{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:47:27Z","timestamp":1791283647003,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":6303,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1074\/jbc.m300401200","type":"journal-article","created":{"date-parts":[[2003,7,12]],"date-time":"2003-07-12T13:05:42Z","timestamp":1058015142000},"page":"26929-26937","source":"Crossref","is-referenced-by-count":109,"title":["Ethanol Impairs Insulin-stimulated Neuronal Survival in the Developing Brain"],"prefix":"10.1016","volume":"278","author":[{"given":"Julia","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Eun","family":"Yeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Tison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Wands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"de la Monte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M300401200_bib1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0022-3476(78)80072-9","volume":"92","author":"Clarren","year":"1978","journal-title":"J. Pediatr."},{"key":"10.1074\/jbc.M300401200_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0741-8329(00)00133-6","volume":"23","author":"Maier","year":"2001","journal-title":"Alcohol"},{"key":"10.1074\/jbc.M300401200_bib3","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1046\/j.1471-4159.2000.0750954.x","volume":"75","author":"Minana","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M300401200_bib4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1023\/A:1009685428847","volume":"5","author":"Olney","year":"2000","journal-title":"Apoptosis"},{"key":"10.1074\/jbc.M300401200_bib5","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1530-0277.1995.tb01608.x","volume":"19","author":"Swanson","year":"1995","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M300401200_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0165-3806(00)00015-8","volume":"120","author":"Yanni","year":"2000","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1074\/jbc.M300401200_bib7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/(SICI)1097-4547(19970601)48:5<439::AID-JNR5>3.0.CO;2-F","volume":"48","author":"Liesi","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M300401200_bib8","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1126\/science.287.5455.1056","volume":"287","author":"Ikonomidou","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M300401200_bib9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1046\/j.1471-4159.1998.71010196.x","volume":"71","author":"Zhang","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M300401200_bib10","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1530-0277.2001.tb02296.x","volume":"25","author":"de La Monte","year":"2001","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M300401200_bib11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1007\/s00018-002-8475-x","volume":"59","author":"de la Monte","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M300401200_bib12","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1530-0277.2001.tb02292.x","volume":"25","author":"Ramachandran","year":"2001","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M300401200_bib13","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1007\/PL00000829","volume":"58","author":"de la Monte","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M300401200_bib14","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1210\/endo-114-4-1187","volume":"114","author":"Goodyer","year":"1984","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M300401200_bib15","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0300-9084(85)80113-9","volume":"67","author":"Gammeltoft","year":"1985","journal-title":"Biochimie (Paris)"},{"key":"10.1074\/jbc.M300401200_bib16","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0306-4522(86)90082-5","volume":"17","author":"Hill","year":"1986","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M300401200_bib17","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1530-0277.2000.tb02044.x","volume":"24","author":"de la Monte","year":"2000","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M300401200_bib18","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/j.1530-0277.2001.tb02317.x","volume":"25","author":"Hallak","year":"2001","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M300401200_bib19","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/313756a0","volume":"313","author":"Ullrich","year":"1985","journal-title":"Nature"},{"key":"10.1074\/jbc.M300401200_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0020-711X(90)90132-M","volume":"22","author":"O'Hare","year":"1990","journal-title":"Int. J. Biochem."},{"key":"10.1074\/jbc.M300401200_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0968-0004(94)90007-8","volume":"19","author":"Myers","year":"1994","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M300401200_bib22","first-page":"455","volume":"13","author":"Shpakov","year":"2000","journal-title":"Membr. Cell Biol."},{"key":"10.1074\/jbc.M300401200_bib23","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1126\/science.8316835","volume":"260","author":"Skolnik","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M300401200_bib24","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1126\/science.8391166","volume":"260","author":"Baltensperger","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M300401200_bib25","first-page":"7418","volume":"13","author":"Sun","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M300401200_bib26","doi-asserted-by":"crossref","first-page":"20648","DOI":"10.1016\/S0021-9258(17)32042-2","volume":"269","author":"Lam","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M300401200_bib27","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1006\/excr.1999.4690","volume":"253","author":"Kandel","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M300401200_bib28","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/376599a0","volume":"376","author":"Burgering","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M300401200_bib29","doi-asserted-by":"crossref","first-page":"19929","DOI":"10.1074\/jbc.273.32.19929","volume":"273","author":"Pap","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M300401200_bib30","doi-asserted-by":"crossref","first-page":"13150","DOI":"10.1074\/jbc.273.21.13150","volume":"273","author":"van Weeren","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M300401200_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0092-8674(00)80405-5","volume":"91","author":"Datta","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M300401200_bib32","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1523\/JNEUROSCI.20-07-02567.2000","volume":"20","author":"Hetman","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M300401200_bib33","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.275.5300.661","volume":"275","author":"Dudek","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M300401200_bib34","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1128\/MCB.18.4.2143","volume":"18","author":"Eves","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M300401200_bib35","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1128\/MCB.21.9.3025-3036.2001","volume":"21","author":"Condorelli","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M300401200_bib36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1042\/bst0280170","volume":"28","author":"Halestrap","year":"2000","journal-title":"Biochem. Soc. Trans."},{"key":"10.1074\/jbc.M300401200_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1007486022411","volume":"14","author":"Hirsch","year":"1998","journal-title":"Cell Biol. Toxicol."},{"key":"10.1074\/jbc.M300401200_bib38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/hmg\/8.2.185","volume":"8","author":"Dahia","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M300401200_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0014-4886(87)90280-9","volume":"97","author":"Mohamed","year":"1987","journal-title":"Exp. Neurol."},{"key":"10.1074\/jbc.M300401200_bib40","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0024-3205(81)90752-9","volume":"28","author":"Urso","year":"1981","journal-title":"Life Sci."},{"key":"10.1074\/jbc.M300401200_bib41","series-title":"Current Protocols in Molecular Biology","first-page":"10.16.1","author":"Bonifacino","year":"1988"},{"key":"10.1074\/jbc.M300401200_bib42","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1111\/j.1530-0277.1998.tb05921.x","volume":"22","author":"Banerjee","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M300401200_bib43","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1530-0277.1999.tb04182.x","volume":"23","author":"de la Monte","year":"1999","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M300401200_bib44","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1101\/gad.10.7.816","volume":"10","author":"Nikolic","year":"1996","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M300401200_bib45","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0092-8674(91)90184-Z","volume":"67","author":"Szabo","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.M300401200_bib46","doi-asserted-by":"crossref","first-page":"23621","DOI":"10.1074\/jbc.273.37.23621","volume":"273","author":"Mao","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M300401200_bib47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1042\/bj3100125","volume":"310","author":"Xu","year":"1995","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M300401200_bib48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0065-2571(92)90014-Q","volume":"32","author":"Alexander","year":"1992","journal-title":"Adv. Enzyme Regul."},{"key":"10.1074\/jbc.M300401200_bib49","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1038\/sj.onc.1201153","volume":"14","author":"Ueno","year":"1997","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M300401200_bib50","doi-asserted-by":"crossref","first-page":"11211","DOI":"10.1073\/pnas.95.19.11211","volume":"95","author":"Delcommenne","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M300401200_bib51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0165-0173(98)00009-5","volume":"27","author":"Luo","year":"1998","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1074\/jbc.M300401200_bib52","series-title":"Ethanol and Intracellular Signaling: From Molecules to Behavior","first-page":"75","author":"Wands","year":"2000"},{"key":"10.1074\/jbc.M300401200_bib53","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0306-4522(94)90551-7","volume":"63","author":"Breese","year":"1994","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M300401200_bib54","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1432-1033.1994.tb18550.x","volume":"219","author":"Mueckler","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M300401200_bib55","first-page":"211","volume":"15","author":"Handa","year":"2000","journal-title":"Metab. Brain Dis."},{"key":"10.1074\/jbc.M300401200_bib56","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/j.1530-0277.1995.tb00998.x","volume":"19","author":"Hu","year":"1995","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M300401200_bib57","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/0024-3205(93)90489-P","volume":"53","author":"Singh","year":"1993","journal-title":"Life Sci."},{"key":"10.1074\/jbc.M300401200_bib58","first-page":"657","volume":"71","author":"Resnicoff","year":"1994","journal-title":"Lab. Invest."},{"key":"10.1074\/jbc.M300401200_bib59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1530-0277.2000.tb04583.x","volume":"24","author":"Seiler","year":"2000","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1074\/jbc.M300401200_bib60","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1074\/jbc.272.2.1377","volume":"272","author":"Welham","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M300401200_bib61","doi-asserted-by":"crossref","first-page":"30334","DOI":"10.1074\/jbc.272.48.30334","volume":"272","author":"Yamada","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M300401200_bib62","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1471-4159.2001.00025.x","volume":"76","author":"Seiler","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M300401200_bib63","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"10.1074\/jbc.M300401200_bib64","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.282.5392.1318","volume":"282","author":"Cardone","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M300401200_bib65","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0962-8924(99)01519-6","volume":"9","author":"Maehama","year":"1999","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M300401200_bib66","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1074\/jbc.M009134200","volume":"276","author":"Torres","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M300401200_bib67","doi-asserted-by":"crossref","first-page":"12889","DOI":"10.1074\/jbc.275.17.12889","volume":"275","author":"Nakashima","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M300401200_bib68","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/hmg\/10.6.605","volume":"10","author":"Weng","year":"2001","journal-title":"Hum. Mol. Genet."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820846547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820846547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M300401200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T21:28:40Z","timestamp":1641418120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820846547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":68,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["S0021925820846547"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m300401200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}