{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:10:33Z","timestamp":1791101433242,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":6619,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1074\/jbc.m206314200","type":"journal-article","created":{"date-parts":[[2002,9,20]],"date-time":"2002-09-20T18:02:52Z","timestamp":1032544972000},"page":"36740-36747","source":"Crossref","is-referenced-by-count":64,"title":["Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and \u03b2-Cell Compensation to Insulin Resistance"],"prefix":"10.1016","volume":"277","author":[{"given":"Yoshiaki","family":"Kido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nakae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Letizia","family":"Hribal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhong","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argiris","family":"Efstratiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Accili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M206314200_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/1566524013364040","volume":"1","author":"Accili","year":"2001","journal-title":"Curr. Mol. Med."},{"key":"10.1074\/jbc.M206314200_bib2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0092-8674(01)00239-2","volume":"104","author":"Saltiel","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M206314200_bib3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/3112","volume":"20","author":"Lauro","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M206314200_bib4","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1097-2765(00)80155-0","volume":"2","author":"Bruning","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M206314200_bib5","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.908001","volume":"15","author":"Fernandez","year":"2001","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M206314200_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0092-8674(00)80546-2","volume":"96","author":"Kulkarni","year":"1999","journal-title":"Cell"},{"key":"10.1074\/jbc.M206314200_bib7","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S1097-2765(01)00251-9","volume":"7","author":"Mu","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M206314200_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng872","volume":"31","author":"Kulkarni","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M206314200_bib9","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1172\/JCI8339","volume":"104","author":"Kulkarni","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M206314200_bib10","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/36116","volume":"391","author":"Withers","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M206314200_bib11","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1210\/endo.141.6.7567","volume":"141","author":"Bonner-Weir","year":"2000","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M206314200_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0196-106","volume":"12","author":"Accili","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M206314200_bib13","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1002\/j.1460-2075.1996.tb00498.x","volume":"15","author":"Joshi","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M206314200_bib14","first-page":"59","volume":"75","author":"Liu","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M206314200_bib15","first-page":"955","volume":"42","author":"Efstratiadis","year":"1998","journal-title":"Int. J. Dev. Biol."},{"key":"10.1074\/jbc.M206314200_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/dbio.1997.8666","volume":"189","author":"Louvi","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1074\/jbc.M206314200_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1006\/dbio.1996.0182","volume":"177","author":"Ludwig","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1074\/jbc.M206314200_bib18","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1172\/JCI119438","volume":"99","author":"Di Cola","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M206314200_bib19","doi-asserted-by":"crossref","first-page":"17491","DOI":"10.1074\/jbc.273.28.17491","volume":"273","author":"Rother","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206314200_bib20","doi-asserted-by":"crossref","first-page":"7517","DOI":"10.1021\/bi9830718","volume":"38","author":"Park","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M206314200_bib21","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/emboj\/19.5.989","volume":"19","author":"Nakae","year":"2000","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M206314200_bib22","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1210\/endo.142.8.8332","volume":"142","author":"Kim","year":"2001","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M206314200_bib23","doi-asserted-by":"crossref","first-page":"24325","DOI":"10.1074\/jbc.272.39.24325","volume":"272","author":"Kalloo-Hosein","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206314200_bib24","doi-asserted-by":"crossref","first-page":"30864","DOI":"10.1074\/jbc.274.43.30864","volume":"274","author":"Urso","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206314200_bib25","series-title":"Genetic Manipulation of Receptor Expression and Function","first-page":"129","author":"Kulkarni","year":"2000"},{"key":"10.1074\/jbc.M206314200_bib26","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.2337\/diab.39.9.1028","volume":"39","author":"Dohm","year":"1990","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M206314200_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-1-4684-5949-4_25","volume":"293","author":"Bilan","year":"1991","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1074\/jbc.M206314200_bib28","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2337\/diab.45.7.869","volume":"45","author":"Jullien","year":"1996","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M206314200_bib29","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1172\/JCI7961","volume":"104","author":"Wojtaszewski","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M206314200_bib30","doi-asserted-by":"crossref","first-page":"20791","DOI":"10.1074\/jbc.274.30.20791","volume":"274","author":"Higaki","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206314200_bib31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2337\/diabetes.49.4.589","volume":"49","author":"Kido","year":"2000","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M206314200_bib32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1172\/JCI7917","volume":"105","author":"Kido","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M206314200_bib33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(05)80085-6","volume":"75","author":"Baker","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M206314200_bib34","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1101\/gad.11.23.3128","volume":"11","author":"Eggenschwiler","year":"1997","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M206314200_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1101\/gad.859401","volume":"15","author":"Kim","year":"2001","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M206314200_bib36","first-page":"3604","volume":"14","author":"Sell","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M206314200_bib37","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0092-8674(00)81896-6","volume":"88","author":"Bruning","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M206314200_bib38","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/dev.129.10.2447","volume":"129","author":"Gu","year":"2002","journal-title":"Development"},{"key":"10.1074\/jbc.M206314200_bib39","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.97.4.1607","volume":"97","author":"Gradwohl","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M206314200_bib40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/386399a0","volume":"386","author":"Sosa-Pineda","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M206314200_bib41","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/387406a0","volume":"387","author":"St-Onge","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M206314200_bib42","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1101\/gad.11.18.2323","volume":"11","author":"Naya","year":"1997","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M206314200_bib43","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1242\/dev.125.12.2213","volume":"125","author":"Sussel","year":"1998","journal-title":"Development"},{"key":"10.1074\/jbc.M206314200_bib44","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/35048589","volume":"408","author":"Hart","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M206314200_bib45","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1172\/JCI5656","volume":"105","author":"Devedjian","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M206314200_bib46","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1172\/JCI0212969","volume":"109","author":"George","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M206314200_bib47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/12631","volume":"23","author":"Withers","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M206314200_bib48","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1074\/jbc.275.2.1226","volume":"275","author":"Garcia-Ocana","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206314200_bib49","doi-asserted-by":"crossref","first-page":"15399","DOI":"10.1074\/jbc.275.20.15399","volume":"275","author":"Vasavada","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M206314200_bib50","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1172\/JCI14454","volume":"108","author":"Accili","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M206314200_bib51","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1002\/j.1460-2075.1996.tb00806.x","volume":"15","author":"Krapp","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M206314200_bib52","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1101\/gad.12.23.3752","volume":"12","author":"Krapp","year":"1998","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M206314200_bib53","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0197-106","volume":"15","author":"Stoffers","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M206314200_bib54","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/371606a0","volume":"371","author":"Jonsson","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M206314200_bib55","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1242\/dev.122.5.1409","volume":"122","author":"Ahlgren","year":"1996","journal-title":"Development"},{"key":"10.1074\/jbc.M206314200_bib56","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1242\/dev.122.3.983","volume":"122","author":"Offield","year":"1996","journal-title":"Development"},{"key":"10.1074\/jbc.M206314200_bib57","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1101\/gad.12.12.1763","volume":"12","author":"Ahlgren","year":"1998","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M206314200_bib58","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1242\/dev.120.12.3451","volume":"120","author":"Sanvito","year":"1994","journal-title":"Development"},{"key":"10.1074\/jbc.M206314200_bib59","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1242\/dev.122.2.439","volume":"122","author":"Gittes","year":"1996","journal-title":"Development"},{"key":"10.1074\/jbc.M206314200_bib60","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0022-3468(99)90372-X","volume":"34","author":"Rose","year":"1999","journal-title":"J. Pediatr. Surg."},{"key":"10.1074\/jbc.M206314200_bib61","first-page":"409","volume":"73","author":"Vila","year":"1995","journal-title":"Lab. Invest."},{"key":"10.1074\/jbc.M206314200_bib62","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1073\/pnas.96.11.6267","volume":"96","author":"Miralles","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M206314200_bib63","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.2337\/diabetes.47.8.1236","volume":"47","author":"Le Bras","year":"1998","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M206314200_bib64","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1083\/jcb.143.3.827","volume":"143","author":"Miralles","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M206314200_bib65","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1091-255X(00)80075-X","volume":"4","author":"Maldonado","year":"2000","journal-title":"J. Gastrointest. Surg."},{"key":"10.1074\/jbc.M206314200_bib66","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/dev.125.6.1017","volume":"125","author":"Miralles","year":"1998","journal-title":"Development"},{"key":"10.1074\/jbc.M206314200_bib67","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1128\/MCB.19.5.3278","volume":"19","author":"Frasca","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M206314200_bib68","doi-asserted-by":"crossref","first-page":"G96","DOI":"10.1152\/ajpcell.1984.246.1.C96","volume":"246","author":"Williams","year":"1984","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M206314200_bib69","doi-asserted-by":"crossref","first-page":"G193","DOI":"10.1152\/ajpcell.1999.276.1.C193","volume":"276","author":"Ludwig","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M206314200_bib70","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1152\/physrev.1996.76.4.1109","volume":"76","author":"O'Brien","year":"1996","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M206314200_bib71","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1242\/dev.121.6.1569","volume":"121","author":"Slack","year":"1995","journal-title":"Development"},{"key":"10.1074\/jbc.M206314200_bib72","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1073\/pnas.88.1.214","volume":"88","author":"Treadway","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M206314200_bib73","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/78693","volume":"6","author":"Zisman","year":"2000","journal-title":"Nat. Med."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818366547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818366547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M206314200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T21:33:16Z","timestamp":1640986396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818366547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":73,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S0021925818366547"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m206314200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}