{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T01:29:51Z","timestamp":1775352591773,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"47","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":1034,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL087001"],"award-info":[{"award-number":["HL087001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA138759"],"award-info":[{"award-number":["CA138759"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA152099"],"award-info":[{"award-number":["CA152099"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1074\/jbc.m116.773093","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:30:21Z","timestamp":1505781021000},"page":"19198-19208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase\u2013deficient mice"],"prefix":"10.1016","volume":"292","author":[{"given":"Ting","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M116.773093_bib1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M116.773093_bib2","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm.2537","article-title":"Tumor angiogenesis: molecular pathways and therapeutic targets","volume":"17","author":"Weis","year":"2011","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M116.773093_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ccr.2005.06.004","article-title":"Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling","volume":"8","author":"Zeng","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M116.773093_bib4","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nrc3628","article-title":"Crossing the endothelial barrier during metastasis","volume":"13","author":"Reymond","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M116.773093_bib5","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s00262-012-1335-0","article-title":"Endothelial cells in the eyes of an immunologist","volume":"61","author":"Young","year":"2012","journal-title":"Cancer Immunol. Immunother"},{"key":"10.1074\/jbc.M116.773093_bib6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/CJI.0b013e3181b91c9c","article-title":"Tumor secretion of VEGF induces endothelial cells to suppress T cell functions through the production of PGE(2)","volume":"33","author":"Mulligan","year":"2010","journal-title":"J. Immunother"},{"key":"10.1074\/jbc.M116.773093_bib7","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.15252\/emmm.201404156","article-title":"Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease","volume":"6","author":"Goveia","year":"2014","journal-title":"EMBO Mol. Med"},{"key":"10.1074\/jbc.M116.773093_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nature13312","article-title":"Metabolism of stromal and immune cells in health and disease","volume":"511","author":"Ghesqui\u00e8re","year":"2014","journal-title":"Nature"},{"key":"10.1074\/jbc.M116.773093_bib9","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.4049\/jimmunol.1301941","article-title":"Myeloid-derived suppressor cells are involved in lysosomal acid lipase deficiency-induced endothelial cell dysfunctions","volume":"193","author":"Zhao","year":"2014","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M116.773093_bib10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5411\/wji.v4.i2.42","article-title":"Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis","volume":"4","author":"Yan","year":"2014","journal-title":"World J. Immunol"},{"key":"10.1074\/jbc.M116.773093_bib11","series-title":"The Online Metabolic and Molecular Bases of Inherited Disease","article-title":"Chapter 142: Lysosomal acid lipase deficiencies: The Wolman disease\/cholesteryl ester storage disease spectrum","author":"Grabowski","year":"2014"},{"key":"10.1074\/jbc.M116.773093_bib12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ncb2204","article-title":"Lysosomal positioning coordinates cellular nutrient responses","volume":"13","author":"Korolchuk","year":"2011","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M116.773093_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: from growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M116.773093_bib14","doi-asserted-by":"crossref","first-page":"e30701","DOI":"10.1371\/journal.pone.0030701","article-title":"Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice","volume":"7","author":"Yan","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M116.773093_bib15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1091\/mbc.11.2.467","article-title":"Rab7: a key to lysosome biogenesis","volume":"11","author":"Bucci","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M116.773093_bib16","doi-asserted-by":"crossref","first-page":"E34","DOI":"10.3390\/cells5030034","article-title":"Multiple roles of the small GTPase Rab7","volume":"5","author":"Guerra","year":"2016","journal-title":"Cells"},{"key":"10.1074\/jbc.M116.773093_bib17","doi-asserted-by":"crossref","first-page":"30123","DOI":"10.18632\/oncotarget.16280","article-title":"Rab7 GTPase controls lipid metabolic signaling in myeloid-derived suppressor cells","volume":"8","author":"Ding","year":"2017","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.M116.773093_bib18","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1158\/0008-5472.CAN-10-1712","article-title":"Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells","volume":"70","author":"Krishnamurthy","year":"2010","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M116.773093_bib19","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.1038\/srep05853","article-title":"Lymphatic endothelial cells support tumor growth in breast cancer","volume":"4","author":"Lee","year":"2014","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.M116.773093_bib20","doi-asserted-by":"crossref","first-page":"e0121001","DOI":"10.1371\/journal.pone.0121001","article-title":"Establishment of lal\u2212\/\u2212 myeloid lineage cell line that resembles myeloid-derived suppressive cells","volume":"10","author":"Ding","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M116.773093_bib21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ajpath.2013.10.015","article-title":"Critical role of the mTOR pathway in development and function of myeloid-derived suppressor cells in lal\u2212\/\u2212 mice","volume":"184","author":"Ding","year":"2014","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M116.773093_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/BSR20090032","article-title":"Rab7: roles in membrane trafficking and disease","volume":"29","author":"Zhang","year":"2009","journal-title":"Biosci. Rep"},{"key":"10.1074\/jbc.M116.773093_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1515\/hsz-2013-0258","article-title":"Endocytic Rabs in membrane trafficking and signaling","volume":"395","author":"Numrich","year":"2014","journal-title":"Biol. Chem"},{"key":"10.1074\/jbc.M116.773093_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ccr.2014.04.030","article-title":"RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway","volume":"26","author":"Alonso-Curbelo","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M116.773093_bib25","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.2353\/ajpath.2010.091063","article-title":"Critical roles of lysosomal acid lipase in myelopoiesis","volume":"176","author":"Qu","year":"2010","journal-title":"Am. J. Pathol"},{"key":"10.1074\/jbc.M116.773093_bib26","doi-asserted-by":"crossref","first-page":"e0135245","DOI":"10.1371\/journal.pone.0135245","article-title":"Endothelial cell mTOR complex-2 regulates sprouting angiogenesis","volume":"10","author":"Farhan","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M116.773093_bib27","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1038\/onc.2014.143","article-title":"Activation of mTOR pathway in myeloid-derived suppressor cells stimulates cancer cell proliferation and metastasis in lal\u2212\/\u2212 mice","volume":"34","author":"Zhao","year":"2015","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M116.773093_bib28","doi-asserted-by":"crossref","first-page":"61121","DOI":"10.18632\/oncotarget.11244","article-title":"Lysosomal acid lipase in mesenchymal stem cell stimulation of tumor growth and metastasis","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.M116.773093_bib29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.M116.773093_bib30","doi-asserted-by":"crossref","first-page":"e0141602","DOI":"10.1371\/journal.pone.0141602","article-title":"Tumor-associated endothelial cells promote tumor metastasis by chaperoning circulating tumor cells and protecting them from anoikis","volume":"10","author":"Yadav","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M116.773093_bib31","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.18632\/oncotarget.6414","article-title":"Critical role of PPAR\u03b3 in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1074\/jbc.M116.773093_bib32","series-title":"Rho GTPases: Methods and Protocols","first-page":"123","author":"Reymond","year":"2012"},{"key":"10.1074\/jbc.M116.773093_bib33","doi-asserted-by":"crossref","first-page":"E110","DOI":"10.1152\/ajpendo.00192.2010","article-title":"MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1","volume":"299","author":"Zhao","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1074\/jbc.M116.773093_bib34","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1161\/CIRCULATIONAHA.106.631465","article-title":"Estrogen receptors \u03b1 and \u03b2 mediate contribution of bone marrow\u2013derived endothelial progenitor cells to functional recovery after myocardial infarction","volume":"114","author":"Hamada","year":"2006","journal-title":"Circulation"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820328921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820328921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M116.773093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T13:03:26Z","timestamp":1639832606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820328921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":34,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0021925820328921"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m116.773093","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase\u2013deficient mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M116.773093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}