{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:56:22Z","timestamp":1787504182481,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"36","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":6608,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1074\/jbc.m204216200","type":"journal-article","created":{"date-parts":[[2002,8,30]],"date-time":"2002-08-30T16:34:56Z","timestamp":1030725296000},"page":"33018-33031","source":"Crossref","is-referenced-by-count":28,"title":["Solution NMR Characterization of an Unusual Distal H-bond Network in the Active Site of the Cyanide-inhibited, Human Heme Oxygenase Complex of the Symmetric Substrate, 2,4-Dimethyldeuterohemin"],"prefix":"10.1016","volume":"277","author":[{"given":"Yiming","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray T.","family":"Syvitski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Auclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Wilks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Ortiz de Montellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd N.","family":"La Mar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M204216200_bib1","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1016\/S0021-9258(18)63477-5","volume":"244","author":"Tenhunen","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib2","doi-asserted-by":"crossref","first-page":"6795","DOI":"10.1016\/S0021-9258(18)48315-9","volume":"262","author":"Mueller","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib3","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1016\/S0021-9258(17)34707-5","volume":"253","author":"Yoshida","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1432-1033.1988.tb13811.x","volume":"171","author":"Yoshida","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M204216200_bib5","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1096\/fasebj.2.10.3290025","volume":"2","author":"Maines","year":"1988","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M204216200_bib6","series-title":"Heme-Oxygenase: Clinical Applications and Functions","author":"Maines","year":"1992"},{"key":"10.1074\/jbc.M204216200_bib7","doi-asserted-by":"crossref","first-page":"22357","DOI":"10.1016\/S0021-9258(18)41536-0","volume":"268","author":"Wilks","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib8","doi-asserted-by":"crossref","first-page":"29553","DOI":"10.1016\/S0021-9258(18)43915-4","volume":"269","author":"Wilks","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib9","doi-asserted-by":"crossref","first-page":"22008","DOI":"10.1074\/jbc.272.35.22008","volume":"272","author":"Torpey","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib10","doi-asserted-by":"crossref","first-page":"26067","DOI":"10.1074\/jbc.271.42.26067","volume":"271","author":"Torpey","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1021\/ar960207q","volume":"31","author":"Ortiz de Montellano","year":"1998","journal-title":"Acc. Chem. Res."},{"key":"10.1074\/jbc.M204216200_bib12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0898-8838(00)51007-1","volume":"51","author":"Ortiz de Montellano","year":"2000","journal-title":"Adv. Inorg. Chem."},{"key":"10.1074\/jbc.M204216200_bib13","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1021\/ja0122391","volume":"124","author":"Davydov","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M204216200_bib14","doi-asserted-by":"crossref","first-page":"13734","DOI":"10.1021\/bi00250a026","volume":"33","author":"Sun","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M204216200_bib15","doi-asserted-by":"crossref","first-page":"14151","DOI":"10.1021\/bi00214a012","volume":"32","author":"Sun","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M204216200_bib16","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/S0021-9258(17)42212-5","volume":"269","author":"Takahashi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib17","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1021\/bi00184a023","volume":"33","author":"Takahashi","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M204216200_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0014-5793(00)01353-3","volume":"471","author":"Sugishima","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M204216200_bib19","first-page":"317","volume":"1","author":"Schuller","year":"2001"},{"key":"10.1074\/jbc.M204216200_bib20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/12319","volume":"6","author":"Schuller","year":"1999","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M204216200_bib21","doi-asserted-by":"crossref","unstructured":"Ortiz de Montellano, P. R. (ed) (1995) Cytochrome P450: Structure, Mechanism, and Biochemistry, 2nd Ed., pp. 245\u2013304, Plenum Press, New York","DOI":"10.1007\/978-1-4757-2391-5"},{"key":"10.1074\/jbc.M204216200_bib22","doi-asserted-by":"crossref","first-page":"10612","DOI":"10.1074\/jbc.M010349200","volume":"276","author":"Koenigs Lightning","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib23","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.1021\/ja010490a","volume":"123","author":"Fujii","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M204216200_bib24","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1021\/bi00187a033","volume":"33","author":"Hern\u00e1ndez","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M204216200_bib25","doi-asserted-by":"crossref","first-page":"8875","DOI":"10.1021\/ja9815475","volume":"120","author":"Gorst","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M204216200_bib26","doi-asserted-by":"crossref","first-page":"15676","DOI":"10.1074\/jbc.M009974200","volume":"276","author":"La Mar","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib27","first-page":"185","volume":"5","author":"La Mar","year":"1999"},{"key":"10.1074\/jbc.M204216200_bib28","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1021\/cr00024a009","volume":"93","author":"Bertini","year":"1993","journal-title":"Chem. Rev."},{"key":"10.1074\/jbc.M204216200_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0010-8545(96)01241-6","volume":"150","author":"Bertini","year":"1996","journal-title":"Coord. Chem. Rev."},{"key":"10.1074\/jbc.M204216200_bib30","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1021\/ja982555o","volume":"121","author":"Nguyen","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M204216200_bib31","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.1021\/ja00127a013","volume":"117","author":"Takahashi","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M204216200_bib32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/(SICI)1097-0134(19990515)35:3<275::AID-PROT1>3.0.CO;2-V","volume":"35","author":"Harris","year":"1999","journal-title":"Proteins Struct. Funct. Genet."},{"key":"10.1074\/jbc.M204216200_bib33","doi-asserted-by":"crossref","first-page":"21319","DOI":"10.1074\/jbc.274.30.21319","volume":"274","author":"Chu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib34","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1128\/JB.182.23.6783-6790.2000","volume":"182","author":"Zhu","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M204216200_bib35","doi-asserted-by":"crossref","first-page":"11552","DOI":"10.1021\/bi0110239","volume":"40","author":"Schuller","year":"2001","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M204216200_bib36","doi-asserted-by":"crossref","unstructured":"Smith, K. M., and Kehres, L. A. (1983) J. Chem. Soc. Perkin Trans. I 2329\u20132335","DOI":"10.1039\/P19830002329"},{"key":"10.1074\/jbc.M204216200_bib37","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1063\/1.438208","volume":"71","author":"Jeener","year":"1979","journal-title":"J. Chem. Phys."},{"key":"10.1074\/jbc.M204216200_bib38","first-page":"355","volume":"65","author":"Griesinger","year":"1988","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M204216200_bib39","first-page":"355","volume":"65","author":"Bax","year":"1985","journal-title":"J. Magn. Reson."},{"key":"10.1074\/jbc.M204216200_bib40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0022-2836(85)90013-0","volume":"183","author":"Williams","year":"1985","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M204216200_bib41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/bip.1979.360180206","volume":"18","author":"Bundi","year":"1979","journal-title":"Biopolymers"},{"key":"10.1074\/jbc.M204216200_bib42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0022-2836(91)90214-Q","volume":"222","author":"Wishart","year":"1991","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M204216200_bib43","first-page":"220","volume":"64","author":"Cross","year":"1985","journal-title":"J. Magn. Reson."},{"key":"10.1074\/jbc.M204216200_bib44","series-title":"NMR of Proteins and Nucleic Acids","first-page":"130","author":"Wu\u00a8thrich","year":"1986"},{"key":"10.1074\/jbc.M204216200_bib45","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1021\/ja00278a033","volume":"108","author":"La Mar","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M204216200_bib46","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s007750050271","volume":"3","author":"Shokhirev","year":"1998","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1074\/jbc.M204216200_bib47","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/bi00013a034","volume":"34","author":"Wilks","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M204216200_bib48","series-title":"An Introduction to Hydrogen Bonding","author":"Jeffrey","year":"1997"},{"key":"10.1074\/jbc.M204216200_bib49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.bb.21.060192.001331","volume":"21","author":"Englander","year":"1992","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1074\/jbc.M204216200_bib50","doi-asserted-by":"crossref","first-page":"24490","DOI":"10.1074\/jbc.274.35.24490","volume":"274","author":"Chu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204216200_bib51","doi-asserted-by":"crossref","first-page":"34501","DOI":"10.1074\/jbc.M004245200","volume":"275","author":"Liu","year":"2000","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820744534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820744534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M204216200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T10:19:23Z","timestamp":1641377963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820744534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":51,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S0021925820744534"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m204216200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}