{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:54:46Z","timestamp":1790744086191,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":1792,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR049069"],"award-info":[{"award-number":["AR049069"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR066508"],"award-info":[{"award-number":["AR066508"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR068103"],"award-info":[{"award-number":["AR068103"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR056950"],"award-info":[{"award-number":["AR056950"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR065753"],"award-info":[{"award-number":["AR065753"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR066342"],"award-info":[{"award-number":["AR066342"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR065397"],"award-info":[{"award-number":["AR065397"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR039588"],"award-info":[{"award-number":["AR039588"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE020194"],"award-info":[{"award-number":["DE020194"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1074\/jbc.m115.672345","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T22:19:48Z","timestamp":1443651588000},"page":"27604-27617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":169,"title":["Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2"],"prefix":"10.1016","volume":"290","author":[{"given":"Amel","family":"Dudakovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily T.","family":"Camilleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Riester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E.","family":"McGee-Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Paradise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Lewallen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Thaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Deyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Noelle","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Lewallen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan B.","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Montecino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Westendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre J.","family":"van Wijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.672345_bib1","series-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","first-page":"1","article-title":"Skeletal Morphogenesis and Embryonic Development","author":"Yang","year":"2013"},{"key":"10.1074\/jbc.M115.672345_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluripotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Jiang","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.672345_bib3","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/jbmr.317","article-title":"Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation","volume":"26","author":"Pike","year":"2011","journal-title":"J. Bone Miner Res"},{"key":"10.1074\/jbc.M115.672345_bib4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nrendo.2011.234","article-title":"MicroRNA control of bone formation and homeostasis","volume":"8","author":"Lian","year":"2012","journal-title":"Nat. Rev. Endocrinol"},{"key":"10.1074\/jbc.M115.672345_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2010.12.003","article-title":"Histone deacetylases in skeletal development and bone mass maintenance","volume":"474","author":"McGee-Lawrence","year":"2011","journal-title":"Gene"},{"key":"10.1074\/jbc.M115.672345_bib6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0002-9343(93)90218-E","article-title":"Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis","volume":"94","year":"1993","journal-title":"Am. J. Med"},{"key":"10.1074\/jbc.M115.672345_bib7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005\u20132025","volume":"22","author":"Burge","year":"2007","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M115.672345_bib8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000063449","article-title":"Epidemiology of osteoporotic fractures","volume":"54","author":"Dennison","year":"2000","journal-title":"Horm. Res"},{"key":"10.1074\/jbc.M115.672345_bib9","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/01.gme.0000222475.93345.b3","article-title":"Management of osteoporosis in postmenopausal women: 2006 position statement of the North American Menopause Society","volume":"13","year":"2006","journal-title":"Menopause"},{"key":"10.1074\/jbc.M115.672345_bib10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/jama.282.7.637","article-title":"Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial: Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators","volume":"282","author":"Ettinger","year":"1999","journal-title":"JAMA"},{"key":"10.1074\/jbc.M115.672345_bib11","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1359\/jbmr.080710","article-title":"Efficacy of bazedoxifene in reducing new vertebral fracture risk in postmenopausal women with osteoporosis: results from a 3-year, randomized, placebo-, and active-controlled clinical trial","volume":"23","author":"Silverman","year":"2008","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M115.672345_bib12","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1359\/JBMR.040305","article-title":"A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women","volume":"19","author":"Bekker","year":"2004","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M115.672345_bib13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M115.672345_bib14","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1210\/jc.2009-2677","article-title":"Update in new anabolic therapies for osteoporosis","volume":"95","author":"Canalis","year":"2010","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M115.672345_bib15","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M115.672345_bib16","first-page":"711","article-title":"Nitrogen-containing bisphosphonate mechanism of action","volume":"4","author":"Reszka","year":"2004","journal-title":"Mini Rev. Med. Chem"},{"key":"10.1074\/jbc.M115.672345_bib17","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.bone.2006.01.141","article-title":"Bisphosphonate actions: physical chemistry revisited","volume":"38","author":"Papapoulos","year":"2006","journal-title":"Bone"},{"key":"10.1074\/jbc.M115.672345_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bone.2010.08.008","article-title":"Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability","volume":"49","author":"Bellido","year":"2011","journal-title":"Bone"},{"key":"10.1074\/jbc.M115.672345_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00003086-200402000-00003","article-title":"Nonunion: general principles and experimental data","author":"Rodriguez-Merchan","year":"2004","journal-title":"Clin. Orthop. Relat. Res"},{"key":"10.1074\/jbc.M115.672345_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/hdy.2010.54","article-title":"Epigenetics and gene expression","volume":"105","author":"Gibney","year":"2010","journal-title":"Heredity"},{"key":"10.1074\/jbc.M115.672345_bib21","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1158\/0008-5472.CAN-13-2837","article-title":"Bookmarking target genes in mitosis: a shared epigenetic trait of phenotypic transcription factors and oncogenes?","volume":"74","author":"Zaidi","year":"2014","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M115.672345_bib22","doi-asserted-by":"crossref","first-page":"516","DOI":"10.4161\/cc.27921","article-title":"Roles of enhancer of zeste homolog 2: from skeletal muscle differentiation to rhabdomyosarcoma carcinogenesis","volume":"13","author":"Marchesi","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.M115.672345_bib23","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1126\/science.1100576","article-title":"Chromatin compaction by a polycomb group protein complex","volume":"306","author":"Francis","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M115.672345_bib24","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1128\/MCB.21.13.4330-4336.2001","article-title":"The polycomb-group gene Ezh2 is required for early mouse development","volume":"21","author":"O'Carroll","year":"2001","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M115.672345_bib25","doi-asserted-by":"crossref","first-page":"e1000598","DOI":"10.1371\/journal.pcbi.1000598","article-title":"An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data","volume":"5","author":"Ramsk\u00f6ld","year":"2009","journal-title":"PLoS Comput. Biol"},{"key":"10.1074\/jbc.M115.672345_bib26","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1128\/MCB.06315-11","article-title":"Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A\/Arf locus in mesenchymal stem cells","volume":"32","author":"Cakouros","year":"2012","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M115.672345_bib27","doi-asserted-by":"crossref","first-page":"e5011","DOI":"10.1371\/journal.pone.0005011","article-title":"CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells","volume":"4","author":"Yang","year":"2009","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M115.672345_bib28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.biochem.78.071107.134639","article-title":"Genome-wide views of chromatin structure","volume":"78","author":"Rando","year":"2009","journal-title":"Annu. Rev. Biochem"},{"key":"10.1074\/jbc.M115.672345_bib29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nrg2732","article-title":"Principles and challenges of genomewide DNA methylation analysis","volume":"11","author":"Laird","year":"2010","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/jbc.M115.672345_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1101\/gad.179804.111","article-title":"A decade of 3C technologies: insights into nuclear organization","volume":"26","author":"de Wit","year":"2012","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M115.672345_bib31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/jcb.10113","article-title":"Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts","volume":"85","author":"Villagra","year":"2002","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/jbc.M115.672345_bib32","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1016-8478(23)17408-5","article-title":"Methylation of the mouse DIx5 and Osx gene promoters regulates cell type-specific gene expression","volume":"22","author":"Lee","year":"2006","journal-title":"Mol. Cells"},{"key":"10.1074\/jbc.M115.672345_bib33","doi-asserted-by":"crossref","first-page":"7982","DOI":"10.1128\/MCB.22.22.7982-7992.2002","article-title":"Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1\/WAF1) promoter","volume":"22","author":"Westendorf","year":"2002","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M115.672345_bib34","doi-asserted-by":"crossref","first-page":"41998","DOI":"10.1074\/jbc.M403702200","article-title":"Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation","volume":"279","author":"Schroeder","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.672345_bib35","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/sj.emboj.7600729","article-title":"Repression of Runx2 function by TGF-\u03b2 through recruitment of class II histone deacetylases by Smad3","volume":"24","author":"Kang","year":"2005","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M115.672345_bib36","doi-asserted-by":"crossref","first-page":"46515","DOI":"10.1074\/jbc.M105757200","article-title":"Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation","volume":"276","author":"Gori","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.672345_bib37","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ydbio.2006.02.031","article-title":"Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development","volume":"295","author":"Gori","year":"2006","journal-title":"Dev. Biol"},{"key":"10.1074\/jbc.M115.672345_bib38","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1359\/JBMR.050813","article-title":"Histone deacetylase inhibitors promote osteoblast maturation","volume":"20","author":"Schroeder","year":"2005","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M115.672345_bib39","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1089\/scd.2008.0172","article-title":"Histone deacetylase inhibitors promote apoptosis and senescence in human mesenchymal stem cells","volume":"18","author":"Di Bernardo","year":"2009","journal-title":"Stem Cells Dev"},{"key":"10.1074\/jbc.M115.672345_bib40","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1365-2184.2009.00633.x","article-title":"Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells","volume":"42","author":"Lee","year":"2009","journal-title":"Cell Prolif"},{"key":"10.1074\/jbc.M115.672345_bib41","doi-asserted-by":"crossref","first-page":"28783","DOI":"10.1074\/jbc.M113.489732","article-title":"Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces Akt phosphorylation","volume":"288","author":"Dudakovic","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.672345_bib42","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3727\/096368910X543376","article-title":"Platelet lysate consisting of a natural repair proteome supports human mesenchymal stem cell proliferation and chromosomal stability","volume":"20","author":"Crespo-Diaz","year":"2011","journal-title":"Cell Transplant"},{"key":"10.1074\/jbc.M115.672345_bib43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1479-5876-11-20","article-title":"Optimizing patient derived mesenchymal stem cells as virus carriers for a phase I clinical trial in ovarian cancer","volume":"11","author":"Mader","year":"2013","journal-title":"J. Transl. Med"},{"key":"10.1074\/jbc.M115.672345_bib44","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/ni876","article-title":"Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement","volume":"4","author":"Su","year":"2003","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M115.672345_bib45","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/gene.10092","article-title":"Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer","volume":"33","author":"Logan","year":"2002","journal-title":"Genesis"},{"key":"10.1074\/jbc.M115.672345_bib46","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M115.672345_bib47","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/jcb.24852","article-title":"High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells","volume":"115","author":"Dudakovic","year":"2014","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/jbc.M115.672345_bib48","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1093\/bioinformatics\/bts340","article-title":"ChromoHub: a data hub for navigators of chromatin-mediated signalling","volume":"28","author":"Liu","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M115.672345_bib49","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/jcp.24680","article-title":"Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells","volume":"230","author":"Dudakovic","year":"2015","journal-title":"J. Cell. Physiol"},{"key":"10.1074\/jbc.M115.672345_bib50","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.molcel.2008.11.004","article-title":"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms","volume":"32","author":"Margueron","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M115.672345_bib51","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1076997","article-title":"Role of histone H3 lysine 27 methylation in polycomb-group silencing","volume":"298","author":"Cao","year":"2002","journal-title":"Science"},{"key":"10.1074\/jbc.M115.672345_bib52","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1074\/jbc.M106826200","article-title":"Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene","volume":"277","author":"L\u00f3pez-Rovira","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.672345_bib53","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1158\/1078-0432.CCR-08-2783","article-title":"Targeting DNA methylation","volume":"15","author":"Issa","year":"2009","journal-title":"Clin. Cancer Res"},{"key":"10.1074\/jbc.M115.672345_bib54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/icb.2011.100","article-title":"HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications","volume":"90","author":"Khan","year":"2012","journal-title":"Immunol. Cell Biol"},{"key":"10.1074\/jbc.M115.672345_bib55","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1196\/annals.1344.018","article-title":"The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials","volume":"1053","author":"Chuang","year":"2005","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1074\/jbc.M115.672345_bib56","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.pneurobio.2010.01.002","article-title":"Epigenetic regulation in the pathophysiology of Alzheimer's disease","volume":"90","author":"Chouliaras","year":"2010","journal-title":"Prog. Neurobiol"},{"key":"10.1074\/jbc.M115.672345_bib57","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1124\/mol.108.054346","article-title":"Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain","volume":"75","author":"Chiechio","year":"2009","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M115.672345_bib58","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaut.2009.03.007","article-title":"The genetics and epigenetics of autoimmune diseases","volume":"33","author":"Hewagama","year":"2009","journal-title":"J. Autoimmun"},{"key":"10.1074\/jbc.M115.672345_bib59","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/gb-2014-15-3-r52","article-title":"Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis","volume":"15","author":"Wu","year":"2014","journal-title":"Genome Biol"},{"key":"10.1074\/jbc.M115.672345_bib60","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bbrc.2013.02.036","article-title":"Downregulated LncRNA-ANCR promotes osteoblast differentiation by targeting EZH2 and regulating Runx2 expression","volume":"432","author":"Zhu","year":"2013","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M115.672345_bib61","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/stem.1573","article-title":"EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification","volume":"32","author":"Hemming","year":"2014","journal-title":"Stem Cells"},{"key":"10.1074\/jbc.M115.672345_bib62","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ncb2139","article-title":"CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells","volume":"13","author":"Wei","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1074\/jbc.M115.672345_bib63","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.joen.2014.01.031","article-title":"EZH2, a potential regulator of dental pulp inflammation and regeneration","volume":"40","author":"Hui","year":"2014","journal-title":"J. Endod"},{"key":"10.1074\/jbc.M115.672345_bib64","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/dev.094342","article-title":"Ezh2 is required for neural crest-derived cartilage and bone formation","volume":"141","author":"Schwarz","year":"2014","journal-title":"Development"},{"key":"10.1074\/jbc.M115.672345_bib65","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.18632\/oncotarget.385","article-title":"Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height","volume":"2","author":"Tatton-Brown","year":"2011","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.M115.672345_bib66","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0022-3476(74)80675-X","article-title":"A new overgrowth syndrome with accelerated skeletal maturation, unusual facies, and camptodactyly","volume":"84","author":"Weaver","year":"1974","journal-title":"J. Pediatr"},{"key":"10.1074\/jbc.M115.672345_bib67","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajhg.2011.11.018","article-title":"Mutations in EZH2 cause Weaver syndrome","volume":"90","author":"Gibson","year":"2012","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M115.672345_bib68","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1242\/dev.063180","article-title":"Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb","volume":"138","author":"Wyngaarden","year":"2011","journal-title":"Development"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820439730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820439730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.672345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T09:55:01Z","timestamp":1718099701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820439730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":68,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0021925820439730"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.672345","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.672345","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}