{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:59:44Z","timestamp":1791910784033,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":6236,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,9]]},"DOI":"10.1074\/jbc.m301224200","type":"journal-article","created":{"date-parts":[[2003,9,19]],"date-time":"2003-09-19T21:04:12Z","timestamp":1064005452000},"page":"37622-37631","source":"Crossref","is-referenced-by-count":73,"title":["Morphine Negatively Regulates Interferon-\u03b3 Promoter Activity in Activated Murine T Cells through Two Distinct Cyclic AMP-dependent Pathways"],"prefix":"10.1016","volume":"278","author":[{"given":"Jinghua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick A.","family":"Barke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Charboneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horace H.","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabita","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M301224200_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0165-5728(97)00216-6","volume":"83","author":"Risdahl","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1074\/jbc.M301224200_bib2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/095646249200300204","volume":"2","author":"Brettle","year":"1992","journal-title":"Int. J. Std. AIDS"},{"key":"10.1074\/jbc.M301224200_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0163-7258(90)90012-Q","volume":"45","author":"Young","year":"1990","journal-title":"Pharmacol. Ther."},{"key":"10.1074\/jbc.M301224200_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1067\/mai.2002.125979","volume":"110","author":"Reuben","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1074\/jbc.M301224200_bib5","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1189\/jlb.71.5.782","volume":"71","author":"Wang","year":"2002","journal-title":"J. Leukocyte Biol."},{"key":"10.1074\/jbc.M301224200_bib6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1189\/jlb.70.4.527","volume":"70","author":"Wang","year":"2001","journal-title":"J. Leukocyte Biol."},{"key":"10.1074\/jbc.M301224200_bib7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/infdis\/159.3.480","volume":"159","author":"Peterson","year":"1989","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M301224200_bib8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1067\/msy.2001.116033","volume":"130","author":"Roy","year":"2001","journal-title":"Surgery"},{"key":"10.1074\/jbc.M301224200_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.pa.30.040190.001011","volume":"30","author":"Loh","year":"1990","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.M301224200_bib10","first-page":"607","volume":"289","author":"Law","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M301224200_bib11","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1111\/j.1471-4159.1990.tb03151.x","volume":"55","author":"Yu","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M301224200_bib12","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.4049\/jimmunol.157.4.1514","volume":"157","author":"Tamir","year":"1996","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M301224200_bib13","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1182\/blood-2002-06-1665","volume":"101","author":"Grader-Beck","year":"2003","journal-title":"Blood"},{"key":"10.1074\/jbc.M301224200_bib14","doi-asserted-by":"crossref","first-page":"34775","DOI":"10.1074\/jbc.273.52.34775","volume":"273","author":"Sweetser","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301224200_bib15","doi-asserted-by":"crossref","first-page":"26783","DOI":"10.1074\/jbc.271.43.26783","volume":"271","author":"Cippitelli","year":"1996","journal-title":"Biol. Chem."},{"key":"10.1074\/jbc.M301224200_bib16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-5793(02)02316-5","volume":"514","author":"Kaminuma","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M301224200_bib17","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/eji.1830270509","volume":"27","author":"Barbulescu","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M301224200_bib18","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.4049\/jimmunol.160.8.3642","volume":"160","author":"Barbulescu","year":"1998","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M301224200_bib19","doi-asserted-by":"crossref","first-page":"30412","DOI":"10.1074\/jbc.272.48.30412","volume":"272","author":"Sica","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301224200_bib20","first-page":"4357","volume":"12","author":"Fraser","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M301224200_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0169-328X(98)00212-5","volume":"61","author":"Roy","year":"1998","journal-title":"Brain. Res. Mol. Brain Res."},{"key":"10.1074\/jbc.M301224200_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0022-1759(01)00466-5","volume":"258","author":"Gunzer","year":"2001","journal-title":"J. Immunol. Methods"},{"key":"10.1074\/jbc.M301224200_bib23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0039-6060(99)70161-3","volume":"126","author":"Roy","year":"1999","journal-title":"Surgery"},{"key":"10.1074\/jbc.M301224200_bib24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.278.5335.58","volume":"278","author":"Nestler","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M301224200_bib25","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1073\/pnas.72.8.3092","volume":"72","author":"Sharma","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M301224200_bib26","first-page":"127","volume":"33","author":"Nestler","year":"1988","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M301224200_bib27","first-page":"1033","volume":"246","author":"Duman","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M301224200_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0898-6568(01)00214-5","volume":"14","author":"Torgersen","year":"2002","journal-title":"Cell Signal."},{"key":"10.1074\/jbc.M301224200_bib29","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1128\/MCB.19.9.5882","volume":"19","author":"Cass","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M301224200_bib30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.cb.11.110195.002035","volume":"11","author":"Sassone-Corsi","year":"1995","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M301224200_bib31","doi-asserted-by":"crossref","first-page":"31964","DOI":"10.1074\/jbc.271.50.31964","volume":"271","author":"Penix","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301224200_bib32","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.4049\/jimmunol.161.11.6105","volume":"161","author":"Zhang","year":"1998","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M301224200_bib33","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.4049\/jimmunol.162.7.3819","volume":"162","author":"Zhang","year":"1999","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M301224200_bib34","doi-asserted-by":"crossref","first-page":"26815","DOI":"10.1074\/jbc.272.43.26815","volume":"272","author":"Chuang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301224200_bib35","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0301-472X(02)00786-5","volume":"30","author":"Rozenfeld-Granot","year":"2002","journal-title":"Exp. Hematol."},{"key":"10.1074\/jbc.M301224200_bib36","doi-asserted-by":"crossref","first-page":"23534","DOI":"10.1074\/jbc.273.36.23534","volume":"273","author":"Polakiewicz","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301224200_bib37","doi-asserted-by":"crossref","first-page":"12402","DOI":"10.1074\/jbc.273.20.12402","volume":"273","author":"Polakiewicz","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301224200_bib38","first-page":"129","volume":"1072","author":"Angel","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M301224200_bib39","doi-asserted-by":"crossref","first-page":"16483","DOI":"10.1074\/jbc.270.28.16483","volume":"270","author":"Karin","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301224200_bib40","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/MCB.16.3.1247","volume":"16","author":"Raingeaud","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M301224200_bib41","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1002\/j.1460-2075.1993.tb06204.x","volume":"12","author":"Janknecht","year":"1993","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M301224200_bib42","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/j.1460-2075.1995.tb07076.x","volume":"14","author":"Gille","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M301224200_bib43","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s001090050063","volume":"74","author":"Whitmarsh","year":"1996","journal-title":"J. Mol. Med."},{"key":"10.1074\/jbc.M301224200_bib44","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1182\/blood.V98.5.1480","volume":"98","author":"Kiani","year":"2001","journal-title":"Blood"},{"key":"10.1074\/jbc.M301224200_bib45","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0167-5699(95)80083-2","volume":"16","author":"Haraguchi","year":"1995","journal-title":"Immunol. Today"},{"key":"10.1074\/jbc.M301224200_bib46","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1084\/jem.178.5.1483","volume":"178","author":"Penix","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M301224200_bib47","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1006\/bbrc.1998.8415","volume":"245","author":"Roy","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M301224200_bib48","first-page":"753","volume":"299","author":"Jimenez","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M301224200_bib49","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.4049\/jimmunol.167.5.2595","volume":"167","author":"Malmberg","year":"2001","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M301224200_bib50","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1084\/jem.179.3.931","volume":"179","author":"Chen","year":"1994","journal-title":"J. Exp. Med."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820833250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820833250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M301224200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T20:10:20Z","timestamp":1704917420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820833250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":50,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["S0021925820833250"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m301224200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}