{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:30:25Z","timestamp":1783517425525,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":1685,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14PRE20390026"],"award-info":[{"award-number":["14PRE20390026"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI091977"],"award-info":[{"award-number":["R01 AI091977"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PO1AI084853"],"award-info":[{"award-number":["PO1AI084853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR047746"],"award-info":[{"award-number":["R01AR047746"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1074\/jbc.m115.681882","type":"journal-article","created":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T02:58:53Z","timestamp":1451617133000},"page":"3359-3370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mucosal Administration of Collagen V Ameliorates the Atherosclerotic Plaque Burden by Inducing Interleukin 35-dependent Tolerance"],"prefix":"10.1016","volume":"291","author":[{"given":"Arick C.","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Jankowska-Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawiyat","family":"Massoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Kernien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario A.","family":"Vignali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Wilkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Burlingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Greenspan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.681882_bib1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1253\/circj.CJ-15-0167","article-title":"Modulation of autoimmunity and atherosclerosis: common targets and promising translational approaches against disease","volume":"79","author":"Ketelhuth","year":"2015","journal-title":"Circ. J"},{"key":"10.1074\/jbc.M115.681882_bib2","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.2174\/1381612811319330003","article-title":"T cell-based therapies for atherosclerosis","volume":"19","author":"Ketelhuth","year":"2013","journal-title":"Curr. Pharm. Des"},{"key":"10.1074\/jbc.M115.681882_bib3","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.ATV.0000206122.61591.ff","article-title":"Adoptive transfer of CD4+ T cells reactive to modified low-density lipoprotein aggravates atherosclerosis","volume":"26","author":"Zhou","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.M115.681882_bib4","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1084\/jem.20092243","article-title":"Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis","volume":"207","author":"Hermansson","year":"2010","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M115.681882_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.atherosclerosis.2008.05.025","article-title":"The autoimmune origin of atherosclerosis","volume":"201","author":"Blasi","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.M115.681882_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nm0603-641","article-title":"Autoimmunity: busting the atherosclerotic plaque","volume":"9","author":"Rose","year":"2003","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.681882_bib7","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.4049\/jimmunol.174.10.6509","article-title":"Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques","volume":"174","author":"Benagiano","year":"2005","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M115.681882_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.atherosclerosis.2009.04.026","article-title":"Heat-shock protein 90: a novel autoantigen in human carotid atherosclerosis","volume":"207","author":"Businaro","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.M115.681882_bib9","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/01.CIR.0000029750.99462.30","article-title":"Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice","volume":"106","author":"Maron","year":"2002","journal-title":"Circulation"},{"key":"10.1074\/jbc.M115.681882_bib10","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.imbio.2011.06.006","article-title":"Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe\u2212\/\u2212 mice","volume":"217","author":"Klingenberg","year":"2012","journal-title":"Immunobiology"},{"key":"10.1074\/jbc.M115.681882_bib11","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1161\/CIRCULATIONAHA.106.615609","article-title":"Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis","volume":"114","author":"van Puijvelde","year":"2006","journal-title":"Circulation"},{"key":"10.1074\/jbc.M115.681882_bib12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cardiores.2004.01.028","article-title":"Suppression of early atherosclerosis in LDL-receptor deficient mice by oral tolerance with \u03b2 2-glycoprotein I","volume":"62","author":"George","year":"2004","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.M115.681882_bib13","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/ATVBAHA.109.202671","article-title":"Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis","volume":"30","author":"Klingenberg","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.M115.681882_bib14","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2796.2010.02311.x","article-title":"Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine","volume":"269","author":"Wigren","year":"2011","journal-title":"J. Intern. Med"},{"key":"10.1074\/jbc.M115.681882_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0368-1319(65)80065-5","article-title":"The influence of age and atherosclerosis on the chemistry of aortic intima: 2: collagen and mucopolysaccharides","volume":"5","author":"Smith","year":"1965","journal-title":"J. Atheroscler. Res"},{"key":"10.1074\/jbc.M115.681882_bib16","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/CIRCRESAHA.107.170662","article-title":"Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice","volume":"102","author":"Franco","year":"2008","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.681882_bib17","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1161\/CIRCRESAHA.110.221069","article-title":"Interleukin-17-dependent autoimmunity to collagen type V in atherosclerosis","volume":"107","author":"Dart","year":"2010","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.681882_bib18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0945-053X(05)80001-0","article-title":"Another look at collagen V and XI molecules","volume":"14","author":"Fichard","year":"1995","journal-title":"Matrix Biol"},{"key":"10.1074\/jbc.M115.681882_bib19","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.7256267","article-title":"Collagen \u03b1 B chain: increased proportion in human atherosclerosis","volume":"213","author":"Ooshima","year":"1981","journal-title":"Science"},{"key":"10.1074\/jbc.M115.681882_bib20","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1073\/pnas.77.9.5206","article-title":"Chinese hamster lung cells synthesize and confine to the cellular domain a collagen composed solely of B chains","volume":"77","author":"Haralson","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.681882_bib21","doi-asserted-by":"crossref","first-page":"24352","DOI":"10.1074\/jbc.M101182200","article-title":"Control of heterotypic fibril formation by collagen V is determined by chain stoichiometry","volume":"276","author":"Chanut-Delalande","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.681882_bib22","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nature06306","article-title":"The inhibitory cytokine IL-35 contributes to regulatory T-cell function","volume":"450","author":"Collison","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.681882_bib23","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/eji.200737810","article-title":"IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells","volume":"37","author":"Niedbala","year":"2007","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/jbc.M115.681882_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fimmu.2013.00315","article-title":"Interleukin 35: a key mediator of suppression and the propagation of infectious tolerance","volume":"4","author":"Olson","year":"2013","journal-title":"Front. Immunol"},{"key":"10.1074\/jbc.M115.681882_bib25","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ni.1952","article-title":"IL-35-mediated induction of a potent regulatory T cell population","volume":"11","author":"Collison","year":"2010","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M115.681882_bib26","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.4049\/jimmunol.179.10.6749","article-title":"Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance","volume":"179","author":"Molitor-Dart","year":"2007","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M115.681882_bib27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/6585","article-title":"The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo","volume":"5","author":"Guevara","year":"1999","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.681882_bib28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature11260","article-title":"Myocardial infarction accelerates atherosclerosis","volume":"487","author":"Dutta","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.681882_bib29","doi-asserted-by":"crossref","first-page":"27511","DOI":"10.1074\/jbc.273.42.27511","article-title":"Bone morphogenetic protein-1 processes the NH2-terminal propeptide, and a furin-like proprotein convertase processes the COOH-terminal propeptide of pro-\u03b11(V) collagen","volume":"273","author":"Imamura","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.681882_bib30","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.ATV.12.4.494","article-title":"Collagens in human atherosclerosis. Immunohistochemical analysis using collagen type-specific antibodies","volume":"12","author":"Katsuda","year":"1992","journal-title":"Arterioscler Thromb"},{"key":"10.1074\/jbc.M115.681882_bib31","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/CIRCRESAHA.112.277525","article-title":"Interleukin-27 receptor limits atherosclerosis in Ldlr\u2212\/\u2212 mice","volume":"111","author":"Koltsova","year":"2012","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.681882_bib32","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1161\/01.CIR.0000038140.80105.AD","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice","volume":"106","author":"Inoue","year":"2002","journal-title":"Circulation"},{"key":"10.1074\/jbc.M115.681882_bib33","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1172\/JCI28031","article-title":"IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants","volume":"117","author":"Burlingham","year":"2007","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.681882_bib34","doi-asserted-by":"crossref","first-page":"e79601","DOI":"10.1371\/journal.pone.0079601","article-title":"Epitope analysis of the collagen type V-specific T cell response in lung transplantation reveals an HLA-DRB1*15 bias in both recipient and donor","volume":"8","author":"Keller","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M115.681882_bib35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1172\/JCI29950","article-title":"Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata","volume":"117","author":"Swirski","year":"2007","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.681882_bib36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.clim.2008.01.009","article-title":"The Th17\/Treg imbalance in patients with acute coronary syndrome","volume":"127","author":"Cheng","year":"2008","journal-title":"Clin. Immunol"},{"key":"10.1074\/jbc.M115.681882_bib37","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nm1343","article-title":"Natural regulatory T cells control the development of atherosclerosis in mice","volume":"12","author":"Ait-Oufella","year":"2006","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.681882_bib38","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/01.ATV.0000259365.31469.89","article-title":"Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis","volume":"27","author":"Mor","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.M115.681882_bib39","doi-asserted-by":"crossref","DOI":"10.1089\/jir.2015.0015","article-title":"Interleukin-35: expanding its job profile","author":"Sawant","year":"2015","journal-title":"J. Interferon. Cytokine Res"},{"key":"10.1074\/jbc.M115.681882_bib40","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2353\/ajpath.2009.080752","article-title":"Epstein-Barr virus-induced gene-3 is expressed in human atheroma plaques","volume":"175","author":"Kempe","year":"2009","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M115.681882_bib41","doi-asserted-by":"crossref","first-page":"e52490","DOI":"10.1371\/journal.pone.0052490","article-title":"Decreased plasma IL-35 levels are related to the left ventricular ejection fraction in coronary artery diseases","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M115.681882_bib42","first-page":"793","article-title":"IL-35: a potential target for the treatment of atherosclerosis","volume":"68","author":"Huang","year":"2013","journal-title":"Pharmazie"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820451592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820451592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.681882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T21:10:47Z","timestamp":1625951447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820451592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0021925820451592"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.681882","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mucosal Administration of Collagen V Ameliorates the Atherosclerotic Plaque Burden by Inducing Interleukin 35-dependent Tolerance","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.681882","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}