{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:18:49Z","timestamp":1789193929137,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":1654,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK54999"],"award-info":[{"award-number":["DK54999"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK099284"],"award-info":[{"award-number":["DK099284"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK 54983"],"award-info":[{"award-number":["DK 54983"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1074\/jbc.m115.707877","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:41:59Z","timestamp":1451958119000},"page":"5259-5269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion"],"prefix":"10.1016","volume":"291","author":[{"given":"Ke","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxiang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile","family":"Boulpaep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenHui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Giebisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M115.707877_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00041552-200309000-00008","article-title":"Bartter syndrome","volume":"12","author":"Hebert","year":"2003","journal-title":"Curr. Opin. Nephrol. Hypertens"},{"key":"10.1074\/jbc.M115.707877_bib2","doi-asserted-by":"crossref","first-page":"37871","DOI":"10.1074\/jbc.M205627200","article-title":"Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome","volume":"277","author":"Lorenz","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.707877_bib3","doi-asserted-by":"crossref","first-page":"37881","DOI":"10.1074\/jbc.M206644200","article-title":"Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice","volume":"277","author":"Lu","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.707877_bib4","doi-asserted-by":"crossref","first-page":"F490","DOI":"10.1152\/ajprenal.00305.2003","article-title":"ROMK is required for expression of the 70-pS K channel in the thick ascending limb","volume":"286","author":"Lu","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.707877_bib5","doi-asserted-by":"crossref","first-page":"F1366","DOI":"10.1152\/ajprenal.00608.2007","article-title":"Mouse model of type II Bartter's syndrome: I. upregulation of thiazide-sensitive Na-Cl cotransport activity","volume":"294","author":"Cantone","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.707877_bib6","doi-asserted-by":"crossref","first-page":"F1373","DOI":"10.1152\/ajprenal.00613.2007","article-title":"Mouse model of type II Bartter's syndrome: II. altered expression of renal sodium- and water-transporting proteins","volume":"294","author":"Wagner","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.707877_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/sj.ki.5000388","article-title":"Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of type II Bartter's syndrome and in adaptation to a high-K diet","volume":"70","author":"Bailey","year":"2006","journal-title":"Kidney Int"},{"key":"10.1074\/jbc.M115.707877_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/362031a0","article-title":"Cloning and expression of an inwardly rectifying ATP-regulated potassium channel","volume":"362","author":"Ho","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M115.707877_bib9","first-page":"F1132","article-title":"ROMK inwardly rectifying ATP-sensitive K+ channel: II. cloning and distribution of alternative forms","volume":"268","author":"Boim","year":"1995","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M115.707877_bib10","doi-asserted-by":"crossref","first-page":"C585","DOI":"10.1152\/ajpcell.1999.276.3.C585","article-title":"Splicing of a retained intron within ROMK K+ channel RNA generates a novel set of isoforms in rat kidney","volume":"276","author":"Beesley","year":"1999","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M115.707877_bib11","doi-asserted-by":"crossref","first-page":"F881","DOI":"10.1152\/ajprenal.00301.2003","article-title":"Protein tyrosine kinase is expressed and regulates ROMK1 location in the cortical collecting duct","volume":"286","author":"Lin","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.707877_bib12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1152\/physiol.00044.2004","article-title":"The protein tyrosine kinase-dependent pathway mediates the effect of K intake on renal K secretion","volume":"20","author":"Lin","year":"2005","journal-title":"Physiology"},{"key":"10.1074\/jbc.M115.707877_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00877954","article-title":"Renal and extrarenal sites of action of diuretics","volume":"7","author":"Giebisch","year":"1993","journal-title":"Cardiovasc. Drugs Ther"},{"key":"10.1074\/jbc.M115.707877_bib14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1085\/jgp.116.2.299","article-title":"Extracellular ATP inhibits the small-conductance K channel on the apical membrane of the cortical collecting duct from mouse kidney","volume":"116","author":"Lu","year":"2000","journal-title":"J. Gen. Physiol"},{"key":"10.1074\/jbc.M115.707877_bib15","doi-asserted-by":"crossref","first-page":"F1507","DOI":"10.1152\/ajprenal.00277.2012","article-title":"Regulation of glomerulotubular balance: II: impact of angiotensin II on flow-dependent transport","volume":"303","author":"Du","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.707877_bib16","doi-asserted-by":"crossref","first-page":"R997","DOI":"10.1152\/ajpregu.00051.2007","article-title":"Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production","volume":"295","author":"Yan","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr Comp. Physiol"},{"key":"10.1074\/jbc.M115.707877_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10157-011-0495-0","article-title":"Renal outer medullary potassium channel knockout models reveal thick ascending limb function and dysfunction","volume":"16","author":"Wang","year":"2012","journal-title":"Clin. Exp. Nephrol"},{"key":"10.1074\/jbc.M115.707877_bib18","doi-asserted-by":"crossref","first-page":"24261","DOI":"10.1016\/S0021-9258(19)51076-6","article-title":"Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel","volume":"269","author":"Shuck","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.707877_bib19","series-title":"The Kidney: Physiology and Pathophysiology","first-page":"2v","author":"Seldin","year":"2000"},{"key":"10.1074\/jbc.M115.707877_bib20","first-page":"F588","article-title":"Arachidonic acid inhibits activity of cloned renal K+ channel, ROMK1","volume":"271","author":"Macica","year":"1996","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M115.707877_bib21","first-page":"F175","article-title":"Role of the NH2 terminus of the cloned renal K+ channel, ROMK1, in arachidonic acid-mediated inhibition","volume":"274","author":"Macica","year":"1998","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M115.707877_bib22","doi-asserted-by":"crossref","first-page":"F14","DOI":"10.1152\/ajprenal.00093.2005","article-title":"Regulation of ROMK (Kir1.1) channels: new mechanisms and aspects","volume":"290","author":"Wang","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.707877_bib23","doi-asserted-by":"crossref","first-page":"F206","DOI":"10.1152\/ajprenal.2001.281.2.F206","article-title":"Effect of dietary K intake on apical small-conductance K channel in CCD: role of protein tyrosine kinase","volume":"281","author":"Wei","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.707877_bib24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ki.1979.79","article-title":"Mechanism of renal potassium conservation in the rat","volume":"15","author":"Linas","year":"1979","journal-title":"Kidney Int"},{"key":"10.1074\/jbc.M115.707877_bib25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1152\/ajplegacy.1964.206.4.674","article-title":"Micropuncture study of renal potassium excretion in the rat","volume":"206","author":"Malnic","year":"1964","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M115.707877_bib26","doi-asserted-by":"crossref","first-page":"F165","DOI":"10.1152\/ajprenal.2000.278.1.F165","article-title":"Protein tyrosine kinase regulates the number of renal secretory K channels","volume":"278","author":"Wang","year":"2000","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.707877_bib27","doi-asserted-by":"crossref","first-page":"F1179","DOI":"10.1152\/ajprenal.00150.2003","article-title":"Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct","volume":"285","author":"Chu","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M115.707877_bib28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1146\/annurev.physiol.66.032102.112025","article-title":"Regulation of renal K transport by dietary K intake","volume":"66","author":"Wang","year":"2004","journal-title":"Annu. Rev. Physiol"},{"key":"10.1074\/jbc.M115.707877_bib29","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1046\/j.1523-1755.2001.060002436.x","article-title":"Renal potassium channels: function, regulation, and structure","volume":"60","author":"Giebisch","year":"2001","journal-title":"Kidney Int"},{"key":"10.1074\/jbc.M115.707877_bib30","doi-asserted-by":"crossref","first-page":"F630","DOI":"10.1152\/ajprenal.00378.2001","article-title":"Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles","volume":"283","author":"Zeng","year":"2002","journal-title":"Am. J. Physiol. Renal. Physiol"},{"key":"10.1074\/jbc.M115.707877_bib31","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1074\/jbc.M109739200","article-title":"Inhibition of protein-tyrosine phosphatase stimulates the dynamin-dependent endocytosis of ROMK1","volume":"277","author":"Sterling","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.707877_bib32","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1074\/jbc.M008671200","article-title":"Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase","volume":"276","author":"Moral","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M115.707877_bib33","doi-asserted-by":"crossref","first-page":"C1188","DOI":"10.1152\/ajpcell.2001.281.4.C1188","article-title":"Effects of protein tyrosine kinase and protein tyrosine phosphatase on apical K+ channels in the TAL","volume":"281","author":"Gu","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M115.707877_bib34","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/sj.embor.7400678","article-title":"Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel","volume":"7","author":"Rapedius","year":"2006","journal-title":"EMBO Rep"},{"key":"10.1074\/jbc.M115.707877_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.22152","article-title":"Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds","volume":"517","author":"Dvoryanchikov","year":"2009","journal-title":"J. Comp. Neurol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582043162X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582043162X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M115.707877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T12:30:50Z","timestamp":1641299450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582043162X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S002192582043162X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m115.707877","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M115.707877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}