{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:21:29Z","timestamp":1791271289603,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":1888,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1074\/jbc.m115.652263","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T00:29:03Z","timestamp":1431131343000},"page":"16502-16516","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":11,"title":["The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers"],"prefix":"10.1016","volume":"290","author":[{"given":"Adam","family":"Cantlon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Sala","family":"Frigerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darragh B.","family":"Freir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Boland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic M.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.652263_bib1","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1007\/s00018-005-5092-5","article-title":"Chromosome 13 dementias","volume":"62","author":"Rostagno","year":"2005","journal-title":"Cell Mol. Life Sci"},{"key":"10.1074\/jbc.M115.652263_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/21637","article-title":"A stop-codon mutation in the BRI gene associated with familial British dementia","volume":"399","author":"Vidal","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.652263_bib3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0968-0004(02)02134-5","article-title":"BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer","volume":"27","author":"S\u00e1nchez-Pulido","year":"2002","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/jbc.M115.652263_bib4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/1756-0500-2-180","article-title":"BRICHOS: a superfamily of multidomain proteins with diverse functions","volume":"2","author":"Hedlund","year":"2009","journal-title":"BMC Res. Notes"},{"key":"10.1074\/jbc.M115.652263_bib5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1096\/fj.03-0730fje","article-title":"Axonal transport of British and Danish amyloid peptides via secretory vesicles","volume":"18","author":"Choi","year":"2004","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M115.652263_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00401-003-0783-1","article-title":"Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain","volume":"107","author":"Akiyama","year":"2004","journal-title":"Acta Neuropathol"},{"key":"10.1074\/jbc.M115.652263_bib7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neurobiolaging.2008.03.004","article-title":"BRI2 homodimerizes with the involvement of intermolecular disulfide bonds","volume":"31","author":"Tsachaki","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M115.652263_bib8","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1074\/jbc.M108739200","article-title":"Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides","volume":"277","author":"Kim","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.652263_bib9","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/14783","article-title":"Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia","volume":"2","author":"Kim","year":"1999","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.M115.652263_bib10","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1021\/bi002287i","article-title":"Effect of the disulfide bridge and the C-terminal extension on the oligomerization of the amyloid peptide ABri implicated in familial British dementia","volume":"40","author":"El-Agnaf","year":"2001","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M115.652263_bib11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s004010050970","article-title":"Cytoskeletal pathology in familial amyloid angiopathy (British type) with non-neuritic plaque formation","volume":"97","author":"Revesz","year":"1999","journal-title":"Acta Neuropathol"},{"key":"10.1074\/jbc.M115.652263_bib12","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0002-9440(10)63993-4","article-title":"Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia","volume":"158","author":"Holton","year":"2001","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M115.652263_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ana.410170313","article-title":"Atypical Alzheimer's disease with spastic paresis and ataxia","volume":"17","author":"Aikawa","year":"1985","journal-title":"Ann. Neurol"},{"key":"10.1074\/jbc.M115.652263_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuron.2011.01.002","article-title":"Anti-abeta therapeutics in Alzheimer's disease: the need for a paradigm shift","volume":"69","author":"Golde","year":"2011","journal-title":"Neuron"},{"key":"10.1074\/jbc.M115.652263_bib15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/brain\/123.5.975","article-title":"Familial British dementia with amyloid angiopathy: early clinical, neuropsychological and imaging findings","volume":"123","author":"Mead","year":"2000","journal-title":"Brain"},{"key":"10.1074\/jbc.M115.652263_bib16","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/brain\/113.3.721","article-title":"Familial cerebral amyloid angiopathy with nonneuritic amyloid plaque formation","volume":"113","author":"Plant","year":"1990","journal-title":"Brain"},{"key":"10.1074\/jbc.M115.652263_bib17","doi-asserted-by":"crossref","first-page":"43909","DOI":"10.1074\/jbc.M105956200","article-title":"Systemic amyloid deposits in familial British dementia","volume":"276","author":"Ghiso","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.652263_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/0929866043407156","article-title":"Properties of neurotoxic peptides related to the Bri gene","volume":"11","author":"El-Agnaf","year":"2004","journal-title":"Protein Pept. Lett"},{"key":"10.1074\/jbc.M115.652263_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/jmbi.2001.4743","article-title":"Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils","volume":"310","author":"El-Agnaf","year":"2001","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M115.652263_bib20","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1042\/BST0331111","article-title":"Structure and neurotoxicity of novel amyloids derived from the BRI gene","volume":"33","author":"Gibson","year":"2005","journal-title":"Biochem. Soc. Trans"},{"key":"10.1074\/jbc.M115.652263_bib21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.nbd.2008.06.001","article-title":"Aggregation and catabolism of disease-associated intra-A\u03b2 mutations: reduced proteolysis of A\u03b2A21G by neprilysin","volume":"31","author":"Betts","year":"2008","journal-title":"Neurobiol. Dis"},{"key":"10.1074\/jbc.M115.652263_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/cn900015v","article-title":"Amyloid \u03b2-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process","volume":"1","author":"Hellstrand","year":"2010","journal-title":"ACS Chem. Neurosci"},{"key":"10.1074\/jbc.M115.652263_bib23","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Anal. Chem"},{"key":"10.1074\/jbc.M115.652263_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2009.01.008","article-title":"\u03b3-Secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons","volume":"1262","author":"Minogue","year":"2009","journal-title":"Brain Res"},{"key":"10.1074\/jbc.M115.652263_bib25","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/j.1742-4658.2008.06862.x","article-title":"A facile method for expression and purification of the Alzheimer's disease-associated amyloid \u03b2-peptide","volume":"276","author":"Walsh","year":"2009","journal-title":"FEBS J"},{"key":"10.1074\/jbc.M115.652263_bib26","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1038\/nprot.2006.356","article-title":"Culturing hippocampal neurons","volume":"1","author":"Kaech","year":"2006","journal-title":"Nat. Protocol"},{"key":"10.1074\/jbc.M115.652263_bib27","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/ncomms1341","article-title":"Interaction between prion protein and toxic amyloid \u03b2 assemblies can be therapeutically targeted at multiple sites","volume":"2","author":"Freir","year":"2011","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M115.652263_bib28","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1523\/JNEUROSCI.1633-03.2004","volume":"24","author":"Wang","year":"2004","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M115.652263_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/(SICI)1097-4547(20000401)60:1<65::AID-JNR7>3.0.CO;2-Q","article-title":"Impairment of hippocampal long-term potentiation by Alzheimer amyloid \u03b2-peptides","volume":"60","author":"Chen","year":"2000","journal-title":"J. Neurosci. Res"},{"key":"10.1074\/jbc.M115.652263_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1385\/0-89603-273-6:91","article-title":"Formation of disulfide bonds in synthetic peptides and proteins","volume":"Vol. 35","author":"Andreu","year":"1994","journal-title":"Methods in Molecular Biology Peptide Synthesis Protocols"},{"key":"10.1074\/jbc.M115.652263_bib31","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jmb.2003.09.001","article-title":"pH-dependent amyloid and protofibril formation by the ABri peptide of familial British dementia","volume":"333","author":"Srinivasan","year":"2003","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M115.652263_bib32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.biochem.66.1.385","article-title":"Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins","volume":"66","author":"Harper","year":"1997","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.M115.652263_bib33","doi-asserted-by":"crossref","first-page":"9758","DOI":"10.1073\/pnas.1218402110","article-title":"Proliferation of amyloid-\u03b242 aggregates occurs through a secondary nucleation mechanism","volume":"110","author":"Cohen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.652263_bib34","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1038\/nprot.2006.202","article-title":"Using circular dichroism spectra to estimate protein secondary structure","volume":"1","author":"Greenfield","year":"2006","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.M115.652263_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/BJ20140219","article-title":"A\u03b2 dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies","volume":"461","author":"O'Malley","year":"2014","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M115.652263_bib36","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1073\/pnas.080076097","article-title":"A decamer duplication in the 3\u2032 region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred","volume":"97","author":"Vidal","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.652263_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1750-3639.2006.tb00563.x","article-title":"Genetic alterations of the BRI2 gene: familial British and Danish dementias","volume":"16","author":"Ghiso","year":"2006","journal-title":"Brain Pathol"},{"key":"10.1074\/jbc.M115.652263_bib38","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1098\/rstb.2002.1230","article-title":"Long-term potentiation and memory","volume":"358","author":"Morris","year":"2003","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci"},{"key":"10.1074\/jbc.M115.652263_bib39","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1128134","article-title":"Learning induces long-term potentiation in the hippocampus","volume":"313","author":"Whitlock","year":"2006","journal-title":"Science"},{"key":"10.1074\/jbc.M115.652263_bib40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nn0411-399","article-title":"State of aggregation","volume":"14","author":"Editorial","year":"2011","journal-title":"Nat. Neurosci"},{"key":"10.1074\/jbc.M115.652263_bib41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2174\/1568013033483311","article-title":"The many faces of A\u03b2: structures and activity","volume":"3","author":"Walsh","year":"2003","journal-title":"Curr. Med. Chem. Immunol. Endo. Metab. Agents"},{"key":"10.1074\/jbc.M115.652263_bib42","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol"},{"key":"10.1074\/jbc.M115.652263_bib43","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0896-6273(00)81109-5","article-title":"Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles","volume":"24","author":"Mesulam","year":"1999","journal-title":"Neuron"},{"key":"10.1074\/jbc.M115.652263_bib44","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1098\/rstb.2002.1240","article-title":"Synaptic plasticity in animal models of early Alzheimer's disease","volume":"358","author":"Rowan","year":"2003","journal-title":"Phil. Trans. R. Soc. B"},{"key":"10.1074\/jbc.M115.652263_bib45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1750-1326-4-48","article-title":"Alzheimer's disease: synaptic dysfunction and A\u03b2","volume":"4","author":"Shankar","year":"2009","journal-title":"Mol. Neurodegener"},{"key":"10.1074\/jbc.M115.652263_bib46","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1523\/JNEUROSCI.5193-11.2012","article-title":"Memory deficits of british dementia knock-in mice are prevented by A\u03b2-precursor protein haploinsufficiency","volume":"32","author":"Tamayev","year":"2012","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M115.652263_bib47","doi-asserted-by":"crossref","first-page":"14915","DOI":"10.1523\/JNEUROSCI.3917-10.2010","article-title":"Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis","volume":"30","author":"Tamayev","year":"2010","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M115.652263_bib48","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-2011-110785","article-title":"Increased A\u03b2PP processing in familial Danish dementia patients","volume":"27","author":"Matsuda","year":"2011","journal-title":"J. Alzheimers Dis"},{"key":"10.1074\/jbc.M115.652263_bib49","doi-asserted-by":"crossref","first-page":"e7900","DOI":"10.1371\/journal.pone.0007900","article-title":"Generation and initial characterization of FDD knock in mice","volume":"4","author":"Giliberto","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M115.652263_bib50","doi-asserted-by":"crossref","first-page":"20822","DOI":"10.1073\/pnas.1011689107","article-title":"Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits","volume":"107","author":"Tamayev","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.652263_bib51","doi-asserted-by":"crossref","first-page":"7969","DOI":"10.1073\/pnas.1001056107","article-title":"Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease","volume":"107","author":"Coomaraswamy","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.652263_bib52","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1750-3639.2008.00164.x","article-title":"Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2","volume":"19","author":"Vidal","year":"2009","journal-title":"Brain Pathol"},{"key":"10.1074\/jbc.M115.652263_bib53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-1326-9-5","article-title":"Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia","volume":"9","author":"Marcora","year":"2014","journal-title":"Mol. Neurodegener"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820402145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820402145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.652263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T10:26:48Z","timestamp":1641292008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820402145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":53,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0021925820402145"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.652263","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}