{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:23:37Z","timestamp":1785936217816,"version":"3.56.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"51","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":1365,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30871311"],"award-info":[{"award-number":["30871311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171155"],"award-info":[{"award-number":["31171155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"crossref","award":["20070487184"],"award-info":[{"award-number":["20070487184"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1074\/jbc.m116.727990","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:07:41Z","timestamp":1473811661000},"page":"26352-26363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by Huntingtin-associated Protein 1"],"prefix":"10.1016","volume":"291","author":[{"given":"Jing-Ying","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Lin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Long","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.727990_bib1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/378398a0","article-title":"A huntingtin-associated protein enriched in brain with implications for pathology","volume":"378","author":"Li","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.727990_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3940(00)00872-7","article-title":"Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse","volume":"282","author":"Dragatsis","year":"2000","journal-title":"Neurosci. Lett"},{"key":"10.1074\/jbc.M116.727990_bib3","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1369\/jhc.5A6662.2005","article-title":"Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat","volume":"53","author":"Liao","year":"2005","journal-title":"J. Histochem. Cytochem"},{"key":"10.1074\/jbc.M116.727990_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1369\/jhc.2009.954479","article-title":"Selective expression of Huntingtin-associated protein 1 in \u03b2-cells of the rat pancreatic islets","volume":"58","author":"Liao","year":"2010","journal-title":"J. Histochem. Cytochem"},{"key":"10.1074\/jbc.M116.727990_bib5","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00018-011-0692-8","article-title":"Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic \u03b2-cells","volume":"69","author":"Cape","year":"2012","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.M116.727990_bib6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/hmg\/ddi053","article-title":"The R6\/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient \u03b2-cell mass and exocytosis","volume":"14","author":"Bj\u00f6rkqvist","year":"2005","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M116.727990_bib7","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1271\/bbb.90147","article-title":"HSP40 ameliorates impairment of insulin secretion by inhibiting huntingtin aggregation in a HD pancreatic \u03b2-cell model","volume":"73","author":"Ye","year":"2009","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"10.1074\/jbc.M116.727990_bib8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1399-0004.1985.tb00185.x","article-title":"Diabetes mellitus in Huntington disease","volume":"27","author":"Farrer","year":"1985","journal-title":"Clin. Genet"},{"key":"10.1074\/jbc.M116.727990_bib9","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1093\/hmg\/ddp336","article-title":"Mutant huntingtin interacts with \u03b2-tubulin and disrupts vesicular transport and insulin secretion","volume":"18","author":"Smith","year":"2009","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.M116.727990_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M116.727990_bib11","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1074\/jbc.M509806200","article-title":"Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons","volume":"281","author":"McGuire","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.727990_bib12","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1523\/JNEUROSCI.1251-06.2006","article-title":"Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth","volume":"26","author":"Rong","year":"2006","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M116.727990_bib13","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1074\/jbc.M609057200","article-title":"14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking","volume":"282","author":"Rong","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.727990_bib14","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1172\/JCI35339","article-title":"Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice","volume":"118","author":"Sheng","year":"2008","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M116.727990_bib15","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1111\/j.1460-9568.2004.03633.x","article-title":"HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons","volume":"20","author":"Tang","year":"2004","journal-title":"Eur. J. Neurosci"},{"key":"10.1074\/jbc.M116.727990_bib16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0896-6273(03)00366-0","article-title":"Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1","volume":"39","author":"Tang","year":"2003","journal-title":"Neuron"},{"key":"10.1074\/jbc.M116.727990_bib17","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/S1262-3636(08)73395-0","article-title":"Pancreatic \u03b1-cell dysfunction in diabetes","volume":"34","author":"Burcelin","year":"2008","journal-title":"Diabetes Metab"},{"key":"10.1074\/jbc.M116.727990_bib18","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1371\/journal.pbio.0040049","article-title":"Oscillations, intercellular coupling, and insulin secretion in pancreatic \u03b2-cells","volume":"4","author":"MacDonald","year":"2006","journal-title":"PLoS Biol"},{"key":"10.1074\/jbc.M116.727990_bib19","doi-asserted-by":"crossref","first-page":"9862","DOI":"10.1074\/jbc.M111.292854","article-title":"cAMP induces stromal interaction molecule 1 (STIM1) puncta but neither Orai1 protein clustering nor store-operated Ca2+ entry (SOCE) in islet cells","volume":"287","author":"Tian","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.727990_bib20","doi-asserted-by":"crossref","first-page":"15757","DOI":"10.1074\/jbc.M110.187757","article-title":"Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release","volume":"286","author":"Gandini","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.727990_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4161\/isl.2.5.12747","article-title":"An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic \u03b2-cell","volume":"2","author":"Arredouani","year":"2010","journal-title":"Islets"},{"key":"10.1074\/jbc.M116.727990_bib22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.57.4.5","article-title":"International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol. Rev"},{"key":"10.1074\/jbc.M116.727990_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00232-004-0692-9","article-title":"Regulation of insulin secretion in islets of Langerhans by Ca2+ channels","volume":"200","author":"Mears","year":"2004","journal-title":"J. Membr. Biol"},{"key":"10.1074\/jbc.M116.727990_bib24","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1210\/mend.11.5.9922","article-title":"L-type calcium channels in insulin-secreting cells: biochemical characterization and phosphorylation in RINm5F cells","volume":"11","author":"Safayhi","year":"1997","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.727990_bib25","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1152\/ajpendo.00042.2004","article-title":"Beta-cell CaV channel regulation in physiology and pathophysiology","volume":"288","author":"Yang","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1074\/jbc.M116.727990_bib26","doi-asserted-by":"crossref","first-page":"948","DOI":"10.2337\/diab.42.7.948","article-title":"Expression of calcium channel mRNAs in rat pancreatic islets and down-regulation after glucose infusion","volume":"42","author":"Iwashima","year":"1993","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M116.727990_bib27","first-page":"E133","article-title":"NIDDM is associated with loss of pancreatic \u03b2-cell L-type Ca2+ channel activity","volume":"270","author":"Roe","year":"1996","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M116.727990_bib28","doi-asserted-by":"crossref","first-page":"C1781","DOI":"10.1152\/ajpcell.1996.271.6.C1781","article-title":"Mechanisms of inhibition of insulin release","volume":"271","author":"Sharp","year":"1996","journal-title":"Am. J. Physiol"},{"key":"10.1074\/jbc.M116.727990_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1248\/bpb.b12-00425","article-title":"The mechanisms of insulin secretion and calcium signaling in pancreatic \u03b2-cells exposed to fluoroquinolones","volume":"36","author":"Bito","year":"2013","journal-title":"Biol. Pharm. Bull"},{"key":"10.1074\/jbc.M116.727990_bib30","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1172\/JCI200113310","article-title":"Requirement for the L-type Ca2+ channel \u03b1(1D) subunit in postnatal pancreatic \u03b2-cell generation","volume":"108","author":"Namkung","year":"2001","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M116.727990_bib31","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1093\/emboj\/cdg389","article-title":"Impaired insulin secretion and glucose tolerance in \u03b2 cell-selective Ca(v) 1.2 Ca2+ channel null mice","volume":"22","author":"Schulla","year":"2003","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M116.727990_bib32","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1002\/jnr.21326","article-title":"Regulation of intracellular HAP1 trafficking","volume":"85","author":"Rong","year":"2007","journal-title":"J. Neurosci. Res"},{"key":"10.1074\/jbc.M116.727990_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tips.2004.11.001","article-title":"HAP1 and intracellular trafficking","volume":"26","author":"Li","year":"2005","journal-title":"Trends Pharmacol. Sci"},{"key":"10.1074\/jbc.M116.727990_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4161\/cam.3.1.7511","article-title":"Huntingtin-associated protein 1 and its functions","volume":"3","author":"Wu","year":"2009","journal-title":"Cell Adh. Migr"},{"key":"10.1074\/jbc.M116.727990_bib35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00418-015-1311-9","article-title":"HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic \u03b2 cells","volume":"144","author":"Wang","year":"2015","journal-title":"Histochem. Cell Biol"},{"key":"10.1074\/jbc.M116.727990_bib36","doi-asserted-by":"crossref","first-page":"6956","DOI":"10.1523\/JNEUROSCI.23-17-06956.2003","article-title":"Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease","volume":"23","author":"Li","year":"2003","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M116.727990_bib37","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0896-6273(95)90213-9","article-title":"From vesicle docking to endocytosis: intermediate reactions of exocytosis","volume":"14","author":"Schweizer","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.M116.727990_bib38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/35008615","article-title":"Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system","volume":"2","author":"Sankaranarayanan","year":"2000","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M116.727990_bib39","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1023\/B:JOBB.0000008032.49504.48","article-title":"Voltage-operated calcium channel heterogeneity in pancreatic \u03b2 cells: physiopathological implications","volume":"35","author":"Sher","year":"2003","journal-title":"J. Bioenerg. Biomembr"},{"key":"10.1074\/jbc.M116.727990_bib40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1385\/ENDO:13:3:251","article-title":"Localized calcium influx in pancreatic \u03b2-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans","volume":"13","author":"Satin","year":"2000","journal-title":"Endocrine"},{"key":"10.1074\/jbc.M116.727990_bib41","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1172\/JCI45680","article-title":"Dynamics of insulin secretion and the clinical implications for obesity and diabetes","volume":"121","author":"Seino","year":"2011","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M116.727990_bib42","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.neuron.2007.07.024","article-title":"The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2","volume":"55","author":"Green","year":"2007","journal-title":"Neuron"},{"key":"10.1074\/jbc.M116.727990_bib43","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1523\/JNEUROSCI.18-19-07674.1998","article-title":"The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human","volume":"18","author":"Gutekunst","year":"1998","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M116.727990_bib44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/(SICI)1096-9861(19990125)403:4<421::AID-CNE1>3.0.CO;2-5","article-title":"Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons","volume":"403","author":"Martin","year":"1999","journal-title":"J. Comp. Neurol"},{"key":"10.1074\/jbc.M116.727990_bib45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/BST0340687","article-title":"The molecular mechanisms of the mammalian exocyst complex in exocytosis","volume":"34","author":"Wang","year":"2006","journal-title":"Biochem. Soc. Trans"},{"key":"10.1074\/jbc.M116.727990_bib46","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1210\/me.2008-0209","article-title":"How peptide hormone vesicles are transported to the secretion site for exocytosis","volume":"22","author":"Park","year":"2008","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.727990_bib47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1432-1327.1999.00043.x","article-title":"Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion","volume":"259","author":"Lang","year":"1999","journal-title":"Eur. J. Biochem"},{"key":"10.1074\/jbc.M116.727990_bib48","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0014-5793(98)01233-2","article-title":"Cysteine-string proteins regulate exocytosis of insulin independent from transmembrane ion fluxes","volume":"437","author":"Zhang","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M116.727990_bib49","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1113\/jphysiol.1993.sp019966","article-title":"Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells","volume":"472","author":"Amm\u00e4l\u00e4","year":"1993","journal-title":"J. Physiol"},{"key":"10.1074\/jbc.M116.727990_bib50","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1073\/pnas.96.1.248","article-title":"The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery","volume":"96","author":"Wiser","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.727990_bib51","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nm1382","article-title":"Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior","volume":"12","author":"Sheng","year":"2006","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M116.727990_bib52","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/jcs.114.7.1253","article-title":"SH3 domains: complexity in moderation","volume":"114","author":"Mayer","year":"2001","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M116.727990_bib53","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/er.2005-0888","article-title":"The role of voltage-gated calcium channels in pancreatic \u03b2-cell physiology and pathophysiology","volume":"27","author":"Yang","year":"2006","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.M116.727990_bib54","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00018-014-1737-6","article-title":"CaV1.2 and CaV1.3 channel hyperactivation in mouse islet \u03b2 cells exposed to type 1 diabetic serum","volume":"72","author":"Yang","year":"2015","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.M116.727990_bib55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cell.2004.09.011","article-title":"Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism","volume":"119","author":"Splawski","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M116.727990_bib56","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1006\/geno.1995.1048","article-title":"The structures of the human calcium channel \u03b11 subunit (CACNL1A2) and \u03b2 subunit (CACNLB3) genes","volume":"27","author":"Yamada","year":"1995","journal-title":"Genomics"},{"key":"10.1074\/jbc.M116.727990_bib57","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/dmrr.193","article-title":"Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients","volume":"17","author":"Yamada","year":"2001","journal-title":"Diabetes Metab. Res. Rev"},{"key":"10.1074\/jbc.M116.727990_bib58","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0140-6736(72)91092-6","article-title":"Increased frequency of diabetes mellitus in patients with Huntington's chorea","volume":"1","author":"Podolsky","year":"1972","journal-title":"Lancet"},{"key":"10.1074\/jbc.M116.727990_bib59","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000212174","article-title":"Abnormal glucose tolerance and arginine tolerance tests in Huntington's disease","volume":"23","author":"Podolsky","year":"1977","journal-title":"Gerontology"},{"key":"10.1074\/jbc.M116.727990_bib60","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jnnp.39.3.244","article-title":"Altered growth hormone release in Huntington's chorea","volume":"39","author":"Keogh","year":"1976","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1074\/jbc.M116.727990_bib61","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cmet.2011.02.013","article-title":"Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits","volume":"13","author":"Hult","year":"2011","journal-title":"Cell Metab"},{"key":"10.1074\/jbc.M116.727990_bib62","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/jnnp.44.5.414","article-title":"Studies of hypothalamic function in Huntington's chorea","volume":"44","author":"Lavin","year":"1981","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1074\/jbc.M116.727990_bib63","doi-asserted-by":"crossref","first-page":"e4962","DOI":"10.1371\/journal.pone.0004962","article-title":"Neuroendocrine disturbances in Huntington's disease","volume":"4","author":"Saleh","year":"2009","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M116.727990_bib64","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1460-9568.2006.04985.x","article-title":"Hypothalamic-endocrine aspects in Huntington's disease","volume":"24","author":"Peters\u00e9n","year":"2006","journal-title":"Eur. J. Neurosci"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820344574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820344574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.727990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T13:12:02Z","timestamp":1639833122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820344574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":64,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0021925820344574"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.727990","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by Huntingtin-associated Protein 1","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.727990","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}