{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:02:33Z","timestamp":1790949753878,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"36","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"vor","delay-in-days":1451,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L027887\/1"],"award-info":[{"award-number":["BB\/L027887\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L02781X\/1"],"award-info":[{"award-number":["BB\/L02781X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2372"],"award-info":[{"award-number":["FOR2372"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1074\/jbc.m116.736157","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:20:03Z","timestamp":1467850803000},"page":"18915-18931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias"],"prefix":"10.1016","volume":"291","author":[{"given":"Daniele","family":"Bolognini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika U.","family":"Petersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iona","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Sergeev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele M.","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evi","family":"Kostenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola","family":"Kurowska-Stolarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niek","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-3519","authenticated-orcid":false,"given":"Graeme","family":"Milligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.736157_bib1","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"den Besten","year":"2013","journal-title":"J. Lipid Res"},{"key":"10.1074\/jbc.M116.736157_bib2","doi-asserted-by":"crossref","first-page":"G900","DOI":"10.1152\/ajpgi.00265.2013","article-title":"Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids","volume":"305","author":"den Besten","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"10.1074\/jbc.M116.736157_bib3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.108.00802","article-title":"International Union of Pharmacology: LXXI. free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions","volume":"60","author":"Stoddart","year":"2008","journal-title":"Pharmacol. Rev"},{"key":"10.1074\/jbc.M116.736157_bib4","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib5","doi-asserted-by":"crossref","first-page":"25481","DOI":"10.1074\/jbc.M301403200","article-title":"Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation","volume":"278","author":"Le Poul","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0006-291X(03)00488-1","article-title":"Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids","volume":"303","author":"Nilsson","year":"2003","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M116.736157_bib7","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1124\/mol.115.102301","article-title":"The pharmacology and function of short chain fatty acid receptors","volume":"89","author":"Bolognini","year":"2016","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2016.03.017","article-title":"Metabolism meets immunity: the role of free fatty acid receptors in the immune system","author":"Alvarez-Curto","year":"2016","journal-title":"Biochem. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fendo.2014.00085","article-title":"The SCFA receptor GPR43 and energy metabolism","volume":"5","author":"Kimura","year":"2014","journal-title":"Front. Endocrinol"},{"key":"10.1074\/jbc.M116.736157_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fimmu.2016.00028","article-title":"GPR41 and GPR43 in obesity and inflammation: protective or causative?","volume":"7","author":"Ang","year":"2016","journal-title":"Front. Immunol"},{"key":"10.1074\/jbc.M116.736157_bib11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2174\/1389450116666150408103557","article-title":"Role of free fatty acid receptor 2 (FFAR2) in the regulation of metabolic homeostasis","volume":"16","author":"Mohammad","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"10.1074\/jbc.M116.736157_bib12","article-title":"Complex pharmacology of the free fatty acid receptors","author":"Milligan","year":"2016","journal-title":"Chem. Rev"},{"key":"10.1074\/jbc.M116.736157_bib13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1476-5381.2009.00421.x","article-title":"Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3","volume":"158","author":"Milligan","year":"2009","journal-title":"Br. J. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib14","doi-asserted-by":"crossref","first-page":"41195","DOI":"10.1074\/jbc.M112.396259","article-title":"Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3","volume":"287","author":"Hudson","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib15","doi-asserted-by":"crossref","first-page":"17296","DOI":"10.1074\/jbc.M113.455337","article-title":"Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor","volume":"288","author":"Hudson","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib16","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1124\/mol.108.049536","article-title":"Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2","volume":"74","author":"Lee","year":"2008","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib17","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bmcl.2009.11.112","article-title":"The first synthetic agonists of FFA2: discovery and SAR of phenylacetamides as allosteric modulators","volume":"20","author":"Wang","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1074\/jbc.M116.736157_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1124\/mol.110.070789","article-title":"Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator","volume":"80","author":"Smith","year":"2011","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib19","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.chembiol.2016.02.014","article-title":"A molecular mechanism for sequential activation of a G protein-coupled receptor","volume":"23","author":"Grundmann","year":"2016","journal-title":"Cell Chem. Biol"},{"key":"10.1074\/jbc.M116.736157_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-61779-126-0_2","article-title":"Using the Flp-InTM T-RexTM system to regulate GPCR expression","volume":"746","author":"Ward","year":"2011","journal-title":"Methods Mol. Biol"},{"key":"10.1074\/jbc.M116.736157_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-6147(02)00027-5","article-title":"Principles: extending the utility of [35S]GTP\u03b3S binding assays","volume":"24","author":"Milligan","year":"2003","journal-title":"Trends Pharmacol. Sci"},{"key":"10.1074\/jbc.M116.736157_bib22","doi-asserted-by":"crossref","first-page":"10156","DOI":"10.1038\/ncomms10156","article-title":"The experimental power of FR900359 to study Gq-regulated biological processes","volume":"6","author":"Schrage","year":"2015","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M116.736157_bib23","doi-asserted-by":"crossref","first-page":"32913","DOI":"10.1074\/jbc.M805601200","article-title":"Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids","volume":"283","author":"Stoddart","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib24","doi-asserted-by":"crossref","first-page":"10628","DOI":"10.1074\/jbc.M110.210872","article-title":"Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3","volume":"286","author":"Schmidt","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1074\/jbc.M115.687939","article-title":"Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands","volume":"291","author":"Sergeev","year":"2016","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-61779-126-0_10","article-title":"Determining allosteric modulator mechanism of action: integration of radioligand binding and functional assay data","volume":"746","author":"Langmead","year":"2011","journal-title":"Methods Mol. Biol"},{"key":"10.1074\/jbc.M116.736157_bib27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/10799893.2010.503964","article-title":"G protein coupled receptors as allosteric proteins and the role of allosteric modulators","volume":"30","author":"Kenakin","year":"2010","journal-title":"J. Recept. Signal. Transduct. Res"},{"key":"10.1074\/jbc.M116.736157_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuropharm.2010.07.010","article-title":"Allosteric modulation of G protein-coupled receptors: a pharmacological perspective","volume":"60","author":"Keov","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1074\/jbc.M116.736157_bib29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/mol.114.094342","article-title":"Advances in G protein-coupled receptor allostery: from function to structure","volume":"86","author":"Christopoulos","year":"2014","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib30","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1210\/en.2005-0545","article-title":"Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43","volume":"146","author":"Hong","year":"2005","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.736157_bib31","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1210\/en.2008-0059","article-title":"Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids","volume":"149","author":"Ge","year":"2008","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.736157_bib32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1042\/BJ20111165","article-title":"Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21","volume":"441","author":"Possenti","year":"2012","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M116.736157_bib33","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nature08530","article-title":"Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43","volume":"461","author":"Maslowski","year":"2009","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.736157_bib34","doi-asserted-by":"crossref","first-page":"10044","DOI":"10.1021\/jm5012885","article-title":"Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic","volume":"57","author":"Pizzonero","year":"2014","journal-title":"J. Med. Chem"},{"key":"10.1074\/jbc.M116.736157_bib35","article-title":"Fatty acids as modulators of neutrophil recruitment, function and survival","author":"Rodrigues","year":"2015","journal-title":"Eur. J. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib36","doi-asserted-by":"crossref","first-page":"e21205","DOI":"10.1371\/journal.pone.0021205","article-title":"SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor","volume":"6","author":"Vinolo","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M116.736157_bib37","doi-asserted-by":"crossref","first-page":"49825","DOI":"10.1074\/jbc.M406892200","article-title":"Characterization of the MEK5-ERK5 module in human neutrophils and its relationship to ERK1\/ERK2 in the chemotactic response","volume":"279","author":"Hii","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib38","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1124\/mol.115.099770","article-title":"The effective application of biased signaling to new drug discovery","volume":"88","author":"Kenakin","year":"2015","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd3954","article-title":"Signalling bias in new drug discovery: detection, quantification and therapeutic impact","volume":"12","author":"Kenakin","year":"2013","journal-title":"Nat. Rev. Drug Discov"},{"key":"10.1074\/jbc.M116.736157_bib40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1124\/mol.115.099630","article-title":"Fulfilling the promise of \u201cbiased\u201d G protein-coupled receptor agonism","volume":"88","author":"Luttrell","year":"2015","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tips.2014.04.007","article-title":"Biased ligands at G-protein-coupled receptors: promise and progress","volume":"35","author":"Violin","year":"2014","journal-title":"Trends Pharmacol. Sci"},{"key":"10.1074\/jbc.M116.736157_bib42","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1124\/jpet.112.201616","article-title":"A G protein-biased ligand at the \u03bc-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine","volume":"344","author":"DeWire","year":"2013","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1074\/jbc.M116.736157_bib43","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/CIRCHEARTFAILURE.112.969220","article-title":"TRV120027, a novel \u03b2-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure","volume":"5","author":"Boerrigter","year":"2012","journal-title":"Circ. Heart Fail"},{"key":"10.1074\/jbc.M116.736157_bib44","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature17198","article-title":"\u03b2-Arrestin biosensors reveal a rapid, receptor-dependent activation\/deactivation cycle","volume":"531","author":"Nuber","year":"2016","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.736157_bib45","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nature17154","article-title":"The conformational signature of \u03b2-arrestin2 predicts its trafficking and signalling functions","volume":"531","author":"Lee","year":"2016","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.736157_bib46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1042\/BJ20150358","article-title":"Biased signalling: the instinctive skill of the cell in the selection of appropriate signalling pathways","volume":"470","author":"Liu","year":"2015","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M116.736157_bib47","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1074\/jbc.M111.277178","article-title":"Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes","volume":"287","author":"Busnelli","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib48","doi-asserted-by":"crossref","first-page":"9542","DOI":"10.1074\/jbc.M114.596098","article-title":"Biased signaling at chemokine receptors","volume":"290","author":"Corbisier","year":"2015","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib49","doi-asserted-by":"crossref","first-page":"27021","DOI":"10.1074\/jbc.M115.659250","article-title":"Agonism, antagonism, and inverse agonism bias at the Ghrelin receptor signalling","volume":"290","author":"M'Kadmi","year":"2015","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib50","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1210\/en.2013-1142","article-title":"GPR41\/FFAR3 and GPR43\/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes","volume":"154","author":"N\u00f8hr","year":"2013","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.736157_bib51","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M116.736157_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2015.12.010","article-title":"Selective novel inverse agonists for human GPR43 augment GLP-1 secretion","volume":"771","author":"Park","year":"2016","journal-title":"Eur. J. Pharmacol"},{"key":"10.1074\/jbc.M116.736157_bib53","author":"Berg","year":"2007","journal-title":"Thiazol-guanidine derivatives used as \u03b1\u03b2-related pathologies"},{"key":"10.1074\/jbc.M116.736157_bib54","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1039\/C5OB02129D","article-title":"A protocol for amide bond formation with electron deficient amines and sterically hindered substrates","volume":"14","author":"Due-Hansen","year":"2016","journal-title":"Org. Biomol. Chem"},{"key":"10.1074\/jbc.M116.736157_bib55","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2982.2006.00853.x","article-title":"The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation","volume":"19","author":"Dass","year":"2007","journal-title":"Neurogastroenterol. Motil"},{"key":"10.1074\/jbc.M116.736157_bib56","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.cmet.2008.11.002","article-title":"Glucose sensing in L cells: a primary cell study","volume":"8","author":"Reimann","year":"2008","journal-title":"Cell Metab"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820307882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820307882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.736157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T21:47:03Z","timestamp":1743371223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820307882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":56,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0021925820307882"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.736157","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.736157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}