{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:21:11Z","timestamp":1790425271868,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":1324,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The State Key Development Program for Basic Research of China","award":["2013CB945203"],"award-info":[{"award-number":["2013CB945203"]}]},{"name":"The State Key Development Program for Basic Research of China","award":["2015CB55360"],"award-info":[{"award-number":["2015CB55360"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1301222"],"award-info":[{"award-number":["U1301222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530070"],"award-info":[{"award-number":["81530070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600964"],"award-info":[{"award-number":["31600964"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270080"],"award-info":[{"award-number":["81270080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"crossref","award":["81625015"],"award-info":[{"award-number":["81625015"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1074\/jbc.m116.744482","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T02:30:35Z","timestamp":1480386635000},"page":"100-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes"],"prefix":"10.1016","volume":"292","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-yan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-peng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-lan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-chun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.744482_bib1","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1093\/brain\/awl165","article-title":"Essential protective roles of reactive astrocytes in traumatic brain injury","volume":"129","author":"Myer","year":"2006","journal-title":"Brain."},{"key":"10.1074\/jbc.M116.744482_bib2","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.nurt.2010.08.002","article-title":"Astrocytes and epilepsy","volume":"7","author":"de Lanerolle","year":"2010","journal-title":"Neurotherapeutics."},{"key":"10.1074\/jbc.M116.744482_bib3","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020628","article-title":"Astrocytes in neurodegenerative disease","volume":"7","author":"Phatnani","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1074\/jbc.M116.744482_bib4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia."},{"key":"10.1074\/jbc.M116.744482_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ceb.2015.02.004","article-title":"Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system","volume":"32","author":"Hol","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M116.744482_bib6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","article-title":"Regeneration beyond the glial scar","volume":"5","author":"Silver","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1074\/jbc.M116.744482_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/cne.900930206","article-title":"Regeneration in the spinal cord of the cat and dog","volume":"93","author":"Windle","year":"1950","journal-title":"J. Comp. Neurol."},{"key":"10.1074\/jbc.M116.744482_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1074\/jbc.M116.744482_bib9","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/nn1144","article-title":"The glial identity of neural stem cells","volume":"6","author":"Doetsch","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M116.744482_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tins.2010.12.001","article-title":"Astrocyte-neuron metabolic relationships: for better and for worse","volume":"34","author":"Allaman","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M116.744482_bib11","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"B\u00e9langer","year":"2011","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M116.744482_bib12","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3389\/fncel.2014.00378","article-title":"Neuron-glia networks: integral gear of brain function","volume":"8","author":"Perea","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1074\/jbc.M116.744482_bib13","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrn1722","article-title":"Astrocytes, from brain glue to communication elements: the revolution continues","volume":"6","author":"Volterra","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1074\/jbc.M116.744482_bib14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0197-0186(99)00137-0","article-title":"Role of astrocytes in the clearance of excess extracellular potassium","volume":"36","author":"Walz","year":"2000","journal-title":"Neurochem. Int."},{"key":"10.1074\/jbc.M116.744482_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature09613","article-title":"Glial and neuronal control of brain blood flow","volume":"468","author":"Attwell","year":"2010","journal-title":"Nature."},{"key":"10.1074\/jbc.M116.744482_bib16","doi-asserted-by":"crossref","first-page":"18291","DOI":"10.1073\/pnas.1208764110","article-title":"Neuronal activity regulates astrocytic Nrf2 signaling","volume":"110","author":"Habas","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M116.744482_bib17","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuron.2014.06.026","article-title":"Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes","volume":"83","author":"Stork","year":"2014","journal-title":"Neuron."},{"key":"10.1074\/jbc.M116.744482_bib18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell."},{"key":"10.1074\/jbc.M116.744482_bib19","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nature04869","article-title":"Ras, PI(3)K and mTOR signalling controls tumour cell growth","volume":"441","author":"Shaw","year":"2006","journal-title":"Nature."},{"key":"10.1074\/jbc.M116.744482_bib20","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/nn.3546","article-title":"mTOR complexes in neurodevelopmental and neuropsychiatric disorders","volume":"16","author":"Costa-Mattioli","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M116.744482_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neuron.2014.09.034","article-title":"The neurology of mTOR","volume":"84","author":"Lipton","year":"2014","journal-title":"Neuron."},{"key":"10.1074\/jbc.M116.744482_bib22","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMra055323","article-title":"The tuberous sclerosis complex","volume":"355","author":"Crino","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M116.744482_bib23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuron.2014.12.019","article-title":"Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes","volume":"85","author":"Lee","year":"2015","journal-title":"Neuron."},{"key":"10.1074\/jbc.M116.744482_bib24","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s12035-012-8314-5","article-title":"The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis","volume":"46","author":"Russo","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1074\/jbc.M116.744482_bib25","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1523\/JNEUROSCI.3294-12.2013","article-title":"Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis","volume":"33","author":"Clo\u00ebtta","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M116.744482_bib26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ana.10283","article-title":"Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures","volume":"52","author":"Uhlmann","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M116.744482_bib27","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1523\/JNEUROSCI.5540-06.2007","article-title":"A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival","volume":"27","author":"Meikle","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M116.744482_bib28","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.stem.2011.09.008","article-title":"Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions","volume":"9","author":"Magri","year":"2011","journal-title":"Cell Stem Cell."},{"key":"10.1074\/jbc.M116.744482_bib29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuron.2014.07.005","article-title":"Astrocyte morphology is controlled by neuron-derived FGF","volume":"83","author":"Agarwal","year":"2014","journal-title":"Neuron."},{"key":"10.1074\/jbc.M116.744482_bib30","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1074\/jbc.M503945200","article-title":"Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis","volume":"281","author":"Zhang","year":"2006","journal-title":"The Journal of biological chemistry."},{"key":"10.1074\/jbc.M116.744482_bib31","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/glia.22684","article-title":"The complex morphology of reactive astrocytes controlled by fibroblast growth factor signaling","volume":"62","author":"Kang","year":"2014","journal-title":"Glia."},{"key":"10.1074\/jbc.M116.744482_bib32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00441-003-0756-7","article-title":"Fibroblast growth factors and their receptors in the central nervous system","volume":"313","author":"Reuss","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1074\/jbc.M116.744482_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/glia.20218","article-title":"Temporal profiles of neuronal degeneration, glial proliferation, and cell death in hNFL+\/+ and NFL\u2212\/\u2212 mice","volume":"52","author":"McLean","year":"2005","journal-title":"Glia."},{"key":"10.1074\/jbc.M116.744482_bib34","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/ana.23670","article-title":"STAT3-mediated astrogliosis protects myelin development in neonatal brain injury","volume":"72","author":"Nobuta","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M116.744482_bib35","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1073\/pnas.1501029112","article-title":"Notch1-STAT3-ETBR signaling axis controls reactive astrocyte proliferation after brain injury","volume":"112","author":"LeComte","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M116.744482_bib36","doi-asserted-by":"crossref","first-page":"E2987","DOI":"10.1073\/pnas.1320401111","article-title":"Astrocyte activation is suppressed in both normal and injured brain by FGF signaling","volume":"111","author":"Kang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M116.744482_bib37","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.neuron.2008.09.037","article-title":"Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative\/repetitive behavior","volume":"60","author":"Hoeffer","year":"2008","journal-title":"Neuron."},{"key":"10.1074\/jbc.M116.744482_bib38","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neuron.2012.08.002","article-title":"Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy","volume":"75","author":"Pun","year":"2012","journal-title":"Neuron."},{"key":"10.1074\/jbc.M116.744482_bib39","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.scr.2013.08.003","article-title":"Differentiation of glutamatergic neurons from mouse embryonic stem cells requires raptor S6K signaling","volume":"11","author":"Chuang","year":"2013","journal-title":"Stem Cell Res."},{"key":"10.1074\/jbc.M116.744482_bib40","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nm1788","article-title":"Reversal of learning deficits in a Tsc2+\/\u2212 mouse model of tuberous sclerosis","volume":"14","author":"Ehninger","year":"2008","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M116.744482_bib41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nn.2477","article-title":"Tsc2-Rheb signaling regulates EphA-mediated axon guidance","volume":"13","author":"Nie","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M116.744482_bib42","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.celrep.2014.04.048","article-title":"Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases","volume":"7","author":"Kassai","year":"2014","journal-title":"Cell Rep."},{"key":"10.1074\/jbc.M116.744482_bib43","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.devcel.2010.11.020","article-title":"Rheb1 is required for mTORC1 and myelination in postnatal brain development","volume":"20","author":"Zou","year":"2011","journal-title":"Dev. Cell."},{"key":"10.1074\/jbc.M116.744482_bib44","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/(SICI)1098-1136(199802)22:2<202::AID-GLIA11>3.0.CO;2-1","article-title":"Regulation of astrocyte GFAP expression by TGF-\u03b21 and FGF-2","volume":"22","author":"Reilly","year":"1998","journal-title":"Glia."},{"key":"10.1074\/jbc.M116.744482_bib45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.0021-8782.2001.00002.x","article-title":"Fibroblast growth factor-2 induces astroglial and microglial reactivity in vivo","volume":"200","author":"Goddard","year":"2002","journal-title":"J. Anat."},{"key":"10.1074\/jbc.M116.744482_bib46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/9780470032244.ch11","article-title":"P2 receptor signalling, proliferation of astrocytes, and expression of molecules involved in cell-cell interactions","volume":"276","author":"Neary","year":"2006","journal-title":"Novartis Found. Symp."},{"key":"10.1074\/jbc.M116.744482_bib47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/gene.1078","article-title":"A CamKII\u03b1 iCre BAC allows brain-specific gene inactivation","volume":"31","author":"Casanova","year":"2001","journal-title":"Genesis."},{"key":"10.1074\/jbc.M116.744482_bib48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.0021-8782.2001.00002.x","article-title":"Fibroblast growth factor-2 induced astroglial and microglial reactivity in vivo","volume":"200","author":"Goddard","year":"2002","journal-title":"J. Anat."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820317336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820317336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.744482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T21:18:31Z","timestamp":1718918311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820317336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0021925820317336"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.744482","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.744482","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}