{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:41:22Z","timestamp":1792194082197,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":1679,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"publisher","award":["MOP185773"],"award-info":[{"award-number":["MOP185773"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"publisher","award":["MOP74456"],"award-info":[{"award-number":["MOP74456"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PO1-HL080101"],"award-info":[{"award-number":["PO1-HL080101"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM007752"],"award-info":[{"award-number":["T32GM007752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1074\/jbc.m115.694984","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T03:33:49Z","timestamp":1452224029000},"page":"4156-4165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic \u03b2-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor \u03baB"],"prefix":"10.1016","volume":"291","author":[{"given":"Brian K.","family":"Panama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Korogyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roozbeh","family":"Aschar-Sobbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.B.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Gang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Heller","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorrie A.","family":"Kirshenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Backx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.694984_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.yjmcc.2009.07.013","article-title":"Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation","volume":"48","author":"Niwa","year":"2010","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M115.694984_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2002.026468","article-title":"Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to))","volume":"546","author":"Sah","year":"2003","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.M115.694984_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/hh0202.103315","article-title":"Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling","volume":"90","author":"Sah","year":"2002","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.694984_bib4","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/cvr\/cvn339","article-title":"A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome","volume":"81","author":"Calloe","year":"2009","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.M115.694984_bib5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/A:1009854325711","article-title":"The control of adrenergic function in heart failure: therapeutic intervention","volume":"5","author":"Clark","year":"2000","journal-title":"Heart Fail. Rev"},{"key":"10.1074\/jbc.M115.694984_bib6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.yjmcc.2008.10.016","article-title":"NFATc3-dependent loss of I(to) gradient across the left ventricular wall during chronic \u03b2 adrenergic stimulation","volume":"46","author":"Rossow","year":"2009","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M115.694984_bib7","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/01.RES.0000128406.08418.34","article-title":"NFATc3-induced reductions in voltage-gated K+ currents after myocardial infarction","volume":"94","author":"Rossow","year":"2004","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.694984_bib8","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1161\/01.RES.0000201956.86258.e1","article-title":"Mitogen-activated protein kinases control cardiac KChIP2 gene expression","volume":"98","author":"Jia","year":"2006","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.694984_bib9","doi-asserted-by":"crossref","first-page":"38498","DOI":"10.1074\/jbc.M607774200","article-title":"Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits","volume":"281","author":"Gong","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.694984_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/CIRCRESAHA.110.229112","article-title":"Nuclear factor {\u03ba}B downregulates the transient outward potassium current Ito,f through control of KChIP2 expression","volume":"108","author":"Panama","year":"2011","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.694984_bib11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/CIRCEP.108.842799","article-title":"Ca\/calmodulin kinase II differentially modulates potassium currents","volume":"2","author":"Wagner","year":"2009","journal-title":"Circ. Arrhythm. Electrophysiol"},{"key":"10.1074\/jbc.M115.694984_bib12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/01.RES.84.6.713","article-title":"Identification and expression of delta-isoforms of the multifunctional Ca2+\/calmodulin-dependent protein kinase in failing and nonfailing human myocardium","volume":"84","author":"Hoch","year":"1999","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.694984_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1023\/A:1010899724222","article-title":"Expression of Ca2+\/calmodulin-dependent protein kinase II \u03b4-subunit isoforms in rats with hypertensive cardiac hypertrophy","volume":"220","author":"Hagemann","year":"2001","journal-title":"Mol. Cell Biochem"},{"key":"10.1074\/jbc.M115.694984_bib14","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/CIRCRESAHA.112.276915","article-title":"Ca2+\/Calmodulin-dependent protein kinase II \u03b4 mediates myocardial ischemia\/reperfusion injury through nuclear factor-\u03baB","volume":"112","author":"Ling","year":"2013","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.694984_bib15","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1074\/jbc.M108525200","article-title":"The cardiac-specific nuclear \u03b4(B) isoform of Ca2+\/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity","volume":"277","author":"Zhang","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.694984_bib16","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.yjmcc.2015.06.007","article-title":"CaMKII\u03b4 mediates \u03b2-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic \u03b2-adrenergic stimulation","volume":"85","author":"Grimm","year":"2015","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M115.694984_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches","volume":"391","author":"Hamill","year":"1981","journal-title":"Pflugers Arch"},{"key":"10.1074\/jbc.M115.694984_bib18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1469-7793.1997.271be.x","article-title":"Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle","volume":"504","author":"Wickenden","year":"1997","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.M115.694984_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00109-002-0325-7","article-title":"Molecular components of transient outward potassium current in cultured neonatal rat ventricular myocytes","volume":"80","author":"Kassiri","year":"2002","journal-title":"J. Mol. Med"},{"key":"10.1074\/jbc.M115.694984_bib20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem"},{"key":"10.1074\/jbc.M115.694984_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-\u0394\u0394C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1074\/jbc.M115.694984_bib22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCHEARTFAILURE.112.000061","article-title":"Bidirectional regulation of nuclear factor-\u03baB and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular myocytes","volume":"6","author":"Dhingra","year":"2013","journal-title":"Circ. Heart Fail"},{"key":"10.1074\/jbc.M115.694984_bib23","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1161\/01.CIR.0000150537.59754.55","article-title":"Nuclear factor-\u03baB represses hypoxia-induced mitochondrial defects and cell death of ventricular myocytes","volume":"110","author":"Regula","year":"2004","journal-title":"Circulation"},{"key":"10.1074\/jbc.M115.694984_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-5793(97)00470-5","article-title":"The endogenous cardiac sarcoplasmic reticulum Ca2+\/calmodulin-dependent kinase is activated in response to \u03b2-adrenergic stimulation and becomes Ca2+-independent in intact beating hearts","volume":"409","author":"Baltas","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M115.694984_bib25","doi-asserted-by":"crossref","first-page":"H1299","DOI":"10.1152\/ajpheart.00017.2006","article-title":"A \u03b21-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction","volume":"291","author":"Sucharov","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"10.1074\/jbc.M115.694984_bib26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1161\/CIRCRESAHA.109.194035","article-title":"CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes","volume":"105","author":"MacDonnell","year":"2009","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.694984_bib27","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/01.RES.0000069685.20258.F1","article-title":"Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release","volume":"92","author":"Maier","year":"2003","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M115.694984_bib28","doi-asserted-by":"crossref","first-page":"30089","DOI":"10.1016\/S0021-9258(18)43777-5","article-title":"Phosphorylation of NF-\u03baB1-p50 is involved in NF-\u03baB activation and stable DNA binding","volume":"269","author":"Li","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.694984_bib29","doi-asserted-by":"crossref","first-page":"34538","DOI":"10.1074\/jbc.M504943200","article-title":"Phosphorylation of RelA\/p65 on serine 536 defines an I{\u03ba}B{\u03b1}-independent NF-{\u03ba}B pathway","volume":"280","author":"Sasaki","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.694984_bib30","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.yjmcc.2009.12.019","article-title":"KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling","volume":"48","author":"Jin","year":"2010","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M115.694984_bib31","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1113\/jphysiol.2013.255836","article-title":"Stabilization of Kv4 protein by the accessory K+ channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K+ currents","volume":"591","author":"Foeger","year":"2013","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.M115.694984_bib32","doi-asserted-by":"crossref","first-page":"H1157","DOI":"10.1152\/ajpheart.00518.2001","article-title":"Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients","volume":"283","author":"Kaprielian","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"10.1074\/jbc.M115.694984_bib33","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1161\/01.CIR.0000033970.22130.93","article-title":"Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes","volume":"106","author":"Zobel","year":"2002","journal-title":"Circulation"},{"key":"10.1074\/jbc.M115.694984_bib34","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0092-8674(01)00588-8","article-title":"A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia","volume":"107","author":"Kuo","year":"2001","journal-title":"Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820437196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820437196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.694984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T12:59:49Z","timestamp":1641301189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820437196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0021925820437196"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.694984","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic \u03b2-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor \u03baB","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.694984","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}