{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:58:59Z","timestamp":1791305939047,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":1679,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1074\/jbc.m115.678029","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T08:42:35Z","timestamp":1455871355000},"page":"3785-3795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Wilms Tumor Suppressor, WT1, Cooperates with MicroRNA-26a and MicroRNA-101 to Suppress Translation of the Polycomb Protein, EZH2, in Mesenchymal Stem Cells"],"prefix":"10.1016","volume":"291","author":[{"given":"Murielle M.","family":"Akpa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeeLee","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"Thi\u00e9baut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Jentoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Torban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Goodyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.678029_bib1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrc1696","article-title":"Wilms' tumour: connecting tumorigenesis and organ development in the kidney","volume":"5","author":"Rivera","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M115.678029_bib2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0092-8674(90)90601-A","article-title":"Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus","volume":"60","author":"Call","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.678029_bib3","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1136\/jcp.2006.043083","article-title":"Sequential WT1 and CTNNB1 mutations and alterations of \u03b2-catenin localisation in intralobar nephrogenic rests and associated Wilms tumours: two case studies","volume":"60","author":"Fukuzawa","year":"2007","journal-title":"J. Clin. Pathol"},{"key":"10.1074\/jbc.M115.678029_bib4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/gcc.20319","article-title":"Target genes of the WNT\/\u03b2-catenin pathway in Wilms tumors","volume":"45","author":"Zirn","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1074\/jbc.M115.678029_bib5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stem.2010.03.016","article-title":"Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network","volume":"6","author":"Aiden","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1074\/jbc.M115.678029_bib6","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1074\/jbc.M114.573576","article-title":"Wilms tumor suppressor, WT1, suppresses epigenetic silencing of the \u03b2-catenin gene","volume":"290","author":"Akpa","year":"2015","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.678029_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/gcc.20553","article-title":"Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors","volume":"47","author":"Ruteshouser","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1074\/jbc.M115.678029_bib8","first-page":"997","article-title":"Evidence for WT1 as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT","volume":"48","author":"Huff","year":"1991","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M115.678029_bib9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/path.4196","article-title":"Biallelic DICER1 mutations occur in Wilms tumours","volume":"230","author":"Wu","year":"2013","journal-title":"J. Pathol"},{"key":"10.1074\/jbc.M115.678029_bib10","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1038\/ncomms5039","article-title":"Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour","volume":"5","author":"Torrezan","year":"2014","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M115.678029_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0092-8674(95)90392-5","article-title":"Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing","volume":"81","author":"Larsson","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.678029_bib12","doi-asserted-by":"crossref","first-page":"9836","DOI":"10.1074\/jbc.M709614200","article-title":"MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis","volume":"283","author":"Wong","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.678029_bib13","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.4161\/cc.8.15.9168","article-title":"The tumor suppressor microRNA-101 becomes an epigenetic player by targeting the polycomb group protein EZH2 in cancer","volume":"8","author":"Friedman","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1074\/jbc.M115.678029_bib14","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1158\/0008-5472.CAN-08-3114","article-title":"The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2","volume":"69","author":"Friedman","year":"2009","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M115.678029_bib15","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1126\/science.1165395","article-title":"Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer","volume":"322","author":"Varambally","year":"2008","journal-title":"Science"},{"key":"10.1074\/jbc.M115.678029_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1242\/jcs.1995.Supplement_19.14","article-title":"Does the Wilms' tumour suppressor gene, WT1, play roles in both splicing and transcription?","volume":"19","author":"Charlieu","year":"1995","journal-title":"J. Cell Sci. Suppl"},{"key":"10.1074\/jbc.M115.678029_bib17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/hmg\/ddh040","article-title":"The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes","volume":"13","author":"Niksic","year":"2004","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M115.678029_bib18","doi-asserted-by":"crossref","first-page":"7562","DOI":"10.1073\/pnas.93.15.7562","article-title":"RNA binding by the Wilms tumor suppressor zinc finger proteins","volume":"93","author":"Caricasole","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.678029_bib19","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1021\/bi001941r","article-title":"Characterization of RNA aptamer binding by the Wilms' tumor suppressor protein WT1","volume":"40","author":"Zhai","year":"2001","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M115.678029_bib20","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1152\/ajprenal.00597.2007","article-title":"New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes","volume":"295","author":"Morrison","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.678029_bib21","first-page":"55","article-title":"The post-transcriptional roles of WT1, a multifunctional zinc-finger protein","volume":"1785","author":"Morrison","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.678029_bib22","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1139\/o06-065","article-title":"The Wilms tumour suppressor protein WT1 (+KTS isoform) binds \u03b1-actinin 1 mRNA via its zinc-finger domain","volume":"84","author":"Morrison","year":"2006","journal-title":"Biochem. Cell Biol"},{"key":"10.1074\/jbc.M115.678029_bib23","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1128\/MCB.15.3.1489","article-title":"Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product","volume":"15","author":"Nakagama","year":"1995","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M115.678029_bib24","first-page":"1747","article-title":"Multiple roles for the Wilms' tumor suppressor, WT1","volume":"59","author":"Davies","year":"1999","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M115.678029_bib25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/15216540410001670142","article-title":"Structural aspects of microRNA biogenesis","volume":"56","author":"Krol","year":"2004","journal-title":"IUBMB Life"},{"key":"10.1074\/jbc.M115.678029_bib26","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: microRNA biogenesis pathways and their regulation","volume":"11","author":"Winter","year":"2009","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M115.678029_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.678029_bib28","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M115.678029_bib29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrm2632","article-title":"Biogenesis of small RNAs in animals","volume":"10","author":"Kim","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M115.678029_bib30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1101\/gad.862301","article-title":"RNA interference is mediated by 21- and 22-nucleotide RNAs","volume":"15","author":"Elbashir","year":"2001","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M115.678029_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/nat.2011.0330","article-title":"Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression","volume":"22","author":"Gagnon","year":"2012","journal-title":"Nucleic Acid Ther"},{"key":"10.1074\/jbc.M115.678029_bib32","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.tibs.2003.08.005","article-title":"The microRNA world: small is mighty","volume":"28","author":"Nelson","year":"2003","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/jbc.M115.678029_bib33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tibs.2007.02.006","article-title":"A developmental view of microRNA function","volume":"32","author":"Zhao","year":"2007","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/jbc.M115.678029_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/bdrc.20071","article-title":"MicroRNAs in mammalian development and tumorigenesis","volume":"78","author":"O'Rourke","year":"2006","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1074\/jbc.M115.678029_bib35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1542\/peds.46.4.587","article-title":"Sir William writes about massive abdominal tumors in children","volume":"46","author":"Cone","year":"1970","journal-title":"Pediatrics"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820436907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820436907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.678029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T12:57:19Z","timestamp":1641301039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820436907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0021925820436907"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.678029","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wilms Tumor Suppressor, WT1, Cooperates with MicroRNA-26a and MicroRNA-101 to Suppress Translation of the Polycomb Protein, EZH2, in Mesenchymal Stem Cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.678029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}