{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:13:39Z","timestamp":1789762419233,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":1707,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1074\/jbc.m115.664003","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T20:36:51Z","timestamp":1449607011000},"page":"2345-2356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae"],"prefix":"10.1016","volume":"291","author":[{"given":"Toshio","family":"Sekiguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kuwasako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Osugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikunobu","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Sasayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honoo","family":"Satake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.664003_bib1","doi-asserted-by":"crossref","first-page":"C19","DOI":"10.1007\/BF01991124","article-title":"The contribution of calcitonin gene-related peptide (CGRP) to neurogenic vasodilator responses","volume":"38","author":"Brain","year":"1993","journal-title":"Agents Actions"},{"key":"10.1074\/jbc.M115.664003_bib2","doi-asserted-by":"crossref","first-page":"7763","DOI":"10.1073\/pnas.85.20.7763","article-title":"Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle","volume":"85","author":"Cooper","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.664003_bib3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/bbrc.1993.1451","article-title":"Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma","volume":"192","author":"Kitamura","year":"1993","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M115.664003_bib4","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1210\/en.2005-1226","article-title":"Central effects of calcitonin receptor-stimulating peptide-1 on energy homeostasis in rats","volume":"147","author":"Sawada","year":"2006","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M115.664003_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ygcen.2014.04.025","article-title":"Calcitonin receptor family evolution and fishing for function using in silico promoter analysis","volume":"209","author":"Martins","year":"2014","journal-title":"Gen. Comp. Endocrinol"},{"key":"10.1074\/jbc.M115.664003_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-4614-2364-5_3","article-title":"Regulation of GPCR trafficking by RAMPs","volume":"744","author":"Bomberger","year":"2012","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1074\/jbc.M115.664003_bib7","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.peptides.2011.05.022","article-title":"Shared and separate functions of the RAMP-based adrenomedullin receptors","volume":"32","author":"Kuwasako","year":"2011","journal-title":"Peptides"},{"key":"10.1074\/jbc.M115.664003_bib8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/30666","article-title":"RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor","volume":"393","author":"McLatchie","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.664003_bib9","doi-asserted-by":"crossref","first-page":"E2028","DOI":"10.1073\/pnas.1219956110","article-title":"Molecular evolution of peptidergic signaling systems in bilaterians","volume":"110","author":"Mirabeau","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.664003_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ygcen.2013.12.002","article-title":"Neuropeptides and polypeptide hormones in echinoderms: new insights from analysis of the transcriptome of the sea cucumber Apostichopus japonicus","volume":"197","author":"Rowe","year":"2014","journal-title":"Gen. Comp. Endocrinol"},{"key":"10.1074\/jbc.M115.664003_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ygcen.2012.09.009","article-title":"The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus","volume":"179","author":"Rowe","year":"2012","journal-title":"Gen. Comp. Endocrinol"},{"key":"10.1074\/jbc.M115.664003_bib12","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1111\/j.1742-4658.2009.07151.x","article-title":"Calcitonin in a protochordate, Ciona intestinalis: the prototype of the vertebrate calcitonin\/calcitonin gene-related peptide superfamily","volume":"276","author":"Sekiguchi","year":"2009","journal-title":"FEBS J"},{"key":"10.1074\/jbc.M115.664003_bib13","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1242\/dev.066720","article-title":"Evolutionary crossroads in developmental biology: amphioxus","volume":"138","author":"Bertrand","year":"2011","journal-title":"Development"},{"key":"10.1074\/jbc.M115.664003_bib14","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nature04336","article-title":"Tunicates and not cephalochordates are the closest living relatives of vertebrates","volume":"439","author":"Delsuc","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.664003_bib15","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nature06967","article-title":"The amphioxus genome and the evolution of the chordate karyotype","volume":"453","author":"Putnam","year":"2008","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.664003_bib16","doi-asserted-by":"crossref","first-page":"W349","DOI":"10.1093\/nar\/gkt381","article-title":"Scalable web services for the PSIPRED Protein Analysis Workbench","volume":"41","author":"Buchan","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M115.664003_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1530\/JOE-11-0410","article-title":"Molecular and functional characterization of cionin receptors in the ascidian, Ciona intestinalis: the evolutionary origin of the vertebrate cholecystokinin\/gastrin family","volume":"213","author":"Sekiguchi","year":"2012","journal-title":"J. Endocrinol"},{"key":"10.1074\/jbc.M115.664003_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0378-1119(88)90330-7","article-title":"CLUSTAL: a package for performing multiple sequence alignment on a microcomputer","volume":"73","author":"Higgins","year":"1988","journal-title":"Gene"},{"key":"10.1074\/jbc.M115.664003_bib19","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol. Biol. Evol"},{"key":"10.1074\/jbc.M115.664003_bib20","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0","volume":"24","author":"Tamura","year":"2007","journal-title":"Mol. Biol. Evol"},{"key":"10.1074\/jbc.M115.664003_bib21","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/dvdy.20401","article-title":"Comparative expression analysis of transcription factor genes in the endostyle of invertebrate chordates","volume":"233","author":"Hiruta","year":"2005","journal-title":"Dev. Dyn"},{"key":"10.1074\/jbc.M115.664003_bib22","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1248\/cpb.38.1920","article-title":"Synthesis and biological property of \u03b1-human atrial natriuretic peptide analogs with a constrained or stereochemically modified cyclic moiety","volume":"38","author":"Minamitake","year":"1990","journal-title":"Chem. Pharm. Bull"},{"key":"10.1074\/jbc.M115.664003_bib23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1476-5381.2011.01803.x","article-title":"The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling","volume":"166","author":"Kuwasako","year":"2012","journal-title":"Br. J. Pharmacol"},{"key":"10.1074\/jbc.M115.664003_bib24","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1210\/en.2011-1668","article-title":"Evidence for differential regulation of GnRH signaling via heterodimerization among GnRH receptor paralogs in the protochordate, Ciona intestinalis","volume":"153","author":"Sakai","year":"2012","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M115.664003_bib25","doi-asserted-by":"crossref","first-page":"9662","DOI":"10.1073\/pnas.86.24.9662","article-title":"Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus","volume":"86","author":"Roberts","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.664003_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/304129a0","article-title":"Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing","volume":"304","author":"Rosenfeld","year":"1983","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.664003_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1615\/CritRevNeurobiol.v11.i2-3.40","article-title":"Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily","volume":"11","author":"Wimalawansa","year":"1997","journal-title":"Crit. Rev. Neurobiol"},{"key":"10.1074\/jbc.M115.664003_bib28","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1210\/en.2004-0722","article-title":"Characterization of crustacean cardioactive peptide as a novel insect midgut factor: isolation, localization, and stimulation of \u03b1-amylase activity and gut contraction","volume":"145","author":"Sakai","year":"2004","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M115.664003_bib29","doi-asserted-by":"crossref","first-page":"11894","DOI":"10.1073\/pnas.91.25.11894","article-title":"Expression of the allatostatin gene in endocrine cells of the cockroach midgut","volume":"91","author":"Reichwald","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.664003_bib30","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.bbrc.2004.05.103","article-title":"Aspartate(69) of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2","volume":"319","author":"Ittner","year":"2004","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M115.664003_bib31","doi-asserted-by":"crossref","first-page":"20387","DOI":"10.1074\/jbc.M313058200","article-title":"Selective inactivation of adrenomedullin over calcitonin gene-related peptide receptor function by the deletion of amino acids 14\u201320 of the mouse calcitonin-like receptor","volume":"279","author":"Koller","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.664003_bib32","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.peptides.2004.06.002","article-title":"Adrenomedullin receptors: pharmacological features and possible pathophysiological roles","volume":"25","author":"Kuwasako","year":"2004","journal-title":"Peptides"},{"key":"10.1074\/jbc.M115.664003_bib33","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pharmthera.2005.06.015","article-title":"GPCR modulation by RAMPs","volume":"109","author":"Hay","year":"2006","journal-title":"Pharmacol. Ther"},{"key":"10.1074\/jbc.M115.664003_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.drudis.2008.12.009","article-title":"Modulating receptor function through RAMPs: can they represent drug targets in themselves?","volume":"14","author":"Sexton","year":"2009","journal-title":"Drug Discov. Today"},{"key":"10.1074\/jbc.M115.664003_bib35","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1210\/en.2007-1735","article-title":"Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors","volume":"149","author":"Morfis","year":"2008","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M115.664003_bib36","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/298240a0","article-title":"Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products","volume":"298","author":"Amara","year":"1982","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.664003_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jemt.10052","article-title":"Adrenomedullin and PAMP: discovery, structures, and cardiovascular functions","volume":"57","author":"Kitamura","year":"2002","journal-title":"Microsc. Res. Tech"},{"key":"10.1074\/jbc.M115.664003_bib38","first-page":"821","article-title":"Calcitonin and calcium metabolism","volume":"103","author":"Copp","year":"1970","journal-title":"Can. Med. Assoc. J"},{"key":"10.1074\/jbc.M115.664003_bib39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ygcen.2007.01.027","article-title":"Evolution of the CT\/CGRP family: comparative study with new data from models of teleosts, the eel, and cephalopod molluscs, the cuttlefish and the nautilus","volume":"153","author":"Lafont","year":"2007","journal-title":"Gen. Comp. Endocrinol"},{"key":"10.1074\/jbc.M115.664003_bib40","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0149-7634(96)00023-1","article-title":"Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors","volume":"21","author":"van Rossum","year":"1997","journal-title":"Neurosci. Biobehav. Rev"},{"key":"10.1074\/jbc.M115.664003_bib41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1006\/gcen.1998.7195","article-title":"Calcitonin cells in the intestine of goldfish and a comparison of the number of cells among saline-fed, soup-fed, or high Ca soup-fed fishes","volume":"113","author":"Okuda","year":"1999","journal-title":"Gen. Comp. Endocrinol"},{"key":"10.1074\/jbc.M115.664003_bib42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0167-0115(96)00005-5","article-title":"Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion","volume":"62","author":"Mulder","year":"1996","journal-title":"Regul. Pept"},{"key":"10.1074\/jbc.M115.664003_bib43","doi-asserted-by":"crossref","first-page":"10333","DOI":"10.1021\/bi0347508","article-title":"N-Glycosylation and conserved cysteine residues in RAMP3 play a critical role for the functional expression of CRLR\/RAMP3 adrenomedullin receptor","volume":"42","author":"Flahaut","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M115.664003_bib44","doi-asserted-by":"crossref","first-page":"22623","DOI":"10.1074\/jbc.M302571200","article-title":"Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity","volume":"278","author":"Kuwasako","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.664003_bib45","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1291\/hypres.26.S25","article-title":"The function of extracellular cysteines in the human adrenomedullin receptor","volume":"26","author":"Kuwasako","year":"2003","journal-title":"Hypertens. Res"},{"key":"10.1074\/jbc.M115.664003_bib46","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1476-5381.2009.00541.x","article-title":"Structure-function relationships of the N-terminus of receptor activity-modifying proteins","volume":"159","author":"Qi","year":"2010","journal-title":"Br. J. Pharmacol"},{"key":"10.1074\/jbc.M115.664003_bib47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/bfgp\/els003","article-title":"How much does the amphioxus genome represent the ancestor of chordates?","volume":"11","author":"Louis","year":"2012","journal-title":"Brief Funct. Genomics"},{"key":"10.1074\/jbc.M115.664003_bib48","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1042\/BST0320843","article-title":"Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin","volume":"32","author":"Conner","year":"2004","journal-title":"Biochem. Soc. Trans"},{"key":"10.1074\/jbc.M115.664003_bib49","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.ibmb.2012.06.006","article-title":"Calcitonin-like diuretic hormones in insects","volume":"42","author":"Zandawala","year":"2012","journal-title":"Insect Biochem. Mol. Biol"},{"key":"10.1074\/jbc.M115.664003_bib50","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1080\/09168451.2015.1018128","article-title":"Identification and characterization of the diuretic hormone 31 receptor in the silkworm Bombyx mori","volume":"79","author":"Iga","year":"2015","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"10.1074\/jbc.M115.664003_bib51","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1242\/jeb.01529","article-title":"A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling","volume":"208","author":"Johnson","year":"2005","journal-title":"J. Exp. Biol"},{"key":"10.1074\/jbc.M115.664003_bib52","doi-asserted-by":"crossref","first-page":"e82466","DOI":"10.1371\/journal.pone.0082466","article-title":"Isolation and functional characterization of calcitonin-like diuretic hormone receptors in Rhodnius prolixus","volume":"8","author":"Zandawala","year":"2013","journal-title":"PLoS One"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820360725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820360725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.664003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T02:44:04Z","timestamp":1641264244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820360725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0021925820360725"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.664003","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.664003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}