{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:52:09Z","timestamp":1740127929563,"version":"3.37.3"},"reference-count":55,"publisher":"Elsevier BV","issue":"41","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":1802,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P23135","P24946"],"award-info":[{"award-number":["P23135","P24946"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1074\/jbc.m115.660316","type":"journal-article","created":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T00:09:44Z","timestamp":1440202184000},"page":"24932-24944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide"],"prefix":"10.1016","volume":"290","author":[{"given":"Christian L.","family":"Heine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Geckl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Schrammel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Gesslbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonius C.F.","family":"Gorren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.660316_bib1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00424-009-0773-9","article-title":"The multiple actions of NO","volume":"459","author":"Gao","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1074\/jbc.M115.660316_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.niox.2013.07.002","article-title":"Hydrogen sulfide chemical biology: pathophysiological roles and detection","volume":"35","author":"Kolluru","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1074\/jbc.M115.660316_bib3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/ars.2013.5309","article-title":"Production and physiological effects of hydrogen sulfide","volume":"20","author":"Kimura","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1074\/jbc.M115.660316_bib4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M115.660316_bib5","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbagen.2006.08.019","article-title":"Nitric-oxide synthase: a cytochrome P450 family foster child","volume":"1770","author":"Gorren","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.660316_bib6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur. Heart J"},{"key":"10.1074\/jbc.M115.660316_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2174\/1389200024605154","article-title":"Tetrahydrobiopterin in nitric oxide synthesis: a novel biological role for pteridines","volume":"3","author":"Gorren","year":"2002","journal-title":"Curr. Drug Metab"},{"key":"10.1074\/jbc.M115.660316_bib8","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1021\/cr0204350","article-title":"Tetrahydrobiopterin radical enzymology","volume":"103","author":"Wei","year":"2003","journal-title":"Chem. Rev"},{"key":"10.1074\/jbc.M115.660316_bib9","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1021\/cr300163e","article-title":"Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery","volume":"113","author":"Paulsen","year":"2013","journal-title":"Chem. Rev"},{"key":"10.1074\/jbc.M115.660316_bib10","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1089\/ars.2013.5339","article-title":"Enzymology of H2S biogenesis, decay and signaling","volume":"20","author":"Kabil","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1074\/jbc.M115.660316_bib11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/tx2005234","article-title":"Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species","volume":"25","author":"Fukuto","year":"2012","journal-title":"Chem. Res. Toxicol"},{"key":"10.1074\/jbc.M115.660316_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2012.11.005","article-title":"Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides","volume":"55","author":"King","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"10.1074\/jbc.M115.660316_bib13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.redox.2013.05.001","article-title":"A tale of two gases: NO and H2S, foes or friends for life?","volume":"1","author":"Kolluru","year":"2013","journal-title":"Redox Biol"},{"key":"10.1074\/jbc.M115.660316_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.niox.2014.05.014","article-title":"Hydrogen sulfide and nitric oxide interactions in inflammation","volume":"41","author":"Lo Faro","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1074\/jbc.M115.660316_bib15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tox.2006.12.023","article-title":"Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension","volume":"232","author":"Kubo","year":"2007","journal-title":"Toxicology"},{"key":"10.1074\/jbc.M115.660316_bib16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tox.2007.08.087","article-title":"Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase","volume":"241","author":"Kubo","year":"2007","journal-title":"Toxicology"},{"key":"10.1074\/jbc.M115.660316_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.niox.2013.07.001","article-title":"Chemical foundations of hydrogen sulfide biology","volume":"35","author":"Li","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1074\/jbc.M115.660316_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.niox.2014.12.009","article-title":"On the chemical biology of the nitrite\/sulfide interaction","volume":"46","author":"Cortese-Krott","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1074\/jbc.M115.660316_bib19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.abb.2011.09.015","article-title":"The reaction of H2S with oxidized thiols: generation of persulfides and implications to H2S biology","volume":"516","author":"Francoleon","year":"2011","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.M115.660316_bib20","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1006\/bbrc.1996.0763","article-title":"High-level expression of mouse inducible nitric oxide synthase in Escherichia coli requires coexpression with calmodulin","volume":"222","author":"Wu","year":"1996","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M115.660316_bib21","doi-asserted-by":"crossref","first-page":"37658","DOI":"10.1074\/jbc.274.53.37658","article-title":"Characterization of recombinant human endothelial nitric-oxide synthase purified from the yeast Pichia pastoris","volume":"274","author":"Leber","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.660316_bib22","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0076-6879(96)68044-6","article-title":"Large-scale purification of rat brain nitric oxide synthase from baculovirus overexpression system","volume":"268","author":"Mayer","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M115.660316_bib23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem"},{"key":"10.1074\/jbc.M115.660316_bib24","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/0028-3908(94)90024-8","article-title":"Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole","volume":"33","author":"Mayer","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1074\/jbc.M115.660316_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(91)81031-3","article-title":"Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase","volume":"288","author":"Mayer","year":"1991","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M115.660316_bib26","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1002\/j.1460-2075.1995.tb00038.x","article-title":"Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer","volume":"14","author":"Klatt","year":"1995","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M115.660316_bib27","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1021\/bi962381s","article-title":"Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition, and enzyme stabilization","volume":"36","author":"Gorren","year":"1997","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M115.660316_bib28","doi-asserted-by":"crossref","first-page":"ra72","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal"},{"key":"10.1074\/jbc.M115.660316_bib29","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/0016-7037(88)90183-4","article-title":"The pK1* for the dissociation of H2S in various ionic media","volume":"52","author":"Hershey","year":"1988","journal-title":"Geochim. Cosmochim. Acta"},{"key":"10.1074\/jbc.M115.660316_bib30","doi-asserted-by":"crossref","first-page":"22997","DOI":"10.1074\/jbc.270.39.22997","article-title":"Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis","volume":"270","author":"Abu-Soud","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.660316_bib31","doi-asserted-by":"crossref","first-page":"17349","DOI":"10.1074\/jbc.M000050200","article-title":"Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase","volume":"275","author":"Abu-Soud","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.660316_bib32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/bj3470475","article-title":"Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyltetrahydrobiopterin","volume":"347","author":"Gorren","year":"2000","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M115.660316_bib33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj3230159","article-title":"Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: Tetrahydrobiopterin binding kinetics and role of haem in dimerization","volume":"323","author":"List","year":"1997","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M115.660316_bib34","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137). New insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"10.1074\/jbc.M115.660316_bib35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.freeradbiomed.2014.08.024","article-title":"Aerobic nitric oxide-induced thiol nitrosation in the presence and absence of magnesium cations","volume":"76","author":"Kolesnik","year":"2014","journal-title":"Free Radic. Biol. Med"},{"key":"10.1074\/jbc.M115.660316_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5381","article-title":"H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway","volume":"5","author":"Eberhardt","year":"2014","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M115.660316_bib37","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1042\/bj3400745","article-title":"Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity","volume":"340","author":"Kotsonis","year":"1999","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M115.660316_bib38","doi-asserted-by":"crossref","first-page":"ra87","DOI":"10.1126\/scisignal.2005478","article-title":"The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide","volume":"7","author":"Altaany","year":"2014","journal-title":"Sci. Signal"},{"key":"10.1074\/jbc.M115.660316_bib39","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nature09599","article-title":"S-Glutathionylation uncouples eNOS and regulates its cellular and vascular function","volume":"468","author":"Chen","year":"2010","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.660316_bib40","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.1021\/bi400404s","article-title":"Redox modulation of endothelial nitric oxide synthase by glutaredoxin-1 through reversible oxidative post-translational modification","volume":"52","author":"Chen","year":"2013","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M115.660316_bib41","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1074\/jbc.M112.415992","article-title":"Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling","volume":"288","author":"Crabtree","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.660316_bib42","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1073\/pnas.0300464101","article-title":"S-Nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity","volume":"101","author":"Ravi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.660316_bib43","doi-asserted-by":"crossref","first-page":"19888","DOI":"10.1074\/jbc.M413058200","article-title":"Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells","volume":"280","author":"Erwin","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.660316_bib44","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1021\/bi0474463","article-title":"S-Nitrosation and regulation of inducible nitric oxide synthase","volume":"44","author":"Mitchell","year":"2005","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M115.660316_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052788","article-title":"N-Methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity","volume":"7","author":"Qu","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M115.660316_bib46","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)81718-3","article-title":"Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center","volume":"95","author":"Raman","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.660316_bib47","doi-asserted-by":"crossref","first-page":"35786","DOI":"10.1074\/jbc.M005976200","article-title":"Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase","volume":"275","author":"Hemmens","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.660316_bib48","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1097\/HJH.0b013e32829b8fd0","article-title":"The novel gaseous vasorelaxant hydrogen sulfide inhibits angiotensin-converting enzyme activity of endothelial cells","volume":"25","author":"Laggner","year":"2007","journal-title":"J. Hypertens"},{"key":"10.1074\/jbc.M115.660316_bib49","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1161\/ATVBAHA.110.209783","article-title":"Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity","volume":"30","author":"Bucci","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.M115.660316_bib50","doi-asserted-by":"crossref","first-page":"31020","DOI":"10.1074\/jbc.M203749200","article-title":"Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III","volume":"277","author":"Panda","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.660316_bib51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.freeradbiomed.2013.04.034","article-title":"Efficient nitrosation of glutathione by nitric oxide","volume":"63","author":"Kolesnik","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"10.1074\/jbc.M115.660316_bib52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.redox.2013.12.031","article-title":"Nitrosopersulfide (SSNO\u2212) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide","volume":"2","author":"Cortese-Krott","year":"2014","journal-title":"Redox Biol"},{"key":"10.1074\/jbc.M115.660316_bib53","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1582-4934.2009.00645.x","article-title":"Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability?","volume":"13","author":"Whiteman","year":"2009","journal-title":"J. Cell. Mol. Med"},{"key":"10.1074\/jbc.M115.660316_bib54","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.niox.2014.05.012","article-title":"Controversies and conundrums in hydrogen sulfide biology","volume":"41","author":"Olson","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1074\/jbc.M115.660316_bib55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.niox.2014.06.003","article-title":"Working with \u201cH2S\u201d: facts and apparent artifacts","volume":"41","author":"Wedmann","year":"2014","journal-title":"Nitric Oxide"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820446174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820446174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.660316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T21:40:53Z","timestamp":1616794853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820446174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":55,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0021925820446174"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.660316","relation":{},"ISSN":["0021-9258"],"issn-type":[{"type":"print","value":"0021-9258"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.660316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}