{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:42:50Z","timestamp":1790563370954,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"42","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":1434,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["RO1 DK043051"],"award-info":[{"award-number":["RO1 DK043051"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK57521"],"award-info":[{"award-number":["P30DK57521"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["RO1 DK106210"],"award-info":[{"award-number":["RO1 DK106210"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5T32DK007516\u201331"],"award-info":[{"award-number":["5T32DK007516\u201331"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust grant","doi-asserted-by":"publisher","award":["2012-PG-MED002"],"award-info":[{"award-number":["2012-PG-MED002"]}],"id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/02218\u20136 and 2011\/15682\u20134"],"award-info":[{"award-number":["2014\/02218\u20136 and 2011\/15682\u20134"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1074\/jbc.m115.703835","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T01:53:02Z","timestamp":1472521982000},"page":"22207-22217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"title":["Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses"],"prefix":"10.1016","volume":"291","author":[{"given":"Jennifer","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro M.","family":"Moraes-Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Castoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Aryal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric U.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Parnas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia J.","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Saghatelian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara B.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.703835_bib1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature03194","article-title":"Lessons from natural molecules","volume":"432","author":"Clardy","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.703835_bib2","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M115.703835_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1021\/ja00705a609","article-title":"Total synthesis of prostaglandins F2-\u03b1 and E2 as the naturally occurring forms","volume":"92","author":"Corey","year":"1970","journal-title":"J. Am. Chem. Soc"},{"key":"10.1074\/jbc.M115.703835_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/hrt.80.2.151","article-title":"Long-term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension","volume":"80","author":"Higenbottam","year":"1998","journal-title":"Heart"},{"key":"10.1074\/jbc.M115.703835_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2165\/00002512-199914050-00006","article-title":"Prostaglandin analogues in the treatment of glaucoma","volume":"14","author":"Lind\u00e9n","year":"1999","journal-title":"Drugs Aging"},{"key":"10.1074\/jbc.M115.703835_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0031-6997(25)06759-6","article-title":"Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin","volume":"30","author":"Moncada","year":"1978","journal-title":"Pharmacol. Rev"},{"key":"10.1074\/jbc.M115.703835_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1124\/mol.111.076109","article-title":"S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis","volume":"81","author":"Gonzalez-Cabrera","year":"2012","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M115.703835_bib8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2014.09.035","article-title":"Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects","volume":"159","author":"Yore","year":"2014","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.703835_bib9","first-page":"5","article-title":"Epidemiological study of ulcerative colitis in Japan: incidence and familial occurrence: the Epidemiology Group of the Research Committee of Inflammatory Bowel Disease in Japan","volume":"30","author":"Kitahora","year":"1995","journal-title":"J. Gastroenterol"},{"key":"10.1074\/jbc.M115.703835_bib10","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3748\/wjg.v10.i3.404","article-title":"Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977\u20132001","volume":"10","author":"Lakatos","year":"2004","journal-title":"World J. Gastroenterol"},{"key":"10.1074\/jbc.M115.703835_bib11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M115.703835_bib12","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.mayocp.2014.07.002","article-title":"Ulcerative colitis: epidemiology, diagnosis, and management","volume":"89","author":"Feuerstein","year":"2014","journal-title":"Mayo Clinic Proc"},{"key":"10.1074\/jbc.M115.703835_bib13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.autrev.2004.03.002","article-title":"Inflammatory bowel disease: the role of environmental factors","volume":"3","author":"Danese","year":"2004","journal-title":"Autoimmun. Rev"},{"key":"10.1074\/jbc.M115.703835_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2036.2004.02047.x","article-title":"Review article: the aetiopathogenesis of inflammatory bowel disease: immunology and repair mechanisms","volume":"20","author":"Dignass","year":"2004","journal-title":"Aliment. Pharmacol. Ther"},{"key":"10.1074\/jbc.M115.703835_bib15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2796.2012.02515.x","article-title":"Innate immune dysfunction in inflammatory bowel disease","volume":"271","author":"Gersemann","year":"2012","journal-title":"J. Internal Med"},{"key":"10.1074\/jbc.M115.703835_bib16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fimmu.2013.00280","article-title":"Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics","volume":"4","author":"Pastorelli","year":"2013","journal-title":"Front. Immunol"},{"key":"10.1074\/jbc.M115.703835_bib17","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.48.4.526","article-title":"The risk of colorectal cancer in ulcerative colitis: a meta-analysis","volume":"48","author":"Eaden","year":"2001","journal-title":"Gut"},{"key":"10.1074\/jbc.M115.703835_bib18","first-page":"614","article-title":"Impact of the age of diagnosis on the natural history of ulcerative colitis","volume":"107","author":"Curdia","year":"2015","journal-title":"Rev. Esp. Enferm. Dig"},{"key":"10.1074\/jbc.M115.703835_bib19","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/ecco-jcc\/jjv118","article-title":"Treating inflammatory bowel disease in pregnancy: the issues we face today","volume":"9","author":"Damas","year":"2015","journal-title":"J. Crohns Colitis"},{"key":"10.1074\/jbc.M115.703835_bib20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.gtc.2014.05.005","article-title":"The use of biologic agents in pregnancy and breastfeeding","volume":"43","author":"Horst","year":"2014","journal-title":"Gastroenterol. Clin. North Am"},{"key":"10.1074\/jbc.M115.703835_bib21","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/1389203716666150630133141","article-title":"They must hold tight: junction proteins, microbiota and immunity in intestinal mucosa","volume":"16","author":"Castoldi","year":"2015","journal-title":"Curr. Protein Pept. Sci"},{"key":"10.1074\/jbc.M115.703835_bib22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nm1168","article-title":"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120","volume":"11","author":"Hirasawa","year":"2005","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M115.703835_bib23","doi-asserted-by":"crossref","first-page":"11303","DOI":"10.1074\/jbc.M211495200","article-title":"The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids","volume":"278","author":"Briscoe","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.703835_bib24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"10.1074\/jbc.M115.703835_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cgh.2006.09.033","article-title":"Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression","volume":"5","author":"Turner","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol"},{"key":"10.1074\/jbc.M115.703835_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/01.MIB.0000437498.14804.50","article-title":"Patient preferences for surgical versus medical therapy for ulcerative colitis","volume":"20","author":"Bewtra","year":"2014","journal-title":"Inflamm. Bowel Dis"},{"key":"10.1074\/jbc.M115.703835_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/mnfr.201000070","article-title":"Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice","volume":"55","author":"Cho","year":"2011","journal-title":"Mol. Nutr. Food Res"},{"key":"10.1074\/jbc.M115.703835_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/ibd.21029","article-title":"Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis","volume":"16","author":"Ishida","year":"2010","journal-title":"Inflamm. Bowel Dis"},{"key":"10.1074\/jbc.M115.703835_bib29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cmet.2007.12.003","article-title":"Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis","volume":"7","author":"Chen","year":"2008","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M115.703835_bib30","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/BF02093614","article-title":"n-3 fatty acids only delay early relapse of ulcerative colitis in remission","volume":"41","author":"Loeschke","year":"1996","journal-title":"Digest. Dis. Sci"},{"key":"10.1074\/jbc.M115.703835_bib31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1572-0241.1998.229_a.x","article-title":"Distal procto-colitis, natural cytotoxicity, and essential fatty acids","volume":"93","author":"Almallah","year":"1998","journal-title":"Am. J. Gastroenterol"},{"key":"10.1074\/jbc.M115.703835_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1476-511X-12-81","article-title":"Effects of increase in fish oil intake on intestinal eicosanoids and inflammation in a mouse model of colitis","volume":"12","author":"Bosco","year":"2013","journal-title":"Lipids Health Dis"},{"key":"10.1074\/jbc.M115.703835_bib33","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1046\/j.1365-2036.2002.01286.x","article-title":"A double-blind, randomized, placebo-controlled trial of essential fatty acid supplementation in the maintenance of remission of ulcerative colitis","volume":"16","author":"Middleton","year":"2002","journal-title":"Aliment. Pharmacol. Ther"},{"key":"10.1074\/jbc.M115.703835_bib34","doi-asserted-by":"crossref","first-page":"7960","DOI":"10.1158\/0008-5472.CAN-10-1396","article-title":"Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis","volume":"70","author":"Woodworth","year":"2010","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M115.703835_bib35","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2174\/138161282007140221100428","article-title":"From gut inflammation to gastrointestinal disorders current update on pathophysiology, molecular mechanism and pharmacological treatment modalities","volume":"20","author":"Sikiric","year":"2014","journal-title":"Curr. Pharm. Des"},{"key":"10.1074\/jbc.M115.703835_bib36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3748\/wjg.v20.i1.6","article-title":"Immunopathology of inflammatory bowel disease","volume":"20","author":"Wallace","year":"2014","journal-title":"World J. Gastroenterol"},{"key":"10.1074\/jbc.M115.703835_bib37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/eji.1830270104","article-title":"Expression of pro-inflammatory cytokines by TCR \u03b1 \u03b2+ and TCR \u03b3 \u03b4+ T cells in an experimental model of colitis","volume":"27","author":"Simpson","year":"1997","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/jbc.M115.703835_bib38","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1053\/j.gastro.2008.04.037","article-title":"TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation","volume":"135","author":"Takedatsu","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M115.703835_bib39","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1136\/gut.2009.182170","article-title":"Differential regulation of interleukin 17 and interferon \u03b3 production in inflammatory bowel disease","volume":"58","author":"Rovedatti","year":"2009","journal-title":"Gut"},{"key":"10.1074\/jbc.M115.703835_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1586\/egh.11.107","article-title":"The IL-23\/IL-17 pathway in inflammatory bowel disease","volume":"6","author":"Geremia","year":"2012","journal-title":"Expert Rev. Gastroenterol. Hepatol"},{"key":"10.1074\/jbc.M115.703835_bib41","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.4049\/jimmunol.1001454","article-title":"Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production","volume":"186","author":"Feng","year":"2011","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M115.703835_bib42","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00018-005-5034-2","article-title":"Innate defenses of the intestinal epithelial barrier","volume":"62","author":"M\u00fcller","year":"2005","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.M115.703835_bib43","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00018-011-0714-6","article-title":"Paneth cell \u03b1-defensins in enteric innate immunity","volume":"68","author":"Ouellette","year":"2011","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.M115.703835_bib44","first-page":"243","article-title":"Paneth cell metaplasia in ulcerative colitis","volume":"38","author":"Paterson","year":"1961","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M115.703835_bib45","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ng.221","article-title":"Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility","volume":"40","author":"Franke","year":"2008","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M115.703835_bib46","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1093\/hmg\/ddu398","article-title":"A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis","volume":"23","author":"Juli\u00e0","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M115.703835_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0558s47","article-title":"Methods of inducing inflammatory bowel disease in mice","author":"Maxwell","year":"2009","journal-title":"Curr. Protoc. Pharmacol"},{"key":"10.1074\/jbc.M115.703835_bib48","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1136\/gutjnl-2014-307477","article-title":"Comparing histological activity indexes in UC","volume":"64","author":"Bressenot","year":"2015","journal-title":"Gut"},{"key":"10.1074\/jbc.M115.703835_bib49","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2014.01.018","article-title":"RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance","volume":"19","author":"Moraes-Vieira","year":"2014","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M115.703835_bib50","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/eji.201343592","article-title":"Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells","volume":"44","author":"Moraes-Vieira","year":"2014","journal-title":"Eur. J. Immunol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820358002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820358002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.703835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T15:18:28Z","timestamp":1749568708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820358002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":50,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0021925820358002"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.703835","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.703835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}