{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:19:01Z","timestamp":1762867141651,"version":"3.44.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"30","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":1157,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR10673\/AGR\/36\/579\/2008","BT\/BI\/25\/066\/2012"],"award-info":[{"award-number":["BT\/PR10673\/AGR\/36\/579\/2008","BT\/BI\/25\/066\/2012"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1074\/jbc.m117.775155","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T20:35:14Z","timestamp":1496694914000},"page":"12577-12588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["An RNAi-based high-throughput screening assay to identify small molecule inhibitors of hepatitis B virus replication"],"prefix":"10.1016","volume":"292","author":[{"given":"Subhanita","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Khurana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Varshney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avishek Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Dahiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra K.","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj K.","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2017","series-title":"Global Hepatitis Report 2017","author":"World Health Organization","key":"10.1074\/jbc.M117.775155_bib1"},{"key":"10.1074\/jbc.M117.775155_bib2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.micro.112408.134243","article-title":"Viruses, microRNAs, and host interactions","volume":"64","author":"Skalsky","year":"2010","journal-title":"Annu. Rev. Microbiol"},{"key":"10.1074\/jbc.M117.775155_bib3","doi-asserted-by":"crossref","first-page":"e1000586","DOI":"10.1371\/journal.pbio.1000586","article-title":"Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses","volume":"9","author":"F\u00e9lix","year":"2011","journal-title":"PLoS Biol"},{"key":"10.1074\/jbc.M117.775155_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1126\/science.1241911","article-title":"RNA interference functions as an antiviral immunity mechanism in mammals","volume":"342","author":"Li","year":"2013","journal-title":"Science"},{"key":"10.1074\/jbc.M117.775155_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1126\/science.1241930","article-title":"Antiviral RNA interference in mammalian cells","volume":"342","author":"Maillard","year":"2013","journal-title":"Science"},{"key":"10.1074\/jbc.M117.775155_bib6","doi-asserted-by":"crossref","first-page":"e1003089","DOI":"10.1371\/journal.ppat.1003089","article-title":"Loss and retention of RNA interference in fungi and parasites","volume":"9","author":"Nicol\u00e1s","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.M117.775155_bib7","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1128\/JVI.01160-10","article-title":"Ebolavirus proteins suppress the effects of small interfering RNA by direct interaction with the mammalian RNA interference pathway","volume":"85","author":"Fabozzi","year":"2011","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M117.775155_bib8","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1099\/vir.0.2008\/002923-0","article-title":"Suppression of short interfering RNA-mediated gene silencing by the structural proteins of hepatitis C virus","volume":"89","author":"Ji","year":"2008","journal-title":"J. Gen. Virol"},{"key":"10.1074\/jbc.M117.775155_bib9","doi-asserted-by":"crossref","first-page":"8870","DOI":"10.1128\/JVI.02774-12","article-title":"Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor","volume":"87","author":"Kakumani","year":"2013","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M117.775155_bib10","doi-asserted-by":"crossref","first-page":"10395","DOI":"10.1128\/JVI.00748-10","article-title":"The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor","volume":"84","author":"Karjee","year":"2010","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M117.775155_bib11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrmicro1395","article-title":"The Tombusvirus-encoded P19: From irrelevance to elegance","volume":"4","author":"Scholthof","year":"2006","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1074\/jbc.M117.775155_bib12","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1096\/fj.08-125120","article-title":"Suppression of RNA silencing by Flock house virus B2 protein is mediated through its interaction with the PAZ domain of Dicer","volume":"23","author":"Singh","year":"2009","journal-title":"FASEB J"},{"key":"10.1074\/jbc.M117.775155_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/BJ20140316","article-title":"Key elements of the RNAi pathway are regulated by hepatitis B virus replication and HBx acts as a viral suppressor of RNA silencing","volume":"462","author":"Chinnappan","year":"2014","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M117.775155_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2005.03.010","article-title":"Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing","volume":"22","author":"Bennasser","year":"2005","journal-title":"Immunity"},{"key":"10.1074\/jbc.M117.775155_bib15","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1371\/journal.ppat.0030086","article-title":"The Ebola virus VP35 protein is a suppressor of RNA silencing","volume":"3","author":"Haasnoot","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.M117.775155_bib16","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1073\/pnas.0308308100","article-title":"Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing","volume":"101","author":"Li","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.775155_bib17","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1093\/emboj\/17.23.7066","article-title":"The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway","volume":"17","author":"Lara-Pezzi","year":"1998","journal-title":"EMBO J"},{"key":"10.1074\/jbc.M117.775155_bib18","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1128\/jvi.66.2.983-991.1992","article-title":"Hepatitis B virus X protein activates transcription factor NF-\u03baB without a requirement for protein kinase C","volume":"66","author":"Lucito","year":"1992","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M117.775155_bib19","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.1827531","article-title":"HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions","volume":"252","author":"Maguire","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M117.775155_bib20","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1073\/pnas.92.9.3819","article-title":"The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB","volume":"92","author":"Williams","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.775155_bib21","doi-asserted-by":"crossref","first-page":"10350","DOI":"10.1073\/pnas.91.22.10350","article-title":"Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade","volume":"91","author":"Benn","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.775155_bib22","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1128\/JVI.77.14.7713-7719.2003","article-title":"Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication","volume":"77","author":"Bouchard","year":"2003","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M117.775155_bib23","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1126\/science.294.5550.2376","article-title":"Calcium signaling by HBx protein in hepatitis B virus DNA replication","volume":"294","author":"Bouchard","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M117.775155_bib24","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1073\/pnas.92.24.11215","article-title":"Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls","volume":"92","author":"Benn","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.775155_bib25","doi-asserted-by":"crossref","first-page":"8162","DOI":"10.1073\/pnas.94.15.8162","article-title":"The hepatitis B virus X gene induces p53-mediated programmed cell death","volume":"94","author":"Chirillo","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.775155_bib26","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1038\/sj.onc.1202432","article-title":"p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro","volume":"17","author":"Terradillos","year":"1998","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M117.775155_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ymthe.2005.10.013","article-title":"Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs","volume":"13","author":"Carmona","year":"2006","journal-title":"Mol. Ther"},{"key":"10.1074\/jbc.M117.775155_bib28","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nbt824","article-title":"Inhibition of hepatitis B virus in mice by RNA interference","volume":"21","author":"McCaffrey","year":"2003","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/jbc.M117.775155_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-5793(03)00400-9","article-title":"Short interfering RNA-directed inhibition of hepatitis B virus replication","volume":"543","author":"Hamasaki","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M117.775155_bib30","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1128\/jvi.67.3.1218-1226.1993","article-title":"The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks","volume":"67","author":"Chen","year":"1993","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M117.775155_bib31","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1128\/jvi.68.3.2026-2030.1994","article-title":"Woodchuck hepatitis virus X protein is required for viral infection in vivo","volume":"68","author":"Zoulim","year":"1994","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M117.775155_bib32","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1099\/vir.0.009928-0","article-title":"Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression","volume":"90","author":"Cha","year":"2009","journal-title":"J. Gen. Virol"},{"key":"10.1074\/jbc.M117.775155_bib33","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1128\/JVI.02020-06","article-title":"Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo","volume":"81","author":"Keasler","year":"2007","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M117.775155_bib34","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1128\/JVI.79.9.5548-5556.2005","article-title":"The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication","volume":"79","author":"Tang","year":"2005","journal-title":"J. Virol"},{"key":"10.1074\/jbc.M117.775155_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/351317a0","article-title":"HBx gene of hepatitis B virus induces liver cancer in transgenic mice","volume":"351","author":"Kim","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M117.775155_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nsmb.1719","article-title":"A promiscuous \u03b1-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery","volume":"17","author":"Li","year":"2010","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.M117.775155_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/jbc.M117.775155_bib38","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem"},{"key":"10.1074\/jbc.M117.775155_bib39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nchem.1243","article-title":"Quantifying the chemical beauty of drugs","volume":"4","author":"Bickerton","year":"2012","journal-title":"Nat. Chem"},{"key":"10.1074\/jbc.M117.775155_bib40","doi-asserted-by":"crossref","first-page":"e1001082","DOI":"10.1371\/journal.ppat.1001082","article-title":"Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner","volume":"6","author":"K\u00f6ck","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.M117.775155_bib41","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1099\/vir.0.19734-0","article-title":"The influenza A virus NS1 protein binds small interfering RNAs and suppresses RNA silencing in plants","volume":"85","author":"Bucher","year":"2004","journal-title":"J. Gen. Virol"},{"key":"10.1074\/jbc.M117.775155_bib42","doi-asserted-by":"crossref","first-page":"16250","DOI":"10.1038\/nmicrobiol.2016.250","article-title":"Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells","volume":"2","author":"Li","year":"2016","journal-title":"Nat. Microbiol"},{"key":"10.1074\/jbc.M117.775155_bib43","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1021\/jm0491804","article-title":"Structure-based drug discovery using GPCR homology modeling: successful virtual screening for antagonists of the alpha1A adrenergic receptor","volume":"48","author":"Evers","year":"2005","journal-title":"J. Med. Chem"},{"key":"10.1074\/jbc.M117.775155_bib44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1021\/cb8002804","article-title":"Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria","volume":"4","author":"Dasgupta","year":"2009","journal-title":"ACS Chem. Biol"},{"key":"10.1074\/jbc.M117.775155_bib45","doi-asserted-by":"crossref","first-page":"e63240","DOI":"10.1371\/journal.pone.0063240","article-title":"Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models","volume":"8","author":"Ekins","year":"2013","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M117.775155_bib46","doi-asserted-by":"crossref","first-page":"389364","DOI":"10.4061\/2011\/389364","article-title":"Screening the MayBridge rule of 3 fragment library for compounds that interact with the Trypanosoma brucei myo-inositol-3-phosphate synthase and\/or show trypanocidal activity","volume":"2011","author":"Major","year":"2011","journal-title":"Mol. Biol. Int"},{"key":"10.1074\/jbc.M117.775155_bib47","doi-asserted-by":"crossref","first-page":"e49075","DOI":"10.1371\/journal.pone.0049075","article-title":"Identification of small molecules that suppress ricin-induced stress-activated signaling pathways","volume":"7","author":"Wahome","year":"2012","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M117.775155_bib48","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nsmb1005","article-title":"Dual modes of RNA-silencing suppression by Flock House virus protein B2","volume":"12","author":"Chao","year":"2005","journal-title":"Nat. Struct. Mol. Biol"},{"key":"10.1074\/jbc.M117.775155_bib49","doi-asserted-by":"crossref","first-page":"15228","DOI":"10.1073\/pnas.232434999","article-title":"A viral suppressor of RNA silencing differentially regulates the accumulation of short interfering RNAs and micro-RNAs in tobacco","volume":"99","author":"Mallory","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.775155_bib50","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1349-7006.2006.00299.x","article-title":"Molecular functions and biological roles of hepatitis B virus x protein","volume":"97","author":"Tang","year":"2006","journal-title":"Cancer Sci"},{"key":"10.1074\/jbc.M117.775155_bib51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/infdis\/jir282","article-title":"Serum HBsAg decline during long-term potent nucleos(t)ide analogue therapy for chronic hepatitis B and prediction of HBsAg loss","volume":"204","author":"Zoutendijk","year":"2011","journal-title":"J. Infect. Dis"},{"key":"10.1074\/jbc.M117.775155_bib52","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","article-title":"GROMACS 4.5: A high-throughput and highly parallel open source molecular simulation toolkit","volume":"29","author":"Pronk","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M117.775155_bib53","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/protein\/8.2.127","article-title":"LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions","volume":"8","author":"Wallace","year":"1995","journal-title":"Protein Eng"},{"key":"10.1074\/jbc.M117.775155_bib54","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1128\/jvi.65.4.1836-1842.1991","article-title":"Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication","volume":"65","author":"Blum","year":"1991","journal-title":"J. Virol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582039637X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582039637X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M117.775155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T17:37:38Z","timestamp":1758217058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582039637X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":54,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S002192582039637X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m117.775155","relation":{},"ISSN":["0021-9258"],"issn-type":[{"type":"print","value":"0021-9258"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An RNAi-based high-throughput screening assay to identify small molecule inhibitors of hepatitis B virus replication","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M117.775155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}