{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:10:13Z","timestamp":1790763013966,"version":"4.1.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"34","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":1858,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1074\/jbc.m115.648998","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T15:25:04Z","timestamp":1435937104000},"page":"21163-21184","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":70,"title":["Activation of Autophagic Flux against Xenoestrogen Bisphenol-A-induced Hippocampal Neurodegeneration via AMP kinase (AMPK)\/Mammalian Target of Rapamycin (mTOR) Pathways"],"prefix":"10.1016","volume":"290","author":[{"given":"Swati","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi Kant","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brashket","family":"Seth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshuman","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubha","family":"Mudawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit Kumar Singh","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Choubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratan Singh","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubha","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnish Kumar","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.648998_bib1","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.fct.2011.03.032","article-title":"Protective effect of N-acetylcysteine on bisphenol A-induced cognitive dysfunction and oxidative stress in rats","volume":"49","author":"Jain","year":"2011","journal-title":"Food Chem. Toxicol"},{"key":"10.1074\/jbc.M115.648998_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1440-1789.2011.01287.x","article-title":"Bisphenol A, an endocrine-disrupting chemical, and brain development","volume":"32","author":"Itoh","year":"2012","journal-title":"Neuropathology"},{"key":"10.1074\/jbc.M115.648998_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxlet.2007.11.001","article-title":"Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons","volume":"176","author":"Le","year":"2008","journal-title":"Toxicol. Lett"},{"key":"10.1074\/jbc.M115.648998_bib4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.toxlet.2011.08.011","article-title":"Rat hyperactivity by bisphenol A, but not by its derivatives, 3-hydroxybisphenol A or bisphenol A 3,4-quinone","volume":"206","author":"Ishido","year":"2011","journal-title":"Toxicol. Lett"},{"key":"10.1074\/jbc.M115.648998_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s12640-012-9353-4","article-title":"Neurotoxic effects of bisphenol AF on calcium-induced ROS and MAPKs","volume":"23","author":"Lee","year":"2013","journal-title":"Neurotox. Res"},{"key":"10.1074\/jbc.M115.648998_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tox.2011.09.006","article-title":"Dose-dependent behavioral disturbances after a single neonatal bisphenol A dose","volume":"290","author":"Viberg","year":"2011","journal-title":"Toxicology"},{"key":"10.1074\/jbc.M115.648998_bib7","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ntt.2011.08.003","article-title":"Prenatal exposure to bisphenol A and phthalates and infant neurobehavior","volume":"33","author":"Yolton","year":"2011","journal-title":"Neurotoxicol. Teratol"},{"key":"10.1074\/jbc.M115.648998_bib8","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1080\/10937404.2011.578557","article-title":"Neurotoxicity of endocrine disruptors: possible involvement in brain development and neurodegeneration","volume":"14","author":"Masuo","year":"2011","journal-title":"J. Toxicol. Environ. Health B Crit. Rev"},{"key":"10.1074\/jbc.M115.648998_bib9","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.taap.2010.09.007","article-title":"Bisphenol-A rapidly promotes dynamic changes in hippocampal dendritic morphology through estrogen receptor-mediated pathway by concomitant phosphorylation of NMDA receptor subunit NR2B","volume":"249","author":"Xu","year":"2010","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1074\/jbc.M115.648998_bib10","article-title":"Inhibitory effects of bisphenol-A on neural stem cells proliferation and differentiation in the rat brain are dependent on Wnt\/\u03b2-catenin pathway","author":"Tiwari","year":"2014","journal-title":"Mol. Neurobiol"},{"key":"10.1074\/jbc.M115.648998_bib11","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1016\/j.fct.2011.09.017","article-title":"Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory","volume":"49","author":"Kim","year":"2011","journal-title":"Food Chem. Toxicol"},{"key":"10.1074\/jbc.M115.648998_bib12","article-title":"Bisphenol-A mediated inhibition of hippocampal neurogenesis attenuated by curcumin via canonical Wnt pathway","author":"Tiwari","year":"2015","journal-title":"Mol. Neurobiol"},{"key":"10.1074\/jbc.M115.648998_bib13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/15376516.2012.753969","article-title":"Prooxidant actions of bisphenol A (BPA) phenoxyl radicals: implications to BPA-related oxidative stress and toxicity","volume":"23","author":"Babu","year":"2013","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1074\/jbc.M115.648998_bib14","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1002\/jnr.21739","article-title":"Signaling pathways of bisphenol A-induced apoptosis in hippocampal neuronal cells: role of calcium-induced reactive oxygen species, mitogen-activated protein kinases, and nuclear factor-\u03baB","volume":"86","author":"Lee","year":"2008","journal-title":"J. Neurosci. Res"},{"key":"10.1074\/jbc.M115.648998_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jns.2014.10.009","article-title":"Melatonin ameliorates oxidative stress, modulates death receptor pathway proteins, and protects the rat cerebrum against bisphenol-A-induced apoptosis","volume":"347","author":"El-Missiry","year":"2014","journal-title":"J. Neurol. Sci"},{"key":"10.1074\/jbc.M115.648998_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0013-9351(03)00062-8","article-title":"Effects of bisphenol A on the metabolisms of active oxygen species in mouse tissues","volume":"93","author":"Kabuto","year":"2003","journal-title":"Environ. Res"},{"key":"10.1074\/jbc.M115.648998_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.toxlet.2014.01.024","article-title":"Bisphenol A regulation of testicular endocrine function in male rats is affected by diet","volume":"225","author":"Nanjappa","year":"2014","journal-title":"Toxicol. Lett"},{"key":"10.1074\/jbc.M115.648998_bib18","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3109\/10715762.2010.510523","article-title":"Generation of reactive oxygen species in sperms of rats as an earlier marker for evaluating the toxicity of endocrine-disrupting chemicals","volume":"44","author":"Minamiyama","year":"2010","journal-title":"Free Radic. Res"},{"key":"10.1074\/jbc.M115.648998_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0300-483X(02)00597-8","article-title":"Induction of oxidative stress by bisphenol A in the epididymal sperm of rats","volume":"185","author":"Chitra","year":"2003","journal-title":"Toxicology"},{"key":"10.1074\/jbc.M115.648998_bib20","article-title":"Bisphenol A alters n-6 fatty acid composition and decreases antioxidant enzyme levels in rat testes: a LC-QTOF-based metabolomics study","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M115.648998_bib21","first-page":"3477","article-title":"Investigation of bisphenol A as an endocrine disruptor, total thiol, malondialdehyde, and C-reactive protein levels in chronic obstructive pulmonary disease","volume":"18","author":"Erden","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci"},{"key":"10.1074\/jbc.M115.648998_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/srep09169","article-title":"Bisphenol-A affects male fertility via fertility-related proteins in spermatozoa","volume":"5","author":"Rahman","year":"2015","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.M115.648998_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pneurobio.2013.10.004","article-title":"Autophagy and apoptosis dysfunction in neurodegenerative disorders","volume":"112","author":"Ghavami","year":"2014","journal-title":"Prog. Neurobiol"},{"key":"10.1074\/jbc.M115.648998_bib24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1205406","article-title":"Autophagy in human health and disease","volume":"368","author":"Choi","year":"2013","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M115.648998_bib25","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.648998_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/cdd.2008.120","article-title":"Autophagy and cell death in model organisms","volume":"16","author":"Kourtis","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M115.648998_bib27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrd3802","article-title":"Autophagy modulation as a potential therapeutic target for diverse diseases","volume":"11","author":"Rubinsztein","year":"2012","journal-title":"Nat. Rev. Drug Discov"},{"key":"10.1074\/jbc.M115.648998_bib28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrneurol.2011.200","article-title":"Control of autophagy as a therapy for neurodegenerative disease","volume":"8","author":"Harris","year":"2012","journal-title":"Nat. Rev. Neurol"},{"key":"10.1074\/jbc.M115.648998_bib29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.etp.2014.01.004","article-title":"Autophagy in arsenic carcinogenesis","volume":"66","author":"Qi","year":"2014","journal-title":"Exp. Toxicol. Pathol"},{"key":"10.1074\/jbc.M115.648998_bib30","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.4161\/auto.25665","article-title":"Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium","volume":"9","author":"Pi","year":"2013","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M115.648998_bib31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.scitotenv.2007.11.009","article-title":"Autophagy as an ultrastructural marker of heavy metal toxicity in human cord blood hematopoietic stem cells","volume":"392","author":"Di Gioacchino","year":"2008","journal-title":"Sci. Total Environ"},{"key":"10.1074\/jbc.M115.648998_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.toxlet.2011.11.029","article-title":"Exposure to dibenzofuran triggers autophagy in lung cells","volume":"209","author":"Duarte","year":"2012","journal-title":"Toxicol. Lett"},{"key":"10.1074\/jbc.M115.648998_bib33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/kft188","article-title":"Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP(+)-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity","volume":"136","author":"Garcia-Garcia","year":"2013","journal-title":"Toxicol. Sci"},{"key":"10.1074\/jbc.M115.648998_bib34","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4161\/auto.21376","article-title":"Autophagy is a protective response to ethanol neurotoxicity","volume":"8","author":"Chen","year":"2012","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M115.648998_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.46","article-title":"TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain","volume":"5","author":"Pla","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1074\/jbc.M115.648998_bib36","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1042\/BST20130134","article-title":"Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers","volume":"41","author":"Sarkar","year":"2013","journal-title":"Biochem. Soc. Trans"},{"key":"10.1074\/jbc.M115.648998_bib37","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M115.648998_bib38","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M115.648998_bib39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.molcel.2008.04.012","article-title":"AMPK and Raptor: matching cell growth to energy supply","volume":"30","author":"Hardie","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M115.648998_bib40","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M115.648998_bib41","doi-asserted-by":"crossref","first-page":"643","DOI":"10.4161\/auto.7.6.15123","article-title":"The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR","volume":"7","author":"Egan","year":"2011","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M115.648998_bib42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1471-4159.2009.05916.x","article-title":"AMPK in the brain: its roles in energy balance and neuroprotection","volume":"109","author":"Ronnett","year":"2009","journal-title":"J. Neurochem"},{"key":"10.1074\/jbc.M115.648998_bib43","doi-asserted-by":"crossref","first-page":"5849","DOI":"10.1073\/pnas.1013660108","article-title":"AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress","volume":"108","author":"Williams","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.648998_bib44","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","article-title":"mTOR regulation of autophagy","volume":"584","author":"Jung","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M115.648998_bib45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1021\/nn405077y","article-title":"Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt\/beta-catenin pathway","volume":"8","author":"Tiwari","year":"2014","journal-title":"ACS Nano"},{"key":"10.1074\/jbc.M115.648998_bib46","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.freeradbiomed.2013.07.042","article-title":"Nicotine-encapsulated poly(lactic-co-glycolic) acid nanoparticles improve neuroprotective efficacy against MPTP-induced parkinsonism","volume":"65","author":"Tiwari","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"10.1074\/jbc.M115.648998_bib47","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M115.648998_bib48","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1074\/jbc.M806088200","article-title":"Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation","volume":"284","author":"Young","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.648998_bib49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/B978-0-12-416618-9.00013-3","article-title":"Methods to monitor ROS production by fluorescence microscopy and fluorometry","volume":"542","author":"Wojtala","year":"2014","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M115.648998_bib50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.freeradbiomed.2014.10.504","article-title":"Even free radicals should follow some rules: a guide to free radical research terminology and methodology","volume":"78","author":"Forman","year":"2015","journal-title":"Free Radic. Biol. Med"},{"key":"10.1074\/jbc.M115.648998_bib51","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1038\/nprot.2006.468","article-title":"In-gel digestion for mass spectrometric characterization of proteins and proteomes","volume":"1","author":"Shevchenko","year":"2006","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.M115.648998_bib52","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/toxsci\/kfs004","article-title":"Prenatal carbofuran exposure inhibits hippocampal neurogenesis and causes learning and memory deficits in offspring","volume":"127","author":"Mishra","year":"2012","journal-title":"Toxicol. Sci"},{"key":"10.1074\/jbc.M115.648998_bib53","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s12035-014-8817-3","article-title":"Bisphenol-A impairs myelination potential during development in the hippocampus of the rat brain","volume":"51","author":"Tiwari","year":"2015","journal-title":"Mol. Neurobiol"},{"key":"10.1074\/jbc.M115.648998_bib54","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1093\/hmg\/dds178","article-title":"Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease","volume":"21","author":"Chaturvedi","year":"2012","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M115.648998_bib55","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nmeth1083","article-title":"Bright far-red fluorescent protein for whole-body imaging","volume":"4","author":"Shcherbo","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1074\/jbc.M115.648998_bib56","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/BJ20081949","article-title":"Far-red fluorescent tags for protein imaging in living tissues","volume":"418","author":"Shcherbo","year":"2009","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M115.648998_bib57","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1021\/nn506408v","article-title":"Trans-blood brain barrier delivery of dopamine-loaded nanoparticles reverses functional deficits in parkinsonian rats","volume":"9","author":"Pahuja","year":"2015","journal-title":"ACS Nano"},{"key":"10.1074\/jbc.M115.648998_bib58","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.648998_bib59","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1091\/mbc.11.1.255","article-title":"Biogenesis of multilamellar bodies via autophagy","volume":"11","author":"Hariri","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M115.648998_bib60","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1247\/csf.23.33","article-title":"Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells","volume":"23","author":"Yamamoto","year":"1998","journal-title":"Cell Struct. Funct"},{"key":"10.1074\/jbc.M115.648998_bib61","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.200911078","article-title":"Endogenous HMGB1 regulates autophagy","volume":"190","author":"Tang","year":"2010","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M115.648998_bib62","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cmet.2014.01.014","article-title":"High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo","volume":"19","author":"Huebener","year":"2014","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M115.648998_bib63","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10059-013-0140-8","article-title":"Autophagy: a critical regulator of cellular metabolism and homeostasis","volume":"36","author":"Ryter","year":"2013","journal-title":"Mol. Cells"},{"key":"10.1074\/jbc.M115.648998_bib64","doi-asserted-by":"crossref","DOI":"10.4161\/auto.26915","article-title":"Keeping the engine clean: a mitophagy task for cellular physiology","volume":"9","author":"Campanella","year":"2013","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M115.648998_bib65","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4161\/auto.7.3.14502","article-title":"Mitochondria removal by autophagy","volume":"7","author":"Wang","year":"2011","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M115.648998_bib66","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.4161\/auto.28615","article-title":"BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria","volume":"10","author":"Choubey","year":"2014","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M115.648998_bib67","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Ceath Differ"},{"key":"10.1074\/jbc.M115.648998_bib68","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.1231031","article-title":"PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria","volume":"340","author":"Chen","year":"2013","journal-title":"Science"},{"key":"10.1074\/jbc.M115.648998_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095288","article-title":"Loss of PINK1 impairs stress-induced autophagy and cell survival","volume":"9","author":"Parganlija","year":"2014","journal-title":"PloS One"},{"key":"10.1074\/jbc.M115.648998_bib70","first-page":"185","article-title":"Exposure to widespread environmental toxicants and children's cognitive development and behavioral problems","volume":"26","author":"Jurewicz","year":"2013","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"10.1074\/jbc.M115.648998_bib71","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neuro.2010.12.009","article-title":"Endocrine disruptors and childhood social impairment","volume":"32","author":"Miodovnik","year":"2011","journal-title":"Neurotoxicology"},{"key":"10.1074\/jbc.M115.648998_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.64","article-title":"Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor","volume":"5","author":"Ma","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1074\/jbc.M115.648998_bib73","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1530\/JOE-13-0386","article-title":"High-fat diet aggravates glucose homeostasis disorder caused by chronic exposure to bisphenol A","volume":"221","author":"Ding","year":"2014","journal-title":"J. Endocrinol"},{"key":"10.1074\/jbc.M115.648998_bib74","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tibs.2006.11.001","article-title":"Cell death by necrosis: towards a molecular definition","volume":"32","author":"Golstein","year":"2007","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/jbc.M115.648998_bib75","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1534\/genetics.112.149013","article-title":"Autophagic processes in yeast: mechanism, machinery and regulation","volume":"194","author":"Reggiori","year":"2013","journal-title":"Genetics"},{"key":"10.1074\/jbc.M115.648998_bib76","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03029","article-title":"The role of autophagy during the early neonatal starvation period","volume":"432","author":"Kuma","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.648998_bib77","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/194829","article-title":"Bisphenol A induces hepatotoxicity through oxidative stress in rat model","volume":"2012","author":"Hassan","year":"2012","journal-title":"Oxid. Med. Cell Longev"},{"key":"10.1074\/jbc.M115.648998_bib78","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/259763","article-title":"Green tea potentially ameliorates bisphenol A-induced oxidative stress: an in vitro and in silico study","volume":"2014","author":"Suthar","year":"2014","journal-title":"Biochem. Res. Int"},{"key":"10.1074\/jbc.M115.648998_bib79","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/B:MCBI.0000041848.57020.57","article-title":"Autophagy: many paths to the same end","volume":"263","author":"Cuervo","year":"2004","journal-title":"Mol. Cell. Biochem"},{"key":"10.1074\/jbc.M115.648998_bib80","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/502676","article-title":"The impact of autophagy on cell death modalities","volume":"2014","author":"Ryter","year":"2014","journal-title":"Int. J. Cell Biol"},{"key":"10.1074\/jbc.M115.648998_bib81","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/cbin.10299","article-title":"AMP-activated protein kinase is involved in induction of protective autophagy in astrocytes exposed to oxygen-glucose deprivation","volume":"38","author":"Gabryel","year":"2014","journal-title":"Cell Biol. Int"},{"key":"10.1074\/jbc.M115.648998_bib82","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.4161\/auto.21052","article-title":"An appetite for destruction: from self-eating to cell cannibalism as a neuronal survival strategy","volume":"8","author":"Poels","year":"2012","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M115.648998_bib83","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev-pharmtox-010611-134537","article-title":"AMPK and mTOR in cellular energy homeostasis and drug targets","volume":"52","author":"Inoki","year":"2012","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"10.1074\/jbc.M115.648998_bib84","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1289\/ehp.7633","article-title":"The environmental estrogen bisphenol A inhibits estradiol-induced hippocampal synaptogenesis","volume":"113","author":"MacLusky","year":"2005","journal-title":"Environ. Health Perspect"},{"key":"10.1074\/jbc.M115.648998_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015394","article-title":"The association of AMPK with ULK1 regulates autophagy","volume":"5","author":"Lee","year":"2010","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M115.648998_bib86","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/MCB.06159-11","article-title":"Role of AMPK-mTOR-Ulk1\/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks","volume":"32","author":"Alers","year":"2012","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M115.648998_bib87","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cmet.2011.01.009","article-title":"AMPK-dependent phosphorylation of ULK1 induces autophagy","volume":"13","author":"Zhao","year":"2011","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M115.648998_bib88","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"10.1074\/jbc.M115.648998_bib89","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/cdd.2009.33","article-title":"Life and death partners: apoptosis, autophagy and the cross-talk between them","volume":"16","author":"Eisenberg-Lerner","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M115.648998_bib90","doi-asserted-by":"crossref","first-page":"862","DOI":"10.4161\/auto.8840","article-title":"A novel link between autophagy and the ubiquitin-proteasome system","volume":"5","author":"Korolchuk","year":"2009","journal-title":"Autophagy"},{"key":"10.1074\/jbc.M115.648998_bib91","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40478-014-0182-y","article-title":"LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease","volume":"3","author":"Rothaug","year":"2015","journal-title":"Acta Neuropathol. Commun"},{"key":"10.1074\/jbc.M115.648998_bib92","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074162","article-title":"Autophagy defect is associated with low glucose-induced apoptosis in 661W photoreceptor cells","volume":"8","author":"Balmer","year":"2013","journal-title":"PLoS One"}],"updated-by":[{"DOI":"10.1074\/jbc.w120.012895","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"record-id":"22737"},{"DOI":"10.1074\/jbc.w120.012895","type":"withdrawal","label":"Withdrawal","source":"publisher","updated":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000}}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820421350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820421350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.648998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T11:47:22Z","timestamp":1641296842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820421350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":92,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0021925820421350"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.648998","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}