{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:56:02Z","timestamp":1771581362989,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"41","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":6590,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1074\/jbc.m203484200","type":"journal-article","created":{"date-parts":[[2002,10,7]],"date-time":"2002-10-07T21:03:54Z","timestamp":1034024634000},"page":"38855-38862","source":"Crossref","is-referenced-by-count":21,"title":["Hepatocyte Fas-associating Death Domain Protein\/Mediator of Receptor-induced Toxicity (FADD\/MORT1) Levels Increase in Response to Pro-apoptotic Stimuli"],"prefix":"10.1016","volume":"277","author":[{"given":"Peter K.M.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinna","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gambotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Myeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Weller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S.","family":"Zuckerbraun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon C.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R.","family":"Billiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M203484200_bib1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1053\/gast.2000.9364","volume":"119","author":"Streetz","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M203484200_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-2007-1007150","volume":"18","author":"Galle","year":"1998","journal-title":"Semin. Liver Dis."},{"key":"10.1074\/jbc.M203484200_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nm0497-409","volume":"3","author":"Kondo","year":"1997","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M203484200_bib4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1053\/gast.1997.v112.pm9041255","volume":"112","author":"Leist","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M203484200_bib5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1006\/excr.1994.1349","volume":"215","author":"Ni","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M203484200_bib6","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1053\/jhep.2000.18291","volume":"32","author":"Kim","year":"2000","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M203484200_bib7","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1074\/jbc.271.9.4961","volume":"271","author":"Chinnaiyan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib8","doi-asserted-by":"crossref","first-page":"7795","DOI":"10.1074\/jbc.270.14.7795","volume":"270","author":"Boldin","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(95)90071-3","volume":"81","author":"Chinnaiyan","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M203484200_bib10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","volume":"88","author":"Nagata","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M203484200_bib11","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1002\/j.1460-2075.1995.tb00245.x","volume":"14","author":"Kischkel","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M203484200_bib12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(95)90070-5","volume":"81","author":"Hsu","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M203484200_bib13","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1074\/jbc.273.8.4345","volume":"273","author":"Martin","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib14","doi-asserted-by":"crossref","first-page":"46639","DOI":"10.1074\/jbc.M105102200","volume":"276","author":"Kischkel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib15","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1074\/jbc.273.5.2926","volume":"273","author":"Muzio","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib16","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M203484200_bib17","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/23730","volume":"400","author":"Yin","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M203484200_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0091-679X(08)61797-5","volume":"13","author":"Seglen","year":"1976","journal-title":"Methods Cell Biol."},{"key":"10.1074\/jbc.M203484200_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1006\/abbi.1993.1173","volume":"302","author":"Stadler","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M203484200_bib20","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/hep.1840150603","volume":"15","author":"McGuire","year":"1992","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M203484200_bib21","doi-asserted-by":"crossref","first-page":"17325","DOI":"10.1074\/jbc.274.24.17325","volume":"274","author":"Li","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib22","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1128\/jvi.71.3.1842-1849.1997","volume":"71","author":"Hardy","year":"1997","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M203484200_bib23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1067\/msy.2000.107415","volume":"128","author":"Takahashi","year":"2000","journal-title":"Surgery"},{"key":"10.1074\/jbc.M203484200_bib24","doi-asserted-by":"crossref","first-page":"31138","DOI":"10.1074\/jbc.272.49.31138","volume":"272","author":"Kim","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib25","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.4049\/jimmunol.153.4.1778","volume":"153","author":"Leist","year":"1994","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M203484200_bib26","first-page":"10","volume":"9","author":"Zhang","year":"2001","journal-title":"Zhonghua Ganzangbing Zazhi"},{"key":"10.1074\/jbc.M203484200_bib27","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1126\/science.279.5358.1954","volume":"279","author":"Yeh","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M203484200_bib28","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1038\/sj.onc.1202292","volume":"17","author":"Sheikh","year":"1998","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M203484200_bib29","doi-asserted-by":"crossref","first-page":"25783","DOI":"10.1074\/jbc.272.41.25783","volume":"272","author":"Rehemtulla","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib30","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1093\/jnci\/92.19.1564","volume":"92","author":"Jolly","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1074\/jbc.M203484200_bib31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0962-8924(00)01874-2","volume":"11","author":"Beere","year":"2001","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M203484200_bib32","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1074\/jbc.272.2.1402","volume":"272","author":"Kim","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib33","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1128\/MCB.20.19.7146-7159.2000","volume":"20","author":"Mosser","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M203484200_bib34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/35019501","volume":"2","author":"Beere","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M203484200_bib35","doi-asserted-by":"crossref","first-page":"24357","DOI":"10.1074\/jbc.M000811200","volume":"275","author":"Wajant","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib36","first-page":"3947","volume":"60","author":"Fulda","year":"2000","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M203484200_bib37","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1083\/jcb.141.5.1255","volume":"141","author":"Perez","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M203484200_bib38","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1083\/jcb.141.5.1243","volume":"141","author":"Siegel","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M203484200_bib39","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1074\/jbc.274.12.7987","volume":"274","author":"Micheau","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib40","doi-asserted-by":"crossref","first-page":"36817","DOI":"10.1074\/jbc.274.51.36817","volume":"274","author":"Khwaja","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M203484200_bib41","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1083\/jcb.151.6.1247","volume":"151","author":"Matsumura","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M203484200_bib42","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/82732","volume":"1","author":"Holler","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M203484200_bib43","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1084\/jem.188.5.919","volume":"188","author":"Vercammen","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M203484200_bib44","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1083\/jcb.143.5.1353","volume":"143","author":"Kawahara","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M203484200_bib45","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/sj.cdd.4400866","volume":"8","author":"Morgan","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M203484200_bib46","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3181\/00379727-221-44386","volume":"221","author":"Suzuki","year":"1999","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1074\/jbc.M203484200_bib47","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1182\/blood.V98.3.787","volume":"98","author":"Hofmann","year":"2001","journal-title":"Blood"},{"key":"10.1074\/jbc.M203484200_bib48","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1089\/hum.1998.9.11-1599","volume":"9","author":"Kondo","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"10.1074\/jbc.M203484200_bib49","first-page":"1015","volume":"19","author":"Komata","year":"2001","journal-title":"Int. J. Oncol."},{"key":"10.1074\/jbc.M203484200_bib50","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00000658-200111000-00015","volume":"234","author":"Seino","year":"2001","journal-title":"Ann. Surg."},{"key":"10.1074\/jbc.M203484200_bib51","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1357-2725(99)00003-5","volume":"31","author":"Strasser","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1074\/jbc.M203484200_bib52","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/35037747","volume":"407","author":"Nicholson","year":"2000","journal-title":"Nature"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818363749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818363749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M203484200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T20:31:09Z","timestamp":1682368269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818363749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":52,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S0021925818363749"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m203484200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}