{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:06:01Z","timestamp":1779451561679,"version":"3.53.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"36","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":1833,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1074\/jbc.m115.658096","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T22:54:47Z","timestamp":1438210487000},"page":"22076-22084","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis"],"prefix":"10.1016","volume":"290","author":[{"given":"Yongge","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi A.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Ashwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene M.","family":"Oltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean W.","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.658096_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2010.12.008","article-title":"NF-\u03baB, inflammation, and metabolic disease","volume":"13","author":"Baker","year":"2011","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M115.658096_bib2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1359-6101(03)00032-7","article-title":"The TNF superfamily","volume":"14","author":"Ware","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1074\/jbc.M115.658096_bib3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1101\/sqb.1999.64.473","article-title":"NF-\u03baB activation by tumor necrosis factor and interleukin-1","volume":"64","author":"Cao","year":"1999","journal-title":"Cold Spring Harb. Symp. Quant. Biol"},{"key":"10.1074\/jbc.M115.658096_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cytogfr.2008.04.014","article-title":"Ubiquitin-mediated regulation of TNFR1 signaling","volume":"19","author":"Wertz","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1074\/jbc.M115.658096_bib5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nature01811","article-title":"Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-\u03baB","volume":"424","author":"Brummelkamp","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.658096_bib6","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nature01802","article-title":"The tumour suppressor CYLD negatively regulates NF-\u03baB signalling by deubiquitination","volume":"424","author":"Kovalenko","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.658096_bib7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature01803","article-title":"CYLD is a deubiquitinating enzyme that negatively regulates NF-\u03baB activation by TNFR family members","volume":"424","author":"Trompouki","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.658096_bib8","doi-asserted-by":"crossref","first-page":"40520","DOI":"10.1074\/jbc.M111.292961","article-title":"The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor \u03b2 (TGF-\u03b2) signaling and the development of regulatory T cells","volume":"286","author":"Zhao","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.658096_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ccr.2007.07.004","article-title":"Frequent engagement of the classical and alternative NF-\u03baB pathways by diverse genetic abnormalities in multiple myeloma","volume":"12","author":"Annunziata","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M115.658096_bib10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/76006","article-title":"Identification of the familial cylindromatosis tumour-suppressor gene","volume":"25","author":"Bignell","year":"2000","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M115.658096_bib11","doi-asserted-by":"crossref","first-page":"7107","DOI":"10.4049\/jimmunol.180.11.7107","article-title":"Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo","volume":"180","author":"Ni","year":"2008","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M115.658096_bib12","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1172\/JCI28746","article-title":"Impaired regulation of NF-\u03baB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice","volume":"116","author":"Zhang","year":"2006","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.658096_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ncb1821","article-title":"Involvement of linear polyubiquitylation of NEMO in NF-\u03baB activation","volume":"11","author":"Tokunaga","year":"2009","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M115.658096_bib14","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1073\/pnas.96.6.2994","article-title":"Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality","volume":"96","author":"Doi","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.658096_bib15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.284.5412.321","article-title":"Severe liver degeneration in mice lacking the I\u03baB kinase 2 gene","volume":"284","author":"Li","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M115.658096_bib16","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.str.2004.07.012","article-title":"The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO\/IKK\u03b3","volume":"12","author":"Saito","year":"2004","journal-title":"Structure"},{"key":"10.1074\/jbc.M115.658096_bib17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/cdd.2009.168","article-title":"Regulation of death receptor signaling by the ubiquitin system","volume":"17","author":"Wertz","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M115.658096_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0092-8674(03)00521-X","article-title":"Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes","volume":"114","author":"Micheau","year":"2003","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.658096_bib19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ncb1384","article-title":"Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-\u03baB activation","volume":"8","author":"Wu","year":"2006","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M115.658096_bib20","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1038\/emboj.2009.241","article-title":"NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain","volume":"28","author":"Laplantine","year":"2009","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M115.658096_bib21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/85277","article-title":"Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia","volume":"2","author":"Jain","year":"2001","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M115.658096_bib22","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1182\/blood-2006-04-017210","article-title":"Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination","volume":"108","author":"Temmerman","year":"2006","journal-title":"Blood"},{"key":"10.1074\/jbc.M115.658096_bib23","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/humu.21439","article-title":"Dendritic cells from humans with hypomorphic mutations in IKBKG\/NEMO have impaired mitogen-activated protein kinase activity","volume":"32","author":"Ma","year":"2011","journal-title":"Hum. Mutat"},{"key":"10.1074\/jbc.M115.658096_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1172\/JCI42534","article-title":"Defective nuclear IKK\u03b1 function in patients with ectodermal dysplasia with immune deficiency","volume":"122","author":"Temmerman","year":"2012","journal-title":"J. Clin. Invest"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820448677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820448677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.658096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:17:03Z","timestamp":1779448623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820448677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":24,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0021925820448677"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.658096","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.658096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}