{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:04:51Z","timestamp":1783533891144,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"44","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":1051,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1074\/jbc.m117.793240","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:30:25Z","timestamp":1504830625000},"page":"18303-18311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Zinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor"],"prefix":"10.1016","volume":"292","author":[{"given":"Shamila","family":"Sarwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadeb","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinak","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M117.793240_bib1","first-page":"433","article-title":"Cholera, 2015","volume":"91","author":"World Health Organization","year":"2016","journal-title":"Weekly Epidemiological Record"},{"key":"10.1074\/jbc.M117.793240_bib2","doi-asserted-by":"crossref","first-page":"e0003832","DOI":"10.1371\/journal.pntd.0003832","article-title":"Updated global burden of cholera in endemic countries","volume":"9","author":"Ali","year":"2015","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/jbc.M117.793240_bib3","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/S0140-6736(12)60436-X","article-title":"Cholera","volume":"379","author":"Harris","year":"2012","journal-title":"Lancet"},{"key":"10.1074\/jbc.M117.793240_bib4","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1128\/JB.01959-06","article-title":"Genetic diversity of toxigenic and nontoxigenic Vibrio cholerae serogroups O1 and O139 revealed by array-based comparative genomic hybridization","volume":"189","author":"Pang","year":"2007","journal-title":"J. Bacteriol"},{"key":"10.1074\/jbc.M117.793240_bib5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S0950268809990550","article-title":"El Tor cholera with severe disease: a new threat to Asia and beyond","volume":"138","author":"Siddique","year":"2010","journal-title":"Epidemiol. Infect"},{"key":"10.1074\/jbc.M117.793240_bib6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3855\/jidc.1966","article-title":"Epidemic cholera in Kakuma Refugee Camp, Kenya, 2009: the importance of sanitation and soap","volume":"6","author":"Mahamud","year":"2012","journal-title":"J. Infect. Dev. Ctries"},{"key":"10.1074\/jbc.M117.793240_bib7","doi-asserted-by":"crossref","first-page":"950","DOI":"10.4269\/ajtmh.12-0492","article-title":"Population vulnerability to biannual cholera outbreaks and associated macro-scale drivers in the Bengal delta","volume":"89","author":"Akanda","year":"2013","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"10.1074\/jbc.M117.793240_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.idc.2004.01.009","article-title":"Impact of infectious diseases on war","volume":"18","author":"Smallman-Raynor","year":"2004","journal-title":"Infect. Dis. Clin"},{"key":"10.1074\/jbc.M117.793240_bib9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1017\/S0950268800048895","article-title":"Epidemiology and infection in famine and disasters","volume":"107","author":"Shears","year":"1991","journal-title":"Epidemiol. Infect"},{"key":"10.1074\/jbc.M117.793240_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jtbi.2011.08.028","article-title":"A model for Vibrio cholerae colonization of the human intestine","volume":"289","author":"Spagnuolo","year":"2011","journal-title":"J. Theor. Biol"},{"key":"10.1074\/jbc.M117.793240_bib11","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00018-008-7496-5","article-title":"Cholera toxin structure, gene regulation and pathophysiological and immunological aspects","volume":"65","author":"S\u00e1nchez","year":"2008","journal-title":"Cell Mol. Life Sci"},{"key":"10.1074\/jbc.M117.793240_bib12","series-title":"Introduction to Fluorescence: Principles of Fluorescence Spectroscopy","first-page":"1","year":"2006"},{"key":"10.1074\/jbc.M117.793240_bib13","doi-asserted-by":"crossref","first-page":"e0004230","DOI":"10.1371\/journal.pntd.0004230","article-title":"Tracking cholera through surveillance of oral rehydration solution sales at pharmacies: insights from urban Bangladesh","volume":"9","author":"Azman","year":"2015","journal-title":"PLoS Negl. Trop. Dis"},{"key":"10.1074\/jbc.M117.793240_bib14","doi-asserted-by":"crossref","first-page":"22582","DOI":"10.1074\/jbc.M802555200","article-title":"Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines","volume":"283","author":"Lockridge","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.793240_bib15","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1001\/jama.291.21.2628","article-title":"Scientific rationale for a change in the composition of oral rehydration solution","volume":"291","author":"Duggan","year":"2004","journal-title":"JAMA"},{"key":"10.1074\/jbc.M117.793240_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJMp1013771","article-title":"Antibiotics for both moderate and severe cholera","volume":"364","author":"Nelson","year":"2011","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.M117.793240_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3329\/jhpn.v30i1.11270","article-title":"Increasing antimicrobial resistance of Vibrio cholerae OI biotype EI Tor strains isolated in a tertiary-care centre in India","volume":"30","author":"Mandal","year":"2012","journal-title":"J. Health Popul. Nutr"},{"key":"10.1074\/jbc.M117.793240_bib18","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0006-3002(52)90045-0","article-title":"The measurement of lysozyme activity and the ultra-violet inactivation of lysozyme","volume":"8","author":"Shugar","year":"1952","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M117.793240_bib19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1099\/jmm.0.023051-0","article-title":"Antibiotic resistance mechanisms of Vibrio cholerae","volume":"60","author":"Kitaoka","year":"2011","journal-title":"J. Med. Microbiol"},{"key":"10.1074\/jbc.M117.793240_bib20","doi-asserted-by":"crossref","first-page":"e836","DOI":"10.3390\/molecules21070836","article-title":"Nanoparticles: alternatives against drug-resistant pathogenic microbes","volume":"21","author":"Rudramurthy","year":"2016","journal-title":"Molecules"},{"key":"10.1074\/jbc.M117.793240_bib21","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1586\/eri.11.121","article-title":"Coping with antibiotic resistance: combining nanoparticles with antibiotics and other antimicrobial agents","volume":"9","author":"Allahverdiyev","year":"2011","journal-title":"Expert Rev. Anti Infect. Ther"},{"key":"10.1074\/jbc.M117.793240_bib22","doi-asserted-by":"crossref","first-page":"8856","DOI":"10.3390\/molecules20058856","article-title":"Silver nanoparticles as potential antibacterial agents","volume":"20","author":"Franci","year":"2015","journal-title":"Molecules"},{"key":"10.1074\/jbc.M117.793240_bib23","doi-asserted-by":"crossref","first-page":"12349","DOI":"10.1021\/ja1028843","article-title":"Small molecule-capped gold nanoparticles as potent antibacterial agents that target Gram-negative bacteria","volume":"132","author":"Zhao","year":"2010","journal-title":"J. Am. Chem. Soc"},{"key":"10.1074\/jbc.M117.793240_bib24","doi-asserted-by":"crossref","first-page":"16162","DOI":"10.1038\/nmicrobiol.2016.162","article-title":"Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers","volume":"1","author":"Lam","year":"2016","journal-title":"Nat. Microbiol"},{"key":"10.1074\/jbc.M117.793240_bib25","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/S0021-9258(18)54100-4","article-title":"Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases","volume":"268","author":"Nadeau","year":"1993","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.793240_bib26","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1136\/bmj.325.7372.1059","article-title":"Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial","volume":"325","author":"Baqui","year":"2002","journal-title":"BMJ"},{"key":"10.1074\/jbc.M117.793240_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/MPG.0b013e318213ca55","article-title":"ORS containing zinc does not reduce duration or stool volume of acute diarrhea in hospitalized children","volume":"53","author":"Wadhwa","year":"2011","journal-title":"J. Pediatr. Gastroenterol. Nutr"},{"key":"10.1074\/jbc.M117.793240_bib28","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.1111\/apa.12645","article-title":"Oral zinc supplements are ineffective for treating acute dehydrating diarrhoea in 5\u201312 year olds","volume":"104","author":"Negi","year":"2015","journal-title":"Acta Paediatr"},{"key":"10.1074\/jbc.M117.793240_bib29","first-page":"2767","article-title":"Antimicrobial applications of nanotechnology: methods and literature","volume":"7","author":"Seil","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1074\/jbc.M117.793240_bib30","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.3390\/ma7042833","article-title":"Zinc oxide: from synthesis to application: a review","volume":"7","author":"Ko\u0142odziejczak-Radzimska","year":"2014","journal-title":"Materials"},{"key":"10.1074\/jbc.M117.793240_bib31","doi-asserted-by":"crossref","first-page":"2139021","DOI":"10.1063\/1.2742324","article-title":"Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems","volume":"90","author":"Reddy","year":"2007","journal-title":"Appl. Phys. Lett"},{"key":"10.1074\/jbc.M117.793240_bib32","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.nano.2016.02.006","article-title":"The antimicrobial activity of ZnO nanoparticles against Vibrio cholerae: variation in response depends on biotype","volume":"12","author":"Sarwar","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1074\/jbc.M117.793240_bib33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2217\/17460913.2.3.335","article-title":"Regulation of virulence in Vibrio cholerae: the ToxR regulon","volume":"2","author":"Childers","year":"2007","journal-title":"Future Microbiol"},{"key":"10.1074\/jbc.M117.793240_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-1-62703-398-5_7","article-title":"Fluorescence techniques in analysis of protein\u2013ligand interactions in protein-ligand Interactions","volume":"1008","author":"Mocz","year":"2013","journal-title":"Methods Mol. Biol"},{"key":"10.1074\/jbc.M117.793240_bib35","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1038\/nprot.2006.229","article-title":"Determination of the folding of proteins as a function of denaturants, osmolytes or ligands using circular dichroism","volume":"1","author":"Greenfield","year":"2006","journal-title":"Nat. Protoc"},{"key":"10.1074\/jbc.M117.793240_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxicon.2016.03.003","article-title":"Vibrio cholerae hemagglutinin(HA)\/protease: an extracellular metalloprotease with multiple pathogenic activities","volume":"115","author":"Benitez","year":"2016","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M117.793240_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0167-7012(91)90020-Q","article-title":"A bioassay for cholera-like toxins using HT29 cells","volume":"14","author":"Charania","year":"1991","journal-title":"J. Microbiol. Methods"},{"key":"10.1074\/jbc.M117.793240_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/09687680410001663267","article-title":"Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (review)","volume":"21","author":"De Haan","year":"2004","journal-title":"Mol. Membr. Biol"},{"key":"10.1074\/jbc.M117.793240_bib39","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1116739","article-title":"Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization","volume":"310","author":"Hung","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M117.793240_bib40","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1073\/pnas.0611643104","article-title":"Virstatin inhibits dimerization of the transcriptional activator ToxT","volume":"104","author":"Shakhnovich","year":"2007","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1074\/jbc.M117.793240_bib41","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1124\/jpet.107.129288","article-title":"A natural plant-derived dihydroisosteviol prevents cholera toxin-induced intestinal fluid secretion","volume":"324","author":"Pariwat","year":"2008","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1074\/jbc.M117.793240_bib42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1574-6968.2010.01931.x","article-title":"Capsaicin, a potential inhibitor of cholera toxin production in Vibrio cholerae","volume":"306","author":"Chatterjee","year":"2010","journal-title":"FEMS Microbiol. Lett"},{"key":"10.1074\/jbc.M117.793240_bib43","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.bbagen.2017.02.007","article-title":"Structure and function of Vibrio cholerae accessory cholera enterotoxin in presence of gold nanoparticles: dependence on morphology","volume":"1861","author":"Chatterjee","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M117.793240_bib44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/infdis\/133.Supplement_1.S31","article-title":"Size and structure of the cholera toxin molecule and its subunits","volume":"133","author":"Ohtomo","year":"1976","journal-title":"J. Infect. Dis"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820330179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820330179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M117.793240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T05:24:13Z","timestamp":1641273853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820330179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":44,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0021925820330179"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m117.793240","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M117.793240","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}