{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:34:49Z","timestamp":1777451689932,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":1366,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1074\/jbc.m116.758680","type":"journal-article","created":{"date-parts":[[2016,11,5]],"date-time":"2016-11-05T00:07:43Z","timestamp":1478304463000},"page":"26636-26646","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity, and Cardiac Function in Zebrafish"],"prefix":"10.1016","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-9047","authenticated-orcid":false,"given":"Martin W.","family":"Berchtold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Triantafyllos","family":"Zacharias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kulej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaela","family":"Torggler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-360X","authenticated-orcid":false,"given":"Thomas","family":"Jespersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8807-3607","authenticated-orcid":false,"given":"Jau-Nian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-0123","authenticated-orcid":false,"given":"Martin R.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas M.","family":"la Cour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.758680_bib1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1152\/physrev.2000.80.3.1215","article-title":"Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease","volume":"80","author":"Berchtold","year":"2000","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.M116.758680_bib2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1172\/JCI62834","article-title":"Calcium cycling proteins and heart failure: mechanisms and therapeutics","volume":"123","author":"Marks","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M116.758680_bib3","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bbamcr.2013.10.021","article-title":"The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer","volume":"1843","author":"Berchtold","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M116.758680_bib4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/geno.1993.1211","article-title":"Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3","volume":"16","author":"Berchtold","year":"1993","journal-title":"Genomics"},{"key":"10.1074\/jbc.M116.758680_bib5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.yjmcc.2011.01.012","article-title":"CaMKII in myocardial hypertrophy and heart failure","volume":"51","author":"Anderson","year":"2011","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M116.758680_bib6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1152\/physrev.00018.2010","article-title":"CaMKII in the cardiovascular system: sensing redox states","volume":"91","author":"Erickson","year":"2011","journal-title":"Physiol. Rev"},{"key":"10.1074\/jbc.M116.758680_bib7","doi-asserted-by":"crossref","first-page":"31658","DOI":"10.1074\/jbc.R112.356485","article-title":"Calcium\/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology","volume":"287","author":"Racioppi","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.758680_bib8","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/CIRCRESAHA.113.301651","article-title":"Mechanisms of altered Ca2+ handling in heart failure","volume":"113","author":"Luo","year":"2013","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M116.758680_bib9","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ajhg.2012.08.015","article-title":"Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death","volume":"91","author":"Nyegaard","year":"2012","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M116.758680_bib10","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/CIRCULATIONAHA.112.001216","article-title":"Calmodulin mutations associated with recurrent cardiac arrest in infants","volume":"127","author":"Crotti","year":"2013","journal-title":"Circulation"},{"key":"10.1074\/jbc.M116.758680_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jacc.2013.07.091","article-title":"A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence","volume":"63","author":"Marsman","year":"2014","journal-title":"J. Am. Coll. Cardiol"},{"key":"10.1074\/jbc.M116.758680_bib12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/CIRCGENETICS.113.000459","article-title":"Novel calmodulin mutations associated with congenital arrhythmia susceptibility","volume":"7","author":"Makita","year":"2014","journal-title":"Circ. Cardiovasc. Genet"},{"key":"10.1074\/jbc.M116.758680_bib13","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.hrthm.2014.10.035","article-title":"CALM3 mutation associated with long QT syndrome","volume":"12","author":"Reed","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1074\/jbc.M116.758680_bib14","doi-asserted-by":"crossref","first-page":"e004161","DOI":"10.1161\/CIRCEP.116.004161","article-title":"Novel CPVT-associated calmodulin mutation in CALM3 (CALM3-A103V) activates arrhythmogenic Ca waves and sparks","volume":"9","author":"Gomez-Hurtado","year":"2016","journal-title":"Circ. Arrhythm. Electrophysiol"},{"key":"10.1074\/jbc.M116.758680_bib15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/CIRCGENETICS.115.001323","article-title":"Spectrum and prevalence of CALM1-, CALM2-, and CALM3-encoded calmodulin variants in long QT syndrome and functional characterization of a novel long QT syndrome-associated calmodulin missense variant, E141G","volume":"9","author":"Boczek","year":"2016","journal-title":"Circ. Cardiovasc. Genet"},{"key":"10.1074\/jbc.M116.758680_bib16","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/j.hrthm.2016.06.038","article-title":"Novel calmodulin mutations associated with congenital long QT syndrome affect calcium current in human cardiomyocytes","volume":"13","author":"Pipilas","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1074\/jbc.M116.758680_bib17","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1161\/CIRCRESAHA.114.303391","article-title":"Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants","volume":"114","author":"Hwang","year":"2014","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M116.758680_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yjmcc.2014.04.022","article-title":"Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca currents and promote proarrhythmic behavior in ventricular myocytes","volume":"74","author":"Limpitikul","year":"2014","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1074\/jbc.M116.758680_bib19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cardiores.2006.11.005","article-title":"Role of Ca2+\/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart","volume":"73","author":"Maier","year":"2007","journal-title":"Cardiovasc. Res"},{"key":"10.1074\/jbc.M116.758680_bib20","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.hrthm.2012.08.026","article-title":"CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome","volume":"9","author":"DeGrande","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1074\/jbc.M116.758680_bib21","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1126\/science.256.5060.1199","article-title":"Calmodulin trapping by calcium-calmodulin-dependent protein kinase","volume":"256","author":"Meyer","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.M116.758680_bib22","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/01.RES.0000069686.31472.C5","article-title":"The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure","volume":"92","author":"Zhang","year":"2003","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M116.758680_bib23","doi-asserted-by":"crossref","first-page":"18173","DOI":"10.1074\/jbc.M112.339382","article-title":"Significance of calcium binding, tyrosine phosphorylation, and lysine trimethylation for the essential function of calmodulin in vertebrate cells analyzed in a novel gene replacement system","volume":"287","author":"Panina","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.758680_bib24","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1046\/j.1365-2567.2001.01259.x","article-title":"Calmodulin protects cells from death under normal growth conditions and mitogenic starvation but plays a mediating role in cell death upon B-cell receptor stimulation","volume":"103","author":"Schmalzigaug","year":"2001","journal-title":"Immunology"},{"key":"10.1074\/jbc.M116.758680_bib25","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.tcm.2014.12.001","article-title":"Role of CaMKII in cardiac arrhythmias","volume":"25","author":"Hund","year":"2015","journal-title":"Trends Cardiovasc. Med"},{"key":"10.1074\/jbc.M116.758680_bib26","doi-asserted-by":"crossref","first-page":"21241","DOI":"10.1073\/pnas.1108261109","article-title":"Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo","volume":"108","author":"Mower","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.758680_bib27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12537","article-title":"Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation","volume":"502","author":"Erickson","year":"2013","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.758680_bib28","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1111\/febs.12337","article-title":"Calmodulin in a heartbeat","volume":"280","author":"Sorensen","year":"2013","journal-title":"FEBS J"},{"key":"10.1074\/jbc.M116.758680_bib29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj20020228","article-title":"Structure-function of the multifunctional Ca2+\/calmodulin-dependent protein kinase II","volume":"364","author":"Hudmon","year":"2002","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M116.758680_bib30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/dvdy.10356","article-title":"Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish","volume":"228","author":"Huang","year":"2003","journal-title":"Dev. Dyn"},{"key":"10.1074\/jbc.M116.758680_bib31","first-page":"583","article-title":"Cardiac involvement in relapsing polychondritis in Japan","volume":"55","author":"Shimizu","year":"2016","journal-title":"Rheumatology"},{"key":"10.1074\/jbc.M116.758680_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"Bers","year":"2008","journal-title":"Annu. Rev. Physiol"},{"key":"10.1074\/jbc.M116.758680_bib33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/FJC.0b013e3181a25078","article-title":"Calcium\/calmodulin-dependent kinase II regulation of cardiac ion channels","volume":"54","author":"Bers","year":"2009","journal-title":"J. Cardiovasc. Pharmacol"},{"key":"10.1074\/jbc.M116.758680_bib34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.hrthm.2011.01.030","article-title":"Ca2+-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling","volume":"8","author":"Bers","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1074\/jbc.M116.758680_bib35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1570-9639(02)00449-1","article-title":"Regulation of calmodulin mRNAs in differentiating human IMR-32 neuroblastoma cells","volume":"1600","author":"Toutenhoofd","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M116.758680_bib36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbrc.2008.02.070","article-title":"Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity","volume":"369","author":"Kwok","year":"2008","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M116.758680_bib37","doi-asserted-by":"crossref","first-page":"17930","DOI":"10.1074\/jbc.M109.069351","article-title":"CaMKII autonomy is substrate-dependent and further stimulated by Ca2+\/calmodulin","volume":"285","author":"Coultrap","year":"2010","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.758680_bib38","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1096\/fj.14-250407","article-title":"Autonomous CaMKII requires further stimulation by Ca2+\/calmodulin for enhancing synaptic strength","volume":"28","author":"Barcomb","year":"2014","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M116.758680_bib39","doi-asserted-by":"crossref","first-page":"13968","DOI":"10.1073\/pnas.0606433103","article-title":"Ca2+\/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums","volume":"103","author":"Shifman","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.758680_bib40","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1128\/MCB.23.5.1647-1655.2003","article-title":"YPXL\/I is a protein interaction motif recognized by Aspergillus PalA and its human homologue, AIP1\/Alix","volume":"23","author":"Vincent","year":"2003","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M116.758680_bib41","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1242\/jeb.01620","article-title":"Cardiac performance in the zebrafish breakdance mutant","volume":"208","author":"Kopp","year":"2005","journal-title":"J. Exp. Biol"},{"key":"10.1074\/jbc.M116.758680_bib42","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1161\/01.RES.0000221822.22971.8c","article-title":"A new role for calmodulin in ion channel biology","volume":"98","author":"Roden","year":"2006","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M116.758680_bib43","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.bbrc.2010.04.157","article-title":"Identification and expression analysis of kcnh2 genes in the zebrafish","volume":"396","author":"Leong","year":"2010","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M116.758680_bib44","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ydbio.2011.12.004","article-title":"Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis","volume":"362","author":"Langenbacher","year":"2012","journal-title":"Dev. Biol"},{"key":"10.1074\/jbc.M116.758680_bib45","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/0006-291X(82)90712-4","article-title":"Ca2+-induced hydrophobic site on calmodulin: application for purification of calmodulin by phenyl-Sepharose affinity chromatography","volume":"104","author":"Gopalakrishna","year":"1982","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M116.758680_bib46","first-page":"870","article-title":"CHELATOR: an improved method for computing metal ion concentrations in physiological solutions","volume":"12","author":"Schoenmakers","year":"1992","journal-title":"BioTechniques"},{"key":"10.1074\/jbc.M116.758680_bib47","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/pr200641x","article-title":"Multidimensional strategy for sensitive phosphoproteomics incorporating protein prefractionation combined with SIMAC, HILIC, and TiO2 chromatography applied to proximal EGF signaling","volume":"10","author":"Engholm-Keller","year":"2011","journal-title":"J. Proteome Res"},{"key":"10.1074\/jbc.M116.758680_bib48","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/0022-2836(92)90324-D","article-title":"Calmodulin structure refined at 1.7 A resolution","volume":"228","author":"Chattopadhyaya","year":"1992","journal-title":"J. Mol. Biol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820344185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820344185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.758680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T06:23:52Z","timestamp":1641277432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820344185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":48,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0021925820344185"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.758680","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity, and Cardiac Function in Zebrafish","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.758680","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}