{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:30:14Z","timestamp":1791646214674,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":1685,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR055903"],"award-info":[{"award-number":["AR055903"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR067726"],"award-info":[{"award-number":["AR067726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1074\/jbc.m115.677427","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T21:53:39Z","timestamp":1450216419000},"page":"3439-3454","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Involvement of Receptor Activator of Nuclear Factor-\u03baB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts"],"prefix":"10.1016","volume":"291","author":[{"given":"Noriko","family":"Takegahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asako","family":"Sakaue-Sawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Miyawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Tomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osami","family":"Kanagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.677427_bib1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.cell.2007.10.022","article-title":"The evolutionary consequences of polyploidy","volume":"131","author":"Otto","year":"2007","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.677427_bib2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.tcb.2013.06.002","article-title":"Physiological significance of polyploidization in mammalian cells","volume":"23","author":"Pandit","year":"2013","journal-title":"Trends Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib3","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.1242\/dev.099226","article-title":"Visualizing developmentally programmed endoreplication in mammals using ubiquitin oscillators","volume":"140","author":"Sakaue-Sawano","year":"2013","journal-title":"Development"},{"key":"10.1074\/jbc.M115.677427_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3756","article-title":"Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth","volume":"15","author":"Edgar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib5","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1101\/gad.1829209","article-title":"Endoreplication: polyploidy with purpose","volume":"23","author":"Lee","year":"2009","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M115.677427_bib6","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.201304054","article-title":"The incredible journey: from megakaryocyte development to platelet formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib7","doi-asserted-by":"crossref","first-page":"282430","DOI":"10.1155\/2012\/282430","article-title":"Hepatocytes polyploidization and cell cycle control in liver physiopathology","volume":"2012","author":"Gentric","year":"2012","journal-title":"Int. J. Hepatol"},{"key":"10.1074\/jbc.M115.677427_bib8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clinre.2011.05.011","article-title":"Polyploidy and liver proliferation","volume":"36","author":"Gentric","year":"2012","journal-title":"Clin. Res. Hepatol. Gastroenterol"},{"key":"10.1074\/jbc.M115.677427_bib9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tig.2013.01.011","article-title":"Genetic basis of cell-cell fusion mechanisms","volume":"29","author":"Aguilar","year":"2013","journal-title":"Trends Genet"},{"key":"10.1074\/jbc.M115.677427_bib10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ng2055","article-title":"A conserved molecular pathway mediates myoblast fusion in insects and vertebrates","volume":"39","author":"Srinivas","year":"2007","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M115.677427_bib11","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M115.677427_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.immunol.24.021605.090646","article-title":"Osteoimmunology: interplay between the immune system and bone metabolism","volume":"24","author":"Walsh","year":"2006","journal-title":"Annu. Rev. Immunol"},{"key":"10.1074\/jbc.M115.677427_bib13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.20050645","article-title":"DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells","volume":"202","author":"Yagi","year":"2005","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M115.677427_bib14","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.tcb.2007.09.004","article-title":"Cell fusion during development","volume":"17","author":"Oren-Suissa","year":"2007","journal-title":"Trends Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1083\/jcb.200806139","article-title":"Identification of cell cycle-arrested quiescent osteoclast precursors in vivo","volume":"184","author":"Mizoguchi","year":"2009","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib16","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/bbrc.2001.4564","article-title":"Osteoclast differentiation factor modulates cell cycle machinery and causes a delay in S phase progression in RAW264 cells","volume":"282","author":"Meiyanto","year":"2001","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M115.677427_bib17","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1359\/JBMR.040321","article-title":"RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1","volume":"19","author":"Sankar","year":"2004","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M115.677427_bib18","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1128\/MCB.26.3.1002-1013.2006","article-title":"Receptor activator of NF-\u03baB ligand regulates the proliferation of mammary epithelial cells via Id2","volume":"26","author":"Kim","year":"2006","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M115.677427_bib19","doi-asserted-by":"crossref","first-page":"12192","DOI":"10.1073\/pnas.1005443107","article-title":"Preferential localization of IgG memory B cells adjacent to contracted germinal centers","volume":"107","author":"Aiba","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.677427_bib20","doi-asserted-by":"crossref","first-page":"e73801","DOI":"10.1371\/journal.pone.0073801","article-title":"Contrasting quiescent G0 phase with mitotic cell cycling in the mouse immune system","volume":"8","author":"Tomura","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1074\/jbc.M115.677427_bib21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cell.2007.12.033","article-title":"Visualizing spatiotemporal dynamics of multicellular cell cycle progression","volume":"132","author":"Sakaue-Sawano","year":"2008","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.677427_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1242\/dev.084111","article-title":"Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter","volume":"140","author":"Abe","year":"2013","journal-title":"Development"},{"key":"10.1074\/jbc.M115.677427_bib23","first-page":"866","article-title":"Dynamic visualization of RANKL and Th17-mediated osteoclast function","volume":"123","author":"Kikuta","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.677427_bib24","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1083\/jcb.201009126","article-title":"Phosphoinositide 3-kinase signaling pathway mediated by p110\u03b1 regulates invadopodia formation","volume":"193","author":"Yamaguchi","year":"2011","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrm1276","article-title":"From polyploidy to aneuploidy, genome instability and cancer","volume":"5","author":"Storchova","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib26","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrg1711","article-title":"The advantages and disadvantages of being polyploid","volume":"6","author":"Comai","year":"2005","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/jbc.M115.677427_bib27","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"Teitelbaum","year":"2003","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/jbc.M115.677427_bib28","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/dbio.1994.1137","article-title":"Postmitotic osteoclast precursors are mononuclear cells which express macrophage-associated phenotypes","volume":"163","author":"Takahashi","year":"1994","journal-title":"Dev. Biol"},{"key":"10.1074\/jbc.M115.677427_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S8756-3282(99)00278-1","article-title":"The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc\/oc) mutants","volume":"26","author":"Scimeca","year":"2000","journal-title":"Bone"},{"key":"10.1074\/jbc.M115.677427_bib30","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/jbmr.1822","article-title":"Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery","volume":"28","author":"Jacome-Galarza","year":"2013","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M115.677427_bib31","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature07713","article-title":"Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis","volume":"458","author":"Ishii","year":"2009","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.677427_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/MOH.0b013e32831ac52e","article-title":"Giant cell formation and function","volume":"16","author":"Brodbeck","year":"2009","journal-title":"Curr. Opin. Hematol"},{"key":"10.1074\/jbc.M115.677427_bib33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.tcb.2005.02.008","article-title":"Macrophage fusion: are somatic and cancer cells possible partners?","volume":"15","author":"Vignery","year":"2005","journal-title":"Trends Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib34","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/jbmr.1575","article-title":"Osteoclast stimulatory transmembrane protein and dendritic cell-specific transmembrane protein cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells","volume":"27","author":"Miyamoto","year":"2012","journal-title":"J. Bone Miner. Res"},{"key":"10.1074\/jbc.M115.677427_bib35","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/nm1514","article-title":"v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation","volume":"12","author":"Lee","year":"2006","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.677427_bib36","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1126\/science.1096896","article-title":"The molecular requirements for cytokinesis","volume":"307","author":"Glotzer","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M115.677427_bib37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.677427_bib38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4049\/jimmunol.1101254","article-title":"Akt induces osteoclast differentiation through regulating the GSK3beta\/NFATc1 signaling cascade","volume":"188","author":"Moon","year":"2012","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M115.677427_bib39","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1084\/jem.20150407","article-title":"CHMP5 controls bone turnover rates by dampening NF-\u03baB activity in osteoclasts","volume":"212","author":"Greenblatt","year":"2015","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M115.677427_bib40","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/08916930701694543","article-title":"Role of the NF-\u03baB axis in immune modulation of osteoclasts and bone loss","volume":"41","author":"Abu-Amer","year":"2008","journal-title":"Autoimmunity"},{"key":"10.1074\/jbc.M115.677427_bib41","first-page":"1880","article-title":"The insulin\/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents","volume":"119","author":"Celton-Morizur","year":"2009","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.677427_bib42","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1172\/JCI8252","article-title":"Akt1\/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization","volume":"106","author":"Hixon","year":"2000","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.677427_bib43","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.4161\/cc.8.16.9335","article-title":"The Akt kinases: isoform specificity in metabolism and cancer","volume":"8","author":"Gonzalez","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.M115.677427_bib44","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1083\/jcb.201111116","article-title":"Tks5-dependent formation of circumferential podosomes\/invadopodia mediates cell-cell fusion","volume":"197","author":"Oikawa","year":"2012","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib45","doi-asserted-by":"crossref","first-page":"ra38","DOI":"10.1126\/scisignal.2000500","article-title":"TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1","volume":"3","author":"Peng","year":"2010","journal-title":"Sci. Signal"},{"key":"10.1074\/jbc.M115.677427_bib46","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ceb.2005.09.008","article-title":"Controlling the size of organs and organisms","volume":"17","author":"Leevers","year":"2005","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1074\/jbc.M115.677427_bib47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/dev.080531","article-title":"Endoreplication and polyploidy: insights into development and disease","volume":"140","author":"Fox","year":"2013","journal-title":"Development"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820451658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820451658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.677427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T20:40:43Z","timestamp":1639687243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820451658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0021925820451658"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.677427","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of Receptor Activator of Nuclear Factor-\u03baB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.677427","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}