{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:23:53Z","timestamp":1791113033533,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"38","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":6619,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1074\/jbc.m205838200","type":"journal-article","created":{"date-parts":[[2002,9,14]],"date-time":"2002-09-14T16:41:40Z","timestamp":1032021700000},"page":"35364-35370","source":"Crossref","is-referenced-by-count":300,"title":["Phosphatidylinositol 3-Kinase\/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin"],"prefix":"10.1016","volume":"277","author":[{"given":"Han C.","family":"Dan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Mei","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien Chen","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nellist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond S.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dicky J.J.","family":"Halley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo V.","family":"Nicosia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J.","family":"Pledger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Q.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M205838200_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s004390000348","volume":"107","author":"Cheadle","year":"2000","journal-title":"Hum. Genet."},{"key":"10.1074\/jbc.M205838200_bib2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","volume":"277","author":"van Slegtenhorst","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M205838200_bib3","first-page":"4766","volume":"58","author":"Plank","year":"1998","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M205838200_bib4","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/hmg\/7.6.1053","volume":"7","author":"van Slegtenhorst","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M205838200_bib5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1383-5742(01)00058-8","volume":"488","author":"Hengstschlager","year":"2001","journal-title":"Mutat. Res."},{"key":"10.1074\/jbc.M205838200_bib6","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1093\/hmg\/10.25.2899","volume":"10","author":"Hodges","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M205838200_bib7","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0092-8674(93)90618-Z","volume":"75","author":"Nellist","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M205838200_bib8","doi-asserted-by":"crossref","first-page":"21017","DOI":"10.1074\/jbc.C100136200","volume":"276","author":"Aicher","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M205838200_bib9","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1093\/hmg\/10.25.2889","volume":"10","author":"Nellist","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M205838200_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0092-8674(01)00333-6","volume":"105","author":"Potter","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M205838200_bib11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(01)00332-4","volume":"105","author":"Tapon","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M205838200_bib12","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1101\/gad.901101","volume":"15","author":"Gao","year":"2001","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M205838200_bib13","first-page":"PE36","volume":"105","author":"Montagne","year":"2001","journal-title":"Sci. STKE"},{"key":"10.1074\/jbc.M205838200_bib14","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1146\/annurev.biochem.68.1.965","volume":"68","author":"Chan","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M205838200_bib15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0968-0004(01)01958-2","volume":"26","author":"Brazil","year":"2001","journal-title":"Trends. Biochem. Sci."},{"key":"10.1074\/jbc.M205838200_bib16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0959-4388(00)00211-7","volume":"11","author":"Brunet","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1074\/jbc.M205838200_bib17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0002-9440(10)61714-2","volume":"159","author":"Sun","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M205838200_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1128\/MCB.20.1.139-148.2000","volume":"20","author":"Jiang","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M205838200_bib19","doi-asserted-by":"crossref","first-page":"35647","DOI":"10.1074\/jbc.274.50.35647","volume":"274","author":"Nellist","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M205838200_bib20","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1073\/pnas.95.26.15653","volume":"95","author":"Soucek","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M205838200_bib21","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1038\/sj.onc.1204627","volume":"20","author":"Soucek","year":"2001","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M205838200_bib22","doi-asserted-by":"crossref","first-page":"21976","DOI":"10.1074\/jbc.M009788200","volume":"276","author":"Mohapatra","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M205838200_bib23","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/35008115","volume":"404","author":"Medema","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M205838200_bib24","doi-asserted-by":"crossref","first-page":"39223","DOI":"10.1074\/jbc.M007291200","volume":"275","author":"Gesbert","year":"2000","journal-title":"J. Biol. Chem."}],"updated-by":[{"DOI":"10.1074\/jbc.a116.205838","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"record-id":"377"},{"DOI":"10.1074\/jbc.a116.205838","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000}}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818367723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818367723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M205838200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T21:36:18Z","timestamp":1640986578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818367723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":24,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S0021925818367723"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m205838200","relation":{"correction":[{"id-type":"doi","id":"10.1074\/jbc.A116.205838","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}