{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:25:19Z","timestamp":1790483119992,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"40","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":1076,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1074\/jbc.m117.776815","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:20:09Z","timestamp":1502756409000},"page":"16571-16577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":220,"title":["A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle"],"prefix":"10.1016","volume":"292","author":[{"given":"Raja F.","family":"Kawas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadie R. Bartholomew","family":"Ingle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvinder S.","family":"Sran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector M.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M117.776815_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults: echocardiographic analysis of 4111 subjects in the CARDIA study. coronary artery risk development in (young) adults","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation"},{"key":"10.1074\/jbc.M117.776815_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/0002-8703(67)90303-1","article-title":"Dynamics of left ventricular emptying in hypertrophic subaortic stenosis: A cinaengiographic and hemodynamic study","volume":"73","author":"Wilson","year":"1967","journal-title":"Am. Heart J"},{"key":"10.1074\/jbc.M117.776815_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/01.CIR.37.1.8","article-title":"Impared rate of left ventricular filling in idiopathic hypertrophic subaortic stenosis and valvular aortic stenosis","volume":"37","author":"Stewart","year":"1968","journal-title":"Circulation"},{"key":"10.1074\/jbc.M117.776815_bib4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/CRD.0b013e318178e525","article-title":"Hypertrophic cardiomyopathy: etiology, diagnosis, and treatment","volume":"16","author":"Ramaraj","year":"2008","journal-title":"Cardiol. Rev"},{"key":"10.1074\/jbc.M117.776815_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrcardio.2011.159","article-title":"Mechanisms of disease: hypertrophic cardiomyopathy","volume":"9","author":"Frey","year":"2011","journal-title":"Nat. Rev. Cardiol"},{"key":"10.1074\/jbc.M117.776815_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physiol.00014.2005","article-title":"Myosins: tails (and heads) of functional diversity","volume":"20","author":"Krendel","year":"2005","journal-title":"Physiology"},{"key":"10.1074\/jbc.M117.776815_bib7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1023\/A:1018613907574","article-title":"The in vitro motility activity of \u03b2-cardiac myosin depends on the nature of the \u03b2-myosin heavy chain gene mutation in hypertrophic cardiomyopathy","volume":"18","author":"Cuda","year":"1997","journal-title":"J. Muscle Res. Cell Motil"},{"key":"10.1074\/jbc.M117.776815_bib8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/01.RES.86.7.737","article-title":"Single-molecule mechanics of R403Q cardiac myosin isolated form the mouse model of familia hypertrophic cardiomyopathy","volume":"86","author":"Tyska","year":"2000","journal-title":"Circ. Res"},{"key":"10.1074\/jbc.M117.776815_bib9","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1073\/pnas.83.10.3542","article-title":"Rate of force generation in muscle: correlation with actomyosin ATPase activity in solution","volume":"83","author":"Brenner","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.776815_bib10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1126\/science.aad3456","article-title":"A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice","volume":"351","author":"Green","year":"2016","journal-title":"Science"},{"key":"10.1074\/jbc.M117.776815_bib11","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.1021\/bi00193a013","article-title":"Direct, real-time measurement of rapid organic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase","volume":"33","author":"Brune","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M117.776815_bib12","doi-asserted-by":"crossref","first-page":"13726","DOI":"10.1073\/pnas.96.24.13726","article-title":"The kinetic mechanism of myosin V","volume":"96","author":"De La Cruz","year":"1999","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1074\/jbc.M117.776815_bib13","doi-asserted-by":"crossref","first-page":"13297","DOI":"10.1021\/bi0260278","article-title":"Evidence that phosphate release is the rate-limiting step on the overall ATPase of psoas myofibrils prevented from shortening by chemical cross-linking","volume":"41","author":"Lionne","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M117.776815_bib14","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10974-004-0812-2","article-title":"Does phosphate release limit the ATPases of soleus myofibrils? Evidence that (A)M\u00b7ADP\u00b7Pi states predominate on the cross-bridge cycle","volume":"25","author":"Iorga","year":"2004","journal-title":"J. Muscle Res. Cell Motil"},{"key":"10.1074\/jbc.M117.776815_bib15","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.bpj.2012.07.014","article-title":"Velocity-dependent actomyosin ATPase cycle revealed by in vitro motility assay with kinetic analysis","volume":"103","author":"Sato","year":"2012","journal-title":"Biophys. J"},{"key":"10.1074\/jbc.M117.776815_bib16","doi-asserted-by":"crossref","first-page":"11235","DOI":"10.1073\/pnas.1510241112","article-title":"Velocities of unloaded muscle filaments are not limited by drag forces imposed by myosin cross-bridges","volume":"112","author":"Brizendine","year":"2015","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1074\/jbc.M117.776815_bib17","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3389\/fphys.2013.00336","article-title":"Novel control of cardiac myofilament response to calcium by S-glutathionylation at specific sites of myosin binding protein C","volume":"4","author":"Patel","year":"2013","journal-title":"Front. Physiol"},{"key":"10.1074\/jbc.M117.776815_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0076-6879(82)85009-X","article-title":"Preparation of myosin and its subfragments from rabbit skeletal muscle","volume":"85","author":"Margossian","year":"1982","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M117.776815_bib19","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s00018-012-0927-3","article-title":"Identification of functional differences between recombinant human \u03b1 and \u03b2 cardiac myosin motors","volume":"69","author":"Deacon","year":"2012","journal-title":"Cell. Mol. Life Sci"},{"key":"10.1074\/jbc.M117.776815_bib20","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1016\/S0021-9258(18)62016-2","article-title":"The regulation of rabbit skeletal muscle contraction. I. Biochemiscal studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin","volume":"246","author":"Spudich","year":"1971","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.776815_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/bj2320343","article-title":"The use of actin labelled with N-(1-pyrenyl)iodoacetamide to study the interaction of actin with myosin subfragments and troponin\/tropomyosin","volume":"232","author":"Criddle","year":"1985","journal-title":"Biochem. J"},{"key":"10.1074\/jbc.M117.776815_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00712034","article-title":"Pyrene actin: documentation of the validity of a sensitive assay for actin polymerization","volume":"4","author":"Cooper","year":"1983","journal-title":"J. Muscle Res. Cell Motil"},{"key":"10.1074\/jbc.M117.776815_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/meth.2000.1086","article-title":"Kinetics: a tool to study molecular motors","volume":"22","author":"Gilbert","year":"2000","journal-title":"Methods"},{"key":"10.1074\/jbc.M117.776815_bib24","doi-asserted-by":"crossref","first-page":"e01603","DOI":"10.7554\/eLife.01603","article-title":"Small molecule-mediated refolding and activation of myosin motor function","volume":"3","author":"Radke","year":"2014","journal-title":"eLife"},{"key":"10.1074\/jbc.M117.776815_bib25","doi-asserted-by":"crossref","first-page":"35557","DOI":"10.1074\/jbc.M405319200","article-title":"Mechanism of blebbistatin inhibition of myosin II","volume":"279","author":"Kov\u00e1cs","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.776815_bib26","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0022-2836(90)90287-V","article-title":"Myosin step size: estimation from slow sliding movement of actin over low densities of heavy meromyosin","volume":"214","author":"Uyeda","year":"1990","journal-title":"J. Mol. Biol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820339685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820339685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M117.776815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T06:06:21Z","timestamp":1641276381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820339685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":26,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0021925820339685"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m117.776815","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M117.776815","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}