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Chem"},{"key":"10.1074\/jbc.M116.733626_bib68","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/bj3300513","article-title":"Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's \u03b2-amyloid precursor protein","volume":"330","author":"Duilio","year":"1998","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M116.733626_bib69","doi-asserted-by":"crossref","first-page":"30853","DOI":"10.1074\/jbc.270.52.30853","article-title":"The regions of the Fe65 protein homologous to the phosphotyrosine interaction\/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein","volume":"270","author":"Fiore","year":"1995","journal-title":"J. Biol. 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