{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:23:20Z","timestamp":1792185800077,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"47","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":6170,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1074\/jbc.m306587200","type":"journal-article","created":{"date-parts":[[2003,11,14]],"date-time":"2003-11-14T15:59:24Z","timestamp":1068825564000},"page":"46252-46260","source":"Crossref","is-referenced-by-count":85,"title":["The Lip Lipoprotein from Neisseria gonorrhoeae Stimulates Cytokine Release and NF-\u03baB Activation in Epithelial Cells in a Toll-like Receptor 2-dependent Manner"],"prefix":"10.1016","volume":"278","author":[{"given":"Philip L.","family":"Fisette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Ram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorunn M.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin R.","family":"Ingalls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M306587200_bib1","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1128\/IAI.69.9.5840-5848.2001","volume":"69","author":"Fichorova","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M306587200_bib2","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1128\/IAI.70.10.5808-5815.2002","volume":"70","author":"Harvey","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M306587200_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1084\/jem.186.2.247","volume":"186","author":"Naumann","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M306587200_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M306587200_bib5","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1074\/jbc.274.16.10689","volume":"274","author":"Chow","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M306587200_bib6","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","volume":"162","author":"Hoshino","year":"1999","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib7","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M306587200_bib8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1126\/science.285.5428.736","volume":"285","author":"Aliprantis","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M306587200_bib9","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1126\/science.285.5428.732","author":"Brightbill","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M306587200_bib10","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.4049\/jimmunol.163.5.2382","volume":"163","author":"Hirschfeld","year":"1999","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib11","doi-asserted-by":"crossref","first-page":"33419","DOI":"10.1074\/jbc.274.47.33419","volume":"274","author":"Lien","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M306587200_bib12","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.4049\/jimmunol.163.7.3920","volume":"163","author":"Means","year":"1999","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib13","doi-asserted-by":"crossref","first-page":"17406","DOI":"10.1074\/jbc.274.25.17406","volume":"274","author":"Schwandner","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M306587200_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.163.1.1","volume":"163","author":"Yoshimura","year":"1999","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.166.1.15","volume":"166","author":"Hajjar","year":"2001","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib16","doi-asserted-by":"crossref","first-page":"13766","DOI":"10.1073\/pnas.250476497","volume":"97","author":"Ozinsky","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M306587200_bib17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4049\/jimmunol.169.1.10","volume":"169","author":"Takeuchi","year":"2002","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib18","doi-asserted-by":"crossref","first-page":"7125","DOI":"10.4049\/jimmunol.165.12.7125","volume":"165","author":"Wyllie","year":"2000","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib19","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/intimm\/13.7.933","volume":"13","author":"Takeuchi","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1074\/jbc.M306587200_bib20","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1128\/IAI.69.4.2230-2236.2001","volume":"69","author":"Ingalls","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M306587200_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1086\/317647","volume":"183","author":"Pridmore","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M306587200_bib22","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.4049\/jimmunol.168.4.1533","volume":"168","author":"Massari","year":"2002","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib23","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1128\/IAI.43.3.994-999.1984","volume":"43","author":"Cannon","year":"1984","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M306587200_bib24","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1128\/JCM.38.8.2914-2916.2000","volume":"38","author":"Trees","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"10.1074\/jbc.M306587200_bib25","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1073\/pnas.80.14.4518","volume":"80","author":"Wagner","year":"1993","journal-title":"Proc. Nat. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M306587200_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2958.1989.tb00102.x","volume":"3","author":"Woods","year":"1989","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M306587200_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1574-6968.1987.tb02153.x","volume":"43","author":"Gotschlich","year":"1987","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1074\/jbc.M306587200_bib28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2958.1987.tb00510.x","volume":"1","author":"Kawula","year":"1987","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M306587200_bib29","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2958.1989.tb00205.x","volume":"3","author":"Woods","year":"1989","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M306587200_bib30","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/infdis\/162.2.506","volume":"162","author":"Apicella","year":"1990","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M306587200_bib31","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.4049\/jimmunol.153.6.2653","volume":"153","author":"Manthey","year":"1994","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib32","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4049\/jimmunol.165.2.618","volume":"165","author":"Hirschfeld","year":"2000","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib33","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1172\/JCI111872","volume":"75","author":"Gnehm","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M306587200_bib34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1172\/JCI113067","volume":"80","author":"Densen","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M306587200_bib35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1515\/znb-1952-0303","volume":"B7","author":"Westphal","year":"1952","journal-title":"Z. Naturforsch."},{"key":"10.1074\/jbc.M306587200_bib36","first-page":"13","volume":"128","author":"Schneider","year":"1982","journal-title":"J. Gen. Microbiol."},{"key":"10.1074\/jbc.M306587200_bib37","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1128\/JB.129.2.983-992.1977","volume":"129","author":"Biswas","year":"1977","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M306587200_bib38","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1365-2958.1990.tb00673.x","volume":"4","author":"Carbonetti","year":"1990","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M306587200_bib39","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1086\/314608","volume":"179","author":"Hobbs","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M306587200_bib40","series-title":"The Pathogenic Neisseriae: Proceedings of the Fourth International Symposium","first-page":"579","author":"Zollinger","year":"1984"},{"key":"10.1074\/jbc.M306587200_bib41","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.4049\/jimmunol.168.5.2424","volume":"168","author":"Fichorova","year":"2002","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M306587200_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0003-2697(84)90320-8","volume":"136","author":"Blake","year":"1984","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M306587200_bib43","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1084\/jem.162.6.2017","volume":"162","author":"Hitchcock","year":"1985","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M306587200_bib44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0167-5699(92)90198-G","volume":"13","author":"Janeway","year":"1992","journal-title":"Immunol. Today"},{"key":"10.1074\/jbc.M306587200_bib45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2958.1989.tb00103.x","volume":"2","author":"Baehr","year":"1989","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M306587200_bib46","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1128\/IAI.56.4.773-778.1988","volume":"56","author":"Bhattacharjee","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M306587200_bib47","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1084\/jem.164.6.2038","volume":"164","author":"Strittmatter","year":"1986","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M306587200_bib48","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1432-1033.1973.tb02757.x","volume":"34","author":"Hantke","year":"1973","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M306587200_bib49","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1084\/jem.185.11.1951","volume":"185","author":"M\u00fchlradt","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M306587200_bib50","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1128\/IAI.60.11.4704-4708.1992","volume":"60","author":"Hoehn","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M306587200_bib51","series-title":"The Pathogenic Neisseriae: Proceedings of the Fourth International Symposium","first-page":"360","author":"Chen","year":"1984"},{"issue":"suppl.","key":"10.1074\/jbc.M306587200_bib52","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1128\/CMR.2.Suppl.S1","volume":"2","author":"Cannon","year":"1989","journal-title":"Clin. Microbiol. Rev."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820759004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820759004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M306587200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T09:22:22Z","timestamp":1682587342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820759004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":52,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["S0021925820759004"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m306587200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,11]]}}}