{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:23:56Z","timestamp":1791329036438,"version":"4.3.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"53","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":1366,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1074\/jbc.m116.736801","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T03:30:34Z","timestamp":1479353434000},"page":"27265-27278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D"],"prefix":"10.1016","volume":"291","author":[{"given":"Natalia","family":"Davydova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Roufail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Paquet-Fifield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musarat","family":"Ishaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor A.","family":"Streltsov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Karnezis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Stacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Achen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.736801_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrc3677","article-title":"Lymphangiogenesis and lymphatic vessel remodelling in cancer","volume":"14","author":"Stacker","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M116.736801_bib2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1172\/JCI71603","article-title":"Lymphangiogenic factors, mechanisms, and applications","volume":"124","author":"Zheng","year":"2014","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M116.736801_bib3","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1182\/blood-2013-04-495432","article-title":"VEGFD regulates blood vascular development by modulating SOX18 activity","volume":"123","author":"Duong","year":"2014","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736801_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/sj.embor.7400047","article-title":"Vegfc is required for vascular development and endoderm morphogenesis in zebrafish","volume":"5","author":"Ober","year":"2004","journal-title":"EMBO Rep"},{"key":"10.1074\/jbc.M116.736801_bib5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ccr.2011.12.026","article-title":"VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium","volume":"21","author":"Karnezis","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M116.736801_bib6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/84635","article-title":"VEGF-D promotes the metastatic spread of tumor cells via the lymphatics","volume":"7","author":"Stacker","year":"2001","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M116.736801_bib7","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/BF03401866","article-title":"VEGF-D is an X-linked\/AP-1 regulated putative onco-angiogen in human glioblastoma multiforme","volume":"7","author":"Debinski","year":"2001","journal-title":"Mol. Med"},{"key":"10.1074\/jbc.M116.736801_bib8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1600-0463.2004.apm11207-0812.x","article-title":"Lymphangiogenic growth factors as markers of tumor metastasis","volume":"112","author":"Stacker","year":"2004","journal-title":"APMIS"},{"key":"10.1074\/jbc.M116.736801_bib9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/08977194.2012.704917","article-title":"Vascular endothelial growth factor-D: signalling mechanisms, biology and clinical relevance","volume":"30","author":"Achen","year":"2012","journal-title":"Growth Factors"},{"key":"10.1074\/jbc.M116.736801_bib10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/84643","article-title":"Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis","volume":"7","author":"Skobe","year":"2001","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M116.736801_bib11","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/emboj\/20.4.672","article-title":"Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis","volume":"20","author":"Mandriota","year":"2001","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M116.736801_bib12","first-page":"1786","article-title":"Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth","volume":"61","author":"Karpanen","year":"2001","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M116.736801_bib13","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/jnci\/94.11.819","article-title":"Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling","volume":"94","author":"He","year":"2002","journal-title":"J. Natl. Cancer Inst"},{"key":"10.1074\/jbc.M116.736801_bib14","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1158\/0008-5472.CAN-04-4576","article-title":"Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels","volume":"65","author":"He","year":"2005","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M116.736801_bib15","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1182\/blood-2006-05-021758","article-title":"VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites","volume":"109","author":"Hirakawa","year":"2007","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736801_bib16","doi-asserted-by":"crossref","first-page":"38004","DOI":"10.1074\/jbc.M301194200","article-title":"Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens","volume":"278","author":"Wise","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736801_bib17","first-page":"297","article-title":"The VEGF signaling pathway in cancer: the road ahead","volume":"32","author":"Stacker","year":"2013","journal-title":"Chin. J. Cancer"},{"key":"10.1074\/jbc.M116.736801_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.celrep.2012.01.005","article-title":"VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics","volume":"1","author":"Lund","year":"2012","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.M116.736801_bib19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1158\/2326-6066.CIR-14-0115","article-title":"Immunomodulatory roles of lymphatic vessels in cancer progression","volume":"2","author":"Swartz","year":"2014","journal-title":"Cancer Immunol. Res"},{"key":"10.1074\/jbc.M116.736801_bib20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jss.2015.02.031","article-title":"Growth factor therapy and lymph node graft for lymphedema","volume":"196","author":"Tervala","year":"2015","journal-title":"J. Surg. Res"},{"key":"10.1074\/jbc.M116.736801_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.gene.2013.03.051","article-title":"Cardiovascular gene therapy with vascular endothelial growth factors","volume":"525","author":"Yl\u00e4-Herttuala","year":"2013","journal-title":"Gene"},{"key":"10.1074\/jbc.M116.736801_bib22","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1073\/pnas.95.2.548","article-title":"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)","volume":"95","author":"Achen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.736801_bib23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/j.1460-2075.1996.tb00359.x","article-title":"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases","volume":"15","author":"Joukov","year":"1996","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M116.736801_bib24","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ceb.2008.12.012","article-title":"VEGFs and receptors involved in angiogenesis versus lymphangiogenesis","volume":"21","author":"Lohela","year":"2009","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1074\/jbc.M116.736801_bib25","doi-asserted-by":"crossref","first-page":"32127","DOI":"10.1074\/jbc.274.45.32127","article-title":"Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers","volume":"274","author":"Stacker","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736801_bib26","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1096\/fj.06-7060com","article-title":"Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2","volume":"21","author":"McColl","year":"2007","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M116.736801_bib27","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1096\/fj.10-179788","article-title":"Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer","volume":"25","author":"Harris","year":"2011","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M116.736801_bib28","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.20030361","article-title":"Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D","volume":"198","author":"McColl","year":"2003","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M116.736801_bib29","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1093\/emboj\/16.13.3898","article-title":"Proteolytic processing regulates receptor specificity and activity of VEGF-C","volume":"16","author":"Joukov","year":"1997","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M116.736801_bib30","doi-asserted-by":"crossref","first-page":"44307","DOI":"10.1074\/jbc.M106188200","article-title":"Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis","volume":"276","author":"Baldwin","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736801_bib31","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1172\/JCI200317220","article-title":"The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis","volume":"111","author":"Siegfried","year":"2003","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M116.736801_bib32","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1182\/blood-2010-08-301549","article-title":"Structural determinants of vascular endothelial growth factor-D receptor binding and specificity","volume":"117","author":"Lepp\u00e4nen","year":"2011","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736801_bib33","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1096\/fj.01-0945rev","article-title":"The role of tumor lymphangiogenesis in metastatic spread","volume":"16","author":"Stacker","year":"2002","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M116.736801_bib34","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/1097-0142(20010801)92:3<556::AID-CNCR1355>3.0.CO;2-Q","article-title":"Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis","volume":"92","author":"O-charoenrat","year":"2001","journal-title":"Cancer"},{"key":"10.1074\/jbc.M116.736801_bib35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/sj.bjc.6600701","article-title":"Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma","volume":"88","author":"Yokoyama","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1074\/jbc.M116.736801_bib36","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1073\/pnas.0914318107","article-title":"Structural determinants of growth factor binding and specificity by VEGF receptor 2","volume":"107","author":"Lepp\u00e4nen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.736801_bib37","doi-asserted-by":"crossref","first-page":"12960","DOI":"10.1073\/pnas.1301415110","article-title":"Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation","volume":"110","author":"Lepp\u00e4nen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.736801_bib38","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jmb.2011.02.009","article-title":"The VD1 neutralizing antibody to vascular endothelial growth factor-D: binding epitope and relationship to receptor binding","volume":"407","author":"Davydova","year":"2011","journal-title":"J. Mol. Biol"},{"key":"10.1074\/jbc.M116.736801_bib39","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1046\/j.1432-1327.2000.01257.x","article-title":"Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3","volume":"267","author":"Achen","year":"2000","journal-title":"Eur. J. Biochem"},{"key":"10.1074\/jbc.M116.736801_bib40","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ceb.2010.08.010","article-title":"Dynamics of endothelial cell behavior in sprouting angiogenesis","volume":"22","author":"Eilken","year":"2010","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1074\/jbc.M116.736801_bib41","doi-asserted-by":"crossref","first-page":"16037","DOI":"10.1074\/jbc.M109.001123","article-title":"Novel vascular endothelial growth factor D variants with increased biological activity","volume":"284","author":"Toivanen","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736801_bib42","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.109.197830","article-title":"Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle","volume":"104","author":"Anisimov","year":"2009","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M116.736801_bib43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1021\/bi401518b","article-title":"Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C","volume":"53","author":"Chiu","year":"2014","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M116.736801_bib44","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1182\/blood-2014-01-549816","article-title":"Control of blood proteins by functional disulfide bonds","volume":"123","author":"Butera","year":"2014","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736801_bib45","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1161\/CIRCULATIONAHA.113.002779","article-title":"CCBE1 enhances lymphangiogenesis via a disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation","volume":"129","author":"Jeltsch","year":"2014","journal-title":"Circulation"},{"key":"10.1074\/jbc.M116.736801_bib46","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1084\/jem.20020587","article-title":"Lymphangiogenic gene therapy with minimal blood vascular side effects","volume":"196","author":"Saaristo","year":"2002","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M116.736801_bib47","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1084\/jem.20062642","article-title":"Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting","volume":"204","author":"Wirzenius","year":"2007","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M116.736801_bib48","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1172\/JCI73777","article-title":"Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer","volume":"124","author":"Lyons","year":"2014","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M116.736801_bib49","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1242\/dev.100495","article-title":"Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis","volume":"141","author":"Le Guen","year":"2014","journal-title":"Development"},{"key":"10.1074\/jbc.M116.736801_bib50","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","article-title":"Lymphangiogenesis: molecular mechanisms and future promise","volume":"140","author":"Tammela","year":"2010","journal-title":"Cell"},{"key":"10.1074\/jbc.M116.736801_bib51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ccr.2005.01.017","article-title":"Focus on lymphangiogenesis in tumor metastasis","volume":"7","author":"Achen","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M116.736801_bib52","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1158\/0008-5472.CAN-12-4539","article-title":"VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis","volume":"73","author":"Alitalo","year":"2013","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M116.736801_bib53","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/path.4708","article-title":"VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury","volume":"239","author":"Sato","year":"2016","journal-title":"J. Pathol"},{"key":"10.1074\/jbc.M116.736801_bib54","doi-asserted-by":"crossref","first-page":"12677","DOI":"10.1073\/pnas.221449198","article-title":"A model for gene therapy of human hereditary lymphedema","volume":"98","author":"Karkkainen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.736801_bib55","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1097\/SLA.0b013e31826ed043","article-title":"Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema","volume":"257","author":"Honkonen","year":"2013","journal-title":"Ann. Surg"},{"key":"10.1074\/jbc.M116.736801_bib56","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/nm1689","article-title":"Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation","volume":"13","author":"Tammela","year":"2007","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M116.736801_bib57","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/jid.2008.351","article-title":"Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis","volume":"129","author":"Kajiya","year":"2009","journal-title":"J. Invest. Dermatol"},{"key":"10.1074\/jbc.M116.736801_bib58","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1084\/jem.20100559","article-title":"Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation","volume":"207","author":"Huggenberger","year":"2010","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M116.736801_bib59","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10456-015-9469-2","article-title":"VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study","volume":"18","author":"Visuri","year":"2015","journal-title":"Angiogenesis"},{"key":"10.1074\/jbc.M116.736801_bib60","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1161\/CIRCULATIONAHA.107.704098","article-title":"Biological basis of therapeutic lymphangiogenesis","volume":"123","author":"Norrm\u00e9n","year":"2011","journal-title":"Circulation"},{"key":"10.1074\/jbc.M116.736801_bib61","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1182\/blood-2010-10-316356","article-title":"An important role of lymphatic vessel activation in limiting acute inflammation","volume":"117","author":"Huggenberger","year":"2011","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736801_bib62","doi-asserted-by":"crossref","first-page":"8176","DOI":"10.1074\/jbc.M112.439299","article-title":"The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology","volume":"288","author":"Harris","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736801_bib63","doi-asserted-by":"crossref","DOI":"10.3791\/53867","article-title":"A simple bioassay for the evaluation of vascular endothelial growth factors","author":"Stacker","year":"2016","journal-title":"J. Vis. Exp"},{"key":"10.1074\/jbc.M116.736801_bib64","doi-asserted-by":"crossref","first-page":"19166","DOI":"10.1074\/jbc.M100097200","article-title":"The specificity of receptor binding by vascular endothelial growth factor-D is different in mouse and man","volume":"276","author":"Baldwin","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.736801_bib65","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.pep.2012.01.001","article-title":"Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies","volume":"82","author":"Davydova","year":"2012","journal-title":"Protein Expr. Purif"},{"key":"10.1074\/jbc.M116.736801_bib66","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1074\/jbc.M116.736801_bib67","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1038\/jid.2013.83","article-title":"Vascular endothelial growth factor-D modulates caliber and function of initial lymphatics in the dermis","volume":"133","author":"Paquet-Fifield","year":"2013","journal-title":"J. Invest. Dermatol"},{"key":"10.1074\/jbc.M116.736801_bib68","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1096\/fj.06-6656com","article-title":"Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis","volume":"21","author":"Goldman","year":"2007","journal-title":"FASEB J"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820343969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820343969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.736801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T05:24:57Z","timestamp":1620537897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820343969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":68,"journal-issue":{"issue":"53","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0021925820343969"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.736801","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.736801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}