{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:48:20Z","timestamp":1790430500634,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":6302,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1074\/jbc.m301232200","type":"journal-article","created":{"date-parts":[[2003,7,3]],"date-time":"2003-07-03T18:11:05Z","timestamp":1057255865000},"page":"25990-25997","source":"Crossref","is-referenced-by-count":74,"title":["Structure-based Inhibitor Discovery against Adenylyl Cyclase Toxins from Pathogenic Bacteria That Cause Anthrax and Whooping Cough"],"prefix":"10.1016","volume":"278","author":[{"given":"Sandriyana","family":"Soelaiman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binqing Q.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Bergson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Sam","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuequan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Mrksich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Shoichet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M301232200_bib1","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1001\/jama.287.17.2236","volume":"287","author":"Inglesby","year":"2002","journal-title":"J. Am. Med. Assoc."},{"key":"10.1074\/jbc.M301232200_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0966-842X(02)02369-7","volume":"10","author":"Mourez","year":"2002","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M301232200_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","volume":"414","author":"Bradley","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M301232200_bib4","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1021\/bi015860m","volume":"41","author":"Mogridge","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301232200_bib5","doi-asserted-by":"crossref","first-page":"10432","DOI":"10.1021\/bi990792d","volume":"38","author":"Miller","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301232200_bib6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/415396a","volume":"415","author":"Drum","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M301232200_bib7","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.280.5364.734","volume":"280","author":"Duesbery","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M301232200_bib8","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1126\/science.1073163","volume":"297","author":"Park","year":"2002","journal-title":"Science"},{"key":"10.1074\/jbc.M301232200_bib9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.micro.55.1.647","volume":"55","author":"Mock","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M301232200_bib10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/n35101998","volume":"414","author":"Pannifer","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M301232200_bib11","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/385833a0","volume":"385","author":"Petosa","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M301232200_bib12","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nbt1001-958","volume":"19","author":"Mourez","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M301232200_bib13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1126\/science.109563","volume":"292","author":"Sellman","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M301232200_bib14","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1073\/pnas.062171599","volume":"99","author":"Cummings","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M301232200_bib15","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/418386a","volume":"418","author":"Tonello","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M301232200_bib16","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1128\/IAI.68.4.1781-1786.2000","volume":"68","author":"Brossier","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M301232200_bib17","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1046\/j.1365-2958.2001.02695.x","volume":"42","author":"Guidi-Rontani","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M301232200_bib18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0966-842X(99)01468-7","volume":"7","author":"Ladant","year":"1999","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M301232200_bib19","doi-asserted-by":"crossref","first-page":"13899","DOI":"10.1073\/pnas.95.23.13899","volume":"95","author":"Yahr","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M301232200_bib20","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1128\/iai.58.10.3445-3447.1990","volume":"58","author":"Goodwin","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M301232200_bib21","first-page":"17","volume":"85","author":"Michankin","year":"1992","journal-title":"Bull. Soc. Pathol. Exot."},{"key":"10.1074\/jbc.M301232200_bib22","first-page":"59","volume":"7","author":"Shevchenko","year":"1987","journal-title":"Zh. Mikrobiol. Epidemiol. Immunobiol."},{"key":"10.1074\/jbc.M301232200_bib23","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/35097083","volume":"413","author":"Parkhill","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M301232200_bib24","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/pro.5560070411","volume":"7","author":"Lorber","year":"1998","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M301232200_bib25","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1110\/ps.2830102","volume":"11","author":"Lorber","year":"2002","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M301232200_bib26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/(SICI)1097-0134(19990101)34:1<4::AID-PROT2>3.0.CO;2-6","volume":"34","author":"Shoichet","year":"1999","journal-title":"Proteins"},{"key":"10.1074\/jbc.M301232200_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0022-2836(02)00777-5","volume":"322","author":"Wei","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M301232200_bib28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0022-2836(82)90153-X","volume":"161","author":"Kuntz","year":"1982","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M301232200_bib29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jcc.540130412","volume":"13","author":"Meng","year":"1992","journal-title":"J. Comput. Chem."},{"key":"10.1074\/jbc.M301232200_bib30","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/jcc.540130311","volume":"13","author":"Shoichet","year":"1992","journal-title":"J. Comput. Chem."},{"key":"10.1074\/jbc.M301232200_bib31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jcc.540120405","volume":"12","author":"Nicholls","year":"1991","journal-title":"J. Comput. Chem."},{"key":"10.1074\/jbc.M301232200_bib32","doi-asserted-by":"crossref","first-page":"16385","DOI":"10.1021\/jp9610776","volume":"100","author":"Chambers","year":"1996","journal-title":"J. Phys. Chem."},{"key":"10.1074\/jbc.M301232200_bib33","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1021\/jp972682r","volume":"102","author":"Li","year":"1998","journal-title":"J. Phys. Chem. A"},{"key":"10.1074\/jbc.M301232200_bib34","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/protein\/6.7.723","volume":"6","author":"Shoichet","year":"1993","journal-title":"Protein Eng."},{"key":"10.1074\/jbc.M301232200_bib35","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/prot.340170305","volume":"17","author":"Meng","year":"1993","journal-title":"Proteins"},{"key":"10.1074\/jbc.M301232200_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0263-7855(88)80054-7","volume":"6","author":"Ferrin","year":"1988","journal-title":"J. Mol. Graph."},{"key":"10.1074\/jbc.M301232200_bib37","doi-asserted-by":"crossref","first-page":"36334","DOI":"10.1074\/jbc.M004778200","volume":"275","author":"Drum","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301232200_bib38","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1093\/emboj\/cdf681","volume":"21","author":"Shen","year":"2002","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M301232200_bib39","doi-asserted-by":"crossref","first-page":"8595","DOI":"10.1016\/S0021-9258(18)93016-4","volume":"266","author":"Tang","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301232200_bib40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/prot.10058","volume":"47","author":"Wang","year":"2002","journal-title":"Proteins"},{"key":"10.1074\/jbc.M301232200_bib41","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1073\/pnas.072685299","volume":"99","author":"Hodneland","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M301232200_bib42","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1128\/IAI.69.10.6532-6536.2001","volume":"69","author":"Kumar","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M301232200_bib43","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/jm010533y","volume":"45","author":"McGovern","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M301232200_bib44","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1367-5931(02)00339-3","volume":"6","author":"Shoichet","year":"2002","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1074\/jbc.M301232200_bib45","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1021\/jm020427b","volume":"46","author":"McGovern","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M301232200_bib46","doi-asserted-by":"crossref","first-page":"29211","DOI":"10.1074\/jbc.271.46.29211","volume":"271","author":"Han","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301232200_bib47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev.cellbio.18.012502.134748","volume":"18","author":"Barbieri","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M301232200_bib48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1124\/mol.54.2.231","volume":"54","author":"Tang","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M301232200_bib49","doi-asserted-by":"crossref","first-page":"14464","DOI":"10.1021\/bi0015562","volume":"39","author":"Tesmer","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301232200_bib50","doi-asserted-by":"crossref","first-page":"47785","DOI":"10.1074\/jbc.M107233200","volume":"276","author":"Onda","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301232200_bib51","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0223-5234(00)90154-5","volume":"35","author":"Bertelli","year":"2000","journal-title":"Eur. J. Med. Chem."},{"key":"10.1074\/jbc.M301232200_bib52","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0969-2126(02)00799-2","volume":"10","author":"Powers","year":"2002","journal-title":"Structure (Camb.)"},{"key":"10.1074\/jbc.M301232200_bib53","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1021\/jm010548w","volume":"45","author":"Doman","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M301232200_bib54","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1367-5931(00)00217-9","volume":"5","author":"Abagyan","year":"2001","journal-title":"Curr. Opin. Chem. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819751278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819751278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M301232200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T20:50:26Z","timestamp":1641243026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819751278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":54,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["S0021925819751278"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m301232200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}