{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:42:34Z","timestamp":1792464154383,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"vor","delay-in-days":1957,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1074\/jbc.m115.650119","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T01:12:51Z","timestamp":1430788371000},"page":"15973-15984","source":"Crossref","is-referenced-by-count":33,"title":["Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors"],"prefix":"10.1016","volume":"290","author":[{"given":"Sergio M.","family":"Pontejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Alcami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.650119_bib1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol"},{"key":"10.1074\/jbc.M115.650119_bib2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/385729a0","article-title":"A metalloproteinase disintegrin that releases tumour necrosis factor-\u03b1 from cells","volume":"385","author":"Black","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.650119_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0092-8674(93)90574-A","article-title":"Lymphotoxin \u03b2, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface","volume":"72","author":"Browning","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.650119_bib4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1126\/science.8171323","article-title":"A lymphotoxin-\u03b2-specific receptor","volume":"264","author":"Crowe","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.M115.650119_bib5","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1371\/journal.ppat.0020004","article-title":"Modulation of tumor necrosis factor by microbial pathogens","volume":"2","author":"Rahman","year":"2006","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.M115.650119_bib6","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/nsmb.1683","article-title":"Crystal structure of TNF\u03b1 complexed with a poxvirus MHC-related TNF binding protein","volume":"16","author":"Yang","year":"2009","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.M115.650119_bib7","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1073\/pnas.0737244100","article-title":"A secreted high affinity inhibitor of human TNF from tanapox virus","volume":"100","author":"Brunetti","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.650119_bib8","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1128\/JVI.79.2.966-977.2005","article-title":"Genome of deerpox virus","volume":"79","author":"Afonso","year":"2005","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M115.650119_bib9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-1-4419-6612-4_21","article-title":"Poxviral TNFRs: properties and role in viral pathogenesis","volume":"691","author":"Alejo","year":"2011","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1074\/jbc.M115.650119_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/viro.1994.1539","article-title":"Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor","volume":"204","author":"Hu","year":"1994","journal-title":"Virology"},{"key":"10.1074\/jbc.M115.650119_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/viro.1996.0462","article-title":"Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT\u03b1","volume":"223","author":"Smith","year":"1996","journal-title":"Virology"},{"key":"10.1074\/jbc.M115.650119_bib12","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1073\/pnas.95.7.3786","article-title":"A third distinct tumor necrosis factor receptor of orthopoxviruses","volume":"95","author":"Loparev","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.650119_bib13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1128\/JVI.75.1.226-233.2001","article-title":"CrmE, a novel soluble tumor necrosis factor receptor encoded by poxviruses","volume":"75","author":"Saraiva","year":"2001","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M115.650119_bib14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1084\/jem.20020319","article-title":"Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus","volume":"196","author":"Saraiva","year":"2002","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M115.650119_bib15","doi-asserted-by":"crossref","first-page":"8348","DOI":"10.1073\/pnas.122238599","article-title":"Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue","volume":"99","author":"Panus","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.650119_bib16","doi-asserted-by":"crossref","first-page":"e5175","DOI":"10.1371\/journal.pone.0005175","article-title":"A method for the generation of ectromelia virus (ECTV) recombinants: in vivo analysis of ECTV vCD30 deletion mutants","volume":"4","author":"Alejo","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M115.650119_bib17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jmb.2007.06.082","article-title":"Structure of CrmE, a virus-encoded tumour necrosis factor receptor","volume":"372","author":"Graham","year":"2007","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M115.650119_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/viro.2001.1236","article-title":"Vaccinia virus CrmE encodes a soluble and cell surface tumor necrosis factor receptor that contributes to virus virulence","volume":"292","author":"Reading","year":"2002","journal-title":"Virology"},{"key":"10.1074\/jbc.M115.650119_bib19","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1128\/jvi.68.3.1737-1749.1994","article-title":"Multigenic evasion of inflammation by poxviruses","volume":"68","author":"Palumbo","year":"1994","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M115.650119_bib20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0042-6822(91)91009-6","article-title":"Identification and DNA sequence of the large subunit of the capping enzyme from Shope fibroma virus","volume":"183","author":"Upton","year":"1991","journal-title":"Virology"},{"key":"10.1074\/jbc.M115.650119_bib21","first-page":"397","article-title":"Smallpox: emergence, global spread, and eradication","volume":"15","author":"Fenner","year":"1993","journal-title":"Hist. Philos. Life Sci"},{"key":"10.1074\/jbc.M115.650119_bib22","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.0510462103","article-title":"A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus","volume":"103","author":"Alejo","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.650119_bib23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2340\/00015555-1227","article-title":"The Munich outbreak of cutaneous cowpox infection: transmission by infected pet rats","volume":"92","author":"Vogel","year":"2012","journal-title":"Acta Derm. Venereol"},{"key":"10.1074\/jbc.M115.650119_bib24","doi-asserted-by":"crossref","first-page":"10139","DOI":"10.1128\/JVI.77.18.10139-10146.2003","article-title":"Genetic variability of immunomodulatory genes in ectromelia virus isolates detected by denaturing high-performance liquid chromatography","volume":"77","author":"Ribas","year":"2003","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M115.650119_bib25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.virol.2014.06.010","article-title":"The genome sequence of ectromelia virus Naval and Cornell isolates from outbreaks in North America","volume":"462","author":"Mavian","year":"2014","journal-title":"Virology"},{"key":"10.1074\/jbc.M115.650119_bib26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0042-6822(03)00520-8","article-title":"The genomic sequence of ectromelia virus, the causative agent of mousepox","volume":"317","author":"Chen","year":"2003","journal-title":"Virology"},{"key":"10.1074\/jbc.M115.650119_bib27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0042-6822(90)90294-2","article-title":"The complete DNA sequence of vaccinia virus","volume":"179","author":"Goebel","year":"1990","journal-title":"Virology"},{"key":"10.1074\/jbc.M115.650119_bib28","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0042-6822(91)90077-O","article-title":"Vaccinia virus homologues of the Shope fibroma virus inverted terminal repeat proteins and a discontinuous ORF related to the tumor necrosis factor receptor family","volume":"180","author":"Howard","year":"1991","journal-title":"Virology"},{"key":"10.1074\/jbc.M115.650119_bib29","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1099\/0022-1317-80-4-949","article-title":"Vaccinia virus strains Lister, USSR, and Evans express soluble and cell-surface tumour necrosis factor receptors","volume":"80","author":"Alcam\u00ed","year":"1999","journal-title":"J. Gen. Virol"},{"key":"10.1074\/jbc.M115.650119_bib30","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pharmthera.2007.10.001","article-title":"Tumor necrosis factor antagonist mechanisms of action: a comprehensive review","volume":"117","author":"Tracey","year":"2008","journal-title":"Pharmacol. Ther"},{"key":"10.1074\/jbc.M115.650119_bib31","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1096\/fj.10-177188","article-title":"Glycosaminoglycans mediate retention of the poxvirus type I interferon binding protein at the cell surface to locally block interferon antiviral responses","volume":"25","author":"Montanuy","year":"2011","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M115.650119_bib32","series-title":"Society for General Microbiology Symposium 64: Molecular Pathogenesis of Virus Infections","first-page":"269","article-title":"Secreted tumour necrosis factor inhibitors encoded by poxviruses","author":"Ruiz-Arguello","year":"2005"},{"key":"10.1074\/jbc.M115.650119_bib33","doi-asserted-by":"crossref","first-page":"ra83","DOI":"10.1126\/scisignal.2000954","article-title":"Solution of the structure of the TNF-TNFR2 complex","volume":"3","author":"Mukai","year":"2010","journal-title":"Sci. Signal"},{"key":"10.1074\/jbc.M115.650119_bib34","doi-asserted-by":"crossref","first-page":"e1002162","DOI":"10.1371\/journal.ppat.1002162","article-title":"Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor","volume":"7","author":"Xue","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.M115.650119_bib35","doi-asserted-by":"crossref","first-page":"e230","DOI":"10.1038\/cddis.2011.111","article-title":"TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members","volume":"2","author":"Vanlangenakker","year":"2011","journal-title":"Cell Death Dis"},{"key":"10.1074\/jbc.M115.650119_bib36","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1084\/jem.183.3.867","article-title":"Signaling through the lymphotoxin \u03b2 receptor induces the death of some adenocarcinoma tumor lines","volume":"183","author":"Browning","year":"1996","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M115.650119_bib37","first-page":"103","article-title":"Activation of the lymphotoxin-\u03b2 receptor induces NFkappaB-dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells","volume":"14","author":"Hehlgans","year":"2003","journal-title":"Eur. Cytokine Netw"},{"key":"10.1074\/jbc.M115.650119_bib38","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.bbapap.2006.09.006","article-title":"Properties of the recombinant TNF-binding proteins from variola, monkeypox, and cowpox viruses are different","volume":"1764","author":"Gileva","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.650119_bib39","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/intimm\/mcg094","article-title":"Membrane lymphotoxin is required for resistance to Theiler's virus infection","volume":"15","author":"Lin","year":"2003","journal-title":"Int. Immunol"},{"key":"10.1074\/jbc.M115.650119_bib40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.0105-2896.2004.00206.x","article-title":"Lymphotoxin and LIGHT signaling pathways and target genes","volume":"202","author":"Schneider","year":"2004","journal-title":"Immunol. Rev"},{"key":"10.1074\/jbc.M115.650119_bib41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1517\/14740338.2012.633509","article-title":"Etanercept: efficacy and safety for approved indications","volume":"11","author":"Kerensky","year":"2012","journal-title":"Expert. Opin. Drug Saf"},{"key":"10.1074\/jbc.M115.650119_bib42","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1243364","article-title":"Nonredundant function of soluble LT\u03b13 produced by innate lymphoid cells in intestinal homeostasis","volume":"342","author":"Kruglov","year":"2013","journal-title":"Science"},{"key":"10.1074\/jbc.M115.650119_bib43","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nri3406","article-title":"Lymphotoxin signalling in immune homeostasis and the control of microorganisms","volume":"13","author":"Upadhyay","year":"2013","journal-title":"Nat. Rev. Immunol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820584317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820584317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.650119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T04:05:09Z","timestamp":1641355509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820584317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":43,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0021925820584317"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.650119","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}