{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:59:46Z","timestamp":1791809986788,"version":"4.3.4"},"reference-count":58,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":880,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["LP130100531"],"award-info":[{"award-number":["LP130100531"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005990","name":"Australian Mathematical Sciences Institute","doi-asserted-by":"publisher","award":["AMSIIntern INT-0265"],"award-info":[{"award-number":["AMSIIntern INT-0265"]}],"id":[{"id":"10.13039\/501100005990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1074\/jbc.m117.817064","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T19:15:12Z","timestamp":1520622912000},"page":"6363-6373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Half-life\u2013extended recombinant coagulation factor IX\u2013albumin fusion protein is recycled via the FcRn-mediated pathway"],"prefix":"10.1016","volume":"293","author":[{"given":"Jenny","family":"Chia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Louber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Glauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg T.","family":"Bass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve K.","family":"Dower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Gleeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Verhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M117.817064_bib1","first-page":"249","article-title":"FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions","volume":"382","author":"Challa","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol"},{"key":"10.1074\/jbc.M117.817064_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0065-2776(09)03004-1","article-title":"Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn","volume":"103","author":"Ward","year":"2009","journal-title":"Adv. Immunol"},{"key":"10.1074\/jbc.M117.817064_bib3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1073\/pnas.89.2.638","article-title":"Expression and crystallization of a soluble and functional form of an Fc receptor related to class I histocompatibility molecules","volume":"89","author":"Gastinel","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.817064_bib4","doi-asserted-by":"crossref","first-page":"14649","DOI":"10.1021\/bi00045a005","article-title":"Analysis of the pH dependence of the neonatal Fc receptor\/immunoglobulin G interaction using antibody and receptor variants","volume":"34","author":"Raghavan","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M117.817064_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1084\/jem.20021829","article-title":"The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan","volume":"197","author":"Chaudhury","year":"2003","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.M117.817064_bib6","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1073\/pnas.93.11.5512","article-title":"The protection receptor for IgG catabolism is the \u03b22-microglobulin-containing neonatal intestinal transport receptor","volume":"93","author":"Junghans","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.817064_bib7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0065-2423(08)60416-3","article-title":"Albumin and \u201ctotal globulin\u201d fractions of blood","volume":"8","author":"Watson","year":"1965","journal-title":"Adv. Clin. Chem"},{"key":"10.1074\/jbc.M117.817064_bib8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0065-3233(08)60065-0","article-title":"Serum albumin","volume":"37","author":"Peters","year":"1985","journal-title":"Adv. Protein Chem"},{"key":"10.1074\/jbc.M117.817064_bib9","first-page":"682","article-title":"Unraveling the interaction between FcRn and albumin: opportunities for design of albumin-based therapeutics","volume":"5","author":"Sand","year":"2014","journal-title":"Front. Immunol"},{"key":"10.1074\/jbc.M117.817064_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/07388551.2013.834293","article-title":"Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics","volume":"35","author":"Rath","year":"2015","journal-title":"Crit. Rev. Biotechnol"},{"key":"10.1074\/jbc.M117.817064_bib11","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1517\/17425247.2015.993313","article-title":"Albumin and its application in drug delivery","volume":"12","author":"Sleep","year":"2015","journal-title":"Expert Opin. Drug Deliv"},{"key":"10.1074\/jbc.M117.817064_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/intimm\/dxg018","article-title":"Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans","volume":"15","author":"Ward","year":"2003","journal-title":"Int. Immunol"},{"key":"10.1074\/jbc.M117.817064_bib13","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.4049\/jimmunol.172.4.2021","article-title":"Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn","volume":"172","author":"Ober","year":"2004","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M117.817064_bib14","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1083\/jcb.200809122","article-title":"The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity","volume":"185","author":"Tzaban","year":"2009","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M117.817064_bib15","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1091\/mbc.e03-11-0832","article-title":"Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor","volume":"15","author":"Claypool","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M117.817064_bib16","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1600-0854.2010.01083.x","article-title":"Comparison of FcRn- and pIgR-mediated transport in MDCK cells by fluorescence confocal microscopy","volume":"11","author":"Jerdeva","year":"2010","journal-title":"Traffic"},{"key":"10.1074\/jbc.M117.817064_bib17","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1074\/jbc.M113.537563","article-title":"Structural insights into neonatal Fc receptor-based recycling mechanisms","volume":"289","author":"Oganesyan","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.817064_bib18","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.4049\/jimmunol.179.7.4580","article-title":"Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism","volume":"179","author":"Akilesh","year":"2007","journal-title":"J. Immunol"},{"key":"10.1074\/jbc.M117.817064_bib19","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1073\/pnas.0810796106","article-title":"Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice","volume":"106","author":"Montoyo","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.817064_bib20","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1681\/ASN.2008090976","article-title":"Renal FcRn reclaims albumin but facilitates elimination of IgG","volume":"20","author":"Sarav","year":"2009","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.M117.817064_bib21","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1681\/ASN.2010050492","article-title":"Cubilin is essential for albumin reabsorption in the renal proximal tubule","volume":"21","author":"Amsellem","year":"2010","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.M117.817064_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1055\/s-0038-1657536","article-title":"Recombinant factor IX","volume":"78","author":"White","year":"1997","journal-title":"Thromb. Haemost"},{"key":"10.1074\/jbc.M117.817064_bib23","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1046\/j.1537-2995.2002.00039.x","article-title":"Pharmacokinetic analysis of plasma-derived and recombinant F IX concentrates in previously treated patients with moderate or severe hemophilia B","volume":"42","author":"Ewenstein","year":"2002","journal-title":"Transfusion"},{"key":"10.1074\/jbc.M117.817064_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-2516.2001.00465.x","article-title":"Pharmacokinetics of recombinant factor IX in relation to age of the patient: implications for dosing in prophylaxis","volume":"7","author":"Bj\u00f6rkman","year":"2001","journal-title":"Haemophilia"},{"key":"10.1074\/jbc.M117.817064_bib25","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1160\/TH09-04-0255","article-title":"Genetic fusion to albumin improves the pharmacokinetic properties of factor IX","volume":"102","author":"Metzner","year":"2009","journal-title":"Thromb. Haemost"},{"key":"10.1074\/jbc.M117.817064_bib26","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/S0049-3848(09)70157-4","article-title":"Half-life extension through albumin fusion technologies","volume":"124","author":"Schulte","year":"2009","journal-title":"Thromb. Res"},{"key":"10.1074\/jbc.M117.817064_bib27","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/j.1538-7836.2012.04826.x","article-title":"Improved kinetics of rIX-FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs","volume":"10","author":"Nolte","year":"2012","journal-title":"J. Thromb. Haemost"},{"key":"10.1074\/jbc.M117.817064_bib28","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.thromres.2014.02.010","article-title":"Biodistribution of the recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in rats","volume":"133","author":"Herzog","year":"2014","journal-title":"Thromb. Res"},{"key":"10.1074\/jbc.M117.817064_bib29","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1182\/blood-2012-05-429688","article-title":"Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients","volume":"120","author":"Santagostino","year":"2012","journal-title":"Blood"},{"key":"10.1074\/jbc.M117.817064_bib30","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/hae.12721","article-title":"Results of a phase I\/II open-label, safety and efficacy trial of coagulation factor IX (recombinant), albumin fusion protein in haemophilia B patients","volume":"21","author":"Martinowitz","year":"2015","journal-title":"Haemophilia"},{"key":"10.1074\/jbc.M117.817064_bib31","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1182\/blood-2015-09-669234","article-title":"Long acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial","volume":"127","author":"Santagostino","year":"2016","journal-title":"Blood"},{"key":"10.1074\/jbc.M117.817064_bib32","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/cyto.a.20786","article-title":"Automated organelle-based colocalization in whole-cell imaging","volume":"75","author":"Woodcroft","year":"2009","journal-title":"Cytometry"},{"key":"10.1074\/jbc.M117.817064_bib33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jim.2013.01.011","article-title":"Qualification of a homogeneous cell-based neonatal Fc receptor (FcRn) binding assay and its application to studies on Fc functionality of IgG-based therapeutics","volume":"390","author":"Mathur","year":"2013","journal-title":"J. Immunol. Methods"},{"key":"10.1074\/jbc.M117.817064_bib34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0304-4157(98)00018-5","article-title":"Lipid-protein interactions in blood coagulation","volume":"1376","author":"Zwaal","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M117.817064_bib35","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1091\/mbc.e04-08-0735","article-title":"From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling","volume":"16","author":"Ward","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M117.817064_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.molimm.2015.02.007","article-title":"Targeting FcRn for the modulation of antibody dynamics","volume":"67","author":"Ward","year":"2015","journal-title":"Mol. Immunol"},{"key":"10.1074\/jbc.M117.817064_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00540","article-title":"There's been a flaw in our thinking","volume":"5","author":"Anderson","year":"2014","journal-title":"Front. Immunol"},{"key":"10.1074\/jbc.M117.817064_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00351","article-title":"Commentary: \u201cThere's been a flaw in our thinking.\u201d","volume":"6","author":"Ward","year":"2015","journal-title":"Front. Immunol"},{"key":"10.1074\/jbc.M117.817064_bib39","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ncomms1607","article-title":"Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor","volume":"3","author":"Andersen","year":"2012","journal-title":"Nat. Commun"},{"key":"10.1074\/jbc.M117.817064_bib40","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1177\/1060028014545807","article-title":"Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes","volume":"48","author":"Trujillo","year":"2014","journal-title":"Ann. Pharmacother"},{"key":"10.1074\/jbc.M117.817064_bib41","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1091\/mbc.e13-04-0174","article-title":"Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules","volume":"24","author":"Weflen","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M117.817064_bib42","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1124\/mol.115.099184","article-title":"Intracellular dynamics and fate of a humanized anti-interleukin-6 receptor monoclonal antibody, tocilizumab","volume":"88","author":"Fujimoto","year":"2015","journal-title":"Mol. Pharmacol"},{"key":"10.1074\/jbc.M117.817064_bib43","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1074\/jbc.M117.794248","article-title":"Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin","volume":"292","author":"Schmidt","year":"2017","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M117.817064_bib44","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1083\/jcb.149.4.901","article-title":"Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11","volume":"149","author":"S\u00f6nnichsen","year":"2000","journal-title":"J. Cell Biol"},{"key":"10.1074\/jbc.M117.817064_bib45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrm2728","article-title":"Rab GTPases as coordinators of vesicle traffic","volume":"10","author":"Stenmark","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M117.817064_bib46","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1242\/jcs.116327","article-title":"Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway","volume":"126","author":"Gan","year":"2013","journal-title":"J. Cell Sci"},{"key":"10.1074\/jbc.M117.817064_bib47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm1315","article-title":"Endocytic recycling","volume":"5","author":"Maxfield","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1074\/jbc.M117.817064_bib48","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbrc.2013.09.001","article-title":"Hepatocyte clearance and pharmacokinetics of recombinant factor IX glycosylation variants","volume":"440","author":"Blasko","year":"2013","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/jbc.M117.817064_bib49","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0076-6879(10)79013-3","article-title":"The Ashwell-Morell receptor","volume":"479","author":"Grewal","year":"2010","journal-title":"Methods Enzymol"},{"key":"10.1074\/jbc.M117.817064_bib50","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nm1760","article-title":"The Ashwell receptor mitigates the lethal coagulopathy of sepsis","volume":"14","author":"Grewal","year":"2008","journal-title":"Nat. Med"},{"key":"10.1074\/jbc.M117.817064_bib51","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1182\/blood.V96.10.3459","article-title":"Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related protein","volume":"96","author":"Neels","year":"2000","journal-title":"Blood"},{"key":"10.1074\/jbc.M117.817064_bib52","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1182\/blood-2002-07-2081","article-title":"Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency","volume":"101","author":"Bovenschen","year":"2003","journal-title":"Blood"},{"key":"10.1074\/jbc.M117.817064_bib53","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1111\/j.1538-7836.2009.03591.x","article-title":"Factor IX binding to collagen","volume":"7","author":"Gailani","year":"2009","journal-title":"J. Thromb. Haemost"},{"key":"10.1074\/jbc.M117.817064_bib54","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1681\/ASN.2013010018","article-title":"Albumin is recycled from the primary urine by tubular transcytosis","volume":"24","author":"Tenten","year":"2013","journal-title":"J. Am. Soc. Nephrol"},{"key":"10.1074\/jbc.M117.817064_bib55","doi-asserted-by":"crossref","first-page":"E2862","DOI":"10.1073\/pnas.1618291114","article-title":"Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury","volume":"114","author":"Pyzik","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.817064_bib56","doi-asserted-by":"crossref","first-page":"11076","DOI":"10.1073\/pnas.0402970101","article-title":"Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level","volume":"101","author":"Ober","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.M117.817064_bib57","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1159\/000321161","article-title":"Recombinant activated factor VII is reabsorbed in renal proximal tubules and is a ligand to megalin and cubilin","volume":"117","author":"Seested","year":"2011","journal-title":"Nephron Exp. Nephrol"},{"key":"10.1074\/jbc.M117.817064_bib58","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/19420862.2015.1119352","article-title":"CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common \u03b2 chain of the IL-3, GM-CSF and IL-5 receptors","volume":"8","author":"Panousis","year":"2016","journal-title":"mAbs"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820397386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820397386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M117.817064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T19:48:36Z","timestamp":1660592916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820397386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":58,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0021925820397386"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m117.817064","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Half-life\u2013extended recombinant coagulation factor IX\u2013albumin fusion protein is recycled via the FcRn-mediated pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M117.817064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by The American Society for Biochemistry and Molecular Biology, Inc.","name":"copyright","label":"Copyright"}]}}