{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T19:35:49Z","timestamp":1769888149589,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"32","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":1532,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000651","name":"Leukaemia and Lymphoma Research","doi-asserted-by":"publisher","award":["06091"],"award-info":[{"award-number":["06091"]}],"id":[{"id":"10.13039\/501100000651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000651","name":"Leukaemia and Lymphoma Research","doi-asserted-by":"publisher","award":["11050"],"award-info":[{"award-number":["11050"]}],"id":[{"id":"10.13039\/501100000651","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1074\/jbc.m116.736868","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T03:34:31Z","timestamp":1465270471000},"page":"16686-16698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA\/JAK2\/STAT3 Pathway in High Grade B-cell Lymphoma"],"prefix":"10.1016","volume":"291","author":[{"given":"Daniel","family":"Beck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Zobel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Barber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sian","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Lezina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Allchin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Blades","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Lord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Ashworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.G.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon D.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.736868_bib1","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMoa0802885","article-title":"Stromal gene signatures in large-B-cell lymphomas","volume":"359","author":"Lenz","year":"2008","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M116.736868_bib2","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1038\/sj.leu.2404856","article-title":"Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma","volume":"21","author":"Iqbal","year":"2007","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M116.736868_bib3","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1182\/blood-2007-09-111948","article-title":"Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-kB pathways in subtypes of diffuse large B-cell lymphoma","volume":"111","author":"Lam","year":"2008","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736868_bib4","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1126\/science.1153629","article-title":"Oncogenic CARD11 mutations in human diffuse large B cell lymphoma","volume":"319","author":"Lenz","year":"2008","journal-title":"Science"},{"key":"10.1074\/jbc.M116.736868_bib5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature08638","article-title":"Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma","volume":"463","author":"Davis","year":"2010","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.736868_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature09671","article-title":"Oncogenically active MYD88 mutations in human lymphoma","volume":"470","author":"Ngo","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.736868_bib7","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1182\/blood-2007-04-087734","article-title":"Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas","volume":"111","author":"Ding","year":"2008","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736868_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4049\/jimmunol.174.1.205","article-title":"BCL-6 negatively regulates expression of the NF-\u03baB1 p105\/p50 subunit","volume":"174","author":"Li","year":"2005","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M116.736868_bib9","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1073\/pnas.93.14.6947","article-title":"BCL-6, a POZ\/zinc-finger protein, is a sequence-specific transcriptional repressor","volume":"93","author":"Chang","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.736868_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng0697-161","article-title":"The BCL-6 proto-oncogene controls germinal centre formation and Th2-type inflammation","volume":"16","author":"Ye","year":"1997","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M116.736868_bib11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1126\/science.276.5312.589","article-title":"Control of inflammation, cytokine expression, and germinal center formation by BCL-6","volume":"276","author":"Dent","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M116.736868_bib12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1056\/NEJM199407143310202","article-title":"Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma","volume":"331","author":"Offit","year":"1994","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M116.736868_bib13","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1182\/blood-2002-11-3387","article-title":"Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma","volume":"101","author":"Pasqualucci","year":"2003","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736868_bib14","doi-asserted-by":"crossref","first-page":"15018","DOI":"10.1073\/pnas.232581199","article-title":"Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas","volume":"99","author":"Wang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.736868_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature10688","article-title":"FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas","volume":"481","author":"Duan","year":"2012","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.736868_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nature09730","article-title":"Inactivating mutations of acetyltransferase genes in B-cell lymphoma","volume":"471","author":"Pasqualucci","year":"2011","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.736868_bib17","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1172\/JCI42869","article-title":"BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy","volume":"120","author":"Cerchietti","year":"2010","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M116.736868_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1074-7613(00)00020-0","article-title":"BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control","volume":"13","author":"Shaffer","year":"2000","journal-title":"Immunity"},{"key":"10.1074\/jbc.M116.736868_bib19","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.4049\/jimmunol.173.2.1158","article-title":"Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation","volume":"173","author":"Tunyaplin","year":"2004","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M116.736868_bib20","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1084\/jem.192.12.1841","article-title":"Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6","volume":"192","author":"Reljic","year":"2000","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M116.736868_bib21","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/ni1245","article-title":"BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells","volume":"6","author":"Phan","year":"2005","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M116.736868_bib22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1101\/gad.929302","article-title":"A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling","volume":"16","author":"Shvarts","year":"2002","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M116.736868_bib23","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ni1478","article-title":"Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR","volume":"8","author":"Ranuncolo","year":"2007","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M116.736868_bib24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nature03147","article-title":"The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells","volume":"432","author":"Phan","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.736868_bib25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/340393a0","article-title":"Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes","volume":"340","author":"Hammerschmidt","year":"1989","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.736868_bib26","doi-asserted-by":"crossref","first-page":"8784","DOI":"10.1128\/JVI.79.14.8784-8792.2005","article-title":"A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that down-regulation of immunoglobulin M is partially CBF1 independent","volume":"79","author":"Maier","year":"2005","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M116.736868_bib27","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nbt1001-940","article-title":"Use of isogenic human cancer cells for high-throughput screening and drug discovery","volume":"19","author":"Torrance","year":"2001","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/jbc.M116.736868_bib28","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrc1691","article-title":"The concept of synthetic lethality in the context of anticancer therapy","volume":"5","author":"Kaelin","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M116.736868_bib29","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/leu.2015.57","article-title":"IL10 receptor is a novel therapeutic target in DLBCLs","volume":"29","author":"B\u00e9guelin","year":"2015","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M116.736868_bib30","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1042\/BJ20091578","article-title":"ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus","volume":"427","author":"Papadopoulou","year":"2010","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M116.736868_bib31","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1182\/blood-2007-01-069575","article-title":"BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms","volume":"110","author":"Parekh","year":"2007","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736868_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M116.736868_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1311s27","article-title":"Extracting biological meaning from large gene lists with DAVID","author":"Huang","year":"2009","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1074\/jbc.M116.736868_bib34","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1182\/blood-2008-12-193037","article-title":"The BCL6 transcriptional program features repression of multiple oncogenes in primary B-cells and is deregulated in DLBCL","volume":"113","author":"Ci","year":"2009","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736868_bib35","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/leu.2013.205","article-title":"Specificity and mechanism-of-action of the JAK2 tyrosine kinase inhibitors ruxolitinib and SAR302503 (TG101348)","volume":"28","author":"Zhou","year":"2014","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M116.736868_bib36","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1182\/blood-2011-10-388538","article-title":"Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation","volume":"119","author":"Gupta","year":"2012","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736868_bib37","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.celrep.2013.06.016","article-title":"A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters","volume":"4","author":"Hatzi","year":"2013","journal-title":"Cell Rep"},{"key":"10.1074\/jbc.M116.736868_bib38","doi-asserted-by":"crossref","first-page":"13520","DOI":"10.1073\/pnas.0804295105","article-title":"Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways","volume":"105","author":"Lenz","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.736868_bib39","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1101\/gad.12.13.1953","article-title":"Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor","volume":"12","author":"Niu","year":"1998","journal-title":"Genes Dev"},{"key":"10.1074\/jbc.M116.736868_bib40","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1084\/jem.20021395","article-title":"BCL6 controls the expression of the B7\u20131\/CD80 costimulatory receptor in germinal center B cells","volume":"198","author":"Niu","year":"2003","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M116.736868_bib41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ccr.2007.08.011","article-title":"A signaling pathway mediating down-regulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma","volume":"12","author":"Saito","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M116.736868_bib42","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1182\/blood-2008-07-168773","article-title":"A peptomimetic inhibitor of BCL6 with potent anti-lymphoma effects in vitro and in vivo","volume":"113","author":"Cerchietti","year":"2009","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736868_bib43","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ccr.2009.12.050","article-title":"A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo","volume":"17","author":"Cerchietti","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M116.736868_bib44","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/nm1134","article-title":"Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells","volume":"10","author":"Polo","year":"2004","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M116.736868_bib45","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1182\/blood-2004-08-3171","article-title":"BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production","volume":"105","author":"Yu","year":"2005","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736868_bib46","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1182\/blood-2009-06-225839","article-title":"Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities","volume":"114","author":"Mottok","year":"2009","journal-title":"Blood"},{"key":"10.1074\/jbc.M116.736868_bib47","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/10428194.2012.708931","article-title":"Lack of JAK2 activating non-synonymous mutations in diffuse large B-cell tumors: JAK2 deregulation still unexplained","volume":"54","author":"Witzig","year":"2013","journal-title":"Leuk. Lymphoma"},{"key":"10.1074\/jbc.M116.736868_bib48","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1200\/JCO.2012.42.5223","article-title":"Phase I study of a novel oral janus kinase 2 inhibitor, SB1518, in patients with relapsed lymphoma: evidence of clinical and biologic activity in multiple lymphoma subtypes","volume":"30","author":"Younes","year":"2012","journal-title":"J. Clin. Oncol"},{"key":"10.1074\/jbc.M116.736868_bib49","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1517\/13543784.2013.775244","article-title":"Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib","volume":"22","author":"Derenzini","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1074\/jbc.M116.736868_bib50","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa012914","article-title":"The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma","volume":"346","author":"Rosenwald","year":"2002","journal-title":"N. Engl. J. Med"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820353904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820353904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.736868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T06:57:31Z","timestamp":1641279451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820353904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":50,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0021925820353904"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.736868","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA\/JAK2\/STAT3 Pathway in High Grade B-cell Lymphoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.736868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}