{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:20:19Z","timestamp":1783599619801,"version":"3.55.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"41","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":1802,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1451619"],"award-info":[{"award-number":["1451619"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1074\/jbc.m115.659375","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T03:34:59Z","timestamp":1439523299000},"page":"24986-25011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Genome-wide Mechanosensitive MicroRNA (MechanomiR) Screen Uncovers Dysregulation of Their Regulatory Networks in the mdm Mouse Model of Muscular Dystrophy"],"prefix":"10.1016","volume":"290","author":[{"given":"Junaith S.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameena","family":"Hajira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladin M.","family":"Boriek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.659375_bib1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0092-8674(87)90579-4","article-title":"Dystrophin: the protein product of the Duchenne muscular dystrophy locus","volume":"51","author":"Hoffman","year":"1987","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.659375_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0092-8674(88)90383-2","article-title":"The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein","volume":"53","author":"Koenig","year":"1988","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.659375_bib3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1086\/342380","article-title":"Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin","volume":"71","author":"Hackman","year":"2002","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M115.659375_bib4","doi-asserted-by":"crossref","first-page":"46493","DOI":"10.1074\/jbc.M203654200","article-title":"Distinct signaling pathways are activated in response to mechanical stress applied axially and transversely to skeletal muscle fibers","volume":"277","author":"Kumar","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.659375_bib5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1096\/fj.02-0542com","article-title":"Mechanical stress activates the nuclear factor-\u03baB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy","volume":"17","author":"Kumar","year":"2003","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M115.659375_bib6","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1096\/fj.04-2414com","article-title":"Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-\u03baB transcription factor","volume":"18","author":"Kumar","year":"2004","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M115.659375_bib7","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1096\/fj.10-158386","article-title":"Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch","volume":"24","author":"Mohamed","year":"2010","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M115.659375_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrm2597","article-title":"Mechanotransduction gone awry","volume":"10","author":"Jaalouk","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M115.659375_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tcm.2006.12.002","article-title":"Consequences of disrupting the dystrophin-sarcoglycan complex in cardiac and skeletal myopathy","volume":"17","author":"Heydemann","year":"2007","journal-title":"Trends Cardiovasc. Med"},{"key":"10.1074\/jbc.M115.659375_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1096\/fj.03-0453com","article-title":"Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers","volume":"18","author":"Kumar","year":"2004","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M115.659375_bib11","doi-asserted-by":"crossref","first-page":"C651","DOI":"10.1152\/ajpcell.00244.2007","article-title":"Direct observation of failing fibers in muscles of dystrophic mice provides mechanistic insight into muscular dystrophy","volume":"294","author":"Claflin","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M115.659375_bib12","doi-asserted-by":"crossref","first-page":"C46","DOI":"10.1152\/ajpcell.2001.280.1.C46","article-title":"Desmin integrates the three-dimensional mechanical properties of muscles","volume":"280","author":"Boriek","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M115.659375_bib13","doi-asserted-by":"crossref","first-page":"C1092","DOI":"10.1152\/ajpcell.16.2008","article-title":"Early mechanical dysfunction of the diaphragm in the muscular dystrophy with myositis (Ttnmdm) model","volume":"295","author":"Lopez","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M115.659375_bib14","doi-asserted-by":"crossref","first-page":"24560","DOI":"10.1074\/jbc.M112.434423","article-title":"Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3 cooperatively inhibit myoblast differentiation by physical interaction","volume":"288","author":"Mohamed","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.659375_bib15","doi-asserted-by":"crossref","first-page":"C962","DOI":"10.1152\/ajpcell.00326.2002","article-title":"Altered muscle force and stiffness of skeletal muscles in \u03b1-sarcoglycan-deficient mice","volume":"284","author":"Patel","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M115.659375_bib16","doi-asserted-by":"crossref","first-page":"C282","DOI":"10.1152\/ajpcell.00362.2003","article-title":"Force transmission, compliance, and viscoelasticity are altered in the \u03b17-integrin-null mouse diaphragm","volume":"288","author":"Lopez","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M115.659375_bib17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.cellbio.23.090506.123406","article-title":"microRNA functions","volume":"23","author":"Bushati","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"10.1074\/jbc.M115.659375_bib18","first-page":"239","article-title":"Mega roles of microRNAs in regulation of skeletal muscle health and disease","volume":"5","author":"Sharma","year":"2014","journal-title":"Front. Physiol"},{"key":"10.1074\/jbc.M115.659375_bib19","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/1440-1681.12281","article-title":"MicroRNAs differentially regulated in cardiac and skeletal muscle in health and disease: potential drug targets?","volume":"41","author":"Winbanks","year":"2014","journal-title":"Clin. Exp. Pharmacol. Physiol"},{"key":"10.1074\/jbc.M115.659375_bib20","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fphys.2013.00266","article-title":"MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease","volume":"4","author":"Zacharewicz","year":"2013","journal-title":"Front. Physiol"},{"key":"10.1074\/jbc.M115.659375_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3181\/0709-MR-237","article-title":"Muscling through the microRNA world","volume":"233","author":"Callis","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1074\/jbc.M115.659375_bib22","doi-asserted-by":"crossref","first-page":"C451","DOI":"10.1152\/ajpcell.00077.2007","article-title":"MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse","volume":"293","author":"McCarthy","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M115.659375_bib23","doi-asserted-by":"crossref","first-page":"29336","DOI":"10.1074\/jbc.M110.101147","article-title":"Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3\u03b2","volume":"285","author":"Mohamed","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.659375_bib24","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1096\/fj.11-185132","article-title":"MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4","volume":"25","author":"Guan","year":"2011","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M115.659375_bib25","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1096\/fj.11-199240","article-title":"miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium","volume":"26","author":"Huang","year":"2012","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M115.659375_bib26","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/j.1478-3231.2012.02791.x","article-title":"Angiogenesis within the duodenum of patients with cirrhosis is modulated by mechanosensitive Kruppel-like factor 2 and microRNA-126","volume":"32","author":"Kobus","year":"2012","journal-title":"Liver Int"},{"key":"10.1074\/jbc.M115.659375_bib27","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1161\/ATVBAHA.114.303425","article-title":"Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs","volume":"34","author":"Kumar","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.M115.659375_bib28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.freeradbiomed.2013.05.034","article-title":"Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state","volume":"64","author":"Marin","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"10.1074\/jbc.M115.659375_bib29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1152\/japplphysiol.00301.2012","article-title":"Mechanical loading and TGF-\u03b2 change the expression of multiple miRNAs in tendon fibroblasts","volume":"113","author":"Mendias","year":"2012","journal-title":"J. Appl. Physiol"},{"key":"10.1074\/jbc.M115.659375_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4000","article-title":"The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis","volume":"4","author":"Son","year":"2013","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M115.659375_bib31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1089\/scd.2014.0191","article-title":"microRNA-21 Mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells","volume":"24","author":"Wei","year":"2015","journal-title":"Stem Cells Dev"},{"key":"10.1074\/jbc.M115.659375_bib32","doi-asserted-by":"crossref","first-page":"43394","DOI":"10.1074\/jbc.M111.235127","article-title":"Desmin regulates airway smooth muscle hypertrophy through early growth-responsive protein-1 and microRNA-26a","volume":"286","author":"Mohamed","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.659375_bib33","doi-asserted-by":"crossref","first-page":"R156","DOI":"10.1152\/ajpregu.2001.280.1.R156","article-title":"Inferences on force transmission from muscle fiber architecture of the canine diaphragm","volume":"280","author":"Boriek","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol"},{"key":"10.1074\/jbc.M115.659375_bib34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/geno.2002.6685","article-title":"The muscular dystrophy with myositis (mdm) mouse mutation disrupts a skeletal muscle-specific domain of titin","volume":"79","author":"Garvey","year":"2002","journal-title":"Genomics"},{"key":"10.1074\/jbc.M115.659375_bib35","doi-asserted-by":"crossref","first-page":"17073","DOI":"10.1074\/jbc.273.27.17073","article-title":"Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A","volume":"273","author":"Ono","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.659375_bib36","doi-asserted-by":"crossref","first-page":"W498","DOI":"10.1093\/nar\/gks494","article-title":"DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways","volume":"40","author":"Vlachos","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M115.659375_bib37","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","article-title":"miRWalk-database: prediction of possible miRNA binding sites by \u201cwalking\u201d the genes of three genomes","volume":"44","author":"Dweep","year":"2011","journal-title":"J. Biomed. Inform"},{"key":"10.1074\/jbc.M115.659375_bib38","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2337\/db13-1364","article-title":"MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1\/PGC-1\u03b1 network in skeletal muscle","volume":"63","author":"Mohamed","year":"2014","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M115.659375_bib39","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1101\/gad.1184404","article-title":"Specificity of microRNA target selection in translational repression","volume":"18","author":"Doench","year":"2004","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M115.659375_bib40","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/cdd.2013.62","article-title":"MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation","volume":"20","author":"Alexander","year":"2013","journal-title":"Cell Death Differ"},{"key":"10.1074\/jbc.M115.659375_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/2044-5040-1-27","article-title":"Regulation of DMD pathology by an ankyrin-encoded miRNA","volume":"1","author":"Alexander","year":"2011","journal-title":"Skelet. Muscle"},{"key":"10.1074\/jbc.M115.659375_bib42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/embor.2010.208","article-title":"miR-31 modulates dystrophin expression: new implications for Duchenne muscular dystrophy therapy","volume":"12","author":"Cacchiarelli","year":"2011","journal-title":"EMBO Rep"},{"key":"10.1074\/jbc.M115.659375_bib43","doi-asserted-by":"crossref","first-page":"17016","DOI":"10.1073\/pnas.0708115104","article-title":"Distinctive patterns of microRNA expression in primary muscular disorders","volume":"104","author":"Eisenberg","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.659375_bib44","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1096\/fj.08-128579","article-title":"Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia","volume":"23","author":"Greco","year":"2009","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M115.659375_bib45","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1038\/mtna.2012.26","article-title":"Expression analysis in multiple muscle groups and serum reveals complexity in the microRNA transcriptome of the mdx mouse with implications for therapy","volume":"1","author":"Roberts","year":"2012","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1074\/jbc.M115.659375_bib46","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/mt.2012.35","article-title":"Loss of miR-29 in myoblasts contributes to dystrophic muscle pathogenesis","volume":"20","author":"Wang","year":"2012","journal-title":"Mol. Ther"},{"key":"10.1074\/jbc.M115.659375_bib47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/mus.21869","article-title":"Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-\u03b21 blocker","volume":"43","author":"Taniguti","year":"2011","journal-title":"Muscle Nerve"},{"key":"10.1074\/jbc.M115.659375_bib48","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.nmd.2005.09.009","article-title":"Temporal and spatial mRNA expression patterns of TGF-\u03b21, 2, 3 and T\u03b2RI, II, III in skeletal muscles of mdx mice","volume":"16","author":"Zhou","year":"2006","journal-title":"Neuromuscul. Disord"},{"key":"10.1074\/jbc.M115.659375_bib49","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1101\/gad.465908","article-title":"Fibrinogen drives dystrophic muscle fibrosis via a TGF\u03b2\/alternative macrophage activation pathway","volume":"22","author":"Vidal","year":"2008","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M115.659375_bib50","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/1097-4598(200103)24:3<428::AID-MUS1018>3.0.CO;2-E","article-title":"Impact of prednisone on TGF-\u03b21 and collagen in diaphragm muscle from mdx mice","volume":"24","author":"Hartel","year":"2001","journal-title":"Muscle Nerve"},{"key":"10.1074\/jbc.M115.659375_bib51","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1172\/JCI118101","article-title":"Expression of transforming growth factor-\u03b21 in dystrophic patient muscles correlates with fibrosis: pathogenetic role of a fibrogenic cytokine","volume":"96","author":"Bernasconi","year":"1995","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.659375_bib52","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nm1536","article-title":"Angiotensin II type 1 receptor blockade attenuates TGF-\u03b2-induced failure of muscle regeneration in multiple myopathic states","volume":"13","author":"Cohn","year":"2007","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.659375_bib53","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1139\/o02-161","article-title":"TGF-beta and the Smad signal transduction pathway","volume":"80","author":"Mehra","year":"2002","journal-title":"Biochem. Cell Biol"},{"key":"10.1074\/jbc.M115.659375_bib54","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1161\/ATVBAHA.114.303425","article-title":"Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs","volume":"34","author":"Kumar","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.M115.659375_bib55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2044-5040-1-21","article-title":"Aberrant repair and fibrosis development in skeletal muscle","volume":"1","author":"Mann","year":"2011","journal-title":"Skelet. Muscle"},{"key":"10.1074\/jbc.M115.659375_bib56","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1093\/hmg\/ddr105","article-title":"Therapeutic approaches to muscular dystrophy","volume":"20","author":"Goyenvalle","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M115.659375_bib57","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.stem.2007.11.003","article-title":"Modified patient stem cells as prelude to autologous treatment of muscular dystrophy","volume":"1","author":"Davies","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1074\/jbc.M115.659375_bib58","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/BOR.0b013e328358df34","article-title":"TGF\u03b2 signaling: its role in fibrosis formation and myopathies","volume":"24","author":"MacDonald","year":"2012","journal-title":"Curr. Opin. Rheumatol"},{"key":"10.1074\/jbc.M115.659375_bib59","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.spen.2006.06.003","article-title":"Congenital muscular dystrophies and the extracellular matrix","volume":"13","author":"Schessl","year":"2006","journal-title":"Semin. Pediatr. Neurol"},{"key":"10.1074\/jbc.M115.659375_bib60","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/352536a0","article-title":"The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy","volume":"352","author":"Stedman","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.659375_bib61","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/NEN.0b013e3181aa31c2","article-title":"Endomysial fibrosis in Duchenne muscular dystrophy: a marker of poor outcome associated with macrophage alternative activation","volume":"68","author":"Desguerre","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1074\/jbc.M115.659375_bib62","first-page":"221","article-title":"Expression of transforming growth factor-\u03b21 and its relation to endomysial fibrosis in progressive muscular dystrophy","volume":"144","author":"Yamazaki","year":"1994","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M115.659375_bib63","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jns.2007.09.043","article-title":"Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy","volume":"267","author":"Sun","year":"2008","journal-title":"J. Neurol. Sci"},{"key":"10.1074\/jbc.M115.659375_bib64","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/mus.20150","article-title":"Localization and early time course of TGF-\u03b21 mRNA expression in dystrophic muscle","volume":"30","author":"Gosselin","year":"2004","journal-title":"Muscle Nerve"},{"key":"10.1074\/jbc.M115.659375_bib65","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jneuroim.2006.03.005","article-title":"Immunomodulation of TGF-\u03b21 in mdx mouse inhibits connective tissue proliferation in diaphragm but increases inflammatory response: implications for antifibrotic therapy","volume":"175","author":"Andreetta","year":"2006","journal-title":"J. Neuroimmunol"},{"key":"10.1074\/jbc.M115.659375_bib66","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nrm2297","article-title":"TGF \u03b2-SMAD signal transduction: molecular specificity and functional flexibility","volume":"8","author":"Schmierer","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M115.659375_bib67","doi-asserted-by":"crossref","first-page":"6722","DOI":"10.1093\/hmg\/ddu390","article-title":"Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy","volume":"23","author":"Goldstein","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M115.659375_bib68","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.659375_bib69","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1261\/rna.2146903","article-title":"New microRNAs from mouse and human","volume":"9","author":"Lagos-Quintana","year":"2003","journal-title":"RNA"},{"key":"10.1074\/jbc.M115.659375_bib70","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tcb.2008.07.007","article-title":"The let-7 family of microRNAs","volume":"18","author":"Roush","year":"2008","journal-title":"Trends Cell Biol"},{"key":"10.1074\/jbc.M115.659375_bib71","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physiolgenomics.00148.2010","article-title":"Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis","volume":"43","author":"Drummond","year":"2011","journal-title":"Physiol. Genomics"},{"key":"10.1074\/jbc.M115.659375_bib72","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1093\/nar\/gkr145","article-title":"The type II poly(A)-binding protein PABP-2 genetically interacts with the let-7 miRNA and elicits heterochronic phenotypes in Caenorhabditis elegans","volume":"39","author":"Hurschler","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M115.659375_bib73","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/ng0298-164","article-title":"Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy","volume":"18","author":"Brais","year":"1998","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M115.659375_bib74","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/emmm.200900045","article-title":"Molecular aging and rejuvenation of human muscle stem cells","volume":"1","author":"Carlson","year":"2009","journal-title":"EMBO Mol. Med"},{"key":"10.1074\/jbc.M115.659375_bib75","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1042\/BJ20141175","article-title":"miR-98 delays skeletal muscle differentiation by down-regulating E2F5","volume":"466","author":"Kropp","year":"2015","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M115.659375_bib76","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1152\/jappl.1994.77.5.2065","article-title":"Inferences on passive diaphragm mechanics from gross anatomy","volume":"77","author":"Boriek","year":"1994","journal-title":"J. Appl. Physiol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820446216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820446216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.659375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T14:43:56Z","timestamp":1718030636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820446216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":76,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0021925820446216"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.659375","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide Mechanosensitive MicroRNA (MechanomiR) Screen Uncovers Dysregulation of Their Regulatory Networks in the mdm Mouse Model of Muscular Dystrophy","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.659375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}