{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:47:17Z","timestamp":1790261237499,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":1617,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-R56HL121409"],"award-info":[{"award-number":["NIH-R56HL121409"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["000900-01"],"award-info":[{"award-number":["000900-01"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1074\/jbc.m115.697011","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T01:07:40Z","timestamp":1454288860000},"page":"7651-7660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism"],"prefix":"10.1016","volume":"291","author":[{"given":"Inamul","family":"Kabir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai H.","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shang","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangping","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Cheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.697011_bib1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M115.697011_bib2","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/S0022-2275(20)34196-1","article-title":"Lipid analysis of human HDL and LDL by MALDI-TOF mass spectrometry and (31)P-NMR","volume":"42","author":"Schiller","year":"2001","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M115.697011_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(99)00177-8","article-title":"Stories about acyl chains","volume":"1483","author":"Lands","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.697011_bib4","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0021-9258(18)70453-5","article-title":"Metabolism of glycerolipids; a comparison of lecithin and triglyceride synthesis","volume":"231","author":"Lands","year":"1958","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.697011_bib5","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1073\/pnas.0712245105","article-title":"Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity","volume":"105","author":"Hishikawa","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.697011_bib6","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1074\/jbc.M710422200","article-title":"Identification and characterization of a major liver lysophosphatidylcholine acyltransferase","volume":"283","author":"Zhao","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.697011_bib7","doi-asserted-by":"crossref","first-page":"20122","DOI":"10.1074\/jbc.M111.334664","article-title":"Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression","volume":"287","author":"Li","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.697011_bib8","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cmet.2013.10.002","article-title":"LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition","volume":"18","author":"Rong","year":"2013","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M115.697011_bib9","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06557.026","article-title":"Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion","author":"Rong","year":"2015","journal-title":"eLife"},{"key":"10.1074\/jbc.M115.697011_bib10","doi-asserted-by":"crossref","first-page":"e06328","DOI":"10.7554\/eLife.06328","article-title":"Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport","volume":"4","author":"Hashidate-Yoshida","year":"2015","journal-title":"eLife"},{"key":"10.1074\/jbc.M115.697011_bib11","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1053\/j.gastro.2015.07.012","article-title":"Deficiency in lysophosphatidylcholine acyltransferase 3 reduces plasma levels of lipids by reducing lipid absorption in mice","volume":"149","author":"Li","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M115.697011_bib12","first-page":"1049","article-title":"Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation","volume":"7","author":"Hayashi","year":"1993","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M115.697011_bib13","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/01.ATV.0000231520.26490.54","article-title":"Complete prevention of atherosclerosis in apoE-deficient mice by hepatic human apoE gene transfer with adeno-associated virus serotypes 7 and 8","volume":"26","author":"Kitajima","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.M115.697011_bib14","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1194\/jlr.M500023-JLR200","article-title":"Evidence for multiple complementary pathways for efficient cholesterol absorption in mice","volume":"46","author":"Iqbal","year":"2005","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M115.697011_bib15","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1161\/ATVBAHA.107.149914","article-title":"Phospholipid transfer protein-deficient mice absorb less cholesterol","volume":"27","author":"Liu","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1074\/jbc.M115.697011_bib16","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/89977","article-title":"Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency","volume":"7","author":"Jiang","year":"2001","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.697011_bib17","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1128\/MCB.05893-11","article-title":"Reducing plasma membrane sphingomyelin increases insulin sensitivity","volume":"31","author":"Li","year":"2011","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M115.697011_bib18","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1053\/j.gastro.2010.03.002","article-title":"Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells","volume":"138","author":"Barker","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M115.697011_bib19","doi-asserted-by":"crossref","first-page":"30432","DOI":"10.1074\/jbc.M113.501247","article-title":"Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice","volume":"288","author":"Iqbal","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.697011_bib20","series-title":"Phospholipid Biosynthesis in Eukaryotes","author":"Vance","year":"2002"},{"key":"10.1074\/jbc.M115.697011_bib21","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1194\/jlr.M009449","article-title":"Lipidomics reveals a remarkable diversity of lipids in human plasma","volume":"51","author":"Quehenberger","year":"2010","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M115.697011_bib22","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1126\/science.1093131","article-title":"Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption","volume":"303","author":"Altmann","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M115.697011_bib23","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1074\/jbc.M301311200","article-title":"Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8","volume":"278","author":"Yu","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.697011_bib24","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.bbalip.2011.09.013","article-title":"Gut triglyceride production","volume":"1821","author":"Pan","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M115.697011_bib25","doi-asserted-by":"crossref","first-page":"19493","DOI":"10.1074\/jbc.M703330200","article-title":"CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine","volume":"282","author":"Nassir","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.697011_bib26","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1172\/JCI111769","article-title":"Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranes","volume":"75","author":"Stremmel","year":"1985","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.697011_bib27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80332-9","article-title":"Identification of the major intestinal fatty acid transport protein","volume":"4","author":"Stahl","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M115.697011_bib28","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nm.3417","article-title":"The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1","volume":"20","author":"Li","year":"2014","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.697011_bib29","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1073\/pnas.1216182110","article-title":"Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding","volume":"110","author":"Koeberle","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.697011_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.1255288","article-title":"Lipid cell biology. Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins","volume":"345","author":"Pinot","year":"2014","journal-title":"Science"},{"key":"10.1074\/jbc.M115.697011_bib31","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1126\/science.1120781","article-title":"The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin","volume":"310","author":"Shaw","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M115.697011_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/BJ20101721","article-title":"LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice","volume":"434","author":"Woods","year":"2011","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M115.697011_bib33","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1172\/JCI107487","article-title":"Lymph chylomicron formation during the inhibition of protein synthesis. Studies of chylomicron apoproteins","volume":"52","author":"Glickman","year":"1973","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.697011_bib34","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1073\/pnas.74.6.2569","article-title":"The intestine as a source of apolipoprotein A1","volume":"74","author":"Glickman","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M115.697011_bib35","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1056\/NEJM197812282992602","article-title":"Apoprotein A-I synthesis in normal intestinal mucosa and in Tangier disease","volume":"299","author":"Glickman","year":"1978","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M115.697011_bib36","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1172\/JCI109564","article-title":"Metabolic fate of chylomicron phospholipids and apoproteins in the rat","volume":"64","author":"Tall","year":"1979","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M115.697011_bib37","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/MOL.0000000000000084","article-title":"Intestinal lipid absorption and lipoprotein formation","volume":"25","author":"Hussain","year":"2014","journal-title":"Curr. Opin. Lipidol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820413171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820413171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.697011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T11:13:05Z","timestamp":1641294785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820413171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":37,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0021925820413171"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.697011","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.697011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}