"112","author":"Sesti","year":"1998","journal-title":"J. Gen. Physiol"},{"key":"10.1074\/jbc.M114.631705_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/270265a0","article-title":"Sodium channels in nerve apparently have two conductance states","volume":"270","author":"Sigworth","year":"1977","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.631705_bib36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1085\/jgp.200810155","article-title":"Channel-like slippage modes in the human anion\/proton exchanger ClC-4","volume":"133","author":"Alekov","year":"2009","journal-title":"J. Gen. Physiol"},{"key":"10.1074\/jbc.M114.631705_bib37","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1074\/jbc.M110.187492","article-title":"Hetero-oligomerization of neuronal glutamate transporters","volume":"286","author":"Nothmann","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631705_bib38","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/j.1460-2075.1986.tb04473.x","article-title":"Different oligosaccharide processing of the membrane-integrated and the secretory form of gp 80 in rat liver","volume":"5","author":"Tauber","year":"1986","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M114.631705_bib39","doi-asserted-by":"crossref","first-page":"9772","DOI":"10.1074\/jbc.M110904200","article-title":"Trafficking and cell surface stability of the epithelial Na+ channel expressed in epithelial Madin-Darby canine kidney cells","volume":"277","author":"Hanwell","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M114.631705_bib40","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.1542\/peds.108.1.e5","article-title":"Hypokalemic salt-losing tubulopathy with chronic renal failure and sensorineural deafness","volume":"108","author":"Jeck","year":"2001","journal-title":"Pediatrics"},{"key":"10.1074\/jbc.M114.631705_bib41","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/ajmg.1320590411","article-title":"Infantile variant of Bartter syndrome and sensorineural deafness: a new autosomal recessive disorder","volume":"59","author":"Landau","year":"1995","journal-title":"Am. J. Med. Genet"},{"key":"10.1074\/jbc.M114.631705_bib42","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1021\/cb400380s","article-title":"Profiling targets of the irreversible palmitoylation inhibitor 2-bromopalmitate","volume":"8","author":"Davda","year":"2013","journal-title":"ACS Chem. Biol"},{"key":"10.1074\/jbc.M114.631705_bib43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature01772","article-title":"T-type calcium channel regulation by specific G-protein \u03b2\u03b3 subunits","volume":"424","author":"Wolfe","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.631705_bib44","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.bbrc.2007.08.097","article-title":"Barttin binds to the outer lateral surface of the ClC-K2 chloride channel","volume":"362","author":"Tajima","year":"2007","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M114.631705_bib45","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/415287a","article-title":"X-ray structure of a ClC chloride channel at 3.0 \u00c5 reveals the molecular basis of anion selectivity","volume":"415","author":"Dutzler","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.631705_bib46","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1529\/biophysj.105.073395","article-title":"Molecular dynamics simulations of model trans-membrane peptides in lipid bilayers: a systematic investigation of hydrophobic mismatch","volume":"90","author":"Kandasamy","year":"2006","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M114.631705_bib47","first-page":"F678","article-title":"Localization and induction by dehydration of ClC-K chloride channels in the rat kidney","volume":"272","author":"Vandewalle","year":"1997","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M114.631705_bib48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1042\/BST20120243","article-title":"Palmitoylation and the trafficking of peripheral membrane proteins","volume":"41","author":"Chamberlain","year":"2013","journal-title":"Biochem. Soc. Trans"},{"key":"10.1074\/jbc.M114.631705_bib49","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature07605","article-title":"Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation","volume":"456","author":"Kang","year":"2008","journal-title":"Nature"},{"key":"10.1074\/jbc.M114.631705_bib50","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cell.2010.04.007","article-title":"The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins","volume":"141","author":"Rocks","year":"2010","journal-title":"Cell"},{"key":"10.1074\/jbc.M114.631705_bib51","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/ndt\/gfl493","article-title":"Unusual adult-onset manifestation of an attenuated Bartter's syndrome type IV renal phenotype caused by a mutation in BSND","volume":"22","author":"Brum","year":"2007","journal-title":"Nephrol. Dial. Transplant"},{"key":"10.1074\/jbc.M114.631705_bib52","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00467-006-0062-1","article-title":"Mutation G47R in the BSND gene causes Bartter syndrome with deafness in two Spanish families","volume":"21","author":"Garc\u00eda-Nieto","year":"2006","journal-title":"Pediatr. Nephrol"},{"key":"10.1074\/jbc.M114.631705_bib53","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1210\/jc.2002-021398","article-title":"Atypical Bartter syndrome with sensorineural deafness with G47R mutation of the \u03b2-subunit for ClC-Ka and ClC-Kb chloride channels, barttin","volume":"88","author":"Miyamura","year":"2003","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M114.631705_bib54","first-page":"69","article-title":"Renal dysfunction and barttin expression in Bartter syndrome Type IV associated with a G47R mutation in BSND in a family","volume":"75","author":"Park","year":"2011","journal-title":"Clin. Nephrol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820353436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820353436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M114.631705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T07:42:02Z","timestamp":1620286922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820353436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":54,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0021925820353436"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m114.631705","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M114.631705","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}