{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:35:40Z","timestamp":1789378540542,"version":"build-2803163510"},"reference-count":69,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":6443,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1074\/jbc.m206278200","type":"journal-article","created":{"date-parts":[[2003,2,28]],"date-time":"2003-02-28T23:24:20Z","timestamp":1046474660000},"page":"8065-8074","source":"Crossref","is-referenced-by-count":66,"title":["The FAR Protein Family of the Nematode Caenorhabditis elegans"],"prefix":"10.1016","volume":"278","author":[{"given":"Antonio","family":"Garofalo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claire","family":"Rowlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngwa A.","family":"Amambua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas C.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm W.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janette E.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M206278200_bib1","series-title":"Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology","first-page":"309","author":"Kennedy","year":"2001"},{"key":"10.1074\/jbc.M206278200_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0167-4838(99)00249-6","volume":"1476","author":"Kennedy","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M206278200_bib3","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1471-4922(01)02036-0","volume":"17","author":"Bradley","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1074\/jbc.M206278200_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3180001","volume":"318","author":"Flower","year":"1996","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M206278200_bib5","doi-asserted-by":"crossref","first-page":"9933","DOI":"10.1074\/jbc.272.15.9933","volume":"272","author":"Mei","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206278200_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1388-1981(00)00046-9","volume":"1486","author":"Storch","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M206278200_bib7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0169-4758(00)01743-9","volume":"16","author":"Kennedy","year":"2000","journal-title":"Parasitol. Today"},{"key":"10.1074\/jbc.M206278200_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0166-6851(94)00204-Z","volume":"69","author":"Tree","year":"1995","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M206278200_bib9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1042\/bj3560387","volume":"356","author":"Prior","year":"2001","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M206278200_bib10","doi-asserted-by":"crossref","first-page":"29442","DOI":"10.1074\/jbc.272.47.29442","volume":"272","author":"Kennedy","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206278200_bib11","series-title":"The Retinoids","first-page":"443","author":"Gudas","year":"1994"},{"key":"10.1074\/jbc.M206278200_bib12","first-page":"11","volume":"15","author":"Bradley","year":"1999","journal-title":"Retinoids"},{"key":"10.1074\/jbc.M206278200_bib13","author":"Garofalo","year":"2003","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1074\/jbc.M206278200_bib14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF00927666","volume":"67","author":"Storey","year":"1982","journal-title":"Z. Parasitenkd."},{"key":"10.1074\/jbc.M206278200_bib15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/bj2140367","volume":"214","author":"Comley","year":"1983","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M206278200_bib16","first-page":"322","volume":"40","author":"Zahner","year":"1989","journal-title":"Trop. Med. Parasitol."},{"key":"10.1074\/jbc.M206278200_bib17","first-page":"169","volume":"41","author":"Lok","year":"1990","journal-title":"Trop. Med. Parasitol."},{"key":"10.1074\/jbc.M206278200_bib18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/expr.1995.1034","volume":"80","author":"Wolff","year":"1995","journal-title":"Exp. Parasitol."},{"key":"10.1074\/jbc.M206278200_bib19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0140-6736(93)92478-C","volume":"341","author":"Semba","year":"1993","journal-title":"Lancet"},{"key":"10.1074\/jbc.M206278200_bib20","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.4049\/jimmunol.152.4.1515","volume":"152","author":"Cantorna","year":"1994","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M206278200_bib21","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.4049\/jimmunol.156.8.2674","volume":"156","author":"Cantorna","year":"1996","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M206278200_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.nutr.21.1.167","volume":"21","author":"Stephensen","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"10.1074\/jbc.M206278200_bib23","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.4049\/jimmunol.168.9.4495","volume":"168","author":"Stephensen","year":"2002","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M206278200_bib24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1084\/jem.175.1.111","volume":"175","author":"Carman","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M206278200_bib25","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1093\/jn\/129.5.934","volume":"129","author":"Nikawa","year":"1999","journal-title":"J. Nutr."},{"key":"10.1074\/jbc.M206278200_bib26","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1126\/science.282.5396.2041","volume":"282","author":"Blaxter","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M206278200_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0166-6851(02)00097-X","volume":"122","author":"Garofalo","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M206278200_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0166-6851(02)00253-0","volume":"126","author":"Basavaraju","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M206278200_bib29","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1126\/science.282.5396.2012","volume":"282","author":"Consortium, T. C. e. S.","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M206278200_bib30","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M206278200_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1074\/jbc.M206278200_bib32","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"2001"},{"key":"10.1074\/jbc.M206278200_bib33","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1002\/j.1460-2075.1996.tb00732.x","volume":"15","author":"Johnstone","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M206278200_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/dna.1996.15.75","volume":"15","author":"Larminie","year":"1996","journal-title":"DNA Cell Biol."},{"key":"10.1074\/jbc.M206278200_bib35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1432-1033.1976.tb10390.x","volume":"65","author":"Cogan","year":"1976","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M206278200_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1021\/bi00504a006","volume":"20","author":"Provencher","year":"1981","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M206278200_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/abio.1993.1079","volume":"209","author":"Sreerama","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M206278200_bib38","first-page":"137","volume":"22","author":"Cooper","year":"1994","journal-title":"Methods Mol. Biol."},{"key":"10.1074\/jbc.M206278200_bib39","series-title":"Protein-Ligand Interactions: Hydrodynamics and Calorimetry","first-page":"287","author":"Cooper","year":"2000"},{"key":"10.1074\/jbc.M206278200_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/protein\/10.1.1","volume":"10","author":"Nielsen","year":"1997","journal-title":"Protein Eng."},{"key":"10.1074\/jbc.M206278200_bib41","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0888-7543(05)80111-9","volume":"14","author":"Nakai","year":"1992","journal-title":"Genomics"},{"key":"10.1074\/jbc.M206278200_bib42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/30.1.235","volume":"30","author":"Falquet","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M206278200_bib43","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M206278200_bib44","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/bioinformatics\/14.10.892","volume":"14","author":"Cuff","year":"1998","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M206278200_bib45","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1073\/pnas.94.13.6815","volume":"94","author":"Strimmer","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M206278200_bib46","first-page":"164","volume":"5","author":"Felsenstein","year":"1989","journal-title":"Cladistics"},{"key":"10.1074\/jbc.M206278200_bib47","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/319070a0","volume":"319","author":"Macgregor","year":"1986","journal-title":"Nature"},{"key":"10.1074\/jbc.M206278200_bib48","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/bj2380419","volume":"238","author":"Wilkinson","year":"1986","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M206278200_bib49","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0167-4838(99)00133-8","volume":"1433","author":"Gasymov","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M206278200_bib50","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1042\/bj3560369","volume":"356","author":"Suire","year":"2001","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M206278200_bib51","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1021\/bi00020a015","volume":"34","author":"Kennedy","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M206278200_bib52","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0022-2836(89)90392-6","volume":"208","author":"Sacchettini","year":"1989","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M206278200_bib53","doi-asserted-by":"crossref","first-page":"18541","DOI":"10.1016\/S0021-9258(19)36996-0","volume":"267","author":"Zanotti","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206278200_bib54","doi-asserted-by":"crossref","first-page":"7874","DOI":"10.1016\/S0021-9258(18)53039-8","volume":"268","author":"Xu","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206278200_bib55","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0005-2760(97)00205-1","volume":"1391","author":"Coe","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M206278200_bib56","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.1074\/jbc.272.11.7140","volume":"272","author":"Thompson","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206278200_bib57","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/bj2970103","volume":"297","author":"Thumser","year":"1994","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M206278200_bib58","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj3490377","volume":"349","author":"Kennedy","year":"2000","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M206278200_bib59","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1126\/science.252.5009.1162","volume":"252","author":"Lupas","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M206278200_bib60","doi-asserted-by":"crossref","first-page":"13253","DOI":"10.1016\/S0021-9258(18)90686-1","volume":"259","author":"Lau","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206278200_bib61","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1021\/bi00140a008","volume":"31","author":"Zhou","year":"1992","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M206278200_bib62","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/S0021-9258(18)45932-7","volume":"267","author":"Zhou","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206278200_bib63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/genetics\/91.1.67","volume":"91","author":"Hodgkin","year":"1979","journal-title":"Genetics"},{"key":"10.1074\/jbc.M206278200_bib64","first-page":"4119","volume":"9","author":"Bird","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M206278200_bib65","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1073\/pnas.98.1.218","volume":"98","author":"Jiang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M206278200_bib66","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0163-7827(96)00006-9","volume":"35","author":"Glatz","year":"1996","journal-title":"Prog. Lipid Res."},{"key":"10.1074\/jbc.M206278200_bib67","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0091-679X(08)61381-3","volume":"48","author":"Lewis","year":"1995","journal-title":"Methods Cell Biol."},{"key":"10.1074\/jbc.M206278200_bib68","series-title":"C. elegans: A Practical Approach","first-page":"51","author":"Stiernagle","year":"1999"},{"key":"10.1074\/jbc.M206278200_bib69","first-page":"345","volume":"5","author":"Dayhoff","year":"1978"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820864217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820864217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M206278200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T05:52:22Z","timestamp":1704779542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820864217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["S0021925820864217"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m206278200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}