{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:27:45Z","timestamp":1789612065250,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":1157,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI115691"],"award-info":[{"award-number":["R01AI115691"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["AQ-1245"],"award-info":[{"award-number":["AQ-1245"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["AQ-1399"],"award-info":[{"award-number":["AQ-1399"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1074\/jbc.m116.766527","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:50:22Z","timestamp":1495587022000},"page":"11154-11164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy"],"prefix":"10.1016","volume":"292","author":[{"given":"Alexander B.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel E.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Donati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara M.","family":"Polcaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Pica-Mattoccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid S.","family":"Tarpley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanton F.","family":"McHardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Cioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip T.","family":"LoVerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. John","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.766527_bib1","unstructured":"World Health Organization (2015) http:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en"},{"key":"10.1074\/jbc.M116.766527_bib2","series-title":"Disease Control Priorities in Developing Countries","first-page":"467","article-title":"Helminth infections: soil-transmitted helminth infections and schistosomiasis","author":"Hotez","year":"2006"},{"key":"10.1074\/jbc.M116.766527_bib3","unstructured":"Centers for Disease Control and Prevention (2012) http:\/\/www.cdc.gov\/parasites\/schistosomiasis"},{"key":"10.1074\/jbc.M116.766527_bib4","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1017\/S0031182013000231","article-title":"New approaches for understanding mechanisms of drug resistance in schistosomes","volume":"140","author":"Greenberg","year":"2013","journal-title":"Parasitology"},{"issue":"Suppl.","key":"10.1074\/jbc.M116.766527_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1590\/S0074-02762001000900025","article-title":"Replacing oxamniquine by praziquantel against Schistosoma mansoni infection in a rural community from the sugar-cane zone of Northeast Brazil: an epidemiological follow-up","volume":"96","author":"Beck","year":"2001","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1074\/jbc.M116.766527_bib6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0014-4894(92)90255-9","article-title":"Schistosoma mansoni: hycanthone\/oxamniquine resistance is controlled by a single autosomal recessive gene","volume":"75","author":"Cioli","year":"1992","journal-title":"Exp. Parasitol"},{"key":"10.1074\/jbc.M116.766527_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.actatropica.2008.09.003","article-title":"Brazilian studies on the genetics of Schistosoma mansoni","volume":"108","author":"Gentile","year":"2008","journal-title":"Acta Trop"},{"key":"10.1074\/jbc.M116.766527_bib8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1590\/S0037-86821973000600008","article-title":"Study of a human strain of Schistosoma mansoni resistant to schistosomicidal agents","volume":"7","author":"Katz","year":"1973","journal-title":"Rev. Soc. Brasil. Med. Trop"},{"key":"10.1074\/jbc.M116.766527_bib9","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.172.3987.1057","article-title":"Hycanthone resistance: development in Schistosoma mansoni","volume":"172","author":"Rogers","year":"1971","journal-title":"Science"},{"key":"10.1074\/jbc.M116.766527_bib10","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1126\/science.1243106","article-title":"Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites","volume":"342","author":"Valentim","year":"2013","journal-title":"Science"},{"key":"10.1074\/jbc.M116.766527_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M116.766527_bib12","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","article-title":"Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions","volume":"60","author":"Krissinel","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr"},{"key":"10.1074\/jbc.M116.766527_bib13","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1038\/ncomms2593","article-title":"Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction","volume":"4","author":"Teramoto","year":"2013","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M116.766527_bib14","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nsb1197-904","article-title":"Crystal structure of estrogen sulphotransferase","volume":"4","author":"Kakuta","year":"1997","journal-title":"Nat. Struct. Biol"},{"key":"10.1074\/jbc.M116.766527_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0968-0004(98)01182-7","article-title":"Conserved structural motifs in the sulfotransferase family","volume":"23","author":"Kakuta","year":"1998","journal-title":"Trends Biochem. Sci"},{"key":"10.1074\/jbc.M116.766527_bib16","doi-asserted-by":"crossref","first-page":"e0004132","DOI":"10.1371\/journal.pntd.0004132","article-title":"Structural and functional characterization of the enantiomers of the antischistosomal drug oxamniquine","volume":"9","author":"Taylor","year":"2015","journal-title":"PLoS Negl. Trop. Dis"},{"issue":"Suppl. 1","key":"10.1074\/jbc.M116.766527_bib17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1590\/S0074-02762006000900048","article-title":"The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase","volume":"101","author":"Pica-Mattoccia","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1074\/jbc.M116.766527_bib18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.abb.2010.12.027","article-title":"Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes","volume":"507","author":"Gulcan","year":"2011","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1074\/jbc.M116.766527_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.mce.2009.12.001","article-title":"Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico\u2014implications for differences in activity, subunit dimerization and substrate inhibition","volume":"317","author":"Stjernschantz","year":"2010","journal-title":"Mol. Cell. Endocrinol"},{"key":"10.1074\/jbc.M116.766527_bib20","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1124\/mol.107.041038","article-title":"Identification and characterization of two amino acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase (SULT2A1)","volume":"73","author":"Lu","year":"2008","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M116.766527_bib21","doi-asserted-by":"crossref","first-page":"18799","DOI":"10.1074\/jbc.M312253200","article-title":"Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3","volume":"279","author":"Barnett","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.766527_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0163-7258(95)00026-7","article-title":"Antischistosomal drugs: past, present, and future?","volume":"68","author":"Cioli","year":"1995","journal-title":"Pharmacol. Ther"},{"key":"10.1074\/jbc.M116.766527_bib23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/00034983.1976.11687128","article-title":"The metabolism of oxamniquine\u2014a new schistosomicide","volume":"70","author":"Kaye","year":"1976","journal-title":"Ann. Trop. Med. Parasitol"},{"key":"10.1074\/jbc.M116.766527_bib24","doi-asserted-by":"crossref","first-page":"27325","DOI":"10.1074\/jbc.273.42.27325","article-title":"The sulfuryl transfer mechanism. Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis","volume":"273","author":"Kakuta","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M116.766527_bib25","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1021\/acs.biochem.5b00343","article-title":"Computational evidence for the catalytic mechanism of tyrosylprotein sulfotransferases: a density functional theory investigation","volume":"54","author":"Marforio","year":"2015","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M116.766527_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbrc.2009.03.146","article-title":"Snapshot of a Michaelis complex in a sulfuryl transfer reaction: crystal structure of a mouse sulfotransferase, mSULT1D1, complexed with donor substrate and accepter substrate","volume":"383","author":"Teramoto","year":"2009","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M116.766527_bib27","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/abio.1999.4383","article-title":"A modular set of prokaryotic and eukaryotic expression vectors","volume":"277","author":"Melcher","year":"2000","journal-title":"Anal. Biochem"},{"key":"10.1074\/jbc.M116.766527_bib28","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Crystallogr"},{"key":"10.1074\/jbc.M116.766527_bib29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr"},{"key":"10.1074\/jbc.M116.766527_bib30","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr"},{"key":"10.1074\/jbc.M116.766527_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"XDS","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr"},{"key":"10.1074\/jbc.M116.766527_bib32","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gkl282","article-title":"CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues","volume":"34","author":"Dundas","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M116.766527_bib33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/bioinformatics\/19.2.311","article-title":"TopDraw: a sketchpad for protein structure topology cartoons","volume":"19","author":"Bond","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M116.766527_bib34","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1021\/bi500267c","article-title":"Characterization of unstable products of flavin- and pterin-dependent enzymes by continuous-flow mass spectrometry","volume":"53","author":"Roberts","year":"2014","journal-title":"Biochemistry"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820369908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820369908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.766527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T14:37:54Z","timestamp":1619879874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820369908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":34,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0021925820369908"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.766527","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.766527","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}