{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:30:19Z","timestamp":1791297019379,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":6236,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,9]]},"DOI":"10.1074\/jbc.m302841200","type":"journal-article","created":{"date-parts":[[2003,9,5]],"date-time":"2003-09-05T19:23:15Z","timestamp":1062789795000},"page":"34918-34924","source":"Crossref","is-referenced-by-count":66,"title":["Kennedy's Disease"],"prefix":"10.1016","volume":"278","author":[{"given":"Michelle A.","family":"LaFevre-Bernt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Ellerby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M302841200_bib1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1023\/A:1005344403603","volume":"20","author":"Fischbeck","year":"1997","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1074\/jbc.M302841200_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/352077a0","volume":"352","author":"La Spada","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M302841200_bib3","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.1073\/pnas.85.21.8151","volume":"85","author":"Brown","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M302841200_bib4","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0140-6736(94)92385-X","volume":"344","author":"Yong","year":"1994","journal-title":"Lancet"},{"key":"10.1074\/jbc.M302841200_bib5","first-page":"456","volume":"15","author":"Pinsky","year":"1992","journal-title":"Clin. Invest. Med."},{"key":"10.1074\/jbc.M302841200_bib6","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0896-6273(95)90138-8","volume":"15","author":"Ross","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.M302841200_bib7","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0092-8674(95)90201-5","volume":"83","author":"Beato","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M302841200_bib8","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M302841200_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1471-4159.1999.0720185.x","volume":"72","author":"Ellerby","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M302841200_bib10","doi-asserted-by":"crossref","first-page":"9158","DOI":"10.1074\/jbc.273.15.9158","volume":"273","author":"Wellington","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M302841200_bib11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/ng0896-442","volume":"13","author":"Goldberg","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M302841200_bib12","doi-asserted-by":"crossref","first-page":"29238","DOI":"10.1074\/jbc.272.46.29238","volume":"272","author":"Miyashita","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M302841200_bib13","doi-asserted-by":"crossref","first-page":"8730","DOI":"10.1074\/jbc.274.13.8730","volume":"274","author":"Ellerby","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M302841200_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/hmg\/10.2.107","volume":"10","author":"Abel","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M302841200_bib15","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0896-6273(02)00834-6","volume":"35","author":"Katsuno","year":"2002","journal-title":"Neuron"},{"key":"10.1074\/jbc.M302841200_bib16","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0896-6273(02)00875-9","volume":"35","author":"Takeyama","year":"2002","journal-title":"Neuron"},{"key":"10.1074\/jbc.M302841200_bib17","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M302841200_bib18","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1523\/JNEUROSCI.22-18-07862.2002","volume":"22","author":"Wellington","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M302841200_bib19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1054-3589(08)60115-5","volume":"47","author":"Brinkmann","year":"2000","journal-title":"Adv. Pharmacol."},{"key":"10.1074\/jbc.M302841200_bib20","doi-asserted-by":"crossref","first-page":"7200","DOI":"10.1073\/pnas.121173298","volume":"98","author":"Lin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M302841200_bib21","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1073\/pnas.96.10.5458","volume":"96","author":"Yeh","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M302841200_bib22","doi-asserted-by":"crossref","unstructured":"Kyriakis, J. M. (2000) Science's STKE http:\/\/STKE.sciencemag.org\/cgi\/content\/full\/sigtrans;2000\/48\/pe1.","DOI":"10.1126\/stke.2000.48.pe1"},{"key":"10.1074\/jbc.M302841200_bib23","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1093\/emboj\/19.20.5406","volume":"19","author":"Migliaccio","year":"2000","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M302841200_bib24","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1074\/jbc.M108255200","volume":"277","author":"Ueda","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M302841200_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-0270(87)90041-0","volume":"20","author":"Koh","year":"1987","journal-title":"J. Neurosci. Methods"},{"key":"10.1074\/jbc.M302841200_bib26","doi-asserted-by":"crossref","first-page":"15174","DOI":"10.1073\/pnas.93.26.15174","volume":"93","author":"Lewis","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M302841200_bib27","doi-asserted-by":"crossref","first-page":"29304","DOI":"10.1074\/jbc.M204131200","volume":"277","author":"Gioeli","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M302841200_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0165-022X(01)00136-1","volume":"48","author":"Sampt","year":"2001","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10.1074\/jbc.M302841200_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0092-8674(00)81781-X","volume":"95","author":"Klement","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M302841200_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mcne.1999.0773","volume":"14","author":"Peters","year":"1999","journal-title":"Mol. Cell Neurosci."},{"key":"10.1074\/jbc.M302841200_bib31","first-page":"2","volume":"2","author":"Nucifora","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M302841200_bib32","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1093\/hmg\/10.26.3063","volume":"10","author":"Welch","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M302841200_bib33","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0896-6273(02)00872-3","volume":"35","author":"Ross","year":"2002","journal-title":"Neuron"},{"key":"10.1074\/jbc.M302841200_bib34","first-page":"4467","volume":"6","author":"Cooper","year":"1986","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M302841200_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.10119","volume":"192","author":"Martindale","year":"2002","journal-title":"J. Cell Physiol."},{"key":"10.1074\/jbc.M302841200_bib36","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0047-6374(02)00025-8","volume":"123","author":"Suh","year":"2002","journal-title":"Mech. Ageing Dev."},{"key":"10.1074\/jbc.M302841200_bib37","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1126\/science.1071552","volume":"296","author":"Vaudry","year":"2002","journal-title":"Science"},{"key":"10.1074\/jbc.M302841200_bib38","doi-asserted-by":"crossref","first-page":"11975","DOI":"10.1073\/pnas.95.20.11975","volume":"95","author":"Murray","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M302841200_bib39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(03)00349-0","volume":"113","author":"Chen","year":"2003","journal-title":"Cell"},{"key":"10.1074\/jbc.M302841200_bib40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0896-6273(03)00258-7","volume":"38","author":"Emamian","year":"2003","journal-title":"Neuron"},{"key":"10.1074\/jbc.M302841200_bib41","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1534-5807(02)00188-0","volume":"2","author":"Humbert","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M302841200_bib42","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.277.5324.373","volume":"277","author":"Kim","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M302841200_bib43","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/21650","volume":"399","author":"Lu","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M302841200_bib44","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1126\/science.1062382","volume":"293","author":"Wittmann","year":"2001","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820835431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820835431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M302841200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T20:48:44Z","timestamp":1641415724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820835431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":44,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["S0021925820835431"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m302841200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}