{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:44:42Z","timestamp":1790995482977,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":1679,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK061659"],"award-info":[{"award-number":["DK061659"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK073681"],"award-info":[{"award-number":["DK073681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AI007605"],"award-info":[{"award-number":["T32 AI007605"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1074\/jbc.m115.694687","type":"journal-article","created":{"date-parts":[[2015,12,25]],"date-time":"2015-12-25T01:07:36Z","timestamp":1451005656000},"page":"4079-4090","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis"],"prefix":"10.1016","volume":"291","author":[{"given":"Cheuk Wun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Menconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaly","family":"Mezei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlinda","family":"Concepcion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chella S.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Kastrinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ohlmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Tomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.694687_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","article-title":"Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)","volume":"87","author":"Hollowell","year":"2002","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M115.694687_bib2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s12026-012-8302-x","article-title":"Genetic and epigenetic mechanisms in thyroid autoimmunity","volume":"54","author":"Hasham","year":"2012","journal-title":"Immunol. Res"},{"key":"10.1074\/jbc.M115.694687_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1568-9972(01)00016-7","article-title":"Iodine: an environmental trigger of thyroiditis","volume":"1","author":"Rose","year":"2002","journal-title":"Autoimmun. Rev"},{"key":"10.1074\/jbc.M115.694687_bib4","first-page":"107","article-title":"Infection, thyroid disease, and autoimmunity","volume":"14","author":"Tomer","year":"1993","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.M115.694687_bib5","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1210\/er.2002-0030","article-title":"Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function","volume":"24","author":"Tomer","year":"2003","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.M115.694687_bib6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5694\/j.1326-5377.2004.tb05866.x","article-title":"5: Diagnosis and management of hyperthyroidism and hypothyroidism","volume":"180","author":"Topliss","year":"2004","journal-title":"Med. J. Aust"},{"key":"10.1074\/jbc.M115.694687_bib7","first-page":"1047","article-title":"Thyroiditis: differential diagnosis and management","volume":"61","author":"Slatosky","year":"2000","journal-title":"Am. Family Physician"},{"key":"10.1074\/jbc.M115.694687_bib8","first-page":"193","article-title":"Radioactive iodine ablation therapy: a viable option in the management of Graves' disease in Nigeria","volume":"41","author":"Adedapo","year":"2012","journal-title":"Afr. J. Med. Med. Sci"},{"key":"10.1074\/jbc.M115.694687_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.5603\/FHC.2014.0013","article-title":"Effect of l-thyroxine treatment on peripheral blood dendritic cell subpopulations in patients with Hashimoto's thyroiditis","volume":"52","author":"Stasiolek","year":"2014","journal-title":"Folia Histochem. Cytobiol"},{"key":"10.1074\/jbc.M115.694687_bib10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4274\/jcrpe.425","article-title":"Clinical course of Hashimoto's thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents","volume":"3","author":"\u00d6zen","year":"2011","journal-title":"J. Clin. Res. Pediatr. Endocrinol"},{"key":"10.1074\/jbc.M115.694687_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.gene.6364059","article-title":"Arginine at position 74 of the HLA-DR \u03b21 chain is associated with Graves' disease","volume":"5","author":"Ban","year":"2004","journal-title":"Genes Immun"},{"key":"10.1074\/jbc.M115.694687_bib12","doi-asserted-by":"crossref","first-page":"14034","DOI":"10.1073\/pnas.0806584105","article-title":"Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice","volume":"105","author":"Menconi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.694687_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1086\/426947","article-title":"Regression mapping of association between the human leukocyte antigen region and Graves disease","volume":"76","author":"Simmonds","year":"2005","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M115.694687_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0065-2776(08)60284-9","article-title":"Thyroid antigens and autoimmunity","volume":"14","author":"Shulman","year":"1971","journal-title":"Adv. Immunol"},{"key":"10.1074\/jbc.M115.694687_bib15","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1210\/en.2010-0321","article-title":"Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies","volume":"151","author":"Chen","year":"2010","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M115.694687_bib16","doi-asserted-by":"crossref","first-page":"15119","DOI":"10.1073\/pnas.2434175100","article-title":"Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease","volume":"100","author":"Ban","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.694687_bib17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/thy.2006.16.351","article-title":"Possible interaction between HLA-DRB1 and thyroglobulin variants in Graves' disease","volume":"16","author":"Hodge","year":"2006","journal-title":"Thyroid"},{"key":"10.1074\/jbc.M115.694687_bib18","doi-asserted-by":"crossref","first-page":"34231","DOI":"10.1074\/jbc.M109.041574","article-title":"Employing a recombinant HLA-DR3 expression system to dissect major histocompatibility complex II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective","volume":"284","author":"Jacobson","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.694687_bib19","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1517\/17460441.2010.484460","article-title":"Virtual screening with AutoDock: theory and practice","volume":"5","author":"Cosconati","year":"2010","journal-title":"Exp. Opin. Drug Discov"},{"key":"10.1074\/jbc.M115.694687_bib20","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s10822-011-9482-5","article-title":"Improving molecular docking through eHiTS' tunable scoring function","volume":"25","author":"Ravitz","year":"2011","journal-title":"J. Comput. Aided Mol. Des"},{"key":"10.1074\/jbc.M115.694687_bib21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1751-0473-5-2","article-title":"Dockres: a computer program that analyzes the output of virtual screening of small molecules","volume":"5","author":"Mezei","year":"2010","journal-title":"Source Code Biol. Med"},{"key":"10.1074\/jbc.M115.694687_bib22","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.132.3434.1115","article-title":"A computer program for classifying plants","volume":"132","author":"Rogers","year":"1960","journal-title":"Science"},{"key":"10.1074\/jbc.M115.694687_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1084\/jem.178.1.27","article-title":"Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles","volume":"178","author":"Chicz","year":"1993","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M115.694687_bib24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0198-8859(94)90268-2","article-title":"HLA-DR \u03b1 chain residues located on the outer loops are involved in nonpolymorphic and polymorphic antibody-binding epitopes","volume":"39","author":"Fu","year":"1994","journal-title":"Hum. Immunol"},{"key":"10.1074\/jbc.M115.694687_bib25","first-page":"104","article-title":"Negative and positive selection by HLA-DR3(DRw17) molecules in transgenic mice","volume":"40","author":"Strauss","year":"1994","journal-title":"Immunogenetics"},{"key":"10.1074\/jbc.M115.694687_bib26","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1172\/JCI119760","article-title":"HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis","volume":"100","author":"Bradley","year":"1997","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.694687_bib27","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1084\/jem.184.3.1167","article-title":"HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene","volume":"184","author":"Kong","year":"1996","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M115.694687_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/jaut.2001.0528","article-title":"Flexibility of TCR repertoire and permissiveness of HLA-DR3 molecules in experimental autoimmune thyroiditis in nonobese diabetic mice","volume":"17","author":"Flynn","year":"2001","journal-title":"J. Autoimmun"},{"key":"10.1074\/jbc.M115.694687_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaut.2010.01.004","article-title":"Tg.2098 is a major human thyroglobulin T-cell epitope","volume":"35","author":"Menconi","year":"2010","journal-title":"J. Autoimmun"},{"key":"10.1074\/jbc.M115.694687_bib30","first-page":"15.7.1","article-title":"Experimental autoimmune thyroiditis in the mouse","author":"Kong","year":"2007","journal-title":"Curr. Protoc. Immunol"},{"key":"10.1074\/jbc.M115.694687_bib31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/clin.1997.4412","article-title":"Epidemiology and estimated population burden of selected autoimmune diseases in the United States","volume":"84","author":"Jacobson","year":"1997","journal-title":"Clin. Immunol. Immunopathol"},{"key":"10.1074\/jbc.M115.694687_bib32","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1210\/jc.2013-2569","article-title":"Analysis of 754 cases of antithyroid drug-induced agranulocytosis over 30 years in Japan","volume":"98","author":"Nakamura","year":"2013","journal-title":"J. Clin. Endocrinol Metab"},{"key":"10.1074\/jbc.M115.694687_bib33","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMc0809750","article-title":"Ending propylthiouracil-induced liver failure in children","volume":"360","author":"Rivkees","year":"2009","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M115.694687_bib34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1056\/NEJM199801083380201","article-title":"Relation between therapy for hyperthyroidism and the course of Graves' ophthalmopathy","volume":"338","author":"Bartalena","year":"1998","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M115.694687_bib35","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-2265.2002.01654.x","article-title":"Psychological well-being in patients on \u201cadequate\u201d doses of l-thyroxine: results of a large, controlled community-based questionnaire study","volume":"57","author":"Saravanan","year":"2002","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1074\/jbc.M115.694687_bib36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1056\/NEJM199902113400603","article-title":"Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism","volume":"340","author":"Bunevicius","year":"1999","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M115.694687_bib37","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1089\/thy.2009.0351","article-title":"Selenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis","volume":"20","author":"Toulis","year":"2010","journal-title":"Thyroid"},{"key":"10.1074\/jbc.M115.694687_bib38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1086\/378588","article-title":"Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families","volume":"73","author":"Tomer","year":"2003","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M115.694687_bib39","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4049\/jimmunol.181.1.795","article-title":"Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands","volume":"181","author":"Muix\u00ed","year":"2008","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M115.694687_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1210\/er.2013-1055","article-title":"Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity","volume":"35","author":"McLachlan","year":"2014","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.M115.694687_bib41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cellimm.2004.07.002","article-title":"Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis","volume":"229","author":"Flynn","year":"2004","journal-title":"Cell. Immunol"},{"key":"10.1074\/jbc.M115.694687_bib42","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1734-1140(11)70500-X","article-title":"Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions","volume":"63","author":"Rogosnitzky","year":"2011","journal-title":"Pharmacol. Rep"},{"key":"10.1074\/jbc.M115.694687_bib43","first-page":"471","article-title":"Effect of cepharanthin on radiotherapy induced leukopenia","volume":"35","author":"Ohta","year":"1990","journal-title":"Rinsho Hoshasen"},{"key":"10.1074\/jbc.M115.694687_bib44","first-page":"2587","article-title":"Clinical effects of cepharanthin (Ceph.) on leukopenia by chemotherapy in lung cancer patients","volume":"24","author":"Saito","year":"1989","journal-title":"Nihon Gan Chiryo Gakkai shi"},{"key":"10.1074\/jbc.M115.694687_bib45","first-page":"647","article-title":"Effects of cepharanthin on leukopenia and thrombocytopenia induced by chemotherapy in lung cancer patients","volume":"19","author":"Suzuki","year":"1992","journal-title":"Gan To Kagaku Ryoho"},{"key":"10.1074\/jbc.M115.694687_bib46","first-page":"2701","article-title":"Effects of cepharanthin on leukopenia and thrombocytopenia caused by CDDP-ACR-CPA therapy of ovarian cancer","volume":"15","author":"Ushiki","year":"1988","journal-title":"Gan To Kagaku Ryoho"},{"key":"10.1074\/jbc.M115.694687_bib47","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.intimp.2012.04.015","article-title":"Low dose cepharanthine ameliorates immune thrombocytopenic purpura associated with multiple myeloma","volume":"13","author":"Tabata","year":"2012","journal-title":"Int. Immunopharmacol"},{"key":"10.1074\/jbc.M115.694687_bib48","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1346-8138.2002.tb00199.x","article-title":"Seventeen cases of alopecia areata: combination of SADBE topical immunotherapy with other therapies","volume":"29","author":"Morita","year":"2002","journal-title":"J. Dermatol"},{"key":"10.1074\/jbc.M115.694687_bib49","first-page":"47","article-title":"Effect of cepharanthine on alopecia areata","volume":"64","author":"Niwa","year":"1969","journal-title":"Hifuka kiyo"},{"key":"10.1074\/jbc.M115.694687_bib50","first-page":"71","article-title":"Therapeutic experience of venomous snakebites by the Japanese viper (Agkistrodon halys Blomhoffii) with low dose of antivenin: report of 43 consecutive cases","volume":"66","author":"Kimoto","year":"1997","journal-title":"Nihon Geka Hokan"},{"key":"10.1074\/jbc.M115.694687_bib51","first-page":"1165","article-title":"Antitumor effect of Cepharanthin in the double grafted tumor system","volume":"17","author":"Ebina","year":"1990","journal-title":"Gan To Kagaku Ryoho"},{"key":"10.1074\/jbc.M115.694687_bib52","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3892\/ijo_00000417","article-title":"Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8","volume":"35","author":"Harada","year":"2009","journal-title":"Int. J. Oncol"},{"key":"10.1074\/jbc.M115.694687_bib53","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0006-2952(91)90012-T","article-title":"Inhibition of 12-O-tetradecanoyl phorbol-13-acetate promoted tumorigenesis by cepharanthine, a biscoclaurine alkaloid, in relation to the inhibitory effect on protein kinase C","volume":"41","author":"Edashige","year":"1991","journal-title":"Biochem. Pharmacol"},{"key":"10.1074\/jbc.M115.694687_bib54","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1254\/jjp.54.464","article-title":"Reversal of resistance to doxorubicin with cepharanthine in murine P388 leukemia cells","volume":"54","author":"Fujimura","year":"1990","journal-title":"Jpn. J. Pharmacol"},{"key":"10.1074\/jbc.M115.694687_bib55","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1349-7006.2003.tb01482.x","article-title":"Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells","volume":"94","author":"Mukai","year":"2003","journal-title":"Cancer Sci"},{"key":"10.1074\/jbc.M115.694687_bib56","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1254\/fpj.88.71","article-title":"Effects of cepharanthine on experimental nasal allergy","volume":"88","author":"Kohno","year":"1986","journal-title":"Nihon Yakurigaku Zasshi"},{"key":"10.1074\/jbc.M115.694687_bib57","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1254\/fpj.90.205","article-title":"Mode of the anti-allergic action of cepharanthine on an experimental model of allergic rhinitis","volume":"90","author":"Kohno","year":"1987","journal-title":"Nihon Yakurigaku Zasshi"},{"key":"10.1074\/jbc.M115.694687_bib58","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.intimp.2011.08.003","article-title":"Inhibitory effect of cepharanthine on dendritic cell activation and function","volume":"11","author":"Uto","year":"2011","journal-title":"Int. Immunopharmacol"},{"key":"10.1074\/jbc.M115.694687_bib59","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1172\/JCI33997","article-title":"The saga of MHC-bound peptides: a renaissance for antigen presentation?","volume":"117","author":"Teyton","year":"2007","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.694687_bib60","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/379343a0","article-title":"Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein","volume":"379","author":"Brocke","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.694687_bib61","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/jaut.1998.0207","article-title":"Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes","volume":"11","author":"Geluk","year":"1998","journal-title":"J. Autoimmun"},{"key":"10.1074\/jbc.M115.694687_bib62","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/80516","article-title":"Encephalitogenic potential of the myelin basic protein peptide (amino acids 83\u201399) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand","volume":"6","author":"Bielekova","year":"2000","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.694687_bib63","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1021\/jm030362s","article-title":"Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein","volume":"47","author":"Koehler","year":"2004","journal-title":"J. Med. Chem"},{"key":"10.1074\/jbc.M115.694687_bib64","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.4049\/jimmunol.1300407","article-title":"Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis","volume":"191","author":"Ji","year":"2013","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M115.694687_bib65","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1021\/ci100444c","article-title":"Identification of small-molecule inhibitors against human leukocyte antigen-death receptor 4 (HLA-DR4) through a comprehensive strategy","volume":"51","author":"Liu","year":"2011","journal-title":"J. Chem. Inf. Model"},{"key":"10.1074\/jbc.M115.694687_bib66","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.4049\/jimmunol.1100746","article-title":"Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation","volume":"187","author":"Michels","year":"2011","journal-title":"J. Immunol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820437135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820437135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.694687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T12:59:59Z","timestamp":1641301199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820437135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":66,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0021925820437135"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.694687","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.694687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}