{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:11:02Z","timestamp":1770534662145,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"43","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":1805,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1074\/jbc.m115.665695","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T01:50:23Z","timestamp":1442281823000},"page":"25907-25919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure"],"prefix":"10.1016","volume":"290","author":[{"given":"Thomas J.","family":"Cahill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Leo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Stockenhuber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nolan W.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyuan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Cereghetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabor","family":"Czibik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Lao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Bellahcene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violetta","family":"Steeples","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safar","family":"Ghaffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Yavari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Poulton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.P.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Scorrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishani T.","family":"Hettiarachchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Peers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Blake","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Neil","family":"Dear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houman","family":"Ashrafian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.665695_bib1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/CIRCRESAHA.113.300282","article-title":"Genetic cardiomyopathies causing heart failure","volume":"113","author":"Cahill","year":"2013","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.665695_bib2","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart: an engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M115.665695_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001000","article-title":"A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy","volume":"6","author":"Ashrafian","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.M115.665695_bib4","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1074\/jbc.M115.665695_bib5","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.bbamcr.2013.02.002","article-title":"New insights into the function and regulation of mitochondrial fission","volume":"1833","author":"Otera","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.665695_bib6","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M115.665695_bib7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M115.665695_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ncb2220","article-title":"During autophagy mitochondria elongate, are spared from degradation and sustain cell viability","volume":"13","author":"Gomes","year":"2011","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M115.665695_bib9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature10992","article-title":"Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure","volume":"485","author":"Oka","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.665695_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.665695_bib11","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1056\/NEJMoa064436","article-title":"A lethal defect of mitochondrial and peroxisomal fission","volume":"356","author":"Waterham","year":"2007","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M115.665695_bib12","doi-asserted-by":"crossref","first-page":"32494","DOI":"10.1074\/jbc.M110.142430","article-title":"A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division","volume":"285","author":"Chang","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.665695_bib13","doi-asserted-by":"crossref","first-page":"15803","DOI":"10.1073\/pnas.0808249105","article-title":"Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria","volume":"105","author":"Cereghetti","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.665695_bib14","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ncb1907","article-title":"Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice","volume":"11","author":"Ishihara","year":"2009","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M115.665695_bib15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.200309082","article-title":"Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis","volume":"164","author":"Karbowski","year":"2004","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M115.665695_bib16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2012.01.017","article-title":"Fumarate Is cardioprotective via activation of the Nrf2 antioxidant pathway","volume":"15","author":"Ashrafian","year":"2012","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M115.665695_bib17","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1084\/jem.20061318","article-title":"Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages","volume":"203","author":"Ling","year":"2006","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M115.665695_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10863-009-9214-x","article-title":"Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cells","volume":"41","author":"Beraud","year":"2009","journal-title":"J. Bioenerg. Biomembr"},{"key":"10.1074\/jbc.M115.665695_bib19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbamcr.2012.03.008","article-title":"Mitochondrial dynamics in heart disease","volume":"1833","author":"Dorn","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.665695_bib20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/brain\/awm335","article-title":"OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion","volume":"131","author":"Zanna","year":"2008","journal-title":"Brain"},{"key":"10.1074\/jbc.M115.665695_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M115.665695_bib22","doi-asserted-by":"crossref","first-page":"20728","DOI":"10.1073\/pnas.0808953105","article-title":"Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase","volume":"105","author":"Saotome","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.665695_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molcel.2004.09.026","article-title":"Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis","volume":"16","author":"Szabadkai","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M115.665695_bib24","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.bbabio.2010.03.018","article-title":"Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes","volume":"1797","author":"Hom","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.665695_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069165","article-title":"Mitochondrial hyperfusion during oxidative stress is coupled to a dysregulation in calcium handling within a C2C12 cell model","volume":"8","author":"Redpath","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M115.665695_bib26","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.yjmcc.2009.03.003","article-title":"Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling","volume":"46","author":"Murgia","year":"2009","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M115.665695_bib27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature07534","article-title":"Mitofusin 2 tethers endoplasmic reticulum to mitochondria","volume":"456","author":"de Brito","year":"2008","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.665695_bib28","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/CIRCRESAHA.114.301863","article-title":"Matrix revisited: mechanisms linking energy substrate metabolism to the function of the heart","volume":"114","author":"Carley","year":"2014","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.665695_bib29","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.1201940","article-title":"Mitochondria and the autophagy-inflammation-cell death axis in organismal aging","volume":"333","author":"Green","year":"2011","journal-title":"Science"},{"key":"10.1074\/jbc.M115.665695_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.665695_bib31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.mib.2013.05.005","article-title":"Mitochondria: sensors and mediators of innate immune receptor signaling","volume":"16","author":"Cloonan","year":"2013","journal-title":"Curr. Opin. Microbiol"},{"key":"10.1074\/jbc.M115.665695_bib32","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.2353\/ajpath.2009.080875","article-title":"Functional significance and morphological characterization of starvation-induced autophagy in the adult heart","volume":"174","author":"Kanamori","year":"2009","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M115.665695_bib33","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/nm.2247","article-title":"Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration","volume":"16","author":"Grumati","year":"2010","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.665695_bib34","doi-asserted-by":"crossref","first-page":"22753","DOI":"10.1074\/jbc.C110.130013","article-title":"Dynamin 2 mutants linked to centronuclear myopathies form abnormally stable polymers","volume":"285","author":"Wang","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.665695_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbagen.2013.09.001","article-title":"A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells","volume":"1840","author":"James","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.665695_bib36","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1161\/CIRCRESAHA.116.303356","article-title":"Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress","volume":"116","author":"Ikeda","year":"2015","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.665695_bib37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2014.12.011","article-title":"Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse Hearts and cultured fibroblasts","volume":"21","author":"Song","year":"2015","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M115.665695_bib38","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.15252\/embj.201488658","article-title":"Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain","volume":"33","author":"Kageyama","year":"2014","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M115.665695_bib39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/CIRCRESAHA.114.305672","article-title":"Gone Fission \u2026 : diverse consequences of cardiac Drp1 deficiency","volume":"116","author":"Dorn","year":"2015","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.665695_bib40","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/embr.201337945","article-title":"Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2","volume":"15","author":"Shintani","year":"2014","journal-title":"EMBO Rep"},{"key":"10.1074\/jbc.M115.665695_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003257","article-title":"Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA","volume":"3","author":"Parone","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M115.665695_bib42","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1161\/CIRCULATIONAHA.109.906610","article-title":"Inhibiting mitochondrial fission protects the heart against ischemia\/reperfusion injury","volume":"121","author":"Ong","year":"2010","journal-title":"Circulation"},{"key":"10.1074\/jbc.M115.665695_bib43","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000461","article-title":"Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction","volume":"2","author":"Disatnik","year":"2013","journal-title":"J. Am. Heart Assoc"}],"updated-by":[{"DOI":"10.1074\/jbc.a115.665695","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T00:00:00Z","timestamp":1480636800000}}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820495729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820495729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.665695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T18:21:27Z","timestamp":1641320487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820495729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":43,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0021925820495729"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.665695","relation":{"correction":[{"id-type":"doi","id":"10.1074\/jbc.A115.665695","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.665695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}