{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:45:43Z","timestamp":1791283543338,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":6596,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1074\/jbc.m205189200","type":"journal-article","created":{"date-parts":[[2002,9,6]],"date-time":"2002-09-06T20:43:06Z","timestamp":1031344986000},"page":"34549-34555","source":"Crossref","is-referenced-by-count":118,"title":["Targeted Disruption of Np95 Gene Renders Murine Embryonic Stem Cells Hypersensitive to DNA Damaging Agents and DNA Replication Blocks"],"prefix":"10.1016","volume":"277","author":[{"given":"Masahiro","family":"Muto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyoshi","family":"Kanari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamami","family":"Takabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Fujimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M205189200_bib1","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1126\/science.274.5293.1664","volume":"274","author":"Elledge","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M205189200_bib2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1126\/science.2683079","volume":"246","author":"Hartwell","year":"1989","journal-title":"Science"},{"key":"10.1074\/jbc.M205189200_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/35044005","volume":"408","author":"Zhou","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M205189200_bib4","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1126\/science.7997877","volume":"266","author":"Hartwell","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.M205189200_bib5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2184.1995.tb00051.x","volume":"28","author":"Muto","year":"1995","journal-title":"Cell Prolif."},{"key":"10.1074\/jbc.M205189200_bib6","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s003359900920","volume":"9","author":"Fujimori","year":"1998","journal-title":"Mamm. Genome"},{"key":"10.1074\/jbc.M205189200_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1247\/csf.25.149","volume":"25","author":"Uemura","year":"2000","journal-title":"Cell Struct. Funct."},{"key":"10.1074\/jbc.M205189200_bib8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1006\/excr.2000.5115","volume":"263","author":"Miura","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M205189200_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0896-6273(95)90238-4","volume":"14","author":"Gomi","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.M205189200_bib10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/326292a0","volume":"326","author":"Hooper","year":"1987","journal-title":"Nature"},{"key":"10.1074\/jbc.M205189200_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0092-8674(93)90112-4","volume":"72","author":"Itohara","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M205189200_bib12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/251156a0","volume":"251","author":"Perry","year":"1974","journal-title":"Nature"},{"key":"10.1074\/jbc.M205189200_bib13","first-page":"147","volume":"184","author":"Kurihara","year":"1987","journal-title":"Mutat. Res."},{"key":"10.1074\/jbc.M205189200_bib14","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1126\/science.277.5334.1996","volume":"277","author":"Chuang","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M205189200_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1242\/jcs.103.1.97","volume":"103","author":"Humbert","year":"1992","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M205189200_bib16","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/bies.950191106","volume":"19","author":"Jonsson","year":"1997","journal-title":"Bioessays"},{"key":"10.1074\/jbc.M205189200_bib17","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0092-8674(94)90014-0","volume":"79","author":"Krishna","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.M205189200_bib18","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/371534a0","volume":"371","author":"Li","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M205189200_bib19","doi-asserted-by":"crossref","first-page":"13856","DOI":"10.1016\/S0021-9258(18)80079-5","volume":"264","author":"Morris","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M205189200_bib20","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.274.5293.1659","volume":"274","author":"Stillman","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M205189200_bib21","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/369574a0","volume":"369","author":"Waga","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M205189200_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/emboj\/17.1.159","volume":"17","author":"Cliby","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M205189200_bib23","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1073\/pnas.95.13.7445","volume":"95","author":"Wright","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M205189200_bib24","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1073\/pnas.77.12.7315","volume":"77","author":"Painter","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M205189200_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0027-5107(81)90190-1","volume":"80","author":"Wit","year":"1981","journal-title":"Mutat Res"},{"key":"10.1074\/jbc.M205189200_bib26","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1080\/09553009414552001","volume":"66","author":"Kleijer","year":"1994","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1074\/jbc.M205189200_bib27","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1080\/09553000110069335","volume":"77","author":"Paunesku","year":"2001","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1074\/jbc.M205189200_bib28","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/j.1460-2075.1992.tb05179.x","volume":"11","author":"Al-Khodairy","year":"1992","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M205189200_bib29","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1101\/gad.12.18.2956","volume":"12","author":"Desany","year":"1998","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M205189200_bib30","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1002\/j.1460-2075.1996.tb01054.x","volume":"15","author":"Bentley","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M205189200_bib31","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1101\/gad.8.6.652","volume":"8","author":"Weinert","year":"1994","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M205189200_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0092-8674(00)81597-4","volume":"94","author":"Weinert","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M205189200_bib33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/35087607","volume":"412","author":"Tercero","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M205189200_bib34","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1073\/pnas.93.7.2850","volume":"93","author":"Cimprich","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M205189200_bib35","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1101\/gad.840500","volume":"14","author":"Liu","year":"2000","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M205189200_bib36","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1101\/gad.14.12.1439","volume":"14","author":"Takai","year":"2000","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M205189200_bib37","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1101\/gad.14.8.927","volume":"14","author":"Wang","year":"2000","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M205189200_bib38","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1038\/sj.onc.1203971","volume":"19","author":"Scully","year":"2000","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M205189200_bib39","doi-asserted-by":"crossref","first-page":"17276","DOI":"10.1074\/jbc.M011681200","volume":"276","author":"Gatei","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M205189200_bib40","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1101\/gad.851000","volume":"14","author":"Tibbetts","year":"2000","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M205189200_bib41","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0092-8674(00)81847-4","volume":"88","author":"Scully","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M205189200_bib42","first-page":"5037","volume":"60","author":"Chen","year":"2000","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M205189200_bib43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0165-4608(99)00191-0","volume":"118","author":"Roy","year":"2000","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1074\/jbc.M205189200_bib44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/mutage\/11.2.183","volume":"11","author":"Cleaver","year":"1996","journal-title":"Mutagenesis"},{"key":"10.1074\/jbc.M205189200_bib45","doi-asserted-by":"crossref","first-page":"5166","DOI":"10.1128\/MCB.19.7.5166","volume":"19","author":"Sonoda","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M205189200_bib46","first-page":"301","author":"German","year":"1998"},{"key":"10.1074\/jbc.M205189200_bib47","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1101\/gad.11.18.2347","volume":"11","author":"Wang","year":"1997","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M205189200_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1097-2765(00)80108-2","volume":"2","author":"Li","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M205189200_bib49","first-page":"6160","volume":"10","author":"Thompson","year":"1990","journal-title":"Mol. Cell. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820743565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820743565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M205189200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T10:32:53Z","timestamp":1682332373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820743565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":49,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S0021925820743565"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m205189200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}