{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:38:34Z","timestamp":1790919514325,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"31","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":6269,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,8]]},"DOI":"10.1074\/jbc.m302837200","type":"journal-article","created":{"date-parts":[[2003,7,25]],"date-time":"2003-07-25T17:45:52Z","timestamp":1059155152000},"page":"29261-29266","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":52,"title":["Calcium Dependence of the Interaction between Calmodulin and Anthrax Edema Factor"],"prefix":"10.1016","volume":"278","author":[{"given":"Tobias S.","family":"Ulmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandriyana","family":"Soelaiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude B.","family":"Klee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad","family":"Bax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M302837200_bib1","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1073\/pnas.79.10.3162","volume":"79","author":"Leppla","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M302837200_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0966-842X(02)02369-7","volume":"10","author":"Mourez","year":"2002","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M302837200_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/n35101998","volume":"414","author":"Pannifer","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M302837200_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","volume":"414","author":"Bradley","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M302837200_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0968-0004(06)80021-6","volume":"21","author":"Ikura","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M302837200_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1023\/A:1009253808876","volume":"11","author":"Nelson","year":"1998","journal-title":"Biometals"},{"key":"10.1074\/jbc.M302837200_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.bb.24.060195.000505","volume":"24","author":"Crivici","year":"1995","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1074\/jbc.M302837200_bib8","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1021\/bi00516a035","volume":"20","author":"Haiech","year":"1981","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M302837200_bib9","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1016\/S0021-9258(18)92938-8","volume":"266","author":"Linse","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M302837200_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0968-0004(84)90160-9","volume":"9","author":"Tsien","year":"1984","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M302837200_bib11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1083\/jcb.94.2.325","volume":"94","author":"Tsien","year":"1982","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M302837200_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0092-8674(02)00682-7","volume":"108","author":"Hoeflich","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M302837200_bib13","doi-asserted-by":"crossref","unstructured":"Huang, C. Y., Chau, V., Chock, P. B., Wang, J. H., and Sharma, R. K. (1981) 78, 871\u2013874","DOI":"10.1073\/pnas.78.2.871"},{"key":"10.1074\/jbc.M302837200_bib14","doi-asserted-by":"crossref","first-page":"36334","DOI":"10.1074\/jbc.M004778200","volume":"275","author":"Drum","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M302837200_bib15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/415396a","volume":"415","author":"Drum","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M302837200_bib16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0006-2952(90)90190-V","volume":"40","author":"Ikura","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M302837200_bib17","series-title":"Critical Stability Constants","author":"Martell","year":"1977"},{"key":"10.1074\/jbc.M302837200_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00197809","volume":"6","author":"Delaglio","year":"1995","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M302837200_bib19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/BF00404272","volume":"4","author":"Johnson","year":"1994","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M302837200_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1023\/A:1008268930690","volume":"12","author":"Pervushin","year":"1998","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M302837200_bib21","doi-asserted-by":"crossref","first-page":"13585","DOI":"10.1073\/pnas.95.23.13585","volume":"95","author":"Salzmann","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M302837200_bib22","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1021\/bi00188a015","volume":"33","author":"Stemmer","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M302837200_bib23","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1093\/emboj\/cdf681","volume":"21","author":"Shen","year":"2002","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M302837200_bib24","series-title":"Biophysical Chemistry","first-page":"591","volume":"1","author":"Edsall","year":"1958"},{"key":"10.1074\/jbc.M302837200_bib25","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1006\/jmbi.1999.3188","volume":"293","author":"Malmendal","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M302837200_bib26","doi-asserted-by":"crossref","first-page":"13744","DOI":"10.1021\/bi9806448","volume":"37","author":"Evenas","year":"1998","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M302837200_bib27","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1021\/bi00309a003","volume":"23","author":"Ikura","year":"1984","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M302837200_bib28","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0968-0004(00)01665-0","volume":"25","author":"Riek","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M302837200_bib29","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1128\/IAI.70.9.4997-5007.2002","volume":"70","author":"Kumar","year":"2002","journal-title":"Infect. Immun."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820844299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820844299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M302837200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T21:21:11Z","timestamp":1641417671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820844299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":29,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["S0021925820844299"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m302837200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}