{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:17:14Z","timestamp":1779243434906,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"34","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":6269,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,8]]},"DOI":"10.1074\/jbc.m304607200","type":"journal-article","created":{"date-parts":[[2003,8,15]],"date-time":"2003-08-15T20:14:13Z","timestamp":1060978453000},"page":"31529-31535","source":"Crossref","is-referenced-by-count":54,"title":["Correlation between Alterations of the Penicillin-binding Protein 2 and Modifications of the Peptidoglycan Structure in Neisseria meningitidis with Reduced Susceptibility to Penicillin G"],"prefix":"10.1016","volume":"278","author":[{"given":"Aude","family":"Antignac","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo G.","family":"Boneca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Rousselle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelkader","family":"Namane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Philippe","family":"Carlier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio A.","family":"V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhamed-Kheir","family":"Taha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M304607200_bib1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1128\/AAC.19.2.316","volume":"19","author":"Barbour","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1128\/AAC.20.1.109","volume":"20","author":"Dougherty","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib3","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1126\/science.287.5459.1809","volume":"287","author":"Tettelin","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M304607200_bib4","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35006655","volume":"404","author":"Parkhill","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M304607200_bib5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF01964130","volume":"8","author":"Fontanals","year":"1989","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1074\/jbc.M304607200_bib6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0140-6736(83)91846-9","volume":"1","author":"Dillon","year":"1983","journal-title":"Lancet"},{"key":"10.1074\/jbc.M304607200_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF01591498","volume":"15","author":"Vazquez","year":"1996","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1074\/jbc.M304607200_bib8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0140-6736(88)91029-X","volume":"1","author":"Botha","year":"1988","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"10.1074\/jbc.M304607200_bib9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/clinids\/24.Supplement_1.S98","volume":"24","author":"Oppenheim","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"10.1074\/jbc.M304607200_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/332173a0","volume":"332","author":"Spratt","year":"1988","journal-title":"Nature"},{"key":"10.1074\/jbc.M304607200_bib11","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1128\/AAC.32.5.706","volume":"32","author":"Mendelman","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1128\/AAC.46.3.769-777.2002","volume":"46","author":"Ropp","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib13","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1093\/oxfordjournals.molbev.a026061","volume":"16","author":"Feil","year":"1999","journal-title":"Mol. Biol. Evol."},{"key":"10.1074\/jbc.M304607200_bib14","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/oxfordjournals.molbev.a026159","volume":"16","author":"Holmes","year":"1999","journal-title":"Mol. Biol. Evol."},{"key":"10.1074\/jbc.M304607200_bib15","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1073\/pnas.86.22.8988","volume":"86","author":"Spratt","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304607200_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00182388","volume":"34","author":"Spratt","year":"1992","journal-title":"J. Mol. Evol."},{"key":"10.1074\/jbc.M304607200_bib17","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1128\/AAC.34.11.2269","volume":"34","author":"Saez-Nieto","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1128\/jb.176.2.333-337.1994","volume":"176","author":"Bowler","year":"1994","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M304607200_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/jac\/47.3.285","volume":"47","author":"Antignac","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1074\/jbc.M304607200_bib20","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1128\/jb.85.6.1274-1279.1963","volume":"85","author":"Kellogg","year":"1963","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M304607200_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0076-6879(90)85008-C","volume":"185","author":"Studier","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M304607200_bib22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1574-6968.1987.tb02626.x","volume":"48","author":"Abdillahi","year":"1987","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1074\/jbc.M304607200_bib23","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/clinids\/7.4.504","volume":"7","author":"Frasch","year":"1985","journal-title":"Rev. Infect. Dis."},{"key":"10.1074\/jbc.M304607200_bib24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1128\/AAC.35.2.300","volume":"35","author":"Lujan","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib25","doi-asserted-by":"crossref","first-page":"10088","DOI":"10.1016\/S0021-9258(19)81481-3","volume":"263","author":"Glauner","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304607200_bib26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/jcm.35.3.745-750.1997","volume":"35","author":"Guibourdenche","year":"1997","journal-title":"J. Clin. Microbiol."},{"key":"10.1074\/jbc.M304607200_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0923-2508(99)80052-7","volume":"150","author":"Kriz","year":"1999","journal-title":"Res. Microbiol."},{"key":"10.1074\/jbc.M304607200_bib28","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1086\/340414","volume":"185","author":"Mayer","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M304607200_bib29","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/emboj\/19.5.1068","volume":"19","author":"Deghmane","year":"2000","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M304607200_bib30","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1073\/pnas.83.1.140","volume":"83","author":"Perkins","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304607200_bib31","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1046\/j.1365-2958.1998.00876.x","volume":"28","author":"Taha","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M304607200_bib32","series-title":"Experiments in Molecular Genetics","first-page":"352","author":"Miller","year":"1972"},{"key":"10.1074\/jbc.M304607200_bib33","doi-asserted-by":"crossref","first-page":"45106","DOI":"10.1074\/jbc.M107608200","volume":"276","author":"Dessen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304607200_bib34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1432-1033.1982.tb06711.x","volume":"125","author":"Naumann","year":"1982","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M304607200_bib35","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s000180050160","volume":"54","author":"Hakenbeck","year":"1998","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M304607200_bib36","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1073\/pnas.97.10.5028","volume":"97","author":"van Heijenoort","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304607200_bib37","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1073\/pnas.87.14.5415","volume":"87","author":"Garcia-Bustos","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304607200_bib38","doi-asserted-by":"crossref","first-page":"16490","DOI":"10.1074\/jbc.M909877199","volume":"275","author":"Mainardi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304607200_bib39","doi-asserted-by":"crossref","first-page":"35801","DOI":"10.1074\/jbc.M204319200","volume":"277","author":"Mainardi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304607200_bib40","doi-asserted-by":"crossref","first-page":"29053","DOI":"10.1074\/jbc.272.46.29053","volume":"272","author":"Boneca","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304607200_bib41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/elps.1150190423","volume":"19","author":"Hakenbeck","year":"1998","journal-title":"Electrophoresis"},{"issue":"Suppl, 1","key":"10.1074\/jbc.M304607200_bib42","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/clinids\/24.Supplement_1.S85","volume":"24","author":"Tomasz","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"10.1074\/jbc.M304607200_bib43","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1073\/pnas.080067697","volume":"97","author":"Filipe","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304607200_bib44","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/jb.178.7.1788-1792.1996","volume":"178","author":"Severin","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M304607200_bib45","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1128\/jb.178.1.168-174.1996","volume":"178","author":"Severin","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M304607200_bib46","doi-asserted-by":"crossref","first-page":"11594","DOI":"10.1016\/S0021-9258(19)50242-3","volume":"268","author":"Burroughs","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304607200_bib47","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/infdis\/167.2.464","volume":"167","author":"Burroughs","year":"1993","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M304607200_bib48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0378-1097(03)00252-0","volume":"222","author":"Alonso","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1074\/jbc.M304607200_bib49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1128\/AAC.31.2.178","volume":"31","author":"Garcia-Bustos","year":"1987","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib50","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1128\/AAC.28.1.90","volume":"28","author":"Dougherty","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1128\/jb.163.1.69-74.1985","volume":"163","author":"Dougherty","year":"1985","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M304607200_bib52","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1128\/AAC.46.7.2208-2218.2002","volume":"46","author":"Dabernat","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib53","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1128\/AAC.45.6.1693-1699.2001","volume":"45","author":"Ubukata","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M304607200_bib54","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1128\/JB.185.7.2178-2186.2003","volume":"185","author":"Ghosh","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M304607200_bib55","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1046\/j.1432-1033.2002.03064.x","volume":"269","author":"Jennings","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M304607200_bib56","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1432-1033.1994.00597.x","volume":"224","author":"Romeis","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M304607200_bib57","doi-asserted-by":"crossref","first-page":"31521","DOI":"10.1074\/jbc.M304749200","volume":"278","author":"Antignac","year":"2003","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582083943X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582083943X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M304607200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T21:05:50Z","timestamp":1641416750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582083943X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":57,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["S002192582083943X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m304607200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}