{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:31:54Z","timestamp":1787063514871,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":1144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2014\/51931-R"],"award-info":[{"award-number":["SAF2014\/51931-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2014-54708-R"],"award-info":[{"award-number":["SAF2014-54708-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2016-81876-REDT"],"award-info":[{"award-number":["SAF2016-81876-REDT"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BES-2015-072729"],"award-info":[{"award-number":["BES-2015-072729"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006221","name":"United States - Israel Binational Science Foundation","doi-asserted-by":"publisher","award":["2009393"],"award-info":[{"award-number":["2009393"]}],"id":[{"id":"10.13039\/100006221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"publisher","award":["920631"],"award-info":[{"award-number":["920631"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["FIS PI13\/01118"],"award-info":[{"award-number":["FIS PI13\/01118"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1074\/jbc.m117.789180","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T20:50:20Z","timestamp":1493239820000},"page":"9680-9689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["The Beh\u00e7et's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing"],"prefix":"10.1016","volume":"292","author":[{"given":"Pablo","family":"Guasp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eilon","family":"Barnea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Francisca","family":"Gonz\u00e1lez-Escribano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Jim\u00e9nez-Reinoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R.","family":"Regueiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Admon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"L\u00f3pez de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M117.789180_bib1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","article-title":"Beh\u00e7et's disease","volume":"341","author":"Sakane","year":"1999","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M117.789180_bib2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng.2520","article-title":"Genome-wide association analysis identifies new susceptibility loci for Beh\u00e7et's disease and epistasis between HLA-B*51 and ERAP1","volume":"45","author":"Kirino","year":"2013","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M117.789180_bib3","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/art.24642","article-title":"HLA-B51\/B5 and the risk of Beh\u00e7et's disease: a systematic review and meta-analysis of case-control genetic association studies","volume":"61","author":"de Menthon","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1074\/jbc.M117.789180_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1399-0039.1997.tb02831.x","article-title":"Complete coding regions of two novel HLA-B alleles detected by phototyping (PCR-SSP) in the British caucasoid population: B*5108 and B*5002","volume":"50","author":"Vilches","year":"1997","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1399-0039.1998.tb03027.x","article-title":"Association of HLA-B51 subtypes and Beh\u00e7et's disease in Spain","volume":"52","author":"Gonz\u00e1lez-Escribano","year":"1998","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1034\/j.1399-0039.1999.540605.x","article-title":"Significant associations of HLA-B*5101 and B*5108, and lack of association of class II alleles with Beh\u00e7et's disease in Italian patients","volume":"54","author":"Kera","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1034\/j.1399-0039.1999.540308.x","article-title":"HLA class I and II typing of the patients with Beh\u00e7et's disease in Saudi Arabia","volume":"54","author":"Yabuki","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1034\/j.1399-0039.2001.057005457.x","article-title":"HLA class I genotyping including HLA-B*51 allele typing in the Iranian patients with Beh\u00e7et's disease","volume":"57","author":"Mizuki","year":"2001","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1034\/j.1399-0039.2001.580304.x","article-title":"Comparative analysis of the association of HLA-B*51 suballeles with Beh\u00e7et's disease in patients of German and Turkish origin","volume":"58","author":"K\u00f6tter","year":"2001","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1034\/j.1399-0039.2001.580307.x","article-title":"Allelic distribution of HLA-B*5 in HLA-B5-positive Israeli patients with Beh\u00e7et's disease","volume":"58","author":"Paul","year":"2001","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1034\/j.1399-0039.2002.590207.x","article-title":"Sequencing-based typing of HLA-B*51 alleles and the significant association of HLA-B*5101 and -B*5108 with Beh\u00e7et's disease in Greek patients","volume":"59","author":"Mizuki","year":"2002","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(02)80012-8","article-title":"Protein degradation and the generation of MHC class I-presented peptides","volume":"80","author":"Rock","year":"2002","journal-title":"Adv. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib13","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ni859","article-title":"An IFN-\u03b3-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides","volume":"3","author":"Saric","year":"2002","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib14","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni1208","article-title":"Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum","volume":"6","author":"Saveanu","year":"2005","journal-title":"Nat. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molimm.2016.08.005","article-title":"Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: towards a unifying view","volume":"77","author":"L\u00f3pez de Castro","year":"2016","journal-title":"Mol. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/BOR.0000000000000189","article-title":"Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics","volume":"27","author":"Ombrello","year":"2015","journal-title":"Curr. Opin. Rheumatol"},{"key":"10.1074\/jbc.M117.789180_bib17","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.febslet.2006.02.041","article-title":"Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)\/ER-aminopeptidase-1","volume":"580","author":"Goto","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1074\/jbc.M117.789180_bib18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/ng.873","article-title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","volume":"43","author":"Evans","year":"2011","journal-title":"Nat. Genet"},{"key":"10.1074\/jbc.M117.789180_bib19","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.4049\/jimmunol.1003337","article-title":"Cutting edge: coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme","volume":"186","author":"Evnouchidou","year":"2011","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib20","doi-asserted-by":"crossref","first-page":"7745","DOI":"10.1073\/pnas.1101262108","article-title":"Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming","volume":"108","author":"Kochan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.789180_bib21","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1074\/jbc.M113.529610","article-title":"Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands","volume":"289","author":"Mart\u00edn-Esteban","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.789180_bib22","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.molimm.2015.07.010","article-title":"Effects of polymorphic variation on the mechanism of endoplasmic reticulum aminopeptidase 1","volume":"67","author":"Stamogiannos","year":"2015","journal-title":"Mol. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4049\/jimmunol.1300598","article-title":"Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity","volume":"191","author":"Reeves","year":"2013","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib24","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1136\/annrheumdis-2015-209059","article-title":"A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Beh\u00e7et's disease in HLA-B*51 carriers","volume":"75","author":"Takeuchi","year":"2016","journal-title":"Ann. Rheum. Dis"},{"key":"10.1074\/jbc.M117.789180_bib25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/art.39430","article-title":"The peptidome of the Beh\u00e7et's disease-associated HLA-B*51:01 includes two sub-peptidomes differentially shaped by ERAP1","volume":"68","author":"Guasp","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1074\/jbc.M117.789180_bib26","doi-asserted-by":"crossref","first-page":"e1001157","DOI":"10.1371\/journal.pgen.1001157","article-title":"Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation","volume":"6","author":"Andr\u00e9s","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1074\/jbc.M117.789180_bib27","article-title":"Heterozygosity of the 721.221-B*51:01 cell line used in the study by Guasp et (Arthritis Rheumatol, February 2016)","author":"Guasp","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1074\/jbc.M117.789180_bib28","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/art.39734","article-title":"Functional interaction of the ankylosing spondylitis associated endoplasmic reticulum aminopeptidase 2 with the HLA-B*27 peptidome in human cells","volume":"68","author":"Mart\u00edn-Esteban","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1074\/jbc.M117.789180_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s002510050201","article-title":"Binding of 8-mer to 11-mer peptides carrying the anchor residues to slow assembling HLA class I molecules (HLA-B*5101)","volume":"45","author":"Sakaguchi","year":"1997","journal-title":"Immunogenetics"},{"key":"10.1074\/jbc.M117.789180_bib30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s002510050269","article-title":"Predominant role of N-terminal residue of nonamer peptides in their binding to HLA-B* 5101 molecules","volume":"46","author":"Sakaguchi","year":"1997","journal-title":"Immunogenetics"},{"key":"10.1074\/jbc.M117.789180_bib31","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/351290a0","article-title":"Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules","volume":"351","author":"Falk","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M117.789180_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00182333","article-title":"Peptide motifs of HLA-B58, B60, B61, and B62 molecules","volume":"41","author":"Falk","year":"1995","journal-title":"Immunogenetics"},{"key":"10.1074\/jbc.M117.789180_bib33","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1002\/eji.200838632","article-title":"Essential differences in ligand presentation and T cell epitope recognition among HLA molecules of the HLA-B44 supertype","volume":"38","author":"Hillen","year":"2008","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib34","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.4049\/jimmunol.1401689","article-title":"Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule","volume":"193","author":"Rasmussen","year":"2014","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib35","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.4049\/jimmunol.0803663","article-title":"The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum","volume":"183","author":"Hearn","year":"2009","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib36","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1399-0039.1994.tb02401.x","article-title":"Characterization of natural peptide ligands for HLA-B*4402 and -B*4403: implications for peptide involvement in allorecognition of a single amino acid change in the HLA-B44 heavy chain","volume":"44","author":"Fleischhauer","year":"1994","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0039.1998.tb02941.x","article-title":"An HLA-B27 polymorphism (B*2710) that is critical for T-cell recognition has limited effects on peptide specificity","volume":"51","author":"Garc\u00eda","year":"1998","journal-title":"Tissue Antigens"},{"key":"10.1074\/jbc.M117.789180_bib38","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.4049\/jimmunol.165.6.3260","article-title":"Nonstandard peptide binding revealed by crystal structures of HLA-B*5101 complexed with HIV immunodominant epitopes","volume":"165","author":"Maenaka","year":"2000","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib39","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1002\/art.20597","article-title":"Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain-related gene A in patients with Beh\u00e7et's disease","volume":"50","author":"Yasuoka","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1074\/jbc.M117.789180_bib40","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1073\/pnas.84.14.5014","article-title":"Site-directed mutagenesis of an HLA-A3 gene identifies amino acid 152 as crucial for major-histocompatibility-complex- restricted and alloreactive cytotoxic-T-lymphocyte recognition","volume":"84","author":"Cowan","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.789180_bib41","first-page":"126","article-title":"Natural killer cells in Beh\u00e7et's disease","volume":"71","author":"Hamzaoui","year":"1988","journal-title":"Clin. Exp. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib42","first-page":"588","article-title":"Increased peripheral blood \u03b3\u03b4+ T cells and natural killer cells in Beh\u00e7et's disease","volume":"19","author":"Suzuki","year":"1992","journal-title":"J. Rheumatol"},{"key":"10.1074\/jbc.M117.789180_bib43","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/ar3005","article-title":"Natural killer cells control a T-helper 1 response in patients with Beh\u00e7et's disease","volume":"12","author":"Yamaguchi","year":"2010","journal-title":"Arthritis Res. Ther"},{"key":"10.1074\/jbc.M117.789180_bib44","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/cei.12939","article-title":"Circulating NK cells and their subsets in Beh\u00e7et's disease","volume":"188","author":"Hasan","year":"2017","journal-title":"Clin. Exp. Immunol"},{"key":"10.1074\/jbc.M117.789180_bib45","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1158\/0008-5472.CAN-14-1643","article-title":"ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors","volume":"75","author":"Cifaldi","year":"2015","journal-title":"Cancer Res"},{"key":"10.1074\/jbc.M117.789180_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0092-8674(78)90296-9","article-title":"Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens: new tools for genetic analysis","volume":"14","author":"Barnstable","year":"1978","journal-title":"Cell"},{"key":"10.1074\/jbc.M117.789180_bib47","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1074\/mcp.M112.019588","article-title":"Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo","volume":"11","author":"Garc\u00eda-Medel","year":"2012","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/jbc.M117.789180_bib48","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0021-9673(02)01402-4","article-title":"Microcolumns with self-assembled particle frits for proteomics","volume":"979","author":"Ishihama","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1074\/jbc.M117.789180_bib49","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/jbc.M117.789180_bib50","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/pr101065j","article-title":"Andromeda: a peptide search engine integrated into the MaxQuant environment","volume":"10","author":"Cox","year":"2011","journal-title":"J. Proteome. Res"},{"key":"10.1074\/jbc.M117.789180_bib51","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00251-011-0579-8","article-title":"NetMHCcons: a consensus method for the major histocompatibility complex class I predictions","volume":"64","author":"Karosiene","year":"2012","journal-title":"Immunogenetics"},{"key":"10.1074\/jbc.M117.789180_bib52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","article-title":"A simple method for displaying the hydropathic character of a protein","volume":"157","author":"Kyte","year":"1982","journal-title":"J. Mol. Biol"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820321530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820321530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M117.789180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T23:48:17Z","timestamp":1641253697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820321530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":52,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0021925820321530"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m117.789180","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Beh\u00e7et's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M117.789180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}