{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:25:18Z","timestamp":1793075118281,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"30","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":1889,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1074\/jbc.m115.641746","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T16:34:38Z","timestamp":1433954078000},"page":"18467-18477","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":191,"title":["\u03b1-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease"],"prefix":"10.1016","volume":"290","author":[{"given":"Tatiana K.","family":"Rostovtseva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Gurnev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Protchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Hoogerheide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thai Leong","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline C.","family":"Philpott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey M.","family":"Bezrukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.641746_bib1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1471-4159.2008.05604.x","article-title":"Mitochondrial alterations in Parkinson's disease: new clues","volume":"107","author":"Vila","year":"2008","journal-title":"J. Neurochem"},{"key":"10.1074\/jbc.M115.641746_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jns.2012.05.030","article-title":"Mitochondria, oxidative stress and neurodegeneration","volume":"322","author":"Federico","year":"2012","journal-title":"J. Neurol. Sci"},{"key":"10.1074\/jbc.M115.641746_bib3","doi-asserted-by":"crossref","first-page":"20710","DOI":"10.1074\/jbc.M110.213538","article-title":"Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein \u03b1-synuclein","volume":"286","author":"Nakamura","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.641746_bib4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.641746_bib5","first-page":"33","article-title":"Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy as \u03b1-synucleinopathies","volume":"62","author":"Goedert","year":"2001","journal-title":"Methods Mol. Med"},{"key":"10.1074\/jbc.M115.641746_bib6","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1074\/jbc.M710012200","article-title":"Mitochondrial import and accumulation of \u03b1-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain","volume":"283","author":"Devi","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.641746_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s13311-013-0182-9","article-title":"\u03b1-Synuclein and mitochondria: partners in crime?","volume":"10","author":"Nakamura","year":"2013","journal-title":"Neurotherapeutics"},{"key":"10.1074\/jbc.M115.641746_bib8","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.febslet.2010.03.012","article-title":"\u03b1-Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease","volume":"584","author":"Banerjee","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M115.641746_bib9","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.neurobiolaging.2013.11.008","article-title":"The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant \u03b1-synuclein transgenic mice","volume":"35","author":"Martin","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M115.641746_bib10","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1097\/WNR.0b013e3282f03db4","article-title":"Localization of \u03b1-synuclein to mitochondria within midbrain of mice","volume":"18","author":"Li","year":"2007","journal-title":"Neuroreport"},{"key":"10.1074\/jbc.M115.641746_bib11","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the \u03b1-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M115.641746_bib12","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","article-title":"\u03b1-Synuclein locus triplication causes Parkinson's disease","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M115.641746_bib13","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1212\/WNL.0b013e31828727ba","article-title":"A novel \u03b1-synuclein missense mutation in Parkinson disease","volume":"80","author":"Proukakis","year":"2013","journal-title":"Neurology"},{"key":"10.1074\/jbc.M115.641746_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/B978-0-12-385883-2.00011-4","article-title":"Molecular insights into Parkinson's disease","volume":"107","author":"Rochet","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci"},{"key":"10.1074\/jbc.M115.641746_bib15","doi-asserted-by":"crossref","first-page":"13709","DOI":"10.1021\/bi961799n","article-title":"NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded","volume":"35","author":"Weinreb","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M115.641746_bib16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbamem.2011.07.032","article-title":"Biophysics of \u03b1-synuclein membrane interactions","volume":"1818","author":"Pfefferkorn","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.641746_bib17","doi-asserted-by":"crossref","first-page":"12305","DOI":"10.1523\/JNEUROSCI.3088-08.2008","article-title":"Optical reporters for the conformation of \u03b1-synuclein reveal a specific interaction with mitochondria","volume":"28","author":"Nakamura","year":"2008","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M115.641746_bib18","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1002\/cbic.201402281","article-title":"\u03b1-Synuclein binds to the inner membrane of mitochondria in an \u03b1-helical conformation","volume":"15","author":"Robotta","year":"2014","journal-title":"Chembiochem"},{"key":"10.1074\/jbc.M115.641746_bib19","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.yexcr.2008.03.012","article-title":"Mitochondrial translocation of \u03b1-synuclein is promoted by intracellular acidification","volume":"314","author":"Cole","year":"2008","journal-title":"Exp. Cell Res"},{"key":"10.1074\/jbc.M115.641746_bib20","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/abbs\/gms114","article-title":"Voltage-dependent anion channel involved in the \u03b1-synuclein-induced dopaminergic neuron toxicity in rats","volume":"45","author":"Lu","year":"2013","journal-title":"Acta Biochim. Biophys. Sin"},{"key":"10.1074\/jbc.M115.641746_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/B:MCBI.0000009862.17396.8d","article-title":"VDAC: the channel at the interface between mitochondria and the cytosol","volume":"256","author":"Colombini","year":"2004","journal-title":"Mol. Cell Biochem"},{"key":"10.1074\/jbc.M115.641746_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbadis.2005.10.006","article-title":"Voltage-dependent anion channel (VDAC) as mitochondrial governator: thinking outside the box","volume":"1762","author":"Lemasters","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.641746_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10863-005-6566-8","article-title":"On the role of VDAC in apoptosis: fact and fiction","volume":"37","author":"Rostovtseva","year":"2005","journal-title":"J. Bioenerg. Biomembr"},{"key":"10.1074\/jbc.M115.641746_bib24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1385\/CBB:39:3:279","article-title":"The voltage-dependent anion channel: characterization, modulation, and role in mitochondrial function in cell life and death","volume":"39","author":"Shoshan-Barmatz","year":"2003","journal-title":"Cell Biochem. Biophys"},{"key":"10.1074\/jbc.M115.641746_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mito.2011.04.001","article-title":"VDAC, a multi-functional mitochondrial protein as a pharmacological target","volume":"12","author":"Shoshan-Barmatz","year":"2012","journal-title":"Mitochondrion"},{"key":"10.1074\/jbc.M115.641746_bib26","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1124\/jpet.112.192153","article-title":"Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells","volume":"342","author":"Maldonado","year":"2012","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1074\/jbc.M115.641746_bib27","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.bbamem.2011.11.004","article-title":"VDAC inhibition by tubulin and its physiological implications","volume":"1818","author":"Rostovtseva","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.641746_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mam.2010.03.002","article-title":"VDAC, a multi-functional mitochondrial protein regulating cell life and death","volume":"31","author":"Shoshan-Barmatz","year":"2010","journal-title":"Mol. Aspects Med"},{"key":"10.1074\/jbc.M115.641746_bib29","doi-asserted-by":"crossref","first-page":"28006","DOI":"10.1074\/jbc.271.45.28006","article-title":"ATP flux is controlled by a voltage-gated channel from the mitochondrial outer membrane","volume":"271","author":"Rostovtseva","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.641746_bib30","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1021\/jp908092e","article-title":"Tryptophan probes at the \u03b1-synuclein and membrane interface","volume":"114","author":"Pfefferkorn","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"10.1074\/jbc.M115.641746_bib31","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.bpj.2013.12.028","article-title":"\u03b1-Synuclein lipid-dependent membrane binding and translocation through the \u03b1-hemolysin channel","volume":"106","author":"Gurnev","year":"2014","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M115.641746_bib32","doi-asserted-by":"crossref","first-page":"37496","DOI":"10.1074\/jbc.M602548200","article-title":"Voltage gating of VDAC is regulated by nonlamellar lipids of mitochondrial membranes","volume":"281","author":"Rostovtseva","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.641746_bib33","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0006-3495(87)83298-8","article-title":"Data transformations for improved display and fitting of single-channel dwell time histograms","volume":"52","author":"Sigworth","year":"1987","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M115.641746_bib34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/cdd.2012.142","article-title":"The Ca2+\/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca2+ levels to \u03b1-synuclein toxicity in Parkinson's disease models","volume":"20","author":"B\u00fcttner","year":"2013","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M115.641746_bib35","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.bbabio.2010.01.031","article-title":"Characterization of human VDAC isoforms: a peculiar function for VDAC3?","volume":"1797","author":"De Pinto","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.641746_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(91)94004-V","article-title":"Getting started with yeast","volume":"194","author":"Sherman","year":"1991","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M115.641746_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055848","article-title":"A powerful yeast model to investigate the synergistic interaction of \u03b1-synuclein and \u03c4 in neurodegeneration","volume":"8","author":"Ciaccioli","year":"2013","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M115.641746_bib38","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.febslet.2011.06.008","article-title":"Tubulin-blocked state of VDAC studied by polymer and ATP partitioning","volume":"585","author":"Gurnev","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M115.641746_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF01871775","article-title":"Voltage gating in the mitochondrial channel, VDAC","volume":"111","author":"Colombini","year":"1989","journal-title":"J. Membr. Biol"},{"key":"10.1074\/jbc.M115.641746_bib40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0005-2736(03)00113-5","article-title":"Probing the volume changes during voltage gating of Porin 31BM channel with nonelectrolyte polymers","volume":"1612","author":"Carneiro","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.641746_bib41","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.bbamem.2014.01.001","article-title":"VDAC electronics: 1. VDAC-hexo(gluco)kinase generator of the mitochondrial outer membrane potential","volume":"1838","author":"Lemeshko","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.641746_bib42","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/S0006-3495(97)78841-6","article-title":"VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial function","volume":"72","author":"Rostovtseva","year":"1997","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M115.641746_bib43","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1085\/jgp.61.6.687","article-title":"Ionic blockage of sodium channels in nerve","volume":"61","author":"Woodhull","year":"1973","journal-title":"J. Gen. Physiol"},{"key":"10.1074\/jbc.M115.641746_bib44","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1085\/jgp.96.5.921","article-title":"Voltage-dependent block of anthrax toxin channels in planar phospholipid bilayer membranes by symmetric tetraalkylammonium ions. Single-channel analysis","volume":"96","author":"Blaustein","year":"1990","journal-title":"J. Gen. Physiol"},{"key":"10.1074\/jbc.M115.641746_bib45","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1529\/biophysj.104.044453","article-title":"Field-dependent effect of crown ether (18-crown-6) on ionic conductance of \u03b1-hemolysin channels","volume":"87","author":"Bezrukov","year":"2004","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M115.641746_bib46","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1529\/biophysj.104.057406","article-title":"Interactions of peptides with a protein pore","volume":"89","author":"Movileanu","year":"2005","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M115.641746_bib47","doi-asserted-by":"crossref","first-page":"14034","DOI":"10.1021\/ja0749340","article-title":"Catalyzing the translocation of polypeptides through attractive interactions","volume":"129","author":"Wolfe","year":"2007","journal-title":"J. Am. Chem. Soc"},{"key":"10.1074\/jbc.M115.641746_bib48","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0298-106","article-title":"Ala30Pro mutation in the gene encoding \u03b1-synuclein in Parkinson's disease","volume":"18","author":"Kr\u00fcger","year":"1998","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M115.641746_bib49","doi-asserted-by":"crossref","first-page":"14369","DOI":"10.1021\/bi701275p","article-title":"Helical \u03b1-synuclein forms highly conductive ion channels","volume":"46","author":"Zakharov","year":"2007","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M115.641746_bib50","doi-asserted-by":"crossref","first-page":"18746","DOI":"10.1073\/pnas.0806303105","article-title":"Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration","volume":"105","author":"Rostovtseva","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.641746_bib51","doi-asserted-by":"crossref","first-page":"19720","DOI":"10.1073\/pnas.0808296105","article-title":"Enhanced translocation of single DNA molecules through \u03b1-hemolysin nanopores by manipulation of internal charge","volume":"105","author":"Maglia","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.641746_bib52","doi-asserted-by":"crossref","first-page":"17742","DOI":"10.1073\/pnas.0809634105","article-title":"The crystal structure of mouse VDAC1 at 2.3 \u00c5 resolution reveals mechanistic insights into metabolite gating","volume":"105","author":"Ujwal","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.641746_bib53","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.cell.2012.03.037","article-title":"Direct observation of the interconversion of normal and toxic forms of \u03b1-synuclein","volume":"149","author":"Cremades","year":"2012","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.641746_bib54","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1073\/pnas.97.9.4897","article-title":"Fiber diffraction of synthetic \u03b1-synuclein filaments shows amyloid-like cross-\u03b2 conformation","volume":"97","author":"Serpell","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.641746_bib55","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1074\/jbc.273.16.9443","article-title":"Stabilization of \u03b1-synuclein secondary structure upon binding to synthetic membranes","volume":"273","author":"Davidson","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.641746_bib56","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/3311","article-title":"Accelerated in vitro fibril formation by a mutant \u03b1-synuclein linked to early-onset Parkinson disease","volume":"4","author":"Conway","year":"1998","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.641746_bib57","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1021\/bi027363r","article-title":"Role of \u03b1-synuclein carboxy-terminus on fibril formation in vitro","volume":"42","author":"Murray","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M115.641746_bib58","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0014-5793(98)01146-6","article-title":"Synthetic filaments assembled from C-terminally truncated \u03b1-synuclein","volume":"436","author":"Crowther","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M115.641746_bib59","doi-asserted-by":"crossref","first-page":"10192","DOI":"10.1158\/0008-5472.CAN-10-2429","article-title":"Free tubulin modulates mitochondrial membrane potential in cancer cells","volume":"70","author":"Maldonado","year":"2010","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M115.641746_bib60","doi-asserted-by":"crossref","first-page":"10190","DOI":"10.1128\/MCB.25.22.10190-10201.2005","article-title":"Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking \u03b1-synuclein","volume":"25","author":"Ellis","year":"2005","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M115.641746_bib61","doi-asserted-by":"crossref","first-page":"21490","DOI":"10.1074\/jbc.M113.545749","article-title":"Soluble, prefibrillar \u03b1-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction","volume":"289","author":"Luth","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.641746_bib62","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neulet.2009.02.056","article-title":"\u03b1-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity","volume":"454","author":"Liu","year":"2009","journal-title":"Neurosci. Lett"},{"key":"10.1074\/jbc.M115.641746_bib63","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1385\/JMN:18:3:229","article-title":"Mutant and wild-type \u03b1-synuclein interact with mitochondrial cytochrome c oxidase","volume":"18","author":"Elkon","year":"2002","journal-title":"J. Mol. Neurosci"},{"key":"10.1074\/jbc.M115.641746_bib64","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0304-3940(02)00016-2","article-title":"Human \u03b1-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine","volume":"320","author":"Junn","year":"2002","journal-title":"Neurosci. Lett"},{"key":"10.1074\/jbc.M115.641746_bib65","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1038\/emboj.2013.228","article-title":"Endonuclease G mediates \u03b1-synuclein cytotoxicity during Parkinson's disease","volume":"32","author":"B\u00fcttner","year":"2013","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M115.641746_bib66","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.1074\/jbc.M708477200","article-title":"Functional mitochondria are required for \u03b1-synuclein toxicity in aging yeast","volume":"283","author":"B\u00fcttner","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.641746_bib67","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1242\/dmm.004267","article-title":"Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models","volume":"3","author":"Su","year":"2010","journal-title":"Dis. Model. Mech"},{"key":"10.1074\/jbc.M115.641746_bib68","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2014.09.046","article-title":"\u03b1-Synuclein amino terminus regulates mitochondrial membrane permeability","volume":"1591","author":"Shen","year":"2014","journal-title":"Brain Res"},{"key":"10.1074\/jbc.M115.641746_bib69","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.bbamem.2011.10.025","article-title":"The role of VDAC in cell death: friend or foe?","volume":"1818","author":"McCommis","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.641746_bib70","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02229","article-title":"The ADP\/ATP translocator is not essential for the mitochondrial permeability transition pore","volume":"427","author":"Kokoszka","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.641746_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.114.095661","article-title":"The mitochondrial complex V-associated large-conductance inner membrane current is regulated by cyclosporine and dexpramipexole","volume":"87","author":"Alavian","year":"2015","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M115.641746_bib72","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1073\/pnas.1217823110","article-title":"Dimers of mitochondrial ATP synthase form the permeability transition pore","volume":"110","author":"Giorgio","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.641746_bib73","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0896-6273(95)90302-X","article-title":"The precursor protein of non-A\u03b2 component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system","volume":"14","author":"Iwai","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.M115.641746_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-4157(85)90002-4","article-title":"Lipids of mitochondria","volume":"822","author":"Daum","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.641746_bib75","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00249-006-0101-7","article-title":"Theoretical evaluation of a possible nature of the outer membrane potential of mitochondria","volume":"36","author":"Lemeshko","year":"2006","journal-title":"Eur. Biophys. J"},{"key":"10.1074\/jbc.M115.641746_bib76","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.bbrc.2004.11.105","article-title":"pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant","volume":"326","author":"Porcelli","year":"2005","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M115.641746_bib77","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.1252884","article-title":"Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins","volume":"344","author":"Wilhelm","year":"2014","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820423269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820423269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.641746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T11:55:02Z","timestamp":1641297302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820423269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":77,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0021925820423269"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.641746","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}