{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:30:33Z","timestamp":1787005833165,"version":"build-2736575974"},"reference-count":87,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":1519,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007579","name":"Auburn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1074\/jbc.m116.729020","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:09:10Z","timestamp":1462838950000},"page":"14585-14599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction"],"prefix":"10.1016","volume":"291","author":[{"given":"Kh.Shamsur","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfan Ullah","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Sachse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Kaltenboeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.729020_bib1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1110\/ps.041059505","article-title":"Benchmarking B-cell epitope prediction: underperformance of existing methods","volume":"14","author":"Blythe","year":"2005","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M116.729020_bib2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/CVI.00102-15","article-title":"Defining species-specific immunodominant B-cell epitopes for molecular serology of Chlamydia species","volume":"22","author":"Rahman","year":"2015","journal-title":"Clin. Vaccine Immunol"},{"key":"10.1074\/jbc.M116.729020_bib3","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1016\/j.molimm.2007.10.016","article-title":"Computational characterization of B-cell epitopes","volume":"45","author":"Rubinstein","year":"2008","journal-title":"Mol. Immunol"},{"key":"10.1074\/jbc.M116.729020_bib4","doi-asserted-by":"crossref","first-page":"6230","DOI":"10.4049\/jimmunol.181.9.6230","article-title":"Automated identification of complementarity determining regions (CDRs) reveals peculiar characteristics of CDRs and B-cell epitopes","volume":"181","author":"Ofran","year":"2008","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M116.729020_bib5","first-page":"1","article-title":"Does difference exist between epitope and non-epitope residues?","volume":"201","author":"Sun","year":"2011","journal-title":"Immunome Res"},{"key":"10.1074\/jbc.M116.729020_bib6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.molimm.2012.03.030","article-title":"An analysis of B-cell epitope discontinuity","volume":"51","author":"Sivalingam","year":"2012","journal-title":"Mol. Immunol"},{"key":"10.1074\/jbc.M116.729020_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molimm.2012.06.001","article-title":"Structural analysis of B-cell epitopes in antibody: protein complexes","volume":"53","author":"Kringelum","year":"2013","journal-title":"Mol. Immunol"},{"key":"10.1074\/jbc.M116.729020_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(78)90078-8","article-title":"A complete immunoglobulin gene is created by somatic recombination","volume":"15","author":"Brack","year":"1978","journal-title":"Cell"},{"key":"10.1074\/jbc.M116.729020_bib9","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.4049\/jimmunol.1001240","article-title":"A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans","volume":"185","author":"Wang","year":"2010","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M116.729020_bib10","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1073\/pnas.78.6.3824","article-title":"Prediction of protein antigenic determinants from amino acid sequences","volume":"78","author":"Hopp","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.729020_bib11","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1021\/bi00367a013","article-title":"New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and x-ray-derived accessible sites","volume":"25","author":"Parker","year":"1986","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M116.729020_bib12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF01195768","article-title":"Prediction of chain flexibility in proteins\u2013a tool for the selection of peptide antigens","volume":"72","author":"Karplus","year":"1985","journal-title":"Naturwissenschaften"},{"key":"10.1074\/jbc.M116.729020_bib13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/jvi.55.3.836-839.1985","article-title":"Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide","volume":"55","author":"Emini","year":"1985","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M116.729020_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-2478(93)90072-A","article-title":"Correlation between the location of antigenic sites and the prediction of turns in proteins","volume":"36","author":"Pellequer","year":"1993","journal-title":"Immunol. Lett"},{"key":"10.1074\/jbc.M116.729020_bib15","series-title":"Artificial Immune Systems","first-page":"197","author":"Saha","year":"2004"},{"key":"10.1074\/jbc.M116.729020_bib16","series-title":"Structural Bioinformatics","first-page":"849","author":"Ponomarenko","year":"2009"},{"key":"10.1074\/jbc.M116.729020_bib17","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","article-title":"A semi-empirical method for prediction of antigenic determinants on protein antigens","volume":"276","author":"Kolaskar","year":"1990","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M116.729020_bib18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00726-006-0485-9","article-title":"Prediction of linear B-cell epitopes using amino acid pair antigenicity scale","volume":"33","author":"Chen","year":"2007","journal-title":"Amino Acids"},{"key":"10.1074\/jbc.M116.729020_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-7580-2-2","article-title":"Improved method for predicting linear B-cell epitopes","volume":"2","author":"Larsen","year":"2006","journal-title":"Immunome Res"},{"key":"10.1074\/jbc.M116.729020_bib20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jmr.893","article-title":"Predicting linear B-cell epitopes using string kernels","volume":"21","author":"El-Manzalawy","year":"2008","journal-title":"J. Mol. Recognit"},{"key":"10.1074\/jbc.M116.729020_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1142\/9781848162648_0011","article-title":"Predicting flexible length linear B-cell epitopes","volume":"7","author":"El-Manzalawy","year":"2008","journal-title":"Comput. Syst. Bioinformatics Conf"},{"key":"10.1074\/jbc.M116.729020_bib22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/protein\/gzn075","article-title":"COBEpro: a novel system for predicting continuous B-cell epitopes","volume":"22","author":"Sweredoski","year":"2009","journal-title":"Protein Eng. Des. Sel"},{"key":"10.1074\/jbc.M116.729020_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-7580-6-6","article-title":"Identification of conformational B-cell epitopes in an antigen from its primary sequence","volume":"6","author":"Ansari","year":"2010","journal-title":"Immunome Res"},{"key":"10.1074\/jbc.M116.729020_bib24","doi-asserted-by":"crossref","first-page":"e62216","DOI":"10.1371\/journal.pone.0062216","article-title":"Improved method for linear B-cell epitope prediction using antigen's primary sequence","volume":"8","author":"Singh","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M116.729020_bib25","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.bbapap.2012.12.008","article-title":"Unusual biophysics of intrinsically disordered proteins","volume":"1834","author":"Uversky","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1074\/jbc.M116.729020_bib26","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/pro.2261","article-title":"A decade and a half of protein intrinsic disorder: biology still waits for physics","volume":"22","author":"Uversky","year":"2013","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M116.729020_bib27","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/pro.2443","article-title":"Advantages of proteins being disordered","volume":"23","author":"Liu","year":"2014","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M116.729020_bib28","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1126\/science.282.5389.754","article-title":"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis","volume":"282","author":"Stephens","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M116.729020_bib29","series-title":"Proteomics Protocols Handbook","first-page":"571","author":"Gasteiger","year":"2005"},{"key":"10.1074\/jbc.M116.729020_bib30","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/ma00145a039","article-title":"Estimation of effective interresidue contact energies from protein crystal structures: quasi-chemical approximation","volume":"18","author":"Miyazawa","year":"1985","journal-title":"Macromolecules"},{"key":"10.1074\/jbc.M116.729020_bib31","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1093\/bioinformatics\/bti541","article-title":"IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content","volume":"21","author":"Doszt\u00e1nyi","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib32","first-page":"45","article-title":"Prediction of the secondary structure of proteins from their amino acid sequence","volume":"47","author":"Chou","year":"1978","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol"},{"key":"10.1074\/jbc.M116.729020_bib33","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/1471-2105-7-208","article-title":"Length-dependent prediction of protein intrinsic disorder","volume":"7","author":"Peng","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib34","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/prot.22193","article-title":"Improving the prediction accuracy of residue solvent accessibility and real-value backbone torsion angles of proteins by guided-learning through a two-layer neural network","volume":"74","author":"Faraggi","year":"2009","journal-title":"Proteins"},{"key":"10.1074\/jbc.M116.729020_bib35","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview Version 2\u2014a multiple sequence alignment editor and analysis workbench","volume":"25","author":"Waterhouse","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib36","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.str.2009.09.006","article-title":"Predicting continuous local structure and the effect of its substitution for secondary structure in fragment-free protein structure prediction","volume":"17","author":"Faraggi","year":"2009","journal-title":"Structure"},{"key":"10.1074\/jbc.M116.729020_bib37","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1093\/bioinformatics\/btt344","article-title":"Porter, PaleAle 4.0: high-accuracy prediction of protein secondary structure and relative solvent accessibility","volume":"29","author":"Mirabello","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib38","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1093\/nar\/gkg519","article-title":"GlobPlot: exploring protein sequences for globularity and disorder","volume":"31","author":"Linding","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M116.729020_bib39","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1093\/bioinformatics\/btl504","article-title":"FoldUnfold: web server for the prediction of disordered regions in protein chain","volume":"22","author":"Galzitskaya","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib40","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkm363","article-title":"PrDOS: prediction of disordered protein regions from amino acid sequence","volume":"35","author":"Ishida","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M116.729020_bib41","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.str.2003.10.002","article-title":"Protein disorder prediction: implications for structural proteomics","volume":"11","author":"Linding","year":"2003","journal-title":"Structure"},{"key":"10.1074\/jbc.M116.729020_bib42","doi-asserted-by":"crossref","first-page":"W264","DOI":"10.1093\/nar\/gku270","article-title":"The DynaMine webserver: predicting protein dynamics from sequence","volume":"42","author":"Cilia","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M116.729020_bib43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1471-2105-13-111","article-title":"MetaDisorder: a meta-server for the prediction of intrinsic disorder in proteins","volume":"13","author":"Kozlowski","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib44","doi-asserted-by":"crossref","first-page":"i489","DOI":"10.1093\/bioinformatics\/btq373","article-title":"Improved sequence-based prediction of disordered regions with multilayer fusion of multiple information sources","volume":"26","author":"Mizianty","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib45","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/bioinformatics\/btn195","article-title":"Prediction of disordered regions in proteins based on the meta approach","volume":"24","author":"Ishida","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0006-3495(85)83877-7","article-title":"Amino acid side-chain partition energies and distribution of residues in soluble proteins","volume":"47","author":"Guy","year":"1985","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M116.729020_bib47","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0022-2836(83)90041-4","article-title":"Correlation of sequence hydrophobicities measures similarity in three-dimensional protein structure","volume":"171","author":"Sweet","year":"1983","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M116.729020_bib48","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/prot.24074","article-title":"SANN: Solvent accessibility prediction of proteins by nearest neighbor method","volume":"80","author":"Joo","year":"2012","journal-title":"Proteins"},{"key":"10.1074\/jbc.M116.729020_bib49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1472-6807-9-51","article-title":"A generic method for assignment of reliability scores applied to solvent accessibility predictions","volume":"9","author":"Petersen","year":"2009","journal-title":"BMC Struct. Biol"},{"key":"10.1074\/jbc.M116.729020_bib50","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1093\/bioinformatics\/btu352","article-title":"SSpro\/ACCpro 5: almost perfect prediction of protein secondary structure and relative solvent accessibility using profiles, machine learning and structural similarity","volume":"30","author":"Magnan","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib51","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1399-3011.1988.tb01258.x","article-title":"Positional flexibilities of amino acid residues in globular proteins","volume":"32","author":"Bhaskaran","year":"1988","journal-title":"Int. J. Pept. Protein Res"},{"key":"10.1074\/jbc.M116.729020_bib52","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/bioinformatics\/16.4.404","article-title":"The PSIPRED protein structure prediction server","volume":"16","author":"McGuffin","year":"2000","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib53","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.4023714","article-title":"Hydrophobicity of amino acid residues in globular proteins","volume":"229","author":"Rose","year":"1985","journal-title":"Science"},{"key":"10.1074\/jbc.M116.729020_bib54","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1021\/bi00613a026","article-title":"Conformational preferences of amino acids in globular proteins","volume":"17","author":"Levitt","year":"1978","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M116.729020_bib55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/protein\/1.4.289","article-title":"An algorithm for protein secondary structure prediction based on class prediction","volume":"1","author":"Del\u00e9age","year":"1987","journal-title":"Protein Eng"},{"key":"10.1074\/jbc.M116.729020_bib56","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1472-6807-7-64","article-title":"Antibody-protein interactions: benchmark datasets and prediction tools evaluation","volume":"7","author":"Ponomarenko","year":"2007","journal-title":"BMC Struct. Biol"},{"key":"10.1074\/jbc.M116.729020_bib57","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jmr.819","article-title":"Identification of discontinuous antigenic determinants on proteins based on shape complementarities","volume":"20","author":"Rapberger","year":"2007","journal-title":"J. Mol. Recognit"},{"key":"10.1074\/jbc.M116.729020_bib58","doi-asserted-by":"crossref","first-page":"W168","DOI":"10.1093\/nar\/gki460","article-title":"CEP: a conformational epitope prediction server","volume":"33","author":"Kulkarni-Kale","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M116.729020_bib59","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1110\/ps.062405906","article-title":"Prediction of residues in discontinuous B-cell epitopes using protein 3D structures","volume":"15","author":"Haste Andersen","year":"2006","journal-title":"Protein Sci"},{"key":"10.1074\/jbc.M116.729020_bib60","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/1471-2105-9-514","article-title":"ElliPro: a new structure-based tool for the prediction of antibody epitopes","volume":"9","author":"Ponomarenko","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib61","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/bioinformatics\/btn199","article-title":"PEPITO: improved discontinuous B-cell epitope prediction using multiple distance thresholds and half sphere exposure","volume":"24","author":"Sweredoski","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib62","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/1471-2105-10-287","article-title":"Epitopia: a web-server for predicting B-cell epitopes","volume":"10","author":"Rubinstein","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/jbc.M116.729020_bib63","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1745-7580-6-S2-S2","article-title":"Recent advances in B-cell epitope prediction methods","volume":"6","author":"El-Manzalawy","year":"2010","journal-title":"Immunome Res"},{"key":"10.1074\/jbc.M116.729020_bib64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jmr.815","article-title":"Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools","volume":"20","author":"Greenbaum","year":"2007","journal-title":"J. Mol. Recognit"},{"key":"10.1074\/jbc.M116.729020_bib65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-59745-450-6_1","article-title":"What is a B-cell epitope?","volume":"524","author":"Van Regenmortel","year":"2009","journal-title":"Methods Mol. Biol"},{"key":"10.1074\/jbc.M116.729020_bib66","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1128\/iai.58.5.1450-1455.1990","article-title":"Mapping antigenic sites on the major outer membrane protein of Chlamydia trachomatis with synthetic peptides","volume":"58","author":"Zhong","year":"1990","journal-title":"Infect. Immun"},{"key":"10.1074\/jbc.M116.729020_bib67","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2958.1988.tb00076.x","article-title":"Epitope mapping with solid-phase peptides: identification of type-, subspecies-, species-and genus-reactive antibody binding domains on the major outer membrane protein of Chlamydia trachomatis","volume":"2","author":"Conlan","year":"1988","journal-title":"Mol. Microbiol"},{"key":"10.1074\/jbc.M116.729020_bib68","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1099\/00221287-139-7-1565","article-title":"Mapping of a surface-exposed B-cell epitope to the variable sequent 3 of the major outer-membrane protein of Chlamydia trachomatis","volume":"139","author":"Pal","year":"1993","journal-title":"J. Gen. Microbiol"},{"key":"10.1074\/jbc.M116.729020_bib69","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1099\/13500872-140-9-2481","article-title":"Determination of neutralizing epitopes in variable domains I and IV of the major outer-membrane protein from Chlamydia trachomatis serovar K","volume":"140","author":"Villeneuve","year":"1994","journal-title":"Microbiology"},{"key":"10.1074\/jbc.M116.729020_bib70","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1128\/iai.64.2.542-547.1996","article-title":"The major outer membrane protein of a single Chlamydia trachomatis serovar can possess more than one serovar-specific epitope","volume":"64","author":"Batteiger","year":"1996","journal-title":"Infect. Immun"},{"key":"10.1074\/jbc.M116.729020_bib71","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0161-5890(86)90095-7","article-title":"Comparison of different methods for localizing antigenic regions in histone H2A","volume":"23","author":"Muller","year":"1986","journal-title":"Mol. Immunol"},{"key":"10.1074\/jbc.M116.729020_bib72","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jmr.747","article-title":"Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling","volume":"18","author":"Uversky","year":"2005","journal-title":"J. Mol. Recognit"},{"key":"10.1074\/jbc.M116.729020_bib73","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/311123a0","article-title":"Correlation between segmental mobility and the location of antigenic determinants in proteins","volume":"311","author":"Westhof","year":"1984","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.729020_bib74","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/312127a0","article-title":"The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein","volume":"312","author":"Tainer","year":"1984","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.729020_bib75","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1073\/pnas.83.2.226","article-title":"Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains)","volume":"83","author":"Novotn\u00fd","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.729020_bib76","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jmb.2004.09.076","article-title":"Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics","volume":"344","author":"Canaves","year":"2004","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M116.729020_bib77","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nbt.1514","article-title":"Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data","volume":"27","author":"Price","year":"2009","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/jbc.M116.729020_bib78","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/prot.20446","article-title":"Addressing the intrinsic disorder bottleneck in structural proteomics","volume":"59","author":"Oldfield","year":"2005","journal-title":"Protein"},{"key":"10.1074\/jbc.M116.729020_bib79","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/prot.10150","article-title":"Simple sequences are rare in the Protein Data Bank","volume":"48","author":"Huntley","year":"2002","journal-title":"Proteins"},{"key":"10.1074\/jbc.M116.729020_bib80","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/07391102.2007.10507123","article-title":"Intrinsic disorder in the protein data bank","volume":"24","author":"Le Gall","year":"2007","journal-title":"J. Biomol. Struct. Dyn"},{"key":"10.1074\/jbc.M116.729020_bib81","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/07391102.2012.675145","article-title":"Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life","volume":"30","author":"Xue","year":"2012","journal-title":"J. Biomol. Struct. Dyn"},{"key":"10.1074\/jbc.M116.729020_bib82","doi-asserted-by":"crossref","first-page":"11504","DOI":"10.1073\/pnas.93.21.11504","article-title":"Structural studies of p21Waf1\/Cip1\/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity","volume":"93","author":"Kriwacki","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.729020_bib83","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/jmbi.1999.3110","article-title":"Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm","volume":"293","author":"Wright","year":"1999","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M116.729020_bib84","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1073\/pnas.160259697","article-title":"Speeding molecular recognition by using the folding funnel: the fly-casting mechanism","volume":"97","author":"Shoemaker","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.729020_bib85","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1093-3263(00)00138-8","article-title":"Intrinsically disordered protein","volume":"9","author":"Dunker","year":"2001","journal-title":"J. Mol. Graph. Model"},{"key":"10.1074\/jbc.M116.729020_bib86","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm1589","article-title":"Intrinsically unstructured proteins and their functions","volume":"6","author":"Dyson","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M116.729020_bib87","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/nature05858","article-title":"Mechanism of coupled folding and binding of an intrinsically disordered protein","volume":"447","author":"Sugase","year":"2007","journal-title":"Nature"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820349176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820349176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.729020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T01:39:56Z","timestamp":1641260396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820349176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":87,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0021925820349176"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.729020","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.729020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}