{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:30:50Z","timestamp":1787005850276,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":6461,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1074\/jbc.m210419200","type":"journal-article","created":{"date-parts":[[2003,2,14]],"date-time":"2003-02-14T14:17:32Z","timestamp":1045232252000},"page":"5984-5992","source":"Crossref","is-referenced-by-count":192,"title":["Familial Amyotrophic Lateral Sclerosis Mutants of Copper\/Zinc Superoxide Dismutase Are Susceptible to Disulfide Reduction"],"prefix":"10.1016","volume":"278","author":[{"given":"Ashutosh","family":"Tiwari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence J.","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M210419200_bib1","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM200105313442207","volume":"344","author":"Rowland","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M210419200_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M210419200_bib3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35097565","volume":"2","author":"Cleveland","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1074\/jbc.M210419200_bib4","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.M210419200_bib5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0896-6273(95)90259-7","volume":"14","author":"Wong","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.M210419200_bib6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1073\/pnas.92.3.689","volume":"92","author":"Ripps","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M210419200_bib7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0896-6273(00)80272-X","volume":"18","author":"Bruijn","year":"1997","journal-title":"Neuron"},{"key":"10.1074\/jbc.M210419200_bib8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s004010050650","volume":"93","author":"Dal Canto","year":"1997","journal-title":"Acta Neuropathol. (Berlin)"},{"key":"10.1074\/jbc.M210419200_bib9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1006\/nbdi.2000.0299","volume":"7","author":"Jaarsma","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M210419200_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ng0596-43","volume":"13","author":"Reaume","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M210419200_bib11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0959-4388(95)80114-6","volume":"5","author":"Brown","year":"1995","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1074\/jbc.M210419200_bib12","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1073\/pnas.132260399","volume":"99","author":"Okado-Matsumoto","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M210419200_bib13","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1073\/pnas.91.17.8292","volume":"91","author":"Borchelt","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M210419200_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0022-510X(96)00031-7","volume":"139","author":"Hoffman","year":"1996","journal-title":"J. Neurol. Sci."},{"key":"10.1074\/jbc.M210419200_bib15","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/hmg\/8.8.1451","volume":"8","author":"Ratovitski","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M210419200_bib16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1046\/j.1471-4159.1999.0720693.x","volume":"72","author":"Bruening","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M210419200_bib17","doi-asserted-by":"crossref","first-page":"12791","DOI":"10.1074\/jbc.M010759200","volume":"276","author":"Shinder","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib18","doi-asserted-by":"crossref","first-page":"15923","DOI":"10.1074\/jbc.M112087200","volume":"277","author":"Hayward","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib19","doi-asserted-by":"crossref","first-page":"15932","DOI":"10.1074\/jbc.M112088200","volume":"277","author":"Rodriguez","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib20","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1074\/jbc.275.2.1007","volume":"275","author":"Goto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib21","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1016\/S0021-9258(19)44055-6","volume":"248","author":"Forman","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib22","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1021\/bi00403a017","volume":"27","author":"Roe","year":"1988","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M210419200_bib23","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1016\/S0021-9258(18)62263-X","volume":"246","author":"Keele","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib24","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.1016\/S0021-9258(19)42109-1","volume":"249","author":"Abernethy","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib25","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1021\/bi00590a005","volume":"18","author":"Malinowski","year":"1979","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M210419200_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0898-8838(08)60026-4","volume":"45","author":"Bertini","year":"1998","journal-title":"Adv. Inorg. Chem."},{"key":"10.1074\/jbc.M210419200_bib27","doi-asserted-by":"crossref","first-page":"11780","DOI":"10.1021\/bi9803473","volume":"37","author":"Banci","year":"1998","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M210419200_bib28","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s007750050353","volume":"4","author":"Banci","year":"1999","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1074\/jbc.M210419200_bib29","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1046\/j.1432-1033.2002.02840.x","volume":"269","author":"Banci","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M210419200_bib30","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0092-8674(89)90043-3","volume":"57","author":"Freedman","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.M210419200_bib31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.micro.51.1.179","volume":"51","author":"Raina","year":"1997","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M210419200_bib32","doi-asserted-by":"crossref","first-page":"30104","DOI":"10.1074\/jbc.273.46.30104","volume":"273","author":"Goto","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib33","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1002\/pro.5560041120","volume":"4","author":"Pace","year":"1995","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M210419200_bib34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M210419200_bib35","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/(SICI)1096-9888(200004)35:4<572::AID-JMS971>3.0.CO;2-2","volume":"35","author":"Lapko","year":"2000","journal-title":"J. Mass Spectrom."},{"key":"10.1074\/jbc.M210419200_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jms.241","volume":"37","author":"Yen","year":"2002","journal-title":"J. Mass Spectrom."},{"key":"10.1074\/jbc.M210419200_bib37","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1089\/152308601317203611","volume":"3","author":"Makmura","year":"2001","journal-title":"Antioxid. Redox Signal."},{"key":"10.1074\/jbc.M210419200_bib38","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1016\/S0021-9258(19)44691-7","volume":"247","author":"Hartz","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0162-0134(00)00212-9","volume":"84","author":"Krezel","year":"2001","journal-title":"J. Inorg. Biochem."},{"key":"10.1074\/jbc.M210419200_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1006\/abio.1994.1290","volume":"220","author":"Han","year":"1994","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M210419200_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/abio.1999.4203","volume":"273","author":"Getz","year":"1999","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M210419200_bib42","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0301-0082(99)00060-X","volume":"62","author":"Dringen","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1074\/jbc.M210419200_bib43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-2236(99)01543-X","volume":"23","author":"Rice","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M210419200_bib44","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0022-2836(82)90174-7","volume":"160","author":"Tainer","year":"1982","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M210419200_bib45","doi-asserted-by":"crossref","first-page":"11182","DOI":"10.1016\/S0021-9258(18)60942-1","volume":"262","author":"Beyer","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/prot.340190105","volume":"19","author":"Fisher","year":"1994","journal-title":"Proteins"},{"key":"10.1074\/jbc.M210419200_bib47","doi-asserted-by":"crossref","first-page":"9108","DOI":"10.1021\/bi000067z","volume":"39","author":"Banci","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M210419200_bib48","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nsb0901-751","volume":"8","author":"Lamb","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M210419200_bib49","doi-asserted-by":"crossref","first-page":"21612","DOI":"10.1016\/S0021-9258(18)45784-5","volume":"265","author":"Lepock","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib50","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1432-1033.1996.0433k.x","volume":"237","author":"Schinina","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M210419200_bib51","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1126\/science.8259521","volume":"262","author":"Derman","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M210419200_bib52","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0014-5793(98)01725-6","volume":"443","author":"Battistoni","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M210419200_bib53","doi-asserted-by":"crossref","first-page":"15661","DOI":"10.1074\/jbc.272.25.15661","volume":"272","author":"Prinz","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M210419200_bib54","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/bbrc.1997.7804","volume":"241","author":"Ogawa","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M210419200_bib55","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1046\/j.1471-4159.2001.t01-1-00231.x","volume":"77","author":"Malaspina","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M210419200_bib56","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1126\/science.286.5449.2498","volume":"286","author":"Estevez","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M210419200_bib57","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nn823","volume":"5","author":"Subramaniam","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M210419200_bib58","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/nbdi.2002.0498","volume":"10","author":"Wang","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M210419200_bib59","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0010-8545(00)00324-6","volume":"202","author":"Williams","year":"2000","journal-title":"Coord. Chem. Rev."},{"key":"10.1074\/jbc.M210419200_bib60","doi-asserted-by":"crossref","first-page":"12571","DOI":"10.1073\/pnas.220417997","volume":"97","author":"Johnston","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M210419200_bib61","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/nbdi.2001.0471","volume":"9","author":"Wang","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M210419200_bib62","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/hmg\/10.19.2013","volume":"10","author":"Oeda","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M210419200_bib63","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1523\/JNEUROSCI.18-09-03241.1998","volume":"18","author":"Kong","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M210419200_bib64","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s100480050010","volume":"1","author":"Zu","year":"1997","journal-title":"Neurogenetics"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820865879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820865879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M210419200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T11:46:27Z","timestamp":1639827987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820865879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":64,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S0021925820865879"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m210419200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}