{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:39:39Z","timestamp":1783568379357,"version":"3.55.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":1307,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-133394"],"award-info":[{"award-number":["MOP-133394"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2015\u201305178"],"award-info":[{"award-number":["2015\u201305178"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1074\/jbc.m116.759167","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T14:55:24Z","timestamp":1482504924000},"page":"2301-2314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells in Vivo"],"prefix":"10.1016","volume":"292","author":[{"given":"Yining","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauthier","family":"Schang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Xia","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.759167_bib1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ng0297-201","article-title":"Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility","volume":"15","author":"Kumar","year":"1997","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M116.759167_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ng0993-83","article-title":"Primary amenorrhoea and infertility due to a mutation in the \u03b2-subunit of follicle-stimulating hormone","volume":"5","author":"Matthews","year":"1993","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M116.759167_bib3","first-page":"739","article-title":"The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology","volume":"18","author":"Simoni","year":"1997","journal-title":"Endocr. Rev"},{"key":"10.1074\/jbc.M116.759167_bib4","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1210\/endo.142.7.8230","article-title":"Analysis of the testicular phenotype of the follicle-stimulating hormone \u03b2-subunit knockout and the activin type II receptor knock-out mice by stereological analysis","volume":"142","author":"Wreford","year":"2001","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib5","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1210\/endo.141.5.7456","article-title":"The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction","volume":"141","author":"Abel","year":"2000","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib6","doi-asserted-by":"crossref","first-page":"13612","DOI":"10.1073\/pnas.95.23.13612","article-title":"Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance","volume":"95","author":"Dierich","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.759167_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1385\/ENDO:26:3:207","article-title":"Mutations in human gonadotropin and gonadotropin-receptor genes","volume":"26","author":"Huhtaniemi","year":"2005","journal-title":"Endocrine"},{"key":"10.1074\/jbc.M116.759167_bib8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1530\/rep.1.00663","article-title":"An update of the pathophysiology of human gonadotrophin subunit and receptor gene mutations and polymorphisms","volume":"130","author":"Themmen","year":"2005","journal-title":"Reproduction"},{"key":"10.1074\/jbc.M116.759167_bib9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11102-007-0061-7","article-title":"Genetic insights into human isolated gonadotropin deficiency","volume":"10","author":"Trarbach","year":"2007","journal-title":"Pituitary"},{"key":"10.1074\/jbc.M116.759167_bib10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0015-0282(02)04660-5","article-title":"Analysis of the Cys82Arg mutation in follicle-stimulating hormone \u03b2 (FSH\u03b2) using a novel FSH expression vector","volume":"79","author":"Clark","year":"2003","journal-title":"Fertil. Steril"},{"key":"10.1074\/jbc.M116.759167_bib11","first-page":"3702","article-title":"FSH\u03b2 gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia","volume":"87","author":"Layman","year":"2002","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1074\/jbc.M116.759167_bib12","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1515\/CCLM.1998.118","article-title":"Follitropin (FSH) deficiency in an infertile male due to FSH\u03b2 gene mutation: a syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations","volume":"36","author":"Lindstedt","year":"1998","journal-title":"Clin. Chem. Lab. Med"},{"key":"10.1074\/jbc.M116.759167_bib13","first-page":"919","article-title":"Human luteinizing hormone and chorionic gonadotropin are targeted to a regulated secretory pathway in GH3 cells","volume":"8","author":"Bielinska","year":"1994","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib14","first-page":"3","article-title":"The gene encoding the common \u03b1 subunit of the four human glycoprotein hormones","volume":"1","author":"Fiddes","year":"1981","journal-title":"J. Mol. Appl. Genet"},{"key":"10.1074\/jbc.M116.759167_bib15","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1016\/S0021-9258(19)40994-0","article-title":"Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands: I. \u03b1 subunit","volume":"250","author":"Rathnam","year":"1975","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.759167_bib16","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.fertnstert.2010.03.034","article-title":"Mechanisms of FSH synthesis: what we know, what we don't, and why you should care","volume":"93","author":"Bernard","year":"2010","journal-title":"Fertil. Steril"},{"key":"10.1074\/jbc.M116.759167_bib17","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1210\/en.2006-0952","article-title":"Activin and glucocorticoids synergistically activate follicle-stimulating hormone \u03b2-subunit gene expression in the immortalized L\u03b2T2 gonadotrope cell line","volume":"148","author":"McGillivray","year":"2007","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib18","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1210\/endo.138.3.4968","article-title":"Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro","volume":"138","author":"Kaiser","year":"1997","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1210\/endo.142.1.7881","article-title":"Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays","volume":"142","author":"Dalkin","year":"2001","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib20","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1210\/mend-3-12-1969","article-title":"Inhibin, activin, and follistatin: regulation of follicle-stimulating hormone messenger ribonucleic acid levels","volume":"3","author":"Carroll","year":"1989","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib21","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1210\/endo.140.2.6483","article-title":"Gonadotropin-releasing hormone regulation of gonadotropin subunit gene expression in female rats: actions on follicle-stimulating hormone \u03b2 messenger ribonucleic acid (mRNA) involve differential expression of pituitary activin (\u03b2-B) and follistatin mRNAs","volume":"140","author":"Dalkin","year":"1999","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib22","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1210\/me.2003-0264","article-title":"Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone \u03b2 subunit in mouse gonadotrope cells","volume":"18","author":"Bernard","year":"2004","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1095\/biolreprod.113.107797","article-title":"Mechanisms of activin-stimulated FSH synthesis: the story of a pig and a FOX","volume":"88","author":"Bernard","year":"2013","journal-title":"Biol. Reprod"},{"key":"10.1074\/jbc.M116.759167_bib24","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1210\/me.2008-0324","article-title":"A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone \u03b2 subunit transcription","volume":"23","author":"Lamba","year":"2009","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib25","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1210\/me.2004-0475","article-title":"Smad3 mediates activin-induced transcription of follicle-stimulating hormone \u03b2-subunit gene","volume":"19","author":"Suszko","year":"2005","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1477-7827-7-66","article-title":"Activin A induces ovine follicle stimulating hormone \u03b2 using \u2212169\/\u221258 bp of its promoter and a simple TATA box","volume":"7","author":"Han","year":"2009","journal-title":"Reprod. Biol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib27","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1210\/en.2011-1763","article-title":"FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone \u03b2-subunit promoter","volume":"153","author":"Ghochani","year":"2012","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib28","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.cellsig.2012.04.006","article-title":"Activin A induction of murine and ovine follicle-stimulating hormone \u03b2 transcription is SMAD-dependent and TAK1 (MAP3K7)\/p38 MAPK-independent in gonadotrope-like cells","volume":"24","author":"Wang","year":"2012","journal-title":"Cell Signal"},{"key":"10.1074\/jbc.M116.759167_bib29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S1043-2760(00)00294-0","article-title":"Activin signal transduction pathways","volume":"11","author":"Pangas","year":"2000","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1074\/jbc.M116.759167_bib30","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1210\/me.2010-0480","article-title":"SMADs and FOXL2 synergistically regulate murine FSH\u03b2 transcription via a conserved proximal promoter element","volume":"25","author":"Tran","year":"2011","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1677\/jme.1.01961","article-title":"Acute regulation of murine follicle-stimulating hormone \u03b2 subunit transcription by activin A","volume":"36","author":"Lamba","year":"2006","journal-title":"J. Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib32","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1210\/en.2010-0605","article-title":"Activin A regulates porcine follicle-stimulating hormone \u03b2-subunit transcription via cooperative actions of SMADs and FOXL2","volume":"151","author":"Lamba","year":"2010","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib33","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1210\/me.2009-0425","article-title":"FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone \u03b2-subunit genes","volume":"24","author":"Corpuz","year":"2010","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib34","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1096\/fj.14-249532","article-title":"Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2","volume":"28","author":"Fortin","year":"2014","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M116.759167_bib35","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1210\/me.2012-1286","article-title":"Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knock-out mice","volume":"27","author":"Tran","year":"2013","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib36","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1096\/fj.13-237818","article-title":"Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells","volume":"28","author":"Fortin","year":"2014","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M116.759167_bib37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0092-8674(00)81600-1","article-title":"Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-\u03b2 signaling","volume":"94","author":"Shi","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M116.759167_bib38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1083\/jcb.108.2.229","article-title":"The scanning model for translation: an update","volume":"108","author":"Kozak","year":"1989","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M116.759167_bib39","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.molcel.2004.07.016","article-title":"Structural basis of heteromeric smad protein assembly in TGF-\u03b2 signaling","volume":"15","author":"Chacko","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M116.759167_bib40","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1074\/jbc.M806676200","article-title":"FoxL2 and Smad3 coordinately regulate follistatin gene transcription","volume":"284","author":"Blount","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.759167_bib41","doi-asserted-by":"crossref","first-page":"33637","DOI":"10.1074\/jbc.274.47.33637","article-title":"Smad4\/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-\u03b2 antiproliferative responses in colon cancer cells","volume":"274","author":"Calonge","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.759167_bib42","first-page":"1387","article-title":"Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer","volume":"12","author":"Goyette","year":"1992","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M116.759167_bib43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1477-7827-4-52","article-title":"Activin B can signal through both ALK4 and ALK7 in gonadotrope cells","volume":"4","author":"Bernard","year":"2006","journal-title":"Reprod. Biol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib44","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/molehr\/6.7.582","article-title":"Expression of GnRH receptor in mouse and rat testicular germ cells","volume":"6","author":"Bull","year":"2000","journal-title":"Mol. Hum. Reprod"},{"key":"10.1074\/jbc.M116.759167_bib45","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.cellsig.2013.03.002","article-title":"Cycloheximide inhibits follicle-stimulating hormone \u03b2 subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells","volume":"25","author":"Rejon","year":"2013","journal-title":"Cell Signal"},{"key":"10.1074\/jbc.M116.759167_bib46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0303-7207(03)00235-1","article-title":"The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein","volume":"206","author":"Ellsworth","year":"2003","journal-title":"Mol. Cell. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib47","doi-asserted-by":"crossref","first-page":"10669","DOI":"10.1073\/pnas.94.20.10669","article-title":"Transforming growth factor \u03b2-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells","volume":"94","author":"Liu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M116.759167_bib48","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1210\/en.2004-0598","article-title":"Regulation of the follicle-stimulating hormone \u03b2 gene by the LHX3 LIM-homeodomain transcription factor","volume":"145","author":"West","year":"2004","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib49","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1210\/endo.142.6.8203","article-title":"Transcriptional regulation of the ovine follicle-stimulating hormone-\u03b2 gene by activin and gonadotropin-releasing hormone (GnRH): involvement of two proximal activator protein-1 sites for GnRH stimulation","volume":"142","author":"Huang","year":"2001","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib50","doi-asserted-by":"crossref","first-page":"F1657","DOI":"10.1152\/ajprenal.00274.2007","article-title":"Interference with TGF-\u03b2 signaling by Smad3-knock-out in mice limits diabetic glomerulosclerosis without affecting albuminuria","volume":"293","author":"Wang","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M116.759167_bib51","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)81730-4","article-title":"Smad3 mutant mice develop metastatic colorectal cancer","volume":"94","author":"Zhu","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M116.759167_bib52","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1128\/MCB.19.4.2495","article-title":"Targeted disruption of Smad3 reveals an essential role in transforming growth factor \u03b2-mediated signal transduction","volume":"19","author":"Datto","year":"1999","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M116.759167_bib53","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/emboj\/18.5.1280","article-title":"Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-\u03b2","volume":"18","author":"Yang","year":"1999","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M116.759167_bib54","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1210\/me.2003-0414","article-title":"Ovarian follicle development requires Smad3","volume":"18","author":"Tomic","year":"2004","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib55","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1210\/me.2005-0047","article-title":"Activin regulates luteinizing hormone \u03b2-subunit gene expression through Smad-binding and homeobox elements","volume":"19","author":"Coss","year":"2005","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M116.759167_bib56","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/sj.onc.1202729","article-title":"A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3","volume":"18","author":"Dennler","year":"1999","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M116.759167_bib57","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1074\/jbc.274.2.703","article-title":"Alternatively spliced variant of Smad2 lacking exon 3: comparison with wild-type Smad2 and Smad3","volume":"274","author":"Yagi","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.759167_bib58","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.cellsig.2010.01.019","article-title":"SMAD3 and EGR1 physically and functionally interact in promoter-specific fashion","volume":"22","author":"Fortin","year":"2010","journal-title":"Cell Signal"},{"key":"10.1074\/jbc.M116.759167_bib59","doi-asserted-by":"crossref","first-page":"e76642","DOI":"10.1371\/journal.pone.0076642","article-title":"The CpG island in the murine foxl2 proximal promoter is differentially methylated in primary and immortalized cells","volume":"8","author":"Tran","year":"2013","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M116.759167_bib60","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1210\/en.2008-0220","article-title":"Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone \u03b2-promoter activity","volume":"149","author":"Wang","year":"2008","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib61","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1128\/MCB.00732-08","article-title":"Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo","volume":"28","author":"Li","year":"2008","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/jbc.M116.759167_bib62","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1210\/en.2007-1502","article-title":"Functional characterization of genetically labeled gonadotropes","volume":"149","author":"Wen","year":"2008","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib63","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/gene.10029","article-title":"Generation of Smad4\/Dpc4 conditional knock-out mice","volume":"32","author":"Yang","year":"2002","journal-title":"Genesis"},{"key":"10.1074\/jbc.M116.759167_bib64","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-213X-1-4","article-title":"Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus","volume":"1","author":"Srinivas","year":"2001","journal-title":"BMC Dev. Biol"},{"key":"10.1074\/jbc.M116.759167_bib65","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1210\/en.2013-1502","article-title":"Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice","volume":"154","author":"Steyn","year":"2013","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M116.759167_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.nsa04is48","article-title":"Assessing reproductive status\/stages in mice","author":"Caligioni","year":"2009","journal-title":"Curr. Protoc. Neurosci"},{"key":"10.1074\/jbc.M116.759167_bib67","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1124\/jpet.107.121699","article-title":"Adverse effects of 5-aza-2\u2032-deoxycytidine on spermatogenesis include reduced sperm function and selective inhibition of de novo DNA methylation","volume":"322","author":"Oakes","year":"2007","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1074\/jbc.M116.759167_bib68","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.mce.2010.10.019","article-title":"Mechanisms of bone morphogenetic protein 2 (BMP2) stimulated inhibitor of DNA binding 3 (Id3) transcription","volume":"332","author":"Ho","year":"2011","journal-title":"Mol. Cell. Endocrinol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820424883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820424883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.759167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T12:00:45Z","timestamp":1641297645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820424883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0021925820424883"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.759167","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells in Vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.759167","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}