{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:49:14Z","timestamp":1791978554802,"version":"4.4.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":1182,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB740"],"award-info":[{"award-number":["SFB740"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["294435 CYTOVOLION"],"award-info":[{"award-number":["294435 CYTOVOLION"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1074\/jbc.m117.784108","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T00:20:21Z","timestamp":1494030021000},"page":"10845-10854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Loss of the Na+\/H+ exchanger NHE8 causes male infertility in mice by disrupting acrosome formation"],"prefix":"10.1016","volume":"292","author":[{"given":"Karina","family":"Oberheide","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro","family":"Puchkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3509-2553","authenticated-orcid":false,"given":"Thomas J.","family":"Jentsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M117.784108_bib1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrg911","article-title":"Mouse models of male infertility","volume":"3","author":"Cooke","year":"2002","journal-title":"Nat. Rev. Genet"},{"key":"10.1074\/jbc.M117.784108_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/humupd\/dml047","article-title":"Globozoospermia revisited","volume":"13","author":"Dam","year":"2007","journal-title":"Hum. Reprod. Update"},{"key":"10.1074\/jbc.M117.784108_bib3","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1242\/dev.090613","article-title":"The cell biology of mammalian fertilization","volume":"140","author":"Okabe","year":"2013","journal-title":"Development"},{"key":"10.1074\/jbc.M117.784108_bib4","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/nature03692","article-title":"Structure of a Na+\/H+ antiporter and insights into mechanism of action and regulation by pH","volume":"435","author":"Hunte","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M117.784108_bib5","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/cphy.c110020","article-title":"Na+\/H+ exchangers","volume":"1","author":"Orlowski","year":"2011","journal-title":"Compr. Physiol"},{"key":"10.1074\/jbc.M117.784108_bib6","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/969","article-title":"Renal and intestinal absorptive defects in mice lacking the NHE3 Na+\/H+ exchanger","volume":"19","author":"Schultheis","year":"1998","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M117.784108_bib7","doi-asserted-by":"crossref","first-page":"C788","DOI":"10.1152\/ajpcell.1999.276.4.C788","article-title":"Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures","volume":"276","author":"Bell","year":"1999","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M117.784108_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0092-8674(01)80016-7","article-title":"Sodium\/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice","volume":"91","author":"Cox","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M117.784108_bib9","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1172\/JCI36581","article-title":"NHE4 is critical for the renal handling of ammonia in rodents","volume":"120","author":"Bourgeois","year":"2010","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M117.784108_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jcp.21744","article-title":"Elevated Golgi pH impairs terminal N-glycosylation by inducing mislocalization of Golgi glycosyltransferases","volume":"220","author":"Rivinoja","year":"2009","journal-title":"J. Cell. Physiol"},{"key":"10.1074\/jbc.M117.784108_bib11","doi-asserted-by":"crossref","first-page":"10058","DOI":"10.1074\/jbc.M110.197889","article-title":"pH-dependent cargo sorting from the Golgi","volume":"286","author":"Huang","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.784108_bib12","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ceb.2007.06.001","article-title":"Emerging roles of alkali cation\/proton exchangers in organellar homeostasis","volume":"19","author":"Orlowski","year":"2007","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1074\/jbc.M117.784108_bib13","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M117.784108_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuron.2013.07.043","article-title":"Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development","volume":"80","author":"Ouyang","year":"2013","journal-title":"Neuron"},{"key":"10.1074\/jbc.M117.784108_bib15","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1038\/ncomms3510","article-title":"Functional evaluation of autism-associated mutations in NHE9","volume":"4","author":"Kondapalli","year":"2013","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M117.784108_bib16","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1091\/mbc.e04-11-0999","article-title":"The yeast endosomal Na+(K+)\/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking","volume":"16","author":"Brett","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M117.784108_bib17","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1074\/jbc.M410041200","article-title":"Four Na+\/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation","volume":"280","author":"Nakamura","year":"2005","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.784108_bib18","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1016\/j.yexcr.2009.07.012","article-title":"Dual degradation mechanisms ensure disposal of NHE6 mutant protein associated with neurological disease","volume":"315","author":"Roxrud","year":"2009","journal-title":"Exp. Cell Res"},{"key":"10.1074\/jbc.M117.784108_bib19","doi-asserted-by":"crossref","first-page":"C1431","DOI":"10.1152\/ajpcell.00154.2011","article-title":"Na+\/H+ exchanger isoform 6 (NHE6\/SLC9A6) is involved in clathrin-dependent endocytosis of transferrin","volume":"301","author":"Xinhan","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M117.784108_bib20","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.ajhg.2008.01.013","article-title":"SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome","volume":"82","author":"Gilfillan","year":"2008","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M117.784108_bib21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1157657","article-title":"Identifying autism loci and genes by tracing recent shared ancestry","volume":"321","author":"Morrow","year":"2008","journal-title":"Science"},{"key":"10.1074\/jbc.M117.784108_bib22","doi-asserted-by":"crossref","first-page":"F467","DOI":"10.1152\/ajprenal.00352.2002","article-title":"Renal expression of novel Na+\/H+ exchanger isoform NHE8","volume":"284","author":"Goyal","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M117.784108_bib23","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1091\/mbc.e09-12-1053","article-title":"The sodium\/proton exchanger NHE8 regulates late endosomal morphology and function","volume":"21","author":"Lawrence","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M117.784108_bib24","doi-asserted-by":"crossref","first-page":"G36","DOI":"10.1152\/ajpgi.00552.2004","article-title":"Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8","volume":"289","author":"Xu","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"10.1074\/jbc.M117.784108_bib25","doi-asserted-by":"crossref","first-page":"F530","DOI":"10.1152\/ajprenal.00229.2004","article-title":"Immunolocalization of NHE8 in rat kidney","volume":"288","author":"Goyal","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M117.784108_bib26","doi-asserted-by":"crossref","first-page":"G335","DOI":"10.1152\/ajpgi.00146.2012","article-title":"Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice","volume":"303","author":"Xu","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"10.1074\/jbc.M117.784108_bib27","doi-asserted-by":"crossref","first-page":"C121","DOI":"10.1152\/ajpcell.00101.2013","article-title":"NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion","volume":"305","author":"Liu","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M117.784108_bib28","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1167\/iovs.14-15735","article-title":"Mouse Slc9a8 mutants exhibit retinal defects due to retinal pigmented epithelium dysfunction","volume":"56","author":"Jadeja","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"10.1074\/jbc.M117.784108_bib29","doi-asserted-by":"crossref","first-page":"9358","DOI":"10.1038\/srep09358","article-title":"NHE8 is essential for RPE cell polarity and photoreceptor survival","volume":"5","author":"Xia","year":"2015","journal-title":"Sci. Rep"},{"key":"10.1074\/jbc.M117.784108_bib30","doi-asserted-by":"crossref","first-page":"C330","DOI":"10.1152\/ajpcell.00289.2014","article-title":"Disruption of NHE8 expression impairs Leydig cell function in the testes","volume":"308","author":"Xu","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1074\/jbc.M117.784108_bib31","doi-asserted-by":"crossref","first-page":"14132","DOI":"10.1073\/pnas.241245898","article-title":"Estrogen action and male fertility: roles of the sodium\/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function","volume":"98","author":"Zhou","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.784108_bib32","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/ncb1072","article-title":"A new sperm-specific Na+\/H+ exchanger required for sperm motility and fertility","volume":"5","author":"Wang","year":"2003","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M117.784108_bib33","doi-asserted-by":"crossref","first-page":"9325","DOI":"10.1073\/pnas.0611296104","article-title":"A sperm-specific Na+\/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC)","volume":"104","author":"Wang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.784108_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1538\/expanim.59.105","article-title":"Transgenic mouse sperm that have green acrosome and red mitochondria allow visualization of sperm and their acrosome reaction in vivo","volume":"59","author":"Hasuwa","year":"2010","journal-title":"Exp. Anim"},{"key":"10.1074\/jbc.M117.784108_bib35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1530\/jrf.0.0810127","article-title":"Specific labelling by peanut agglutinin of the outer acrosomal membrane of the human spermatozoon","volume":"81","author":"Mortimer","year":"1987","journal-title":"J. Reprod. Fertil"},{"key":"10.1074\/jbc.M117.784108_bib36","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/humupd\/dmp016","article-title":"Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells","volume":"15","author":"Ramalho-Santos","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"10.1074\/jbc.M117.784108_bib37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1210\/mend.15.1.0582","article-title":"Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice","volume":"15","author":"Zhang","year":"2001","journal-title":"Mol. Endocrinol"},{"key":"10.1074\/jbc.M117.784108_bib38","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1091\/mbc.e03-04-0226","article-title":"Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head","volume":"14","author":"Kierszenbaum","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M117.784108_bib39","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/gene.10100","article-title":"Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice","volume":"33","author":"L\u00e9cureuil","year":"2002","journal-title":"Genesis"},{"key":"10.1074\/jbc.M117.784108_bib40","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/dvg.20437","article-title":"Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic mice","volume":"46","author":"Sadate-Ngatchou","year":"2008","journal-title":"Genesis"},{"key":"10.1074\/jbc.M117.784108_bib41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M117.784108_bib42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1055\/s-0028-1106747","article-title":"[Round headed spermatozoa: a cause of male infertility]","volume":"98","author":"Holstein","year":"1973","journal-title":"Dtsch. Med. Wochenschr"},{"key":"10.1074\/jbc.M117.784108_bib43","first-page":"117","article-title":"On the morphogenesis of roundheaded spermatozoa of human","volume":"3","author":"Shirren Sen","year":"1971","journal-title":"Andrologia"},{"key":"10.1074\/jbc.M117.784108_bib44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/bies.201000108","article-title":"Ion flux and the function of endosomes and lysosomes: pH is just the start: the flux of ions across endosomal membranes influences endosome function not only through regulation of the luminal pH","volume":"33","author":"Scott","year":"2011","journal-title":"BioEssays"},{"key":"10.1074\/jbc.M117.784108_bib45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.semcdb.2016.01.013","article-title":"Towards defining an \u201corigin\u201d\u2013The case for the mammalian acrosome","volume":"59","author":"Berruti","year":"2016","journal-title":"Semin. Cell Dev. Biol"},{"key":"10.1074\/jbc.M117.784108_bib46","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nature03362","article-title":"The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs","volume":"434","author":"Inoue","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M117.784108_bib47","doi-asserted-by":"crossref","first-page":"11211","DOI":"10.1073\/pnas.162027899","article-title":"Lack of acrosome formation in mice lacking a Golgi protein, GOPC","volume":"99","author":"Yao","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.784108_bib48","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.1063665","article-title":"Lack of acrosome formation in Hrb-deficient mice","volume":"294","author":"Kang-Decker","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M117.784108_bib49","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1172\/JCI36230","article-title":"PICK1 deficiency causes male infertility in mice by disrupting acrosome formation","volume":"119","author":"Xiao","year":"2009","journal-title":"J. Clin. Invest"},{"key":"10.1074\/jbc.M117.784108_bib50","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/mrd.20581","article-title":"The mammalian acrosome as a secretory lysosome: new and old evidence","volume":"73","author":"Moreno","year":"2006","journal-title":"Mol. Reprod. Dev"},{"key":"10.1074\/jbc.M117.784108_bib51","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4161\/spmg.1.2.16820","article-title":"Acrosome biogenesis: revisiting old questions to yield new insights","volume":"1","author":"Berruti","year":"2011","journal-title":"Spermatogenesis"},{"key":"10.1074\/jbc.M117.784108_bib52","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1242\/jcs.067637","article-title":"The Na+\/H+ exchanger Nhx1p regulates the initiation of Saccharomyces cerevisiae vacuole fusion","volume":"123","author":"Qiu","year":"2010","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M117.784108_bib53","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.febslet.2009.12.056","article-title":"Mucolipins: intracellular TRPML1\u20133 channels","volume":"584","author":"Cheng","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M117.784108_bib54","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1091\/mbc.e13-09-0523","article-title":"NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa","volume":"25","author":"Arndt","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M117.784108_bib55","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1042\/BST0351088","article-title":"The role of calcium and other ions in sorting and delivery in the late endocytic pathway","volume":"35","author":"Luzio","year":"2007","journal-title":"Biochem. Soc. Trans"},{"key":"10.1074\/jbc.M117.784108_bib56","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/26.2.24069","article-title":"The pH of the hamster sperm acrosome","volume":"26","author":"Meizel","year":"1978","journal-title":"J. Histochem. Cytochem"},{"key":"10.1074\/jbc.M117.784108_bib57","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/dbio.2001.0353","article-title":"Alkalinization of acrosome measured by GFP as a pH indicator and its relation to sperm capacitation","volume":"237","author":"Nakanishi","year":"2001","journal-title":"Dev. Biol"},{"key":"10.1074\/jbc.M117.784108_bib58","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nnano.2013.92","article-title":"Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell","volume":"8","author":"Modi","year":"2013","journal-title":"Nat. Nanotechnol"},{"key":"10.1074\/jbc.M117.784108_bib59","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1523\/JNEUROSCI.1930-11.2013","article-title":"The Angelman syndrome protein Ube3a\/E6AP is required for Golgi acidification and surface protein sialylation","volume":"33","author":"Condon","year":"2013","journal-title":"J. Neurosci"},{"key":"10.1074\/jbc.M117.784108_bib60","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/ncb1773","article-title":"GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus","volume":"10","author":"Maeda","year":"2008","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M117.784108_bib61","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ceb.2008.03.015","article-title":"The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function","volume":"20","author":"Marshansky","year":"2008","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1074\/jbc.M117.784108_bib62","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0021-9258(17)42302-7","article-title":"Vacuolar ATPase activity is required for endosomal carrier vesicle formation","volume":"269","author":"Clague","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.784108_bib63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/ncb1348","article-title":"V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway","volume":"8","author":"Hurtado-Lorenzo","year":"2006","journal-title":"Nat. Cell Biol"},{"key":"10.1074\/jbc.M117.784108_bib64","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/aja.2010.47","article-title":"A newly discovered mutation in PICK1 in a human with globozoospermia","volume":"12","author":"Liu","year":"2010","journal-title":"Asian J. Androl"},{"key":"10.1074\/jbc.M117.784108_bib65","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ajhg.2011.01.018","article-title":"DPY19L2 deletion as a major cause of globozoospermia","volume":"88","author":"Koscinski","year":"2011","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M117.784108_bib66","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1086\/521314","article-title":"Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia","volume":"81","author":"Dam","year":"2007","journal-title":"Am. J. Hum. Genet"},{"key":"10.1074\/jbc.M117.784108_bib67","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1093\/nar\/23.24.5080","article-title":"A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells","volume":"23","author":"Schwenk","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/jbc.M117.784108_bib68","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<106::AID-GENE30>3.0.CO;2-T","article-title":"Widespread recombinase expression using FLPeR (flipper) mice","volume":"28","author":"Farley","year":"2000","journal-title":"Genesis"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820365005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820365005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M117.784108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T21:46:50Z","timestamp":1634161610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820365005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":68,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0021925820365005"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m117.784108","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of the Na+\/H+ exchanger NHE8 causes male infertility in mice by disrupting acrosome formation","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M117.784108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}